GREMLIN Database
DICT - Sensory domain in DIguanylate Cyclases and Two-component system
PFAM: PF10069 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (106)
Sequences: 2431 (1641)
Seq/√Len: 159.4
META: 0.812

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A111_F4.6691.00
47_A62_Y3.6011.00
22_K54_F2.8481.00
46_F75_F2.3431.00
30_R58_E2.1291.00
56_R59_A2.0421.00
50_Q110_W2.0101.00
26_L30_R2.0091.00
59_A63_R1.9231.00
29_S123_L1.9121.00
33_E110_W1.8951.00
22_K26_L1.8911.00
44_V71_Q1.8511.00
64_R67_R1.8071.00
34_D61_R1.7181.00
101_D104_D1.6621.00
51_R107_A1.5941.00
49_F110_W1.5941.00
45_L114_V1.5831.00
113_V122_A1.5831.00
41_E116_G1.5761.00
55_Y59_A1.5451.00
36_A43_P1.5201.00
55_Y95_V1.5061.00
91_P94_G1.4751.00
29_S112_V1.4631.00
43_P114_V1.4071.00
46_F73_V1.3991.00
51_R54_F1.3121.00
100_L107_A1.2971.00
25_L125_A1.2631.00
52_E56_R1.2481.00
91_P96_R1.2421.00
29_S110_W1.2071.00
26_L29_S1.2061.00
111_F124_V1.1911.00
21_S24_T1.1821.00
36_A114_V1.1431.00
51_R77_D1.1331.00
42_R70_D1.1311.00
32_I121_A1.1291.00
63_R92_A1.1281.00
112_V123_L1.1271.00
35_E38_A1.1251.00
52_E76_A1.1191.00
35_E39_R1.1161.00
36_A112_V1.1081.00
58_E62_Y1.1021.00
22_K25_L1.1021.00
33_E49_F1.0800.99
32_I114_V1.0550.99
62_Y124_V1.0430.99
31_A34_D1.0410.99
60_E63_R1.0390.99
33_E65_L1.0210.99
33_E50_Q1.0130.99
34_D37_L1.0100.99
25_L44_V1.0070.99
29_S50_Q0.9890.99
62_Y114_V0.9830.99
45_L69_A0.9700.99
48_A100_L0.9630.99
28_L31_A0.9400.98
103_D107_A0.9380.98
104_D107_A0.9370.98
24_T119_F0.9330.98
36_A116_G0.9330.98
100_L104_D0.9330.98
39_R43_P0.9130.98
115_D120_A0.9080.98
40_A43_P0.9060.98
50_Q127_E0.8960.98
66_A95_V0.8950.98
39_R42_R0.8780.98
100_L109_E0.8780.98
44_V122_A0.8780.98
21_S48_A0.8740.98
29_S33_E0.8640.97
18_Q45_L0.8510.97
32_I123_L0.8510.97
65_L110_W0.8450.97
62_Y72_V0.8450.97
22_K50_Q0.8440.97
44_V73_V0.8390.97
86_E89_R0.8270.97
20_L24_T0.8260.97
35_E40_A0.8160.96
90_E97_G0.8150.96
122_A125_A0.8050.96
29_S65_L0.7950.96
90_E93_P0.7910.96
32_I112_V0.7840.95
31_A35_E0.7800.95
55_Y74_V0.7790.95
27_A48_A0.7730.95
25_L49_F0.7590.94
24_T31_A0.7420.94
31_A38_A0.7390.94
45_L72_V0.7380.94
37_L120_A0.7370.94
86_E92_A0.7130.92
36_A41_E0.7120.92
45_L65_L0.7070.92
26_L51_R0.6920.91
43_P69_A0.6900.91
36_A117_P0.6840.91
38_A47_A0.6790.90
106_L119_F0.6630.89
102_P107_A0.6620.89
39_R116_G0.6610.89
29_S49_F0.6530.89
44_V115_D0.6530.89
31_A121_A0.6530.89
33_E76_A0.6500.88
84_F89_R0.6450.88
32_I115_D0.6440.88
107_A111_F0.6310.87
28_L38_A0.6190.86
85_A93_P0.6130.85
89_R97_G0.6120.85
36_A119_F0.6050.85
28_L32_I0.6020.84
53_R89_R0.6010.84
50_Q65_L0.5940.84
25_L92_A0.5830.82
30_R51_R0.5820.82
42_R105_P0.5800.82
60_E73_V0.5790.82
43_P48_A0.5770.82
64_R68_T0.5720.81
27_A45_L0.5670.81
65_L68_T0.5660.81
18_Q115_D0.5660.81
34_D58_E0.5640.80
23_R37_L0.5550.79
90_E96_R0.5540.79
23_R107_A0.5530.79
91_P97_G0.5480.78
75_F111_F0.5450.78
34_D38_A0.5430.78
88_P91_P0.5420.78
69_A75_F0.5410.78
18_Q60_E0.5380.77
71_Q96_R0.5370.77
46_F109_E0.5370.77
114_V119_F0.5350.77
37_L62_Y0.5240.75
70_D111_F0.5210.75
92_A95_V0.5190.75
99_P122_A0.5190.75
16_R103_D0.5110.74
37_L64_R0.5090.73
27_A31_A0.5090.73
41_E114_V0.5080.73
49_F56_R0.5060.73
88_P99_P0.5030.72
16_R123_L0.5030.72
91_P95_V0.5010.72
39_R123_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ju2A 1 0.3516 14.8 0.911 Contact Map
1gpeA 2 0.3359 9.3 0.919 Contact Map
2i0zA 1 0.1641 3.9 0.932 Contact Map
2e1mA 2 0.4688 3.3 0.934 Contact Map
3pl8A 4 0.1562 2.9 0.936 Contact Map
2dkhA 2 0.3984 2.7 0.938 Contact Map
3hdqA 4 0.1875 2.6 0.938 Contact Map
2zxiA 2 0.2188 2.6 0.938 Contact Map
1kaeA 2 0.4297 2.2 0.94 Contact Map
4ci6B 1 0.7656 2.2 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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