GREMLIN Database
DUF2313 - Uncharacterized protein conserved in bacteria (DUF2313)
PFAM: PF10076 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (162)
Sequences: 2955 (2419)
Seq/√Len: 190.0
META: 0.703

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E74_R3.5361.00
61_L78_V3.2701.00
91_A95_E2.9311.00
37_R52_E2.7541.00
61_L82_L2.7451.00
4_L21_K2.7241.00
44_E51_T2.5611.00
165_E168_K2.5081.00
115_A120_A2.5021.00
110_F131_T2.3891.00
164_I174_V2.3741.00
108_T133_N2.3401.00
54_L71_L2.1921.00
48_R79_L2.1551.00
110_F127_R2.0111.00
115_A148_A2.0041.00
56_D59_R1.9711.00
70_T73_E1.9351.00
28_A32_D1.9341.00
30_E33_R1.9311.00
57_W82_L1.8921.00
4_L24_L1.8841.00
115_A119_R1.8291.00
98_A104_T1.7771.00
106_T133_N1.6361.00
120_A148_A1.6091.00
66_D69_K1.5801.00
56_D60_V1.5641.00
130_W168_K1.5611.00
50_A53_L1.5521.00
7_L24_L1.5491.00
3_L24_L1.5441.00
69_K77_R1.5401.00
72_E75_R1.5321.00
144_G149_G1.5011.00
40_D52_E1.4941.00
10_G13_W1.4911.00
90_R94_I1.4621.00
113_F118_S1.4451.00
96_L167_I1.4091.00
116_G120_A1.3981.00
14_P19_E1.3851.00
22_A25_E1.3781.00
69_K73_E1.3711.00
90_R109_E1.3621.00
108_T131_T1.3501.00
117_R120_A1.3451.00
97_A105_I1.3311.00
50_A54_L1.2791.00
161_E178_Y1.2681.00
54_L75_R1.2621.00
3_L31_L1.2551.00
94_I106_T1.2441.00
113_F117_R1.2361.00
148_A152_L1.2321.00
116_G144_G1.2001.00
116_G149_G1.1991.00
105_I132_V1.1891.00
64_P162_C1.1841.00
168_K172_T1.1791.00
44_E52_E1.1721.00
130_W174_V1.1441.00
161_E165_E1.1431.00
161_E176_F1.1411.00
115_A123_L1.1391.00
9_P13_W1.1281.00
106_T135_P1.1101.00
110_F129_T1.0951.00
27_L31_L1.0951.00
40_D51_T1.0831.00
7_L20_L1.0751.00
130_W172_T1.0721.00
93_F130_W1.0701.00
144_G148_A1.0611.00
84_G92_Y1.0591.00
40_D44_E1.0581.00
94_I98_A1.0481.00
113_F116_G1.0331.00
131_T177_A1.0271.00
114_R117_R1.0231.00
119_R144_G1.0151.00
114_R119_R1.0141.00
113_F123_L0.9880.99
78_V82_L0.9870.99
132_V164_I0.9830.99
37_R40_D0.9800.99
97_A160_L0.9720.99
119_R122_P0.9690.99
83_R99_A0.9630.99
151_N154_D0.9600.99
120_A123_L0.9450.99
80_A99_A0.9410.99
47_P82_L0.9370.99
22_A26_A0.9340.99
165_E176_F0.9300.99
79_L83_R0.9120.99
32_D36_A0.9090.99
65_D81_K0.9000.99
114_R120_A0.8940.99
116_G119_R0.8890.99
72_E76_A0.8860.99
3_L6_L0.8820.99
73_E77_R0.8760.99
90_R107_I0.8750.99
47_P79_L0.8670.99
113_F121_D0.8640.99
65_D166_R0.8580.98
115_A118_S0.8540.98
23_L27_L0.8530.98
39_D43_D0.8460.98
94_I107_I0.8450.98
65_D162_C0.8340.98
91_A94_I0.8240.98
104_T135_P0.8220.98
93_F167_I0.8180.98
9_P12_A0.8170.98
97_A164_I0.8160.98
71_L78_V0.8120.98
115_A152_L0.8090.98
5_A28_A0.8070.98
150_E153_R0.8060.98
24_L27_L0.8050.98
92_Y96_L0.8020.98
98_A105_I0.8010.98
129_T175_I0.8010.98
86_G92_Y0.8000.98
120_A149_G0.7910.97
