GREMLIN Database
DUF2293 - Uncharacterized conserved protein (DUF2293)
PFAM: PF10056 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (84)
Sequences: 4364 (2607)
Seq/√Len: 284.5
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E53_T4.6821.00
17_I45_V2.9811.00
76_R79_E2.8011.00
15_R19_E2.6511.00
74_A78_D2.6351.00
42_E46_I2.2161.00
37_L40_R2.0611.00
36_P40_R2.0521.00
55_D76_R2.0181.00
39_E42_E2.0181.00
55_D58_E1.9921.00
65_D68_E1.9411.00
48_H53_T1.8041.00
3_R14_A1.7541.00
5_L42_E1.7371.00
64_V72_F1.5561.00
80_V83_R1.5341.00
48_H52_Q1.4881.00
61_I69_A1.4771.00
7_P10_P1.4451.00
22_C25_G1.4231.00
16_A52_Q1.3941.00
49_V80_V1.3831.00
68_E72_F1.3701.00
55_D72_F1.3411.00
75_D78_D1.2941.00
46_I81_L1.2911.00
6_F42_E1.2781.00
73_V77_V1.2701.00
75_D79_E1.2471.00
67_R71_R1.2031.00
71_R74_A1.1831.00
49_V77_V1.1801.00
18_A22_C1.1771.00
59_L69_A1.1261.00
55_D59_L1.1261.00
60_L66_R1.0941.00
22_C35_A1.0341.00
76_R80_V1.0241.00
31_R34_A0.9931.00
46_I74_A0.9681.00
79_E83_R0.9641.00
62_P72_F0.9631.00
26_S32_T0.9541.00
7_P11_A0.9451.00
80_V84_W0.9401.00
12_G16_A0.9321.00
46_I78_D0.9271.00
19_E23_P0.9201.00
26_S31_R0.9191.00
26_S30_G0.9091.00
29_V32_T0.8801.00
76_R84_W0.8721.00
42_E85_R0.8551.00
20_H47_A0.8451.00
32_T35_A0.8431.00
58_E62_P0.8431.00
27_G31_R0.8391.00
6_F10_P0.8361.00
9_C17_I0.8361.00
49_V81_L0.8261.00
82_A85_R0.8211.00
22_C48_H0.8120.99
53_T80_V0.8030.99
67_R79_E0.8010.99
68_E71_R0.7920.99
47_A51_H0.7740.99
25_G41_A0.7710.99
72_F76_R0.7590.99
21_A41_A0.7570.99
63_G68_E0.7480.99
6_F9_C0.7410.99
21_A30_G0.7400.99
28_R31_R0.7280.99
36_P39_E0.7280.99
20_H26_S0.7180.99
42_E78_D0.6870.98
2_I14_A0.6840.98
29_V47_A0.6820.98
46_I77_V0.6700.98
69_A73_V0.6650.98
25_G35_A0.6440.97
5_L39_E0.6410.97
24_K35_A0.6280.97
60_L69_A0.6230.97
21_A44_A0.6160.97
28_R44_A0.6110.96
44_A47_A0.6090.96
45_V49_V0.6050.96
39_E78_D0.6000.96
15_R55_D0.5970.96
13_E49_V0.5900.96
40_R43_L0.5810.95
6_F45_V0.5770.95
9_C49_V0.5750.95
76_R85_R0.5730.95
13_E48_H0.5680.95
3_R84_W0.5650.95
15_R18_A0.5590.94
10_P43_L0.5570.94
4_E15_R0.5470.94
64_V68_E0.5460.94
4_E7_P0.5460.94
51_H56_Y0.5450.93
51_H70_R0.5450.93
49_V54_T0.5440.93
7_P60_L0.5420.93
15_R76_R0.5410.93
53_T61_I0.5410.93
2_I18_A0.5380.93
25_G29_V0.5330.93
51_H54_T0.5320.93
23_P48_H0.5290.92
18_A28_R0.5260.92
21_A47_A0.5230.92
26_S29_V0.5220.92
60_L72_F0.5210.92
24_K27_G0.5200.92
7_P15_R0.5190.92
9_C14_A0.5170.92
10_P84_W0.5090.91
23_P66_R0.5090.91
69_A84_W0.5080.91
27_G32_T0.5060.91
25_G31_R0.5000.90
63_G69_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ragA 2 0.9647 15.3 0.895 Contact Map
3id7A 1 0.9294 13.9 0.897 Contact Map
4g3oA 1 0.4235 12.4 0.899 Contact Map
1rvgA 3 0.8118 8.8 0.905 Contact Map
3hglA 1 0.4 8.5 0.906 Contact Map
3n9rA 3 0.8118 7.6 0.908 Contact Map
2iswA 2 0.8118 7.3 0.909 Contact Map
2i5gA 2 0.9765 6.6 0.911 Contact Map
4hnzA 5 0.4941 6.5 0.911 Contact Map
1p3qQ 2 0.4353 6.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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