GREMLIN Database
DUF2330 - Uncharacterized protein conserved in bacteria (DUF2330)
PFAM: PF10092 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 351 (345)
Sequences: 2967 (2219)
Seq/√Len: 119.5
META: 0.943

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_V134_L5.1891.00
118_L146_T5.0651.00
264_R267_E4.3981.00
145_E160_E4.3851.00
76_S332_L4.1111.00
253_E256_D3.9891.00
118_L150_E3.9421.00
58_V172_K3.8891.00
24_Q223_Y3.7221.00
30_D227_R3.4641.00
340_D343_H3.4221.00
146_T150_E3.2261.00
214_A217_P2.9351.00
125_Q134_L2.8591.00
164_G168_K2.7551.00
43_Q215_D2.7311.00
76_S223_Y2.7051.00
232_T237_T2.6491.00
182_E185_K2.6031.00
248_D251_K2.5721.00
217_P340_D2.5611.00
62_H197_A2.4091.00
278_A331_F2.4001.00
70_D74_A2.3911.00
35_V197_A2.3301.00
163_L167_I2.3011.00
30_D33_R2.2901.00
104_A107_A2.2881.00
127_T182_E2.2461.00
26_V69_F2.2131.00
61_I126_Y2.1861.00
119_G143_G2.1011.00
145_E149_R2.0721.00
123_E137_S2.0671.00
103_A106_A2.0481.00
207_I344_F1.9891.00
283_W288_A1.9491.00
246_V250_V1.9351.00
232_T273_V1.8981.00
260_A263_D1.8801.00
26_V72_L1.8551.00
42_Y46_P1.8551.00
256_D259_K1.8421.00
64_G197_A1.8071.00
91_R94_Y1.7991.00
295_E299_T1.7991.00
257_F261_L1.7711.00
39_Q69_F1.7661.00
114_G117_A1.7351.00
33_R197_A1.7251.00
63_V194_L1.7251.00
266_V270_G1.7241.00
20_N23_S1.7211.00
27_L224_A1.7031.00
90_A93_M1.6641.00
226_T230_V1.6601.00
33_R199_E1.6601.00
162_V165_P1.6491.00
145_E155_I1.6321.00
6_F9_F1.6251.00
238_V272_A1.6151.00
138_A144_L1.6091.00
36_L198_Y1.6071.00
21_K215_D1.6061.00
169_Q208_R1.5821.00
46_P183_Q1.5631.00
224_A230_V1.5461.00
21_K43_Q1.5411.00
100_G103_A1.5371.00
162_V212_V1.5251.00
61_I124_A1.5231.00
110_A113_A1.4951.00
123_E172_K1.4891.00
91_R95_E1.4841.00
66_R70_D1.4801.00
130_E192_R1.4771.00
126_Y133_I1.4631.00
232_T275_T1.4601.00
142_D146_T1.4601.00
255_G259_K1.4571.00
57_T172_K1.4571.00
24_Q66_R1.4511.00
118_L143_G1.4451.00
222_V350_F1.4391.00
284_C287_C1.4261.00
98_A101_A1.4241.00
105_A109_A1.4161.00
122_V125_Q1.4131.00
267_E270_G1.4131.00
45_D48_D1.3971.00
176_A194_L1.3861.00
245_D248_D1.3841.00
42_Y51_M1.3691.00
165_P211_M1.3491.00
229_R275_T1.3481.00
259_K263_D1.3431.00
67_A70_D1.3311.00
127_T132_D1.3311.00
149_R160_E1.3261.00
39_Q66_R1.3251.00
127_T179_N1.3161.00
37_T69_F1.3081.00
92_R95_E1.3071.00
231_E237_T1.2911.00
214_A218_Q1.2731.00
145_E163_L1.2490.99
65_D299_T1.2470.99
64_G195_Q1.2420.99
294_P298_R1.2300.99
240_L265_A1.2250.99
57_T171_M1.2190.99
214_A340_D1.2170.99
92_R96_A1.2160.99
237_T275_T1.2120.99
97_G100_G1.2090.99
337_V344_F1.2090.99
262_F274_F1.2080.99
133_I194_L1.2030.99
94_Y97_G1.2000.99
302_V330_V1.1860.99
337_V343_H1.1830.99
147_W151_N1.1550.99
347_D350_F1.1520.99
121_T139_K1.1450.99
147_W175_V1.1400.99
24_Q190_Y1.1360.99
