GREMLIN Database
DUF2262 - Uncharacterized protein conserved in bacteria (DUF2262)
PFAM: PF10020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (135)
Sequences: 1266 (1022)
Seq/√Len: 88.0
META: 0.825

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D63_R4.4091.00
118_D124_G3.4321.00
59_D116_F2.7301.00
99_I127_I2.6911.00
132_D136_G2.5771.00
68_E92_E2.5521.00
7_F18_G2.4991.00
10_D17_E2.4101.00
112_F131_G2.3901.00
131_G136_G2.2781.00
4_L52_L2.2191.00
29_L48_A2.1651.00
98_R119_G2.1451.00
74_A78_L2.1411.00
78_L88_P2.0811.00
67_A96_A2.0501.00
22_W55_Q1.9971.00
101_L114_F1.9291.00
22_W58_W1.9271.00
77_W125_H1.8521.00
113_E128_I1.8441.00
66_A129_V1.8381.00
70_L127_I1.8371.00
58_W112_F1.8051.00
62_I114_F1.7761.00
19_E26_E1.7011.00
9_L16_F1.6771.00
120_D124_G1.6291.00
71_L75_N1.5701.00
133_L136_G1.5671.00
3_V7_F1.5261.00
21_D24_G1.5261.00
132_D135_G1.4810.99
64_E96_A1.4800.99
54_N57_E1.4750.99
57_E61_K1.4240.99
54_N58_W1.3850.99
115_Y126_S1.3800.99
66_A99_I1.3700.99
115_Y128_I1.3280.99
64_E92_E1.3260.99
51_L106_I1.3190.99
9_L14_D1.3140.99
101_L116_F1.3010.99
90_I121_L1.2470.98
62_I137_F1.2410.98
77_W122_F1.2260.98
75_N78_L1.2210.98
48_A62_I1.2070.98
92_E96_A1.2000.98
65_F69_E1.1960.98
51_L131_G1.1850.98
91_T94_E1.1770.97
22_W59_D1.1730.97
98_R118_D1.1600.97
99_I118_D1.1330.97
75_N121_L1.1150.96
120_D123_W1.1120.96
71_L121_L1.1010.96
102_E117_D1.0930.96
78_L123_W1.0840.96
47_T112_F1.0830.96
30_S115_Y1.0370.95
51_L55_Q1.0240.94
10_D13_L1.0090.94
67_A71_L1.0090.94
11_R15_W0.9570.92
56_E59_D0.9370.91
60_K64_E0.9320.91
107_Y113_E0.9230.90
49_K53_A0.9150.90
118_D121_L0.9030.90
93_E97_K0.9000.89
104_I114_F0.8980.89
94_E98_R0.8960.89
3_V53_A0.8960.89
17_E28_E0.8930.89
37_D40_D0.8870.89
11_R16_F0.8870.89
74_A122_F0.8740.88
51_L112_F0.8610.87
74_A82_E0.8570.87
31_L44_A0.8560.87
113_E130_S0.8550.87
73_L77_W0.8480.86
58_W62_I0.8460.86
112_F133_L0.8430.86
66_A70_L0.8400.86
38_E41_L0.8370.86
71_L91_T0.8320.85
28_E103_S0.8310.85
29_L49_K0.8270.85
69_E72_E0.8260.85
119_G124_G0.8250.85
63_R67_A0.8210.85
70_L73_L0.8130.84
7_F48_A0.7980.83
98_R121_L0.7970.83
55_Q58_W0.7960.83
122_F125_H0.7950.83
19_E100_S0.7820.82
58_W131_G0.7750.81
26_E97_K0.7590.80
128_I141_D0.7570.79
94_E97_K0.7500.79
130_S139_D0.7440.78
132_D137_F0.7430.78
32_D105_S0.7420.78
17_E30_S0.7410.78
96_A99_I0.7370.78
76_D81_D0.7350.77
13_L108_S0.7320.77
4_L67_A0.7300.77
101_L104_I0.7290.77
32_D107_Y0.7270.77
105_S115_Y0.7220.76
45_L116_F0.7200.76
22_W51_L0.7150.75
31_L105_S0.7150.75
27_I31_L0.7060.74
20_I52_L0.7050.74
64_E101_L0.6960.73
55_Q62_I0.6920.73
23_L27_I0.6900.73
18_G48_A0.6860.72
58_W61_K0.6830.72
41_L44_A0.6810.72
73_L76_D0.6810.72
88_P93_E0.6810.72
63_R96_A0.6710.71
51_L62_I0.6700.71
21_D93_E0.6680.70
77_W82_E0.6550.69
50_K53_A0.6490.68
58_W114_F0.6370.67
31_L79_E0.6340.66
78_L81_D0.6310.66
42_E46_A0.6290.66
50_K54_N0.6240.65
51_L114_F0.6190.65
95_F127_I0.6190.65
55_Q101_L0.6140.64
118_D123_W0.6110.64
82_E88_P0.6100.63
23_L56_E0.6090.63
78_L86_E0.6060.63
67_A116_F0.6030.63
16_F59_D0.5970.62
95_F122_F0.5950.61
103_S126_S0.5920.61
74_A90_I0.5910.61
75_N95_F0.5910.61
121_L128_I0.5890.61
33_V41_L0.5890.61
99_I121_L0.5850.60
69_E109_D0.5850.60
43_K72_E0.5830.60
71_L90_I0.5810.60
8_T18_G0.5810.60
70_L125_H0.5790.59
7_F31_L0.5750.59
127_I140_A0.5740.59
75_N94_E0.5720.58
114_F131_G0.5720.58
7_F106_I0.5710.58
22_W131_G0.5690.58
41_L48_A0.5690.58
78_L89_E0.5650.58
108_S111_S0.5640.57
98_R120_D0.5580.57
115_Y118_D0.5510.56
102_E110_G0.5510.56
134_D137_F0.5460.55
99_I116_F0.5440.55
23_L59_D0.5440.55
73_L122_F0.5440.55
62_I131_G0.5410.54
48_A52_L0.5330.53
72_E130_S0.5320.53
102_E115_Y0.5290.53
16_F74_A0.5290.53
116_F126_S0.5240.52
22_W133_L0.5220.52
129_V133_L0.5190.51
59_D72_E0.5190.51
90_I94_E0.5180.51
26_E76_D0.5170.51
30_S42_E0.5140.51
56_E93_E0.5120.50
62_I116_F0.5110.50
71_L96_A0.5100.50
70_L95_F0.5100.50
11_R61_K0.5090.50
3_V56_E0.5090.50
71_L74_A0.5080.50
131_G135_G0.5070.50
41_L55_Q0.5070.50
90_I98_R0.5030.49
46_A49_K0.5030.49
71_L92_E0.5020.49
95_F120_D0.5010.49
71_L122_F0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epuA 3 0.3803 13.2 0.912 Contact Map
1k3eA 2 0.3803 8 0.92 Contact Map
2cqkA 1 0.3662 6.9 0.923 Contact Map
3r6fA 2 0.3662 5.5 0.926 Contact Map
3f02A 1 0.9014 5.1 0.928 Contact Map
3ddcB 2 0.3592 4.4 0.929 Contact Map
3op1A 4 0.4225 3.7 0.932 Contact Map
2h4pA 1 0.9155 3.4 0.933 Contact Map
3pzfA 1 0.8803 3.3 0.934 Contact Map
3efyA 2 0.5211 3.2 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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