GREMLIN Database
DUF2284 - Predicted metal-binding protein (DUF2284)
PFAM: PF10050 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (159)
Sequences: 5629 (4183)
Seq/√Len: 331.7
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_T124_A3.7681.00
42_R46_K3.1831.00
137_K141_K2.6491.00
34_A112_Y2.5711.00
4_D7_D2.5281.00
7_D142_A2.3991.00
134_D137_K2.3951.00
85_E125_R2.3551.00
37_S40_E2.3471.00
16_L19_R2.3401.00
120_F123_K2.3331.00
7_D141_K2.3171.00
81_L98_A2.3051.00
56_T77_H2.3051.00
54_F81_L2.3031.00
29_W112_Y2.1611.00
10_V45_L2.1141.00
39_E43_E1.9981.00
128_M133_I1.9651.00
111_A119_R1.9551.00
8_I133_I1.8591.00
41_C131_C1.8181.00
86_R123_K1.8081.00
4_D50_R1.8001.00
79_E123_K1.7771.00
38_P132_G1.7211.00
109_E114_D1.7151.00
150_K154_N1.6761.00
9_V137_K1.5861.00
86_R90_L1.5851.00
133_I138_T1.5631.00
99_L131_C1.5581.00
11_D134_D1.5321.00
57_E155_T1.5221.00
12_E42_R1.4901.00
139_A159_Y1.4801.00
55_Q144_L1.4781.00
128_M135_V1.4461.00
47_E95_K1.3971.00
12_E47_E1.3881.00
83_E87_E1.3791.00
81_L160_G1.3761.00
137_K140_R1.3711.00
9_V141_K1.3671.00
53_L142_A1.3481.00
78_N100_G1.3331.00
26_G33_P1.3321.00
72_E76_K1.3081.00
12_E16_L1.3081.00
145_P159_Y1.3051.00
55_Q157_T1.2781.00
9_V138_T1.2531.00
106_L123_K1.2421.00
12_E43_E1.2251.00
35_V130_A1.2221.00
24_N27_K1.2101.00
129_E135_V1.1821.00
74_K78_N1.1781.00
79_E83_E1.1691.00
88_A162_V1.1671.00
128_M161_L1.1651.00
111_A116_E1.1641.00
19_R25_Y1.1581.00
126_P131_C1.1531.00
29_W111_A1.1141.00
51_A161_L1.1131.00
87_E91_D1.0991.00
75_R79_E1.0941.00
15_R38_P1.0821.00
11_D137_K1.0661.00
17_K20_F1.0261.00
114_D119_R1.0231.00
147_E154_N1.0171.00
77_H101_A1.0051.00
58_G73_A0.9961.00
29_W113_P0.9921.00
29_W34_A0.9891.00
78_N82_L0.9881.00
43_E46_K0.9851.00
16_L44_I0.9821.00
55_Q159_Y0.9771.00
57_E157_T0.9721.00
144_L159_Y0.9691.00
102_G127_S0.9591.00
13_R95_K0.9551.00
85_E98_A0.9551.00
94_Y137_K0.9481.00
15_R37_S0.9341.00
15_R19_R0.9291.00
85_E96_A0.9261.00
98_A125_R0.9211.00
76_K79_E0.9051.00
56_T80_I0.9051.00
39_E42_R0.9051.00
53_L128_M0.9041.00
74_K105_K0.9011.00
84_L162_V0.8991.00
89_F92_G0.8991.00
111_A117_P0.8961.00
66_R71_R0.8951.00
81_L162_V0.8901.00
14_V129_E0.8811.00
13_R16_L0.8801.00
109_E113_P0.8771.00
136_F148_V0.8681.00
35_V131_C0.8651.00
82_L85_E0.8621.00
12_E39_E0.8591.00
28_N105_K0.8521.00
45_L133_I0.8511.00
146_I149_G0.8501.00
106_L120_F0.8481.00
14_V134_D0.8391.00
5_P50_R0.8391.00
24_N103_S0.8381.00
87_E90_L0.8331.00
106_L124_A0.8301.00
156_V160_G0.8271.00
138_T141_K0.8271.00
102_G129_E0.8261.00
89_F93_Y0.8261.00
24_N105_K0.8221.00
13_R134_D0.8191.00
82_L123_K0.8181.00
12_E38_P0.8081.00
54_F98_A0.8031.00