63_V192_R1.1320.99
165_P169_Q1.1240.99
94_Y98_A1.1200.99
92_R98_A1.1140.99
293_S296_E1.1110.99
106_A109_A1.1090.99
53_V196_V1.1080.99
114_G150_E1.1060.99
308_D311_L1.1020.99
320_R323_P1.0950.99
96_A99_M1.0930.99
97_G101_A1.0890.98
217_P263_D1.0880.98
232_T348_L1.0870.98
228_K329_N1.0860.98
217_P270_G1.0790.98
321_R324_P1.0730.98
240_L261_L1.0690.98
265_A274_F1.0640.98
124_A135_I1.0620.98
11_V15_D1.0600.98
93_M97_G1.0550.98
138_A143_G1.0440.98
233_T351_Q1.0330.98
52_V55_V1.0320.98
240_L243_N1.0310.98
25_V205_L1.0250.98
266_V274_F1.0190.98
98_A103_A1.0180.98
102_A105_A1.0170.98
340_D344_F1.0140.98
268_E272_A1.0110.98
24_Q76_S1.0100.97
149_R155_I1.0060.97
249_F253_E1.0030.97
281_M292_L0.9950.97
183_Q186_L0.9940.97
28_V302_V0.9930.97
280_D329_N0.9920.97
112_A115_A0.9910.97
105_A108_G0.9900.97
55_V174_F0.9900.97
268_E274_F0.9890.97
298_R302_V0.9880.97
99_M102_A0.9850.97
17_K70_D0.9820.97
17_K21_K0.9740.97
155_I212_V0.9660.97
18_L23_S0.9640.97
103_A107_A0.9630.97
108_G111_A0.9510.96
13_K16_A0.9490.96
90_A94_Y0.9470.96
231_E351_Q0.9460.96
61_I128_V0.9370.96
98_A102_A0.9360.96
248_D252_D0.9350.96
167_I173_F0.9290.96
95_E105_A0.9240.96
95_E101_A0.9220.96
107_A110_A0.9210.96
302_V305_L0.9200.96
171_M202_K0.9080.95
292_L296_E0.9040.95
100_G110_A0.9040.95
104_A114_G0.9030.95
269_G272_A0.8990.95
273_V348_L0.8990.95
101_A105_A0.8990.95
322_A325_G0.8950.95
310_A314_Q0.8910.95
263_D270_G0.8900.95
32_D199_E0.8890.95
35_V62_H0.8880.95
156_P159_A0.8830.95
183_Q188_F0.8820.95
44_G49_F0.8810.94
73_D77_A0.8800.94
113_A117_A0.8790.94
6_F10_Y0.8710.94
236_R268_E0.8680.94
97_G110_A0.8650.94
219_D259_K0.8590.94
294_P306_D0.8540.94
96_A101_A0.8540.94
40_N69_F0.8500.93
21_K170_G0.8490.93
6_F11_V0.8470.93
26_V300_L0.8380.93
76_S211_M0.8370.93
93_M96_A0.8360.93
134_L175_V0.8350.93
95_E99_M0.8350.93
281_M330_V0.8340.93
151_N177_K0.8300.93
24_Q39_Q0.8270.92
48_D154_R0.8270.92
241_P257_F0.8270.92
263_D267_E0.8230.92
219_D337_V0.8220.92
283_W292_L0.8210.92
248_D270_G0.8160.92
227_R329_N0.8100.92
66_R69_F0.8100.92
149_R154_R0.8090.92
28_V225_L0.8060.91
135_I174_F0.8020.91
93_M99_M0.8010.91
93_M98_A0.8000.91
309_D313_A0.7990.91
58_V124_A0.7980.91
100_G111_A0.7950.91
238_V268_E0.7950.91
23_S210_G0.7880.90
127_T185_K0.7870.90
63_V128_V0.7870.90
171_M204_M0.7860.90
69_F165_P0.7860.90
243_N261_L0.7820.90
298_R303_F0.7750.90
337_V348_L0.7660.89
139_K143_G0.7650.89
21_K41_D0.7650.89
210_G218_Q0.7630.89
307_G310_A0.7620.89
13_K19_F0.7590.89
99_M103_A0.7580.89
100_G108_G0.7570.89
12_A19_F0.7570.89
160_E164_G0.7560.89
99_M105_A0.7550.89
20_N25_V0.7550.89
291_P296_E0.7520.88
182_E186_L0.7500.88
99_M112_A0.7500.88
38_M196_V0.7480.88
283_W291_P0.7470.88
91_R97_G0.7450.88
197_A303_F0.7410.88