146_S150_E0.7830.97
105_I134_F0.7820.97
88_Q92_Y0.7810.97
47_P78_V0.7780.97
134_F160_L0.7770.97
119_R123_L0.7770.97
153_R161_E0.7770.97
35_D39_D0.7770.97
114_R118_S0.7740.97
50_A75_R0.7670.97
100_L163_L0.7660.97
25_E29_P0.7640.97
147_G150_E0.7570.97
11_Y20_L0.7560.97
118_S121_D0.7560.97
51_T75_R0.7540.97
14_P21_K0.7500.96
110_F126_W0.7410.96
133_N177_A0.7400.96
46_F49_T0.7360.96
88_Q93_F0.7310.96
75_R79_L0.7270.96
95_E99_A0.7260.96
73_E76_A0.7250.96
19_E22_A0.7240.96
114_R122_P0.7200.95
152_L161_E0.7160.95
12_A15_R0.7140.95
63_L77_R0.7130.95
113_F119_R0.7070.95
30_E34_L0.6980.95
3_L28_A0.6980.95
54_L78_V0.6970.95
2_A5_A0.6920.94
113_F120_A0.6920.94
28_A31_L0.6860.94
168_K174_V0.6850.94
40_D43_D0.6830.94
76_A80_A0.6830.94
111_R126_W0.6810.94
33_R37_R0.6780.94
120_A145_T0.6740.94
93_F169_P0.6740.94
55_P59_R0.6740.94
117_R121_D0.6730.94
129_T173_I0.6730.94
96_L163_L0.6690.93
147_G151_N0.6670.93
162_C166_R0.6660.93
94_I105_I0.6650.93
118_S122_P0.6640.93
146_S149_G0.6580.93
44_E53_L0.6550.93
77_R80_A0.6520.92
126_W129_T0.6460.92
164_I168_K0.6440.92
4_L15_R0.6430.92
107_I130_W0.6420.92
72_E146_S0.6400.92
96_L99_A0.6380.92
44_E50_A0.6320.91
126_W134_F0.6300.91
44_E57_W0.6110.90
116_G121_D0.6090.90
42_L45_A0.5980.89
145_T149_G0.5970.89
109_E172_T0.5970.89
55_P67_A0.5970.89
42_L46_F0.5950.89
130_W164_I0.5940.89
112_P127_R0.5930.88
14_P20_L0.5930.88
12_A20_L0.5920.88
144_G147_G0.5910.88
43_D49_T0.5890.88
32_D35_D0.5850.88
68_S77_R0.5830.88
165_E174_V0.5780.87
92_Y95_E0.5770.87
75_R78_V0.5690.86
81_K166_R0.5650.86
112_P115_A0.5650.86
131_T175_I0.5600.85
163_L167_I0.5600.85
50_A78_V0.5560.85
4_L28_A0.5510.85
111_R127_R0.5500.84
144_G150_E0.5460.84
47_P50_A0.5430.84
11_Y15_R0.5400.83
118_S125_D0.5390.83
159_V163_L0.5380.83
71_L75_R0.5380.83
44_E75_R0.5310.82
48_R83_R0.5300.82
113_F122_P0.5290.82
13_W21_K0.5270.82
89_T93_F0.5250.82
58_E63_L0.5220.81
114_R127_R0.5200.81
60_V82_L0.5190.81
164_I167_I0.5180.81
112_P159_V0.5160.81
114_R125_D0.5140.80
94_I97_A0.5130.80
63_L66_D0.5100.80
4_L12_A0.5100.80
38_A42_L0.5100.80
41_L52_E0.5060.79
117_R124_E0.5060.79
120_A144_G0.5050.79
165_E170_A0.5020.79
84_G96_L0.5020.79
112_P117_R0.5010.79
126_W153_R0.5000.78
117_R123_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nptA 1 0.324 11.1 0.927 Contact Map
3hzsA 3 0.5475 10.7 0.927 Contact Map
3vmtA 1 0.5531 9.3 0.93 Contact Map
2ycuA 1 0.3799 9.3 0.93 Contact Map
3smaA 2 0.3799 9 0.93 Contact Map
3ab3B 1 0.1844 8.7 0.93 Contact Map
3vlfB 1 0.4022 7.8 0.932 Contact Map
3ujpA 4 0.7374 7.2 0.933 Contact Map
1pq4A 1 0.7654 6.8 0.934 Contact Map
4utoA 1 0.7374 6.6 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.