GREMLIN Database
DUF2333 - Uncharacterized protein conserved in bacteria (DUF2333)
PFAM: PF10095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 330 (321)
Sequences: 1465 (943)
Seq/√Len: 52.7
META: 0.797

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_D162_R5.7391.00
93_N238_D5.5811.00
71_D150_R3.9111.00
105_L253_F3.8991.00
288_V293_I3.7871.00
66_A153_I3.6881.00
65_V253_F3.5701.00
133_F152_G3.5271.00
135_F145_T3.3321.00
29_S88_L2.9561.00
132_Q151_K2.9331.00
67_E71_D2.8321.00
125_D158_R2.8061.00
66_A133_F2.7841.00
67_E157_E2.7711.00
17_Y21_L2.6631.00
111_N186_D2.6441.00
125_D162_R2.5211.00
258_E275_R2.5051.00
45_A56_Y2.4561.00
77_L92_P2.3681.00
66_A102_V2.3511.00
148_E151_K2.2001.00
150_R154_E2.1981.00
101_Q246_T2.1831.00
107_R130_E2.1701.00
144_S147_S2.1661.00
262_A266_E2.1611.00
96_F100_V2.1291.00
128_I155_A2.0421.00
62_L102_V2.0191.00
76_Y145_T1.9991.00
40_N64_R1.9911.00
58_T105_L1.9841.00
77_L85_G1.9501.00
23_V27_Y1.9451.00
60_A160_L1.9441.00
102_V133_F1.9000.99
78_S137_N1.8970.99
155_A158_R1.8710.99
128_I132_Q1.8580.99
62_L105_L1.8490.99
67_E153_I1.8390.99
57_T259_V1.8350.99
25_G88_L1.8230.99
35_F252_H1.8070.99
186_D189_K1.8040.99
99_L137_N1.7950.99
111_N189_K1.7720.99
54_T175_A1.7670.99
266_E271_L1.7550.99
21_L87_W1.7450.99
30_R73_P1.6980.99
63_I157_E1.6970.99
65_V102_V1.6830.99
132_Q152_G1.6770.99
132_Q148_E1.6520.98
28_W85_G1.6420.98
141_I144_S1.6170.98
247_A313_I1.6120.98
17_Y82_L1.5980.98
135_F148_E1.5950.98
305_H308_V1.5910.98
255_K282_E1.5900.98
59_T63_I1.5880.98
107_R112_D1.5560.98
12_A16_V1.5520.98
214_D217_A1.5460.98
101_Q183_W1.5360.97
206_R210_D1.4970.97
135_F139_S1.4890.97
27_Y73_P1.4810.97
132_Q155_A1.4590.97
130_E134_N1.4580.97
111_N182_E1.4540.96
18_L87_W1.4530.96
131_P134_N1.4430.96
113_F257_I1.4430.96
125_D155_A1.4270.96
219_Q223_T1.4110.96
205_R226_E1.4020.96
207_L272_V1.3970.96
187_V250_L1.3800.95
215_P267_K1.3780.95
258_E271_L1.3750.95
262_A271_L1.3740.95
61_T65_V1.3720.95
64_R67_E1.3630.95
62_L106_A1.3520.95
183_W253_F1.3310.94
271_L275_R1.3310.94
254_L274_L1.3250.94
107_R135_F1.3200.94
29_S91_M1.3130.94
100_V130_E1.2930.93
26_W30_R1.2800.93
185_A188_E1.2780.93
206_R229_V1.2750.93
35_F61_T1.2690.93
82_L85_G1.2690.93
182_E186_D1.2660.93
325_E328_S1.2460.92
36_D39_E1.2370.92
206_R209_T1.2230.91
211_L221_T1.2230.91
211_L217_A1.2220.91
24_L28_W1.2170.91
213_G221_T1.2000.90
17_Y85_G1.1950.90
59_T156_L1.1850.90
57_T61_T1.1790.90
139_S148_E1.1760.89
107_R134_N1.1710.89
235_E238_D1.1600.89
121_T193_S1.1590.89
107_R186_D1.1580.89
292_M302_F1.1570.89