3_A6_F0.7400.88
297_L302_V0.7390.87
20_N210_G0.7380.87
111_A114_G0.7360.87
185_K188_F0.7300.87
290_D327_A0.7290.87
112_A116_A0.7280.87
140_E143_G0.7270.87
12_A15_D0.7260.87
302_V306_D0.7250.86
289_A327_A0.7250.86
69_F332_L0.7240.86
323_P327_A0.7230.86
294_P327_A0.7210.86
319_R322_A0.7200.86
170_G201_P0.7190.86
96_A104_A0.7180.86
96_A103_A0.7180.86
311_L314_Q0.7170.86
344_F348_L0.7170.86
263_D338_R0.7150.86
246_V249_F0.7150.86
189_A240_L0.7060.85
325_G329_N0.7030.85
281_M288_A0.7030.85
225_L280_D0.7030.85
238_V274_F0.7030.85
40_N207_I0.7010.85
41_D188_F0.7010.85
71_H293_S0.6990.84
11_V14_A0.6990.84
112_A117_A0.6990.84
160_E199_E0.6960.84
98_A108_G0.6950.84
109_A112_A0.6940.84
309_D312_P0.6930.84
51_M257_F0.6920.84
310_A313_A0.6910.84
253_E261_L0.6900.84
282_S328_Q0.6890.84
104_A113_A0.6860.83
155_I158_G0.6840.83
36_L53_V0.6830.83
134_L147_W0.6810.83
93_M109_A0.6790.83
32_D201_P0.6780.83
326_G329_N0.6780.83
102_A106_A0.6770.82
324_P327_A0.6750.82
108_G112_A0.6750.82
51_M194_L0.6740.82
345_P351_Q0.6720.82
164_G212_V0.6710.82
225_L330_V0.6710.82
57_T199_E0.6710.82
260_A264_R0.6700.82
342_E349_V0.6680.82
96_A106_A0.6680.82
107_A113_A0.6660.81
97_G105_A0.6650.81
269_G333_T0.6650.81
280_D283_W0.6650.81
127_T196_V0.6640.81
92_R100_G0.6620.81
36_L40_N0.6620.81
22_A25_V0.6620.81
84_F248_D0.6610.81
71_H296_E0.6600.81
132_D182_E0.6580.81
83_Y87_D0.6560.80
96_A100_G0.6550.80
100_G104_A0.6530.80
53_V209_L0.6500.80
92_R112_A0.6490.80
145_E164_G0.6480.80
181_K185_K0.6480.80
93_M101_A0.6470.80
131_Y193_P0.6450.79
138_A173_F0.6420.79
107_A112_A0.6410.79
22_A219_D0.6400.79
144_L173_F0.6400.79
158_G212_V0.6390.79
283_W290_D0.6390.79
322_A326_G0.6390.79
119_G146_T0.6370.78
294_P328_Q0.6350.78
91_R110_A0.6340.78
52_V208_R0.6330.78
82_E85_D0.6310.78
64_G182_E0.6300.78
38_M56_P0.6300.78
97_G103_A0.6300.78
138_A141_S0.6280.78
83_Y285_D0.6280.78
60_Q197_A0.6260.77
210_G213_N0.6250.77
10_Y36_L0.6230.77
27_L36_L0.6220.77
322_A329_N0.6220.77
297_L300_L0.6220.77
86_Q92_R0.6200.77
319_R327_A0.6200.77
66_R223_Y0.6150.76
132_D179_N0.6140.76
346_E349_V0.6130.76
99_M106_A0.6130.76
101_A104_A0.6120.76
144_L163_L0.6120.76
111_A115_A0.6100.75
298_R308_D0.6090.75
102_A114_G0.6090.75
95_E98_A0.6080.75
290_D293_S0.6060.75
56_P198_Y0.6040.75
275_T333_T0.6040.75
136_L144_L0.6020.75
23_S37_T0.6020.75
56_P200_S0.6020.75
319_R323_P0.6010.74
219_D338_R0.6000.74
98_A105_A0.6000.74
99_M107_A0.5990.74
102_A107_A0.5980.74
26_V225_L0.5980.74
107_A111_A0.5940.74
68_L71_H0.5920.73
91_R109_A0.5920.73
71_H288_A0.5920.73
96_A112_A0.5920.73
127_T181_K0.5920.73
295_E311_L0.5910.73
343_H346_E0.5910.73
162_V278_A0.5900.73
118_L151_N0.5900.73
329_N342_E0.5900.73
139_K142_D0.5890.73
106_A110_A0.5890.73
207_I212_V0.5880.73
