GREMLIN Database
DUF2282 - Predicted integral membrane protein (DUF2282)
PFAM: PF10048 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (51)
Sequences: 6964 (1691)
Seq/√Len: 236.8
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_H36_A3.0981.00
32_Y49_V2.6911.00
2_E43_G2.3081.00
22_H27_T2.1231.00
30_V33_D1.9611.00
15_C24_C1.5811.00
17_A21_T1.5331.00
1_K41_P1.5291.00
9_K31_D1.5181.00
40_V44_T1.4641.00
33_D36_A1.3961.00
18_G21_T1.3921.00
23_S27_T1.3661.00
9_K32_Y1.3261.00
18_G35_N1.3051.00
44_T48_I1.2861.00
13_N28_S1.2781.00
22_H28_S1.2421.00
44_T47_K1.1651.00
32_Y50_G1.1541.00
27_T36_A1.1441.00
28_S36_A1.1161.00
19_A35_N1.1051.00
41_P44_T1.0851.00
2_E40_V1.0811.00
21_T35_N1.0501.00
16_A37_W1.0431.00
9_K12_K1.0431.00
38_K48_I1.0271.00
28_S33_D1.0201.00
16_A25_A1.0001.00
46_E49_V0.9861.00
1_K5_Y0.9781.00
17_A35_N0.9691.00
38_K49_V0.9511.00
32_Y38_K0.9491.00
7_V48_I0.9321.00
5_Y8_A0.9251.00
12_K38_K0.9161.00
3_K37_W0.9031.00
47_K50_G0.8810.99
8_A31_D0.8630.99
42_K46_E0.7960.99
31_D49_V0.7920.99
4_C45_C0.7870.99
14_D39_Y0.7740.99
38_K50_G0.7630.98
14_D38_K0.7620.98
25_A37_W0.7360.98
17_A22_H0.7360.98
40_V43_G0.7200.98
7_V40_V0.7200.98
41_P47_K0.7080.97
20_G37_W0.6890.97
11_G44_T0.6530.96
11_G31_D0.6270.95
8_A40_V0.6150.94
38_K44_T0.6040.94
17_A20_G0.5950.93
3_K27_T0.5830.93
16_A27_T0.5790.92
38_K41_P0.5730.92
10_A29_K0.5700.92
18_G34_G0.5680.92
12_K46_E0.5600.91
2_E42_K0.5550.91
17_A25_A0.5490.90
5_Y37_W0.5470.90
10_A31_D0.5360.89
16_A19_A0.5350.89
29_K33_D0.5260.88
1_K39_Y0.5240.88
17_A36_A0.5130.87
6_G26_G0.5130.87
5_Y40_V0.5070.86
13_N24_C0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ycuA 1 0.434 5 0.896 Contact Map
1wktA 1 0.8679 4.7 0.897 Contact Map
2kkxA 1 0.3396 1.2 0.925 Contact Map
1tujA 1 0.5849 1.2 0.925 Contact Map
3r1pA 1 0.7547 1.2 0.925 Contact Map
3vsfA 1 0.8868 1.2 0.926 Contact Map
2jp6A 1 0.2453 1.2 0.926 Contact Map
1oohA 1 0.6792 1.1 0.927 Contact Map
3jqoC 1 0.3962 1.1 0.927 Contact Map
4anjA 1 0.3585 1.1 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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