GREMLIN Database
BLOC1_2 - Biogenesis of lysosome-related organelles complex-1 subunit 2
PFAM: PF10046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (91)
Sequences: 671 (562)
Seq/√Len: 58.9
META: 0.498

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_L91_L2.8521.00
34_E37_A2.8101.00
72_E76_E2.6431.00
29_N36_Y2.6031.00
42_V47_E2.2221.00
51_E65_Q2.0891.00
27_K48_K2.0821.00
61_Q65_Q2.0721.00
75_T89_K1.9851.00
10_Y14_E1.9371.00
25_L39_M1.9101.00
53_L77_L1.8641.00
5_E9_K1.7490.99
80_A85_D1.6890.99
8_R11_L1.6470.99
64_L71_E1.5530.98
53_L94_K1.5520.98
76_E83_E1.5500.98
14_E24_L1.4740.98
14_E21_D1.4500.97
6_E11_L1.4360.97
31_A62_P1.3910.97
24_L29_N1.3840.97
78_E85_D1.3810.97
9_K12_E1.3730.96
51_E58_E1.3550.96
34_E72_E1.3020.95
7_V12_E1.2970.95
32_T60_L1.2710.95
7_V11_L1.2390.94
18_T32_T1.2340.94
16_E44_A1.2260.93
68_D89_K1.2260.93
34_E38_E1.2000.93
71_E74_V1.1940.93
24_L43_A1.1890.92
87_Y91_L1.1780.92
50_V74_V1.1690.92
23_E30_K1.1650.92
82_D91_L1.1500.91
6_E9_K1.1260.90
85_D92_E1.1100.89
27_K55_E1.0750.88
51_E55_E1.0660.87
30_K37_A1.0490.87
53_L56_K1.0270.85
25_L36_Y1.0190.85
11_L22_Y1.0160.85
31_A74_V1.0160.85
43_A67_I1.0020.84
17_A41_D1.0010.84
71_E78_E0.9860.83
56_K63_Y0.9670.82
27_K41_D0.9640.82
72_E86_E0.9570.81
21_D35_K0.9530.81
49_G88_S0.9400.80
21_D26_E0.9230.79
5_E58_E0.9200.78
40_E54_N0.9180.78
61_Q69_E0.9120.78
17_A45_E0.9110.78
60_L81_V0.9090.78
35_K49_G0.8730.75
37_A41_D0.8700.74
64_L81_V0.8640.74
21_D29_N0.8590.74
5_E12_E0.8540.73
6_E10_Y0.8530.73
67_I84_L0.8440.72
8_R12_E0.8170.70
44_A89_K0.8080.69
13_S65_Q0.8000.68
33_A37_A0.7850.67
30_K44_A0.7840.67
16_E20_E0.7800.66
34_E41_D0.7770.66
71_E75_T0.7750.66
41_D79_A0.7690.65
21_D60_L0.7620.64
61_Q75_T0.7590.64
48_K74_V0.7540.64
17_A27_K0.7420.62
25_L29_N0.7410.62
27_K33_A0.7390.62
56_K70_I0.7390.62
19_K30_K0.7330.61
78_E92_E0.7090.59
40_E47_E0.7050.58
83_E86_E0.7040.58
70_I82_D0.7010.58
66_Q80_A0.6930.57
49_G73_Q0.6890.57
46_L53_L0.6810.56
12_E28_M0.6720.55
74_V88_S0.6710.55
87_Y90_R0.6650.54
72_E83_E0.6370.51
83_E90_R0.6310.50
58_E61_Q0.6250.50
53_L80_A0.6230.49
70_I84_L0.6220.49
19_K88_S0.6130.48
6_E22_Y0.6070.48
23_E62_P0.6060.47
77_L84_L0.6040.47
45_E48_K0.6010.47
51_E79_A0.6010.47
28_M32_T0.6000.47
63_Y66_Q0.6000.47
41_D65_Q0.5990.47
16_E76_E0.5960.46
50_V54_N0.5950.46
35_K46_L0.5910.46
38_E84_L0.5860.45
22_Y67_I0.5780.44
6_E12_E0.5770.44
26_E30_K0.5720.44
23_E40_E0.5700.43
80_A86_E0.5610.42
32_T68_D0.5580.42
79_A93_A0.5470.41
32_T40_E0.5440.41
37_A51_E0.5400.40
25_L77_L0.5320.39
36_Y50_V0.5270.39
29_N81_V0.5270.39
47_E71_E0.5210.38
84_L88_S0.5160.38
67_I71_E0.5160.38
64_L73_Q0.5130.37
21_D25_L0.5100.37
69_E72_E0.5090.37
15_L68_D0.5080.37
44_A68_D0.5030.36
64_L68_D0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c9iA 5 0.9688 95.3 0.552 Contact Map
4linA 5 0.9688 94.9 0.562 Contact Map
2dfsA 2 0.9688 85.5 0.654 Contact Map
4ll8A 1 0.4583 85.3 0.655 Contact Map
1deqA 1 1 83.5 0.663 Contact Map
1i84S 2 0.2917 81.6 0.669 Contact Map
3ghgA 2 0.9479 81.3 0.67 Contact Map
1wyyA 3 0.9167 76 0.686 Contact Map
2ch7A 2 1 75.4 0.688 Contact Map
4iloA 3 0.9896 72.1 0.695 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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