DUF2207 - PFAM28P - GREMLIN Contacts

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DUF2207 - Predicted membrane protein (DUF2207)

PFAM:	PF09972	Sequences: RITSFDVDITVNPDGSLDVTETITVDFDGIRHGIYRYRDIPTRYYDVDGNGRRVRFKVRDGAPEPYHTESEGNGTLVPGEHTYVITYRVRGALRFFDDHDELYWNVTGNGWDVPIDNASATVTLPAGGAAAGDVRAYTGPGTDGTAVIVDGGTVFFTTRPLPPGEGLTVRVGFPTSPAGAKVINGNGLEEILAEEAKIAEPSAAQRALAFLLDNLLLLLLLLLLLLLLLYYFLLWRRVGRDPKPGPIVPEYEEPPDGLSPAEVGYLLDMGKVDPRDITATLVDLAVRGYLKIEEEEKKGLLGKKTLLKLKKDDADLSPYERALLDALFGGSGDGVSLSGLGDEVKLSSKLKNKFYKALPALKKALYKVEKGYFDKNPDKVRGRLIALGILLLVLGVALALLLAAALGGLLGGAGLLGLALGLIGLIVLLLFARLMPARTAKGAELLDRWLGFKRYLEDRLRLKEAPPETPELFEKYLPYAIALGVEKKWAKAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	493 (452)
Sequences:	8866 (7873)
Seq/√Len:	370.3
META:	0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_D	123_T	4.034	1.00
6_D	119_S	3.775	1.00
12_N	18_D	3.748	1.00
18_D	88_R	3.624	1.00
452_F	476_Y	3.464	1.00
10_T	123_T	3.391	1.00
136_A	139_G	3.288	1.00
18_D	86_T	3.171	1.00
283_D	287_R	3.124	1.00
20_T	86_T	3.003	1.00
59_R	64_E	2.989	1.00
282_V	481_I	2.939	1.00
264_G	276_D	2.910	1.00
141_G	144_G	2.794	1.00
162_P	165_E	2.794	1.00
12_N	16_S	2.747	1.00
22_T	84_V	2.737	1.00
263_V	449_W	2.646	1.00
38_R	41_P	2.599	1.00
115_I	118_A	2.559	1.00
22_T	82_T	2.454	1.00
322_A	364_A	2.420	1.00
24_T	82_T	2.417	1.00
26_D	80_E	2.397	1.00
107_T	118_A	2.346	1.00
250_E	448_R	2.334	1.00
456_L	485_V	2.288	1.00
122_V	169_V	2.263	1.00
17_L	102_L	2.262	1.00
135_R	138_T	2.259	1.00
459_R	463_K	2.243	1.00
3_T	26_D	2.240	1.00
89_V	92_A	2.228	1.00
264_G	273_D	2.199	1.00
8_D	121_T	2.187	1.00
10_T	20_T	2.136	1.00
444_E	448_R	2.135	1.00
258_L	263_V	2.130	1.00
453_K	457_E	2.122	1.00
4_S	117_N	2.106	1.00
107_T	115_I	2.102	1.00
283_D	286_V	2.067	1.00
283_D	320_E	2.062	1.00
261_A	280_T	2.005	1.00
105_N	168_T	1.982	1.00
287_R	320_E	1.973	1.00
24_T	80_E	1.959	1.00
106_V	120_A	1.946	1.00
5_F	107_T	1.941	1.00
109_N	166_G	1.930	1.00
308_K	311_K	1.928	1.00
293_E	307_L	1.906	1.00
439_T	442_G	1.901	1.00
260_P	283_D	1.894	1.00
108_G	111_W	1.840	1.00
321_R	325_D	1.840	1.00
20_T	84_V	1.820	1.00
141_G	145_T	1.819	1.00
137_Y	140_P	1.816	1.00
236_R	240_R	1.776	1.00
256_D	448_R	1.773	1.00
3_T	116_D	1.760	1.00
393_V	397_A	1.727	1.00
443_A	447_D	1.725	1.00
460_L	463_K	1.713	1.00
132_G	139_G	1.710	1.00
49_G	52_R	1.705	1.00