252_D256_D0.5880.73
71_H289_A0.5860.73
284_C288_A0.5860.73
91_R96_A0.5850.72
30_D42_Y0.5830.72
95_E117_A0.5820.72
96_A113_A0.5810.72
94_Y99_M0.5810.72
61_I176_A0.5790.72
21_K201_P0.5790.72
63_V133_I0.5790.72
290_D296_E0.5760.71
17_K20_N0.5750.71
190_Y253_E0.5750.71
47_K51_M0.5740.71
97_G107_A0.5720.71
145_E158_G0.5710.71
104_A111_A0.5700.70
91_R98_A0.5680.70
295_E298_R0.5680.70
337_V345_P0.5680.70
64_G199_E0.5680.70
159_A212_V0.5650.70
59_E172_K0.5650.70
69_F243_N0.5640.70
14_A19_F0.5640.70
240_L262_F0.5630.70
103_A111_A0.5630.70
78_P276_E0.5630.70
287_C301_G0.5630.70
64_G68_L0.5620.69
12_A51_M0.5590.69
51_M196_V0.5590.69
167_I170_G0.5590.69
92_R107_A0.5580.69
71_H74_A0.5580.69
345_P348_L0.5580.69
40_N212_V0.5570.69
165_P196_V0.5560.69
236_R269_G0.5550.68
16_A19_F0.5540.68
126_Y195_Q0.5530.68
322_A327_A0.5530.68
75_Y277_Y0.5530.68
103_A110_A0.5520.68
270_G340_D0.5520.68
93_M100_G0.5520.68
336_H339_Y0.5500.68
167_I211_M0.5490.68
95_E112_A0.5480.67
101_A106_A0.5480.67
102_A111_A0.5470.67
185_K189_A0.5460.67
65_D267_E0.5450.67
172_K196_V0.5450.67
133_I174_F0.5440.67
10_Y23_S0.5440.67
291_P294_P0.5430.67
46_P211_M0.5420.67
207_I339_Y0.5400.66
15_D154_R0.5380.66
296_E299_T0.5370.66
183_Q343_H0.5360.66
106_A115_A0.5350.66
308_D312_P0.5350.66
133_I136_L0.5330.65
94_Y105_A0.5310.65
10_Y13_K0.5300.65
303_F332_L0.5300.65
266_V300_L0.5260.64
28_V42_Y0.5260.64
190_Y269_G0.5240.64
141_S163_L0.5240.64
91_R113_A0.5230.64
53_V165_P0.5220.64
51_M69_F0.5220.64
279_W286_P0.5220.64
10_Y20_N0.5200.63
98_A269_G0.5180.63
93_M112_A0.5170.63
171_M198_Y0.5160.63
4_A36_L0.5150.63
107_A116_A0.5140.63
83_Y89_C0.5140.63
62_H195_Q0.5130.62
289_A297_L0.5130.62
291_P300_L0.5130.62
99_M110_A0.5120.62
36_L207_I0.5120.62
170_G271_R0.5110.62
332_L346_E0.5100.62
23_S218_Q0.5100.62
294_P305_L0.5100.62
106_A111_A0.5090.62
139_K157_A0.5060.61
125_Q153_Y0.5060.61
301_G304_W0.5060.61
62_H199_E0.5060.61
150_E181_K0.5060.61
91_R100_G0.5060.61
181_K184_A0.5050.61
95_E107_A0.5050.61
133_I176_A0.5050.61
177_K256_D0.5040.61
300_L304_W0.5030.61
14_A73_D0.5030.61
85_D88_P0.5020.61
50_A56_P0.5020.61
55_V198_Y0.5010.61
18_L25_V0.5010.61
341_A348_L0.5010.61
126_Y136_L0.5000.60
161_P341_A0.5000.60
265_A268_E0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kngA 1 0.1481 21.7 0.968 Contact Map
2kxeA 1 0.1994 13.9 0.97 Contact Map
2cu1A 1 0.2336 8.2 0.973 Contact Map
2m7cA 1 0.057 5.6 0.975 Contact Map
1ng7A 2 0.1652 4.3 0.977 Contact Map
3na7A 1 0.114 4.2 0.977 Contact Map
4iloA 3 0.1111 4.2 0.977 Contact Map
2e8mA 1 0.2821 3.6 0.978 Contact Map
2pqrC 1 0.1282 3.5 0.978 Contact Map
3f6cA 2 0.359 3.2 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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