38_R259_V1.1560.89
98_V246_T1.1560.89
41_A52_L1.1560.89
212_A217_A1.1550.89
153_I157_E1.1500.88
59_T109_L1.1460.88
264_V267_K1.1310.88
68_T248_W1.1310.88
29_S73_P1.1290.87
34_L251_L1.1210.87
45_A52_L1.1070.86
56_Y160_L1.1040.86
41_A45_A1.0980.86
54_T218_R1.0970.86
112_D182_E1.0890.85
162_R171_A1.0810.85
31_E241_Y1.0730.85
102_V152_G1.0730.85
130_E135_F1.0710.84
210_D229_V1.0650.84
102_V106_A1.0610.84
25_G29_S1.0590.84
22_L26_W1.0570.84
112_D189_K1.0560.84
325_E329_Q1.0560.84
217_A220_S1.0510.83
216_A267_K1.0450.83
65_V105_L1.0430.83
93_N235_E1.0360.82
213_G217_A1.0350.82
61_T64_R1.0330.82
117_Q273_S1.0280.82
21_L24_L1.0200.81
319_A322_D1.0180.81
30_R33_D1.0070.81
18_L21_L1.0030.80
241_Y288_V1.0000.80
101_Q253_F0.9970.80
112_D186_D0.9960.80
139_S145_T0.9900.79
63_I153_I0.9870.79
21_L85_G0.9860.79
115_R178_D0.9770.79
157_E161_A0.9730.78
39_E42_Q0.9670.78
36_D41_A0.9670.78
196_Q200_A0.9630.78
63_I67_E0.9620.78
56_Y60_A0.9600.77
42_Q48_D0.9560.77
99_L145_T0.9560.77
252_H255_K0.9520.77
58_T260_D0.9520.77
213_G219_Q0.9490.77
172_Q219_Q0.9470.76
183_W257_I0.9430.76
197_R242_E0.9410.76
25_G28_W0.9410.76
183_W246_T0.9400.76
39_E43_A0.9390.76
44_R64_R0.9380.76
150_R153_I0.9370.76
151_K154_E0.9350.75
41_A57_T0.9310.75
66_A69_L0.9290.75
172_Q213_G0.9240.75
201_S314_S0.9200.74
68_T94_W0.9140.74
35_F64_R0.9120.74
166_P169_P0.9120.74
188_E324_R0.9100.73
141_I147_S0.9070.73
172_Q221_T0.9020.73
66_A152_G0.8960.72
65_V98_V0.8790.71
257_I274_L0.8710.70
298_G310_A0.8680.70
132_Q139_S0.8650.70
326_L330_G0.8610.69
205_R228_E0.8590.69
130_E186_D0.8580.69
137_N145_T0.8550.69
208_N211_L0.8550.69
100_V111_N0.8520.68
211_L219_Q0.8500.68
327_L330_G0.8430.68
121_T197_R0.8400.67
213_G220_S0.8290.66
182_E189_K0.8280.66
76_Y137_N0.8210.66
109_L156_L0.8120.65
272_V275_R0.8110.65
52_L57_T0.8110.65
254_L257_I0.8090.64
45_A51_K0.8060.64
217_A221_T0.8040.64
42_Q51_K0.8040.64
160_L164_S0.8030.64
122_E127_A0.8030.64
182_E185_A0.8020.64
218_R263_D0.7940.63
176_R192_G0.7940.63
209_T219_Q0.7910.63
107_R145_T0.7910.63
48_D56_Y0.7900.63
17_Y20_V0.7880.62
11_G19_L0.7860.62
56_Y112_D0.7850.62
26_W31_E0.7810.62
45_A49_G0.7790.61
21_L25_G0.7790.61
100_V246_T0.7770.61
181_R328_S0.7770.61
167_D170_D0.7760.61
233_W236_I0.7750.61
125_D171_A0.7750.61
108_A186_D0.7710.61
98_V247_A0.7700.61
65_V248_W0.7690.60
318_A321_I0.7680.60
37_V41_A0.7670.60
100_V107_R0.7650.60
138_D145_T0.7630.60
208_N227_V0.7630.60
209_T213_G0.7620.60
106_A156_L0.7610.60
104_D190_R0.7600.60
234_L238_D0.7590.59
141_I148_E0.7530.59
211_L220_S0.7470.58
