GREMLIN Database
DUF2285 - Uncharacterized conserved protein (DUF2285)
PFAM: PF10074 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (102)
Sequences: 2430 (1652)
Seq/√Len: 163.6
META: 0.813

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_L98_M5.4971.00
55_L98_M3.2061.00
47_A93_R2.7861.00
54_R95_R2.6171.00
53_A58_A2.4211.00
60_Y91_V2.2161.00
60_Y88_R2.1471.00
49_R53_A2.0121.00
46_L49_R1.9781.00
50_A91_V1.9731.00
46_L86_R1.8281.00
82_S86_R1.8121.00
60_Y84_R1.7291.00
45_I49_R1.6751.00
53_A63_I1.6591.00
51_L94_G1.6041.00
13_A16_R1.5721.00
53_A66_A1.5521.00
5_D11_R1.4571.00
73_V83_L1.4361.00
69_G73_V1.4121.00
47_A94_G1.4011.00
12_L16_R1.3771.00
49_R58_A1.3581.00
54_R91_V1.3511.00
16_R20_R1.3511.00
97_L101_G1.3451.00
58_A66_A1.3161.00
95_R99_R1.3111.00
61_R78_W1.3081.00
81_S84_R1.2961.00
59_S62_E1.2851.00
72_R77_D1.2741.00
8_F15_A1.2711.00
85_D88_R1.2651.00
58_A62_E1.2281.00
82_S85_D1.1971.00
68_F87_V1.1951.00
79_K88_R1.1781.00
41_R44_L1.1751.00
78_W106_L1.1701.00
50_A63_I1.1701.00
43_R89_R1.1571.00
81_S85_D1.1521.00
65_E73_V1.1471.00
54_R94_G1.1111.00
18_L21_A1.1021.00
87_V91_V1.1001.00
20_R24_G1.0991.00
50_A54_R1.0851.00
47_A90_L1.0750.99
50_A94_G1.0750.99
24_G28_G1.0720.99
65_E70_A1.0480.99
54_R60_Y1.0430.99
42_R46_L1.0240.99
88_R91_V1.0220.99
46_L90_L0.9830.99
87_V90_L0.9810.99
7_D107_R0.9610.99
77_D82_S0.9600.99
40_R44_L0.9220.98
49_R67_L0.9120.98
19_W23_A0.9090.98
71_D75_A0.8990.98
14_A18_L0.8940.98
19_W22_L0.8890.98
101_G104_R0.8860.98
69_G83_L0.8860.98
16_R19_W0.8790.98
51_L55_L0.8770.98
9_E16_R0.8760.98
50_A87_V0.8690.98
15_A19_W0.8690.98
70_A74_A0.8510.97
80_T83_L0.8290.97
90_L94_G0.8180.97
43_R47_A0.8120.96
8_F19_W0.8040.96
83_L86_R0.8000.96
27_P30_D0.7980.96
23_A63_I0.7940.96
68_F73_V0.7930.96
68_F83_L0.7890.96
63_I87_V0.7750.95
96_A104_R0.7740.95
13_A31_P0.7550.95
73_V78_W0.7530.95
24_G30_D0.7490.94
38_P75_A0.7380.94
60_Y63_I0.7210.93
88_R92_R0.7150.93
93_R97_L0.7140.93
102_Y105_L0.7110.93
22_L92_R0.7070.93
55_L91_V0.7070.93
80_T85_D0.7010.92
27_P31_P0.6940.92
30_D33_A0.6880.92
97_L105_L0.6790.91
43_R46_L0.6560.90
24_G27_P0.6530.89
96_A100_G0.6470.89
11_R89_R0.6410.88
48_L58_A0.6390.88
79_K83_L0.6330.88
16_R31_P0.6320.88
96_A101_G0.6300.88
47_A84_R0.6300.88
20_R35_P0.6190.87
43_R82_S0.6140.86
37_P40_R0.6090.86
37_P45_I0.6080.86
100_G103_R0.6070.86
9_E13_A0.6050.85
15_A18_L0.6000.85
26_R29_P0.6000.85
80_T93_R0.5990.85
31_P35_P0.5960.85
26_R32_R0.5930.84
44_L85_D0.5890.84
38_P41_R0.5840.83
59_S81_S0.5800.83
9_E19_W0.5670.82
43_R93_R0.5660.81
93_R96_A0.5650.81
49_R56_A0.5630.81
7_D10_A0.5610.81
13_A21_A0.5580.81
89_R94_G0.5490.79
6_A9_E0.5470.79
48_L93_R0.5470.79
63_I91_V0.5470.79
10_A15_A0.5420.79
78_W84_R0.5380.78
80_T105_L0.5370.78
49_R84_R0.5370.78
30_D34_L0.5320.77
72_R79_K0.5320.77
85_D92_R0.5310.77
77_D80_T0.5300.77
72_R78_W0.5270.77
26_R30_D0.5270.77
44_L86_R0.5220.76
12_L15_A0.5220.76
71_D83_L0.5180.75
37_P41_R0.5090.74
47_A50_A0.5060.74
85_D91_V0.5030.73
27_P44_L0.5020.73
12_L17_R0.5020.73
72_R83_L0.5000.73
42_R86_R0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r3uA 2 0.6355 16 0.887 Contact Map
3korA 2 0.8224 16 0.887 Contact Map
2ns0A 1 0.5701 9.5 0.898 Contact Map
3frwA 2 0.8131 9.4 0.898 Contact Map
2jpcA 1 0.5607 8.6 0.9 Contact Map
1j5yA 4 0.5888 6.3 0.906 Contact Map
1tc3C 1 0.4766 6.1 0.906 Contact Map
1r7jA 2 0.5514 5.7 0.908 Contact Map
1je8A 2 0.5327 5.5 0.909 Contact Map
3fozA 2 0.9439 5.3 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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