GREMLIN Database
DUF2335 - Predicted membrane protein (DUF2335)
PFAM: PF10097 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 50 (49)
Sequences: 3473 (3086)
Seq/√Len: 440.8
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A11_E2.4401.00
28_Q32_H2.1801.00
13_L16_A2.1481.00
2_P5_I2.1291.00
26_K29_A2.1281.00
16_A21_L2.1241.00
33_E36_K2.1121.00
10_E15_G1.9481.00
19_R25_E1.8391.00
18_E22_A1.7911.00
10_E17_A1.7881.00
27_Q31_R1.6611.00
22_A26_K1.5631.00
37_K40_E1.4491.00
30_H35_E1.4331.00
44_R47_R1.3571.00
4_E8_E1.3351.00
26_K32_H1.1921.00
27_Q32_H1.1881.00
8_E11_E1.1421.00
30_H34_L1.0991.00
23_M28_Q1.0791.00
5_I8_E1.0591.00
7_A12_I1.0551.00
13_L18_E1.0351.00
22_A25_E1.0051.00
42_N45_R0.9591.00
38_V42_N0.9311.00
10_E13_L0.9121.00
31_R35_E0.9061.00
44_R48_R0.8861.00
29_A33_E0.8631.00
13_L21_L0.8431.00
6_L17_A0.8361.00
24_A28_Q0.8061.00
42_N46_S0.8021.00
34_L39_L0.7911.00
33_E37_K0.7801.00
15_G18_E0.7611.00
43_I47_R0.7531.00
34_L38_V0.7481.00
36_K40_E0.7291.00
27_Q35_E0.7191.00
43_I46_S0.7151.00
41_A45_R0.7121.00
23_M32_H0.6891.00
22_A29_A0.6851.00
29_A32_H0.6801.00
6_L12_I0.6771.00
13_L17_A0.6681.00
41_A47_R0.6671.00
33_E40_E0.6621.00
40_E44_R0.6270.99
16_A20_I0.6250.99
6_L21_L0.6220.99
12_I17_A0.6190.99
19_R23_M0.6150.99
37_K43_I0.6140.99
3_P9_Y0.6100.99
3_P8_E0.6060.99
20_I24_A0.5990.99
12_I20_I0.5960.99
10_E16_A0.5840.99
37_K41_A0.5730.99
10_E14_P0.5720.99
4_E7_A0.5480.98
46_S49_G0.5480.98
39_L42_N0.5330.98
41_A44_R0.5250.98
19_R24_A0.5110.97
7_A10_E0.5070.97
32_H36_K0.5040.97
15_G21_L0.5010.97
9_Y20_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhoA 1 0.28 6.9 0.836 Contact Map
3erxA 3 0.58 4.8 0.847 Contact Map
4gfjA 1 0 4.2 0.852 Contact Map
1h3oA 1 0.52 4.1 0.853 Contact Map
3u1wA 3 0.96 4.1 0.853 Contact Map
1gqiA 2 0.44 3.8 0.855 Contact Map
3j7yq 1 0.98 3.5 0.857 Contact Map
4g09A 2 1 3.5 0.858 Contact Map
1kaeA 2 1 3.4 0.859 Contact Map
1pazA 1 0.52 3.1 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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