GREMLIN Database
DUF2281 - Protein of unknown function (DUF2281)
PFAM: PF10047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (63)
Sequences: 3955 (2938)
Seq/√Len: 370.2
META: 0.944

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_K25_E3.4891.00
8_K24_V2.6611.00
8_K28_L2.5451.00
20_V24_V2.5091.00
6_E10_E2.2341.00
16_L31_R2.1041.00
22_D26_F2.0621.00
19_E30_K1.8401.00
59_L63_K1.7961.00
43_G46_K1.7681.00
26_F30_K1.6811.00
11_E28_L1.6791.00
13_P16_L1.5931.00
52_S55_F1.5021.00
23_F26_F1.4201.00
18_K21_L1.3601.00
5_L9_I1.3581.00
14_P17_Q1.3341.00
20_V27_L1.3221.00
40_R44_S1.2971.00
45_W48_A1.2331.00
12_L24_V1.2301.00
19_E22_D1.2221.00
41_L45_W1.1891.00
18_K22_D1.1731.00
8_K21_L1.1131.00
19_E26_F1.1031.00
9_I17_Q1.0801.00
13_P31_R1.0691.00
26_F29_E1.0111.00
45_W49_L0.9911.00
54_D57_T0.9881.00
62_Q65_Y0.9661.00
12_L16_L0.9471.00
51_M55_F0.9441.00
7_E10_E0.9231.00
16_L23_F0.9201.00
4_Q7_E0.9191.00
6_E17_Q0.9041.00
19_E23_F0.8751.00
51_M54_D0.8641.00
22_D30_K0.8511.00
44_S48_A0.8441.00
40_R43_G0.8321.00
55_F58_P0.8201.00
57_T61_L0.8081.00
17_Q21_L0.8051.00
4_Q25_E0.8041.00
9_I21_L0.8041.00
9_I24_V0.7991.00
43_G48_A0.7941.00
41_L44_S0.7891.00
42_F45_W0.7711.00
21_L25_E0.7681.00
25_E28_L0.7591.00
4_Q21_L0.7551.00
15_E31_R0.7361.00
25_E30_K0.7251.00
21_L24_V0.7151.00
53_D56_D0.6960.99
3_E6_E0.6850.99
16_L19_E0.6840.99
52_S56_D0.6770.99
12_L17_Q0.6670.99
50_K53_D0.6660.99
57_T62_Q0.6660.99
4_Q8_K0.6640.99
38_K44_S0.6530.99
39_K45_W0.6400.99
14_P18_K0.6320.99
23_F31_R0.6230.99
6_E9_I0.6130.99
56_D59_L0.6070.98
56_D62_Q0.6010.98
52_S59_L0.5940.98
61_L65_Y0.5900.98
3_E7_E0.5850.98
3_E11_E0.5850.98
58_P61_L0.5640.97
52_S63_K0.5620.97
54_D58_P0.5520.97
60_E63_K0.5430.97
36_K40_R0.5420.97
42_F48_A0.5330.96
32_K35_K0.5320.96
3_E10_E0.5290.96
40_R45_W0.5290.96
59_L62_Q0.5280.96
5_L21_L0.5210.96
8_K11_E0.5210.96
58_P62_Q0.5160.96
3_E21_L0.5060.95
5_L24_V0.5010.95
52_S57_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jcyA 2 0.3485 48.5 0.778 Contact Map
3r1fA 2 0.5152 39.4 0.79 Contact Map
4ndwA 2 0.5152 39.1 0.79 Contact Map
3op9A 4 0.5 23.6 0.812 Contact Map
3qwgA 2 0 16 0.827 Contact Map
1wixA 1 0.5455 15.6 0.827 Contact Map
3mavA 2 0.4394 14.6 0.83 Contact Map
2ebyA 2 0.5 14.2 0.83 Contact Map
4o8bA 2 0.4848 13.9 0.831 Contact Map
3ivpA 2 0.5303 13.8 0.831 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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