69_G72_E0.7951.00
77_H160_G0.7951.00
40_E43_E0.7951.00
135_V138_T0.7921.00
44_I97_F0.7861.00
76_K80_I0.7821.00
10_V46_K0.7771.00
55_Q145_P0.7751.00
24_N28_N0.7711.00
27_K113_P0.7691.00
85_E89_F0.7621.00
8_I138_T0.7561.00
148_V157_T0.7541.00
81_L85_E0.7470.99
8_I51_A0.7460.99
23_G122_E0.7400.99
18_C22_C0.7400.99
62_D65_D0.7370.99
53_L138_T0.7330.99
62_D68_E0.7310.99
61_E65_D0.7290.99
14_V17_K0.7250.99
29_W117_P0.7240.99
40_E44_I0.7160.99
77_H81_L0.7150.99
90_L150_K0.7070.99
30_T126_P0.6980.99
107_C110_C0.6970.99
70_M73_A0.6800.99
5_P51_A0.6750.99
22_C31_C0.6740.99
77_H80_I0.6740.99
149_G154_N0.6740.99
53_L139_A0.6660.99
54_F160_G0.6650.99
57_E148_V0.6640.99
71_R74_K0.6630.99
107_C118_C0.6610.99
26_G32_P0.6590.99
26_G34_A0.6570.99
55_Q139_A0.6550.99
140_R146_I0.6500.99
41_C99_L0.6440.98
98_A162_V0.6440.98
72_E75_R0.6410.98
11_D47_E0.6410.98
104_C118_C0.6410.98
156_V159_Y0.6410.98
61_E68_E0.6400.98
136_F140_R0.6380.98
82_L125_R0.6380.98
37_S41_C0.6370.98
118_C121_P0.6340.98
103_S127_S0.6310.98
71_R75_R0.6290.98
80_I84_L0.6240.98
106_L109_E0.6190.98
26_G112_Y0.6130.98
116_E119_R0.6120.98
38_P42_R0.6030.98
146_I159_Y0.5970.97
69_G73_A0.5960.97
149_G156_V0.5960.97
5_P46_K0.5940.97
61_E64_F0.5920.97
151_D154_N0.5910.97
156_V161_L0.5900.97
56_T76_K0.5860.97
154_N157_T0.5860.97
59_P155_T0.5810.97
21_G97_F0.5810.97
94_Y140_R0.5740.97
78_N105_K0.5720.97
28_N113_P0.5710.97
147_E155_T0.5700.97
34_A113_P0.5690.97
58_G77_H0.5680.97
2_I52_L0.5640.96
140_R147_E0.5630.96
61_E69_G0.5620.96
126_P130_A0.5600.96
112_Y115_G0.5580.96
31_C103_S0.5530.96
68_E71_R0.5490.96
157_T160_G0.5480.96
10_V13_R0.5480.96
10_V133_I0.5470.96
15_R25_Y0.5460.96
58_G76_K0.5450.96
43_E47_E0.5450.96
88_A93_Y0.5440.96
85_E88_A0.5430.96
48_Y95_K0.5420.96
8_I45_L0.5380.95
64_F69_G0.5340.95
2_I5_P0.5320.95
4_D51_A0.5310.95
10_V41_C0.5270.95
41_C45_L0.5250.95
63_S69_G0.5250.95
36_P40_E0.5250.95
10_V42_R0.5240.95
155_T159_Y0.5220.95
14_V136_F0.5220.95
28_N124_A0.5150.94
155_T158_Y0.5060.94
101_A160_G0.5060.94
99_L128_M0.5050.94
96_A162_V0.5040.93
28_N103_S0.5040.93
48_Y97_F0.5020.93
60_L66_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ercA 1 0.2073 4.3 0.948 Contact Map
2l9zA 1 0.2378 3.2 0.951 Contact Map
4fw2A 2 0.25 2.8 0.952 Contact Map
4nfnA 1 0.8232 2.8 0.952 Contact Map
2apoB 1 0.3354 2.6 0.953 Contact Map
4udxX 2 0.5671 2.5 0.954 Contact Map
2jiiA 1 0.8537 2.3 0.955 Contact Map
3dinD 1 0.1585 2.2 0.955 Contact Map
2lzyA 1 0.1768 2.2 0.955 Contact Map
3dl8C 1 0.0488 2.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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