101_E	170_R	1.698	1.00
76_L	81_H	1.687	1.00
308_K	316_L	1.679	1.00
8_D	22_T	1.678	1.00
461_R	465_A	1.670	1.00
284_L	324_L	1.655	1.00
112_D	164_G	1.647	1.00
280_T	320_E	1.627	1.00
458_D	461_R	1.625	1.00
17_L	92_A	1.624	1.00
273_D	276_D	1.618	1.00
77_V	81_H	1.616	1.00
96_F	99_H	1.607	1.00
3_T	80_E	1.587	1.00
386_A	390_L	1.576	1.00
144_G	147_V	1.571	1.00
441_K	444_E	1.558	1.00
135_R	139_G	1.522	1.00
384_L	388_G	1.519	1.00
259_S	319_Y	1.481	1.00
205_Q	209_A	1.480	1.00
89_V	104_W	1.470	1.00
17_L	89_V	1.469	1.00
69_E	72_G	1.466	1.00
227_L	231_Y	1.466	1.00
150_D	153_T	1.465	1.00
458_D	462_L	1.459	1.00
440_A	444_E	1.458	1.00
457_E	485_V	1.457	1.00
4_S	24_T	1.445	1.00
312_D	316_L	1.445	1.00
16_S	88_R	1.436	1.00
132_G	138_T	1.434	1.00
383_R	387_L	1.426	1.00
202_S	206_R	1.419	1.00
456_L	476_Y	1.417	1.00
264_G	268_D	1.410	1.00
460_L	464_E	1.406	1.00
388_G	392_L	1.406	1.00
25_V	34_I	1.402	1.00
174_P	197_K	1.388	1.00
21_E	38_R	1.388	1.00
285_A	292_I	1.386	1.00
268_D	276_D	1.386	1.00
419_A	423_I	1.380	1.00
310_K	313_D	1.380	1.00
267_L	453_K	1.370	1.00
202_S	205_Q	1.361	1.00
5_F	23_I	1.352	1.00
259_S	262_E	1.344	1.00
450_L	453_K	1.341	1.00
445_L	448_R	1.340	1.00
340_L	344_V	1.334	1.00
307_L	310_K	1.331	1.00
355_Y	359_P	1.330	1.00
71_E	74_G	1.327	1.00
103_Y	170_R	1.316	1.00
254_P	452_F	1.314	1.00
438_R	446_L	1.304	1.00
420_L	424_G	1.293	1.00
293_E	305_T	1.292	1.00
201_P	205_Q	1.292	1.00
122_V	171_V	1.289	1.00
395_G	399_A	1.288	1.00
96_F	101_E	1.281	1.00
306_L	309_L	1.279	1.00
461_R	464_E	1.273	1.00
462_L	465_A	1.270	1.00
9_I	17_L	1.269	1.00
305_T	308_K	1.261	1.00
286_V	474_E	1.257	1.00
46_D	50_N	1.257	1.00
249_P	454_R	1.249	1.00
145_T	148_I	1.247	1.00
374_D	377_P	1.245	1.00
133_D	136_A	1.240	1.00
3_T	24_T	1.233	1.00
281_L	290_L	1.226	1.00
53_R	58_V	1.225	1.00
459_R	462_L	1.223	1.00
123_T	153_T	1.220	1.00
210_F	214_N	1.219	1.00
385_I	389_I	1.218	1.00
149_V	152_G	1.213	1.00
7_V	106_V	1.213	1.00
446_L	450_L	1.212	1.00
211_L	214_N	1.211	1.00
489_W	493_F	1.206	1.00
9_I	106_V	1.204	1.00
460_L	465_A	1.202	1.00
473_F	493_F	1.201	1.00
78_P	81_H	1.200	1.00
208_L	211_L	1.192	1.00
148_I	151_G	1.191	1.00
69_E	73_N	1.190	1.00
358_L	362_K	1.188	1.00
280_T	283_D	1.185	1.00
428_L	431_F	1.183	1.00
99_H	170_R	1.183	1.00
472_L	476_Y	1.177	1.00
312_D	315_D	1.174	1.00
93_L	102_L	1.168	1.00
466_P	469_T	1.151	1.00
