GREMLIN Database
DUF2242 - Uncharacterized protein conserved in bacteria (DUF2242)
PFAM: PF10001 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (121)
Sequences: 640 (338)
Seq/√Len: 30.8
META: 0.822

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_S116_L4.1431.00
39_I104_I2.7531.00
2_E5_R2.7321.00
26_R40_E2.7291.00
77_V85_V2.4090.99
61_A65_R2.3080.99
20_A23_V2.1670.98
58_F120_Y2.1380.98
32_E35_V2.1070.98
24_T42_R2.0140.97
7_A10_S1.9920.97
42_R60_N1.9360.97
81_A89_F1.8720.96
17_R20_A1.8710.96
53_G59_V1.8160.95
57_V117_V1.7900.95
69_K112_R1.7760.95
29_F104_I1.7760.95
100_A112_R1.7490.94
84_S88_P1.7480.94
18_A58_F1.6950.93
43_V113_F1.6650.92
72_N90_G1.6350.92
28_S85_V1.5870.90
64_D101_S1.5740.90
108_D118_E1.5630.90
4_A43_V1.5370.89
20_A120_Y1.5340.89
29_F41_F1.5030.88
1_C4_A1.4840.87
59_V107_P1.4490.86
49_G52_G1.4470.86
61_A91_S1.4280.85
61_A109_F1.4110.84
102_E106_D1.3870.83
96_L117_V1.3340.81
35_V67_A1.3330.81
115_A118_E1.3110.80
77_V80_G1.2670.77
111_D119_R1.2630.77
8_L12_G1.2480.76
27_K112_R1.2440.76
75_A94_D1.2110.74
62_L74_S1.1940.73
77_V86_S1.1480.70
49_G57_V1.1300.69
19_D58_F1.1240.68
47_P53_G1.1150.67
47_P51_G1.0980.66
65_R69_K1.0940.66
25_G102_E1.0910.66
53_G108_D1.0900.66
62_L120_Y1.0760.65
40_E56_T1.0740.65
47_P57_V1.0480.63
68_L95_S1.0480.63
25_G32_E1.0420.62
2_E6_R1.0390.62
28_S38_E1.0370.62
57_V82_L1.0280.61
38_E69_K1.0130.60
15_I49_G0.9940.58
39_I60_N0.9920.58
70_K76_S0.9890.58
64_D67_A0.9750.57
48_D54_G0.9610.56
71_S81_A0.9600.56
16_D104_I0.9540.55
75_A83_G0.9530.55
29_F63_Q0.9470.55
33_P56_T0.9460.55
39_I72_N0.9320.54
62_L66_Y0.9110.52
75_A85_V0.9060.51
73_N96_L0.9050.51
82_L99_V0.9030.51
37_V57_V0.8890.50
6_R55_S0.8850.50
16_D41_F0.8800.49
25_G56_T0.8730.49
38_E58_F0.8710.49
81_A106_D0.8460.47
14_V118_E0.8440.46
30_Q61_A0.8390.46
11_Q96_L0.8360.46
60_N92_S0.8350.46
41_F59_V0.8290.45
67_A94_D0.8270.45
30_Q36_H0.8230.45
4_A69_K0.8130.44
39_I106_D0.8110.44
17_R55_S0.8100.44
67_A112_R0.8010.43
43_V80_G0.7980.43
70_K94_D0.7920.42
27_K63_Q0.7860.42
18_A23_V0.7840.42
28_S96_L0.7840.42
25_G118_E0.7710.41
13_Y45_C0.7690.41
1_C8_L0.7690.41
57_V105_T0.7680.40
74_S86_S0.7680.40
2_E20_A0.7650.40
23_V62_L0.7620.40
75_A92_S0.7570.40
77_V87_L0.7510.39
95_S98_K0.7500.39
100_A105_T0.7460.39
28_S61_A0.7460.39
39_I65_R0.7410.38
15_I50_K0.7350.38
2_E97_V0.7270.37
32_E52_G0.7260.37
15_I18_A0.7250.37
73_N91_S0.7180.37
24_T60_N0.7160.36
57_V116_L0.7160.36
69_K85_V0.7150.36
21_D63_Q0.7150.36
63_Q90_G0.7100.36
49_G54_G0.7080.36
60_N107_P0.7070.36
64_D78_G0.7020.35
23_V90_G0.6990.35
88_P96_L0.6900.35
26_R58_F0.6740.33
23_V58_F0.6690.33
5_R14_V0.6590.32
24_T54_G0.6510.32
72_N85_V0.6510.32
54_G59_V0.6500.32
94_D97_V0.6490.32
43_V70_K0.6450.31
40_E55_S0.6450.31
11_Q99_V0.6440.31
31_P35_V0.6440.31
1_C6_R0.6390.31
57_V112_R0.6370.31
44_V99_V0.6290.30
96_L99_V0.6250.30
25_G46_A0.6230.30
9_L12_G0.6210.30
15_I65_R0.6210.30
25_G49_G0.6200.30
15_I73_N0.6190.30
10_S30_Q0.6180.30
55_S107_P0.6120.29
71_S74_S0.6010.28
30_Q101_S0.6010.28
64_D74_S0.5920.28
14_V91_S0.5860.27
32_E38_E0.5850.27
77_V98_K0.5810.27
29_F79_V0.5810.27
1_C5_R0.5790.27
33_P50_K0.5710.26
36_H101_S0.5630.26
1_C12_G0.5560.26
6_R86_S0.5520.25
38_E86_S0.5520.25
64_D83_G0.5510.25
37_V80_G0.5470.25
24_T46_A0.5440.25
75_A86_S0.5420.25
22_L58_F0.5350.24
52_G107_P0.5350.24
33_P107_P0.5310.24
27_K45_C0.5290.24
38_E77_V0.5270.24
7_A11_Q0.5250.24
63_Q111_D0.5230.24
42_R104_I0.5220.24
2_E23_V0.5180.23
17_R49_G0.5120.23
87_L108_D0.5110.23
91_S109_F0.5070.23
92_S95_S0.5070.23
87_L97_V0.5040.23
70_K95_S0.5000.22
37_V85_V0.5000.22
68_L99_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ab1A 1 0.3719 13.3 0.944 Contact Map
3qneA 2 0.0661 9.7 0.947 Contact Map
4e18B 1 0.1488 8 0.949 Contact Map
3nrkA 3 0.2479 7.6 0.95 Contact Map
3p9yA 1 0.5785 6.8 0.95 Contact Map
4ywtA 1 0.8264 6.1 0.951 Contact Map
2dulA 2 0.3223 5.9 0.952 Contact Map
5a21G 1 0.3802 4.8 0.954 Contact Map
4ixjA 1 0.7355 4.6 0.954 Contact Map
1mk4A 2 0.3471 4.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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