101_Q105_L0.7470.58
284_T299_F0.7460.58
14_L18_L0.7420.58
81_V85_G0.7420.58
44_R60_A0.7400.58
42_Q52_L0.7390.57
283_A287_P0.7370.57
204_Q283_A0.7320.57
40_N43_A0.7310.57
133_F153_I0.7310.57
246_T253_F0.7310.57
187_V320_I0.7300.56
118_S130_E0.7300.56
157_E160_L0.7280.56
101_Q123_D0.7270.56
12_A19_L0.7260.56
165_D222_P0.7250.56
107_R185_A0.7230.56
203_G230_K0.7230.56
134_N145_T0.7160.55
188_E298_G0.7070.54
289_W302_F0.7070.54
218_R223_T0.7060.54
40_N60_A0.7060.54
284_T309_M0.7040.54
94_W98_V0.7040.54
93_N234_L0.7030.54
30_R91_M0.7020.54
44_R157_E0.7010.53
189_K320_I0.7000.53
133_F156_L0.6970.53
13_L17_Y0.6960.53
307_L310_A0.6930.53
178_D192_G0.6930.53
10_I13_L0.6930.53
297_S302_F0.6920.53
72_K75_G0.6890.52
48_D51_K0.6890.52
132_Q135_F0.6860.52
276_Q279_R0.6860.52
264_V269_N0.6840.52
317_N321_I0.6830.52
208_N213_G0.6820.51
37_V61_T0.6810.51
172_Q220_S0.6790.51
183_W267_K0.6790.51
232_P235_E0.6740.51
278_I282_E0.6730.51
86_V167_D0.6720.50
234_L243_A0.6690.50
22_L25_G0.6680.50
23_V26_W0.6680.50
246_T320_I0.6660.50
34_L252_H0.6640.50
106_A133_F0.6630.49
128_I158_R0.6610.49
114_S311_S0.6600.49
102_V253_F0.6590.49
308_V325_E0.6590.49
100_V118_S0.6580.49
203_G272_V0.6560.49
28_W73_P0.6560.49
38_R42_Q0.6540.49
111_N132_Q0.6530.48
40_N44_R0.6530.48
127_A137_N0.6510.48
193_S197_R0.6510.48
195_S241_Y0.6510.48
115_R179_N0.6510.48
54_T142_L0.6510.48
25_G30_R0.6500.48
78_S96_F0.6490.48
117_Q322_D0.6420.47
121_T124_P0.6390.47
36_D57_T0.6390.47
111_N144_S0.6370.47
109_L186_D0.6370.47
310_A314_S0.6350.47
49_G52_L0.6350.47
11_G16_V0.6330.46
309_M318_A0.6310.46
239_V243_A0.6310.46
11_G18_L0.6290.46
47_A52_L0.6290.46
116_S175_A0.6290.46
200_A206_R0.6290.46
18_L23_V0.6280.46
81_V141_I0.6250.45
131_P186_D0.6220.45
36_D255_K0.6210.45
70_L150_R0.6210.45
35_F41_A0.6200.45
46_A56_Y0.6190.45
59_T62_L0.6180.45
115_R192_G0.6170.45
193_S241_Y0.6150.44
211_L214_D0.6150.44
17_Y24_L0.6120.44
82_L86_V0.6110.44
63_I160_L0.6100.44
57_T60_A0.6090.44
204_Q210_D0.6080.44
62_L65_V0.6070.44
285_Q299_F0.6070.44
207_L275_R0.6060.44
131_P135_F0.6050.43
131_P246_T0.6050.43
117_Q178_D0.6040.43
251_L284_T0.6040.43
307_L315_R0.6040.43
128_I131_P0.6040.43
131_P137_N0.6020.43
210_D227_V0.6010.43
105_L183_W0.5990.43
273_S279_R0.5990.43
263_D267_K0.5980.43
37_V57_T0.5980.43
109_L113_F0.5980.43
321_I326_L0.5970.43
12_A154_E0.5960.42
80_D146_E0.5940.42
127_A145_T0.5930.42
27_Y88_L0.5910.42
151_K155_A0.5910.42
23_V30_R0.5910.42
91_M294_L0.5880.42
313_I318_A0.5860.41
12_A86_V0.5840.41
101_Q162_R0.5820.41
117_Q120_S0.5790.41
186_D246_T0.5790.41