54_V	58_V	1.148	1.00
198_I	201_P	1.147	1.00
313_D	316_L	1.145	1.00
133_D	139_G	1.141	1.00
103_Y	168_T	1.141	1.00
459_R	465_A	1.135	1.00
69_E	74_G	1.125	1.00
441_K	445_L	1.125	1.00
143_D	146_A	1.122	1.00
136_A	140_P	1.116	1.00
12_N	88_R	1.113	1.00
322_A	360_A	1.113	1.00
280_T	323_L	1.102	1.00
351_K	355_Y	1.101	1.00
427_V	430_L	1.099	1.00
343_E	346_L	1.096	1.00
51_G	54_V	1.095	1.00
261_A	365_L	1.094	1.00
397_A	401_L	1.093	1.00
382_G	386_A	1.093	1.00
107_T	166_G	1.089	1.00
307_L	311_K	1.087	1.00
291_K	307_L	1.087	1.00
201_P	204_A	1.083	1.00
457_E	488_K	1.083	1.00
142_T	145_T	1.082	1.00
214_N	218_L	1.077	1.00
309_L	312_D	1.077	1.00
425_L	429_L	1.074	1.00
132_G	137_Y	1.072	1.00
373_F	376_N	1.072	1.00
382_G	385_I	1.069	1.00
359_P	363_K	1.066	1.00
392_L	395_G	1.063	1.00
118_A	167_L	1.059	1.00
209_A	213_D	1.059	1.00
291_K	309_L	1.056	1.00
124_L	173_F	1.054	1.00
226_L	230_Y	1.052	1.00
159_R	165_E	1.048	1.00
70_S	73_N	1.047	1.00
134_V	137_Y	1.042	1.00
134_V	139_G	1.041	1.00
268_D	273_D	1.040	1.00
55_R	58_V	1.039	1.00
134_V	138_T	1.037	1.00
130_A	133_D	1.037	1.00
235_W	241_D	1.037	1.00
445_L	449_W	1.029	1.00
46_D	51_G	1.029	1.00
224_L	228_L	1.026	1.00
58_V	66_Y	1.025	1.00
326_A	357_A	1.023	1.00
310_K	316_L	1.021	1.00
10_T	18_D	1.021	1.00
95_F	100_D	1.018	1.00
121_T	153_T	1.017	1.00
317_S	320_E	1.014	1.00
232_F	236_R	1.003	1.00
106_V	118_A	1.003	1.00
305_T	310_K	1.003	1.00
390_L	394_L	1.001	1.00
426_I	430_L	0.995	1.00
149_V	154_V	0.992	1.00
133_D	137_Y	0.990	1.00
280_T	319_Y	0.987	1.00
47_V	51_G	0.982	1.00
47_V	52_R	0.981	1.00
306_L	310_K	0.973	1.00
373_F	377_P	0.966	1.00
35_Y	39_D	0.966	1.00
215_L	218_L	0.965	1.00
203_A	207_A	0.963	1.00
161_L	166_G	0.961	1.00
352_N	355_Y	0.961	1.00
488_K	492_A	0.958	1.00
149_V	153_T	0.956	1.00
415_L	419_A	0.954	1.00
47_V	54_V	0.952	1.00
443_A	446_L	0.950	1.00
111_W	115_I	0.950	1.00
105_N	166_G	0.948	1.00
117_N	157_T	0.948	1.00
4_S	119_S	0.945	1.00
305_T	309_L	0.944	1.00
66_Y	70_S	0.940	1.00
44_Y	48_D	0.939	1.00
16_S	90_R	0.938	1.00
49_G	54_V	0.937	1.00
221_L	225_L	0.935	1.00
219_L	223_L	0.933	1.00
76_L	79_G	0.933	1.00
424_G	431_F	0.933	1.00
449_W	483_L	0.932	1.00
144_G	148_I	0.930	1.00
210_F	213_D	0.928	1.00
51_G	58_V	0.928	1.00
345_K	348_S	0.926	1.00
299_G	302_G	0.925	1.00
281_L	327_L	0.923	1.00
11_V	102_L	0.921	1.00
309_L	316_L	0.919	1.00
