GREMLIN Database
DUF2243 - Predicted membrane protein (DUF2243)
PFAM: PF10002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 2107 (1558)
Seq/√Len: 132.6
META: 0.727

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_L120_L3.4441.00
11_G54_T3.0911.00
112_G115_P2.9751.00
36_T39_G2.5591.00
29_S34_P2.5051.00
28_L46_W2.4841.00
2_G84_G2.3351.00
108_H119_D2.3241.00
120_L124_A2.3231.00
7_L57_A2.1961.00
87_L130_L2.1681.00
24_W110_R2.1361.00
117_P121_G2.0411.00
81_L85_L1.9801.00
125_F129_L1.9541.00
13_V55_W1.9421.00
69_R76_W1.9341.00
111_Y115_P1.8521.00
12_F51_H1.8221.00
78_G82_W1.7921.00
116_L119_D1.5951.00
21_I52_A1.5941.00
38_S42_V1.5751.00
45_L49_L1.5631.00
26_H40_L1.5391.00
83_G137_L1.5171.00
23_Q45_L1.5161.00
94_L130_L1.5031.00
4_L60_A1.4611.00
96_E102_Q1.4581.00
23_Q44_T1.4501.00
131_V135_L1.4461.00
34_P39_G1.4381.00
89_W129_L1.4191.00
56_L60_A1.3951.00
86_L132_A1.3911.00
9_L85_L1.3901.00
97_G122_F1.3611.00
10_G89_W1.3211.00
40_L44_T1.3181.00
110_R118_W1.3121.00
9_L59_V1.3081.00
12_F58_T1.2991.00
13_V52_A1.2831.00
30_S111_Y1.2391.00
46_W49_L1.2351.00
7_L91_L1.2321.00
95_V100_D1.2261.00
18_L24_W1.2241.00
20_Q51_H1.1870.99
100_D106_I1.1800.99
31_G106_I1.1800.99
9_L58_T1.1780.99
67_R70_R1.1740.99
21_I49_L1.1670.99
23_Q41_E1.1640.99
5_L61_G1.1630.99
128_L132_A1.1480.99
67_R71_R1.1380.99
59_V63_F1.1090.99
14_D19_H1.1090.99
84_G137_L1.0970.99
102_Q105_G1.0870.99
98_L102_Q1.0860.99
112_G117_P1.0840.99
94_L126_G1.0770.99
12_F55_W1.0710.99
12_F20_Q1.0670.99
87_L134_W1.0630.99
5_L62_L1.0630.99
94_L127_A1.0550.99
55_W58_T1.0480.99
30_S105_G1.0390.99
15_G20_Q1.0180.98
27_M100_D1.0120.98
66_W69_R1.0090.98
113_P117_P0.9970.98
93_N97_G0.9790.98
38_S41_E0.9690.98
8_G58_T0.9680.98
114_N117_P0.9670.98
93_N122_F0.9670.98
31_G39_G0.9670.98
1_A81_L0.9660.98
34_P37_V0.9640.98
1_A5_L0.9570.97
125_F128_L0.9560.97
135_L138_R0.9450.97
26_H44_T0.9360.97
35_T39_G0.9360.97
87_L137_L0.9340.97
97_G103_L0.9260.97
108_H115_P0.9150.97
42_V46_W0.9140.97
87_L91_L0.9070.97
4_L57_A0.9050.96
53_A56_L0.8800.96
96_E109_V0.8760.96
12_F15_G0.8730.96
27_M96_E0.8610.95
126_G129_L0.8500.95
17_V22_L0.8470.95
134_W137_L0.8460.95
112_G116_L0.8420.95
71_R74_V0.8360.95
2_G81_L0.8180.94
70_R74_V0.8150.94
121_G124_A0.8100.94
94_L123_L0.8040.93
21_I45_L0.8010.93
113_P116_L0.7980.93
110_R115_P0.7940.93
53_A57_A0.7910.93
61_G81_L0.7870.93
12_F50_F0.7750.92
96_E122_F0.7710.92
12_F54_T0.7450.90
32_Y42_V0.7450.90
33_P39_G0.7430.90
94_L125_F0.7430.90
110_R114_N0.7350.90
131_V134_W0.7300.89
37_V40_L0.7290.89
61_G65_L0.7240.89
64_L67_R0.7190.89
63_F82_W0.7160.89
69_R72_G0.7140.88
69_R73_R0.7060.88
78_G81_L0.7040.88
118_W121_G0.6950.87
17_V21_I0.6950.87
3_I91_L0.6940.87
92_F97_G0.6920.87
17_V52_A0.6880.87
102_Q115_P0.6850.86
32_Y36_T0.6840.86
109_V123_L0.6810.86
16_I23_Q0.6790.86
93_N105_G0.6740.85
37_V44_T0.6730.85
131_V138_R0.6670.85
65_L69_R0.6640.85
99_V102_Q0.6620.84
120_L127_A0.6540.84
63_F67_R0.6540.84
15_G51_H0.6540.84
63_F135_L0.6470.83
12_F16_I0.6460.83
29_S46_W0.6460.83
70_R76_W0.6420.83
31_G35_T0.6420.83
29_S37_V0.6370.82
28_L34_P0.6370.82
97_G100_D0.6350.82
32_Y39_G0.6350.82
69_R81_L0.6350.82
96_E100_D0.6320.82
93_N100_D0.6290.81
90_G94_L0.6260.81
5_L81_L0.6220.81
19_H51_H0.6150.80
96_E123_L0.6130.80
39_G42_V0.6120.79
41_E44_T0.6030.78
66_W81_L0.6020.78
54_T58_T0.5940.77
83_G87_L0.5880.77
115_P118_W0.5830.76
100_D109_V0.5770.75
62_L65_L0.5690.74
43_N46_W0.5650.74
66_W78_G0.5560.73
33_P43_N0.5550.73
61_G77_S0.5540.72
115_P120_L0.5520.72
22_L26_H0.5510.72
10_G50_F0.5500.72
80_R84_G0.5480.72
7_L53_A0.5480.72
94_L98_L0.5460.71
29_S43_N0.5440.71
16_I100_D0.5420.71
15_G50_F0.5370.70
102_Q120_L0.5320.69
121_G126_G0.5310.69
17_V28_L0.5300.69
31_G46_W0.5290.69
74_V80_R0.5250.68
75_A80_R0.5200.68
15_G96_E0.5190.68
127_A134_W0.5180.67
34_P46_W0.5180.67
68_A72_G0.5170.67
51_H95_V0.5170.67
33_P36_T0.5130.67
10_G54_T0.5120.66
50_F95_V0.5120.66
58_T70_R0.5100.66
33_P37_V0.5080.66
23_Q54_T0.5080.66
68_A84_G0.5060.66
84_G87_L0.5060.66
5_L58_T0.5050.65
16_I95_V0.5040.65
10_G16_I0.5030.65
97_G123_L0.5030.65
3_I84_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jo1A 1 0.2302 5.6 0.954 Contact Map
2jp3A 1 0.2374 3.4 0.958 Contact Map
2ks1B 1 0.3094 2.1 0.963 Contact Map
3mk7C 2 0.554 2 0.963 Contact Map
2zxeG 1 0.2302 2 0.963 Contact Map
3wu2C 1 0.964 1.9 0.963 Contact Map
2ipbA 2 0.259 1.8 0.964 Contact Map
3j1zP 8 0.8058 1.8 0.964 Contact Map
2mkvA 1 0.2878 1.7 0.964 Contact Map
4o6yA 2 0.9712 1.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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