GREMLIN Database
DUF2304 - Uncharacterized conserved protein (DUF2304)
PFAM: PF10066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 14237 (10680)
Seq/√Len: 1047.2
META: 0.931

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_R65_D3.0081.00
53_W57_L2.8561.00
75_L79_L2.7291.00
99_E104_E2.7201.00
99_E103_L2.6641.00
89_L93_I2.3631.00
47_F50_L2.3011.00
19_E23_R2.0741.00
43_V50_L2.0201.00
7_I46_L1.9881.00
82_L86_I1.8701.00
55_A66_L1.7901.00
95_R99_E1.7501.00
52_D56_R1.7371.00
94_T98_Q1.7261.00
49_D52_D1.7241.00
100_L103_L1.6921.00
10_S45_A1.6841.00
71_A75_L1.6561.00
88_R92_Q1.6411.00
68_F72_I1.6361.00
21_V31_A1.6331.00
93_I97_A1.5871.00
52_D63_P1.5681.00
19_E22_R1.5281.00
15_L19_E1.4851.00
65_D68_F1.4781.00
53_W56_R1.4691.00
86_I89_L1.4211.00
10_S42_L1.3851.00
79_L82_L1.3781.00
41_L45_A1.3431.00
20_L80_L1.3051.00
72_I75_L1.2781.00
50_L53_W1.2711.00
20_L25_R1.2681.00
89_L92_Q1.2541.00
55_A60_I1.2351.00
85_R90_E1.2291.00
60_I64_P1.2031.00
12_L16_L1.1981.00
44_L51_L1.1701.00
10_S38_A1.1631.00
93_I96_L1.1601.00
4_I8_I1.1461.00
96_L100_L1.1421.00
60_I69_Y1.1081.00
7_I42_L1.1041.00
14_L35_L1.0961.00
77_L81_H1.0771.00
34_W83_S1.0701.00
64_P69_Y1.0681.00
60_I66_L1.0351.00
85_R88_R1.0301.00
16_L20_L1.0261.00
64_P68_F0.9861.00
91_R95_R0.9691.00
65_D69_Y0.9621.00
34_W80_L0.9391.00
49_D53_W0.9241.00
14_L38_A0.9111.00
17_V38_A0.8971.00
27_R91_R0.8911.00
78_L82_L0.8751.00
6_L45_A0.8741.00
60_I65_D0.8731.00
81_H85_R0.8681.00
93_I100_L0.8551.00
91_R94_T0.8511.00
48_P52_D0.8471.00
35_L39_L0.8421.00
98_Q101_A0.8391.00
90_E94_T0.8291.00
28_E31_A0.8251.00
20_L84_V0.8211.00
71_A76_L0.8201.00
51_L63_P0.8181.00
30_Y87_S0.8151.00
36_L40_V0.8151.00
17_V26_L0.7931.00
97_A100_L0.7901.00
11_L15_L0.7871.00
3_Q48_P0.7831.00
78_L81_H0.7711.00
8_I12_L0.7581.00
100_L104_E0.7561.00
44_L50_L0.7511.00
87_S90_E0.7411.00
17_V31_A0.7401.00
17_V34_W0.7391.00
21_V28_E0.7281.00
73_L77_L0.7231.00
55_A63_P0.7211.00
44_L48_P0.7181.00
31_A35_L0.7161.00
20_L24_R0.7161.00
12_L15_L0.7121.00
43_V47_F0.7031.00
18_L35_L0.6951.00
13_L38_A0.6911.00
2_I60_I0.6871.00
30_Y33_L0.6851.00
51_L67_L0.6841.00
7_I45_A0.6841.00
85_R89_L0.6791.00
17_V21_V0.6791.00
52_D55_A0.6701.00
70_L74_F0.6621.00
71_A78_L0.6611.00
38_A80_L0.6601.00
39_L43_V0.6591.00
25_R88_R0.6561.00
30_Y85_R0.6531.00
20_L23_R0.6471.00
2_I6_L0.6461.00
37_V74_F0.6421.00
7_I10_S0.6411.00
30_Y82_L0.6361.00
10_S41_L0.6221.00
27_R30_Y0.6161.00
52_D64_P0.6101.00
51_L55_A0.6081.00
32_L36_L0.6061.00
26_L84_V0.6061.00
93_I103_L0.6041.00
6_L64_P0.5931.00
34_W84_V0.5881.00
41_L73_L0.5861.00
89_L100_L0.5841.00
26_L30_Y0.5821.00
64_P67_L0.5741.00
58_L66_L0.5671.00
16_L80_L0.5631.00
81_H84_V0.5611.00
26_L31_A0.5581.00
61_G64_P0.5531.00
6_L9_L0.5501.00
102_L105_A0.5481.00
61_G65_D0.5441.00
33_L37_V0.5441.00
67_L71_A0.5381.00
56_R61_G0.5321.00
27_R90_E0.5321.00
17_V80_L0.5311.00
3_Q6_L0.5271.00
94_T97_A0.5241.00
24_R27_R0.5211.00
37_V41_L0.5211.00
97_A101_A0.5171.00
33_L78_L0.5161.00
88_R91_R0.5121.00
66_L69_Y0.5081.00
55_A58_L0.5051.00
30_Y81_H0.5021.00
90_E93_I0.5001.00
69_Y73_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ra3B 1 0.1981 28 0.838 Contact Map
2wq1A 3 0.2075 13.3 0.861 Contact Map
3w92A 3 0.1981 12.4 0.862 Contact Map
3c3gA 2 0.1226 9.6 0.869 Contact Map
2r2vA 3 0.217 9 0.871 Contact Map
1kd8A 1 0.2075 7.5 0.875 Contact Map
4hjbC 3 0.1981 6.8 0.878 Contact Map
2hy6A 3 0.1981 6.6 0.879 Contact Map
4tl1A 2 0.1981 6.6 0.879 Contact Map
3c3fA 3 0.1604 6.5 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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