342_D	346_L	0.918	1.00
44_Y	47_V	0.917	1.00
65_P	69_E	0.914	1.00
289_Y	324_L	0.913	1.00
377_P	380_V	0.912	1.00
8_D	20_T	0.909	1.00
283_D	319_Y	0.903	1.00
374_D	437_A	0.901	1.00
23_I	111_W	0.898	1.00
32_H	76_L	0.897	1.00
147_V	151_G	0.895	1.00
220_L	224_L	0.893	1.00
31_R	34_I	0.893	1.00
450_L	454_R	0.892	1.00
66_Y	69_E	0.890	1.00
248_V	251_Y	0.889	1.00
59_R	62_A	0.889	1.00
199_A	202_S	0.888	1.00
222_L	226_L	0.887	1.00
225_L	229_L	0.886	1.00
233_L	237_R	0.885	1.00
278_T	481_I	0.884	1.00
207_A	211_L	0.882	1.00
200_E	206_R	0.882	1.00
143_D	147_V	0.881	1.00
204_A	208_L	0.879	1.00
206_R	209_A	0.877	1.00
468_E	492_A	0.875	1.00
23_I	34_I	0.875	1.00
6_D	121_T	0.875	1.00
465_A	469_T	0.874	1.00
265_Y	272_V	0.874	1.00
389_I	393_V	0.869	1.00
9_I	122_V	0.867	1.00
458_D	465_A	0.866	1.00
93_L	100_D	0.865	1.00
59_R	63_P	0.865	1.00
203_A	206_R	0.865	1.00
322_A	326_A	0.864	1.00
340_L	346_L	0.863	1.00
259_S	317_S	0.860	1.00
387_L	391_L	0.859	1.00
244_P	247_I	0.859	1.00
218_L	224_L	0.857	1.00
458_D	463_K	0.857	1.00
46_D	49_G	0.853	1.00
228_L	232_F	0.849	1.00
52_R	55_R	0.847	1.00
134_V	140_P	0.847	1.00
453_K	485_V	0.846	1.00
344_V	348_S	0.846	1.00
25_V	35_Y	0.841	1.00
205_Q	208_L	0.840	1.00
396_V	400_L	0.839	1.00
380_V	384_L	0.837	1.00
306_L	316_L	0.830	1.00
25_V	30_I	0.830	1.00
378_D	381_R	0.829	1.00
245_G	447_D	0.827	1.00
227_L	230_Y	0.826	1.00
64_E	69_E	0.825	1.00
438_R	443_A	0.820	1.00
106_V	169_V	0.819	1.00
381_R	384_L	0.817	1.00
411_G	415_L	0.815	1.00
350_L	357_A	0.812	1.00
121_T	155_F	0.812	1.00
284_L	316_L	0.812	1.00
132_G	136_A	0.807	1.00
223_L	227_L	0.806	1.00
272_V	276_D	0.805	1.00
308_K	312_D	0.804	1.00
263_V	482_A	0.802	1.00
201_P	214_N	0.802	1.00
60_D	64_E	0.797	1.00
119_S	155_F	0.795	1.00
230_Y	234_L	0.795	1.00
235_W	239_G	0.793	1.00
473_F	490_A	0.790	1.00
129_A	136_A	0.789	1.00
459_R	464_E	0.788	1.00
308_K	313_D	0.788	1.00
473_F	478_P	0.786	1.00
208_L	212_L	0.784	1.00
53_R	56_F	0.780	1.00
32_H	75_T	0.779	1.00
371_G	441_K	0.779	1.00
256_D	445_L	0.777	1.00
473_F	489_W	0.777	1.00
265_Y	366_Y	0.776	1.00
67_H	70_S	0.775	1.00
239_G	435_M	0.775	1.00
198_I	202_S	0.773	1.00
96_F	170_R	0.773	1.00
116_D	160_P	0.772	1.00
388_G	391_L	0.769	1.00
263_V	479_Y	0.769	1.00
284_L	323_L	0.767	1.00
260_P	279_A	0.767	1.00
392_L	396_V	0.767	1.00
135_R	140_P	0.766	1.00
99_H	172_G	0.765	1.00