169_P221_T0.5780.41
44_R160_L0.5780.41
38_R161_A0.5760.40
313_I322_D0.5760.40
33_D287_P0.5730.40
165_D168_Q0.5700.40
151_K286_E0.5700.40
100_V186_D0.5690.40
59_T160_L0.5680.40
259_V271_L0.5670.40
161_A225_S0.5670.40
176_R179_N0.5640.39
61_T253_F0.5630.39
209_T221_T0.5620.39
105_L144_S0.5610.39
64_R218_R0.5610.39
234_L293_I0.5610.39
119_Q248_W0.5580.39
59_T159_Y0.5580.39
204_Q207_L0.5570.39
206_R297_S0.5570.39
40_N160_L0.5560.38
46_A49_G0.5560.38
112_D155_A0.5560.38
38_R43_A0.5550.38
207_L226_E0.5530.38
113_F289_W0.5510.38
283_A286_E0.5510.38
234_L292_M0.5500.38
149_Y260_D0.5500.38
235_E239_V0.5490.38
62_L253_F0.5490.38
194_L246_T0.5480.38
100_V127_A0.5470.38
182_E257_I0.5470.38
134_N156_L0.5470.38
195_S314_S0.5460.37
52_L56_Y0.5460.37
26_W73_P0.5450.37
168_Q224_P0.5450.37
41_A60_A0.5450.37
128_I151_K0.5450.37
14_L44_R0.5440.37
46_A51_K0.5440.37
61_T98_V0.5430.37
205_R224_P0.5420.37
138_D235_E0.5420.37
116_S201_S0.5420.37
255_K278_I0.5410.37
25_G130_E0.5410.37
52_L235_E0.5380.37
188_E325_E0.5380.37
13_L16_V0.5370.37
110_R179_N0.5360.36
129_A156_L0.5360.36
112_D289_W0.5360.36
43_A49_G0.5350.36
158_R170_D0.5340.36
263_D266_E0.5320.36
179_N192_G0.5310.36
27_Y50_Q0.5300.36
46_A52_L0.5290.36
16_V303_A0.5280.36
164_S251_L0.5280.36
154_E157_E0.5270.36
115_R119_Q0.5270.36
42_Q47_A0.5260.35
135_F144_S0.5260.35
94_W252_H0.5250.35
134_N186_D0.5250.35
114_S126_L0.5240.35
35_F57_T0.5230.35
224_P227_V0.5230.35
209_T227_V0.5220.35
175_A216_A0.5220.35
140_W233_W0.5210.35
154_E274_L0.5210.35
56_Y188_E0.5200.35
323_L330_G0.5190.35
50_Q161_A0.5180.35
303_A308_V0.5180.35
124_P166_P0.5170.35
34_L255_K0.5170.35
226_E293_I0.5140.34
100_V135_F0.5130.34
51_K96_F0.5110.34
78_S145_T0.5110.34
23_V263_D0.5100.34
42_Q45_A0.5100.34
254_L320_I0.5100.34
206_R220_S0.5070.34
11_G15_A0.5070.34
284_T287_P0.5070.34
106_A152_G0.5060.34
25_G85_G0.5060.34
13_L22_L0.5040.33
236_I324_R0.5040.33
209_T212_A0.5040.33
108_A113_F0.5030.33
56_Y247_A0.5020.33
147_S266_E0.5010.33
112_D134_N0.5010.33
72_K95_E0.5000.33
37_V259_V0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j2cA 1 0.2818 61.3 0.97 Contact Map
2vhjA 3 0.2394 25.7 0.976 Contact Map
4dndA 1 0.2606 22.8 0.977 Contact Map
2rt6A 1 0.197 11.8 0.979 Contact Map
3nw0A 1 0.1939 10.1 0.98 Contact Map
4a5xA 1 0.1848 8.1 0.981 Contact Map
5a2fA 1 0 7.7 0.981 Contact Map
3ls0A 1 0.3091 6.9 0.982 Contact Map
1h7bA 2 0.1727 6.4 0.982 Contact Map
3zvlA 1 0.2909 6.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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