GREMLIN Database
Tad_C - Putative Tad-like Flp pilus-assembly
PFAM: PF09977 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (90)
Sequences: 7243 (6477)
Seq/√Len: 682.7
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_R92_T3.1231.00
40_E67_R2.7481.00
17_R21_A2.6821.00
76_L87_V2.6271.00
18_A22_A2.3011.00
69_T92_T2.2991.00
19_A22_A2.2641.00
76_L79_A1.9631.00
65_A94_T1.8831.00
23_A26_L1.7291.00
22_A26_L1.7011.00
13_T17_R1.6961.00
15_A19_A1.6901.00
5_A8_D1.6591.00
14_A18_A1.6581.00
80_R85_S1.6111.00
53_T56_F1.6051.00
67_R94_T1.5901.00
6_L10_S1.5441.00
19_A23_A1.5421.00
31_A34_G1.5041.00
73_T88_T1.4981.00
52_T55_T1.4271.00
71_R90_S1.4111.00
38_D71_R1.3321.00
79_A82_F1.3091.00
7_A11_A1.3001.00
16_A20_A1.2991.00
41_F44_W1.2761.00
4_A8_D1.2641.00
76_L80_R1.2591.00
4_A7_A1.2551.00
51_A56_F1.2391.00
54_R57_T1.2101.00
5_A10_S1.1841.00
24_A29_V1.1731.00
23_A27_N1.1701.00
21_A25_A1.1571.00
38_D41_F1.1531.00
5_A9_A1.1221.00
69_T90_S1.1161.00
48_P51_A1.1081.00
84_I87_V1.0851.00
18_A21_A1.0751.00
70_V91_A1.0721.00
24_A28_G1.0211.00
76_L84_I1.0071.00
6_L11_A1.0051.00
6_L9_A1.0011.00
71_R88_T1.0011.00
39_V42_G0.9801.00
4_A11_A0.9611.00
41_F45_D0.9571.00
7_A10_S0.9561.00
49_T53_T0.9531.00
40_E69_T0.9441.00
24_A27_N0.9331.00
43_Y46_P0.9321.00
37_A41_F0.9161.00
57_T60_A0.9081.00
40_E58_P0.8731.00
74_V87_V0.8651.00
80_R84_I0.8651.00
50_T53_T0.8641.00
16_A27_N0.8641.00
59_G62_P0.8621.00
43_Y64_N0.8621.00
43_Y62_P0.8571.00
51_A54_R0.8551.00
5_A19_A0.8481.00
64_N74_V0.8391.00
51_A55_T0.8291.00
21_A24_A0.8221.00
43_Y63_P0.8171.00
44_W65_A0.8161.00
4_A10_S0.8121.00
42_G45_D0.7961.00
48_P55_T0.7941.00
15_A18_A0.7911.00
56_F59_G0.7901.00
49_T52_T0.7721.00
37_A40_E0.7581.00
26_L29_V0.7451.00
79_A87_V0.7271.00
36_S39_V0.7271.00
23_A29_V0.7231.00
50_T54_R0.6961.00
50_T57_T0.6851.00
64_N70_V0.6731.00
70_V74_V0.6641.00
73_T86_S0.6621.00
8_D11_A0.6541.00
14_A17_R0.6541.00
21_A27_N0.6521.00
22_A27_N0.6481.00
36_S41_F0.6471.00
55_T58_P0.6461.00
51_A57_T0.6451.00
52_T56_F0.6451.00
36_S40_E0.6451.00
75_P80_R0.6221.00
39_V45_D0.6171.00
42_G46_P0.6101.00
32_A35_N0.6061.00
20_A24_A0.5951.00
55_T59_G0.5901.00
48_P54_R0.5851.00
20_A68_V0.5851.00
48_P53_T0.5771.00
51_A58_P0.5721.00
41_F66_V0.5711.00
4_A9_A0.5701.00
59_G63_P0.5661.00
29_V70_V0.5651.00
77_F80_R0.5641.00
56_F60_A0.5501.00
31_A37_A0.5411.00
40_E43_Y0.5401.00
50_T55_T0.5391.00
76_L83_G0.5371.00
53_T57_T0.5351.00
24_A70_V0.5351.00
33_G37_A0.5341.00
9_A15_A0.5221.00
14_A27_N0.5210.99
17_R41_F0.5210.99
23_A28_G0.5150.99
40_E45_D0.5140.99
77_F82_F0.5100.99
19_A26_L0.5100.99
77_F81_I0.5030.99
49_T56_F0.5010.99
54_R60_A0.5010.99
65_A77_F0.5000.99
13_T16_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rmgA 1 0.2947 1.2 0.906 Contact Map
2pjvA 1 0.2526 1.1 0.907 Contact Map
2rmhA 1 0.2947 0.8 0.915 Contact Map
2h9uA 2 0.3789 0.7 0.918 Contact Map
4ui9T 1 0.2105 0.7 0.919 Contact Map
4nnoA 1 0.3263 0.7 0.92 Contact Map
3mfqA 1 0.3368 0.6 0.922 Contact Map
4cl2A 1 0.3263 0.6 0.922 Contact Map
1pq4A 1 0.3368 0.6 0.924 Contact Map
2bkyA 2 0.3368 0.6 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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