GREMLIN Database
DUF2326 - Uncharacterized protein conserved in bacteria (DUF2326)
PFAM: PF10088 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (135)
Sequences: 2455 (1780)
Seq/√Len: 153.2
META: 0.846

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_E87_E5.1531.00
52_L88_K3.2181.00
4_E10_K2.5931.00
86_R90_E2.4701.00
88_K91_E2.3431.00
121_V127_L2.2971.00
124_L127_L2.1881.00
132_K137_R2.1431.00
87_E91_E2.0691.00
125_L131_G1.9511.00
83_E112_E1.9441.00
129_E137_R1.8511.00
78_K104_D1.8011.00
80_K83_E1.7401.00
75_D106_P1.6791.00
119_E122_L1.6261.00
44_F81_L1.5871.00
77_Q80_K1.5691.00
29_E33_D1.5691.00
110_E115_F1.5651.00
111_F115_F1.5351.00
123_R126_D1.5261.00
2_I84_L1.5161.00
13_L27_I1.4961.00
18_N24_E1.4691.00
74_D77_Q1.4361.00
89_A94_F1.4081.00
122_L126_D1.4081.00
66_H96_Y1.3991.00
47_D66_H1.3891.00
68_S72_G1.3861.00
39_K42_K1.3701.00
38_I41_M1.3451.00
2_I52_L1.3421.00
108_E117_L1.3281.00
18_N26_K1.3141.00
16_D26_K1.3071.00
52_L92_L1.3041.00
120_I124_L1.3041.00
107_D112_E1.3001.00
51_L94_F1.2981.00
9_E31_E1.2901.00
114_E117_L1.2881.00
75_D103_D1.2871.00
129_E132_K1.2801.00
131_G135_G1.2761.00
6_L41_M1.2691.00
51_L64_L1.2521.00
109_L115_F1.2511.00
34_G39_K1.2331.00
120_I126_D1.2311.00
48_L84_L1.2291.00
33_D42_K1.2261.00
122_L125_L1.2161.00
125_L129_E1.1881.00
56_E92_L1.1811.00
110_E113_E1.1811.00
120_I123_R1.1761.00
112_E115_F1.1731.00
83_E87_E1.1481.00
48_L85_A1.1381.00
2_I88_K1.1301.00
41_M73_V1.1211.00
74_D101_N1.1070.99
36_T72_G1.0960.99
132_K135_G1.0740.99
109_L112_E1.0620.99
64_L96_Y1.0530.99
107_D110_E1.0530.99
79_A83_E1.0520.99
109_L113_E1.0510.99
7_Y77_Q1.0500.99
115_F118_D1.0390.99
52_L84_L1.0350.99
5_E84_L1.0280.99
32_G36_T1.0240.99
72_G104_D1.0180.99
2_I5_E0.9810.99
65_I99_T0.9780.99
121_V124_L0.9700.99
41_M77_Q0.9690.99
110_E114_E0.9660.99
79_A111_F0.9600.98
85_A96_Y0.9450.98
7_Y41_M0.9450.98
44_F96_Y0.9410.98
21_N24_E0.9390.98
38_I77_Q0.9150.98
127_L130_D0.9050.98
128_S131_G0.8910.98
8_G12_A0.8900.98
24_E27_I0.8880.97
110_E118_D0.8780.97
71_E104_D0.8690.97
4_E8_G0.8670.97
30_I45_C0.8660.97
35_S43_I0.8660.97
5_E80_K0.8590.97
84_L88_K0.8570.97
127_L131_G0.8540.97
106_P133_L0.8410.96
80_K84_L0.8380.96
108_E111_F0.8360.96
30_I42_K0.8270.96
5_E83_E0.8270.96
3_S9_E0.8270.96
54_A59_P0.8190.96
128_S132_K0.8130.96
54_A58_I0.8120.96
43_I66_H0.8110.96
26_K29_E0.8110.96
17_I21_N0.8010.95
68_S99_T0.7980.95
70_F82_L0.7880.95
125_L130_D0.7870.95
3_S30_I0.7860.95
84_L87_E0.7830.95
68_S102_S0.7810.95
89_A92_L0.7800.95
107_D111_F0.7760.95
30_I33_D0.7740.94
46_F69_L0.7720.94
85_A98_V0.7700.94
88_K94_F0.7640.94
102_S106_P0.7580.94
66_H69_L0.7540.94
48_L88_K0.7520.94
32_G132_K0.7450.93
65_I97_I0.7440.93
112_E118_D0.7430.93
86_R119_E0.7300.93
117_L123_R0.7140.92
49_A100_L0.7090.91
74_D102_S0.6910.90
46_F88_K0.6900.90
119_E123_R0.6890.90
6_L77_Q0.6840.90
119_E127_L0.6830.90
62_R93_G0.6810.90
116_D119_E0.6780.90
20_K59_P0.6770.89
55_Y58_I0.6760.89
9_E12_A0.6720.89
44_F73_V0.6700.89
49_A52_L0.6680.89
14_S23_L0.6670.89
82_L100_L0.6610.88
73_V81_L0.6610.88
107_D115_F0.6600.88
85_A89_A0.6580.88
90_E116_D0.6520.88
109_L117_L0.6460.87
46_F104_D0.6410.87
41_M44_F0.6400.87
113_E117_L0.6370.86
75_D78_K0.6300.86
23_L27_I0.6240.85
89_A96_Y0.6190.85
47_D74_D0.6130.84
25_F61_P0.6110.84
58_I62_R0.6070.84
17_I24_E0.6070.84
3_S8_G0.6070.84
6_L22_G0.6070.84
91_E116_D0.5990.83
20_K23_L0.5920.82
2_I10_K0.5920.82
21_N25_F0.5880.82
54_A57_R0.5860.82
7_Y38_I0.5820.81
61_P69_L0.5800.81
49_A53_L0.5790.81
119_E128_S0.5740.80
7_Y73_V0.5720.80
110_E117_L0.5720.80
58_I90_E0.5700.80
75_D101_N0.5670.79
57_R91_E0.5660.79
70_F98_V0.5610.79
68_S78_K0.5570.78
107_D114_E0.5550.78
27_I30_I0.5540.78
121_V125_L0.5530.78
55_Y62_R0.5480.77
83_E111_F0.5480.77
85_A88_K0.5460.77
70_F100_L0.5450.77
71_E101_N0.5400.76
88_K92_L0.5390.76
36_T40_Y0.5390.76
46_F75_D0.5360.75
43_I96_Y0.5340.75
77_Q101_N0.5240.74
108_E113_E0.5190.73
81_L96_Y0.5170.73
101_N134_F0.5170.73
69_L98_V0.5100.72
11_G41_M0.5060.71
40_Y71_E0.5060.71
12_A29_E0.5040.71
26_K32_G0.5020.71
29_E34_G0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eujA 2 0.8913 80.3 0.864 Contact Map
3ktaB 1 0.8841 59.8 0.883 Contact Map
1w1wA 2 0.8913 50 0.89 Contact Map
4ux3A 1 0.8986 48.9 0.89 Contact Map
3qktA 2 0.8913 37.2 0.898 Contact Map
2o5vA 1 0.8986 32.9 0.901 Contact Map
3zgxA 2 0.8406 31.4 0.902 Contact Map
4i99A 2 0.8841 19.4 0.911 Contact Map
4abyA 1 0.9348 19.1 0.911 Contact Map
3auyA 2 0.8841 17.8 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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