131_A	134_V	0.765	1.00
344_V	347_S	0.765	1.00
204_A	207_A	0.763	1.00
146_A	151_G	0.761	1.00
258_L	262_E	0.757	1.00
350_L	354_F	0.757	1.00
488_K	491_K	0.757	1.00
362_K	366_Y	0.755	1.00
46_D	54_V	0.755	1.00
148_I	152_G	0.753	1.00
381_R	388_G	0.751	1.00
67_H	73_N	0.751	1.00
161_L	167_L	0.751	1.00
275_R	482_A	0.751	1.00
233_L	236_R	0.749	1.00
470_P	473_F	0.749	1.00
55_R	90_R	0.747	1.00
316_L	320_E	0.746	1.00
209_A	214_N	0.745	1.00
5_F	115_I	0.740	1.00
119_S	157_T	0.737	1.00
77_V	83_Y	0.737	1.00
347_S	351_K	0.735	1.00
385_I	388_G	0.735	1.00
139_G	168_T	0.734	1.00
199_A	203_A	0.734	1.00
354_F	357_A	0.733	1.00
228_L	231_Y	0.733	1.00
224_L	227_L	0.732	1.00
132_G	135_R	0.731	1.00
357_A	361_L	0.729	1.00
368_V	376_N	0.728	1.00
49_G	53_R	0.727	1.00
398_L	402_L	0.726	1.00
60_D	63_P	0.726	1.00
201_P	206_R	0.725	1.00
25_V	113_V	0.724	1.00
360_A	364_A	0.720	1.00
47_V	58_V	0.720	1.00
101_E	172_G	0.719	1.00
51_G	56_F	0.718	1.00
120_A	155_F	0.716	1.00
242_P	443_A	0.715	1.00
444_E	447_D	0.714	1.00
209_A	212_L	0.713	1.00
391_L	395_G	0.712	1.00
23_I	115_I	0.711	0.99
262_E	317_S	0.710	0.99
234_L	238_V	0.708	0.99
9_I	19_V	0.707	0.99
259_S	280_T	0.706	0.99
311_K	316_L	0.705	0.99
204_A	209_A	0.703	0.99
6_D	22_T	0.703	0.99
300_L	304_K	0.702	0.99
212_L	216_L	0.701	0.99
435_M	438_R	0.701	0.99
154_V	171_V	0.698	0.99
66_Y	71_E	0.698	0.99
206_R	210_F	0.696	0.99
372_Y	376_N	0.695	0.99
155_F	158_T	0.695	0.99
490_A	493_F	0.695	0.99
61_G	64_E	0.694	0.99
420_L	431_F	0.694	0.99
200_E	204_A	0.692	0.99
317_S	370_K	0.692	0.99
420_L	425_L	0.690	0.99
7_V	107_T	0.690	0.99
29_G	112_D	0.690	0.99
244_P	447_D	0.688	0.99
141_G	146_A	0.687	0.99
202_S	209_A	0.687	0.99
47_V	50_N	0.686	0.99
102_L	173_F	0.685	0.99
280_T	284_L	0.684	0.99
51_G	55_R	0.682	0.99
418_L	421_G	0.679	0.99
25_V	31_R	0.678	0.99
44_Y	52_R	0.678	0.99
464_E	468_E	0.675	0.99
299_G	303_K	0.674	0.99
212_L	215_L	0.674	0.99
363_K	367_K	0.670	0.99
370_K	441_K	0.670	0.99
48_D	52_R	0.668	0.99
130_A	134_V	0.667	0.99
267_L	450_L	0.667	0.99
60_D	81_H	0.666	0.99
258_L	372_Y	0.665	0.99
129_A	133_D	0.665	0.99
258_L	445_L	0.664	0.99
213_D	216_L	0.664	0.99
52_R	56_F	0.663	0.99
50_N	54_V	0.662	0.99
206_R	211_L	0.662	0.99
200_E	205_Q	0.661	0.99
63_P	66_Y	0.660	0.99
301_L	304_K	0.660	0.99
350_L	355_Y	0.659	0.99
469_T	472_L	0.659	0.99
399_A	402_L	0.659	0.99
232_F	235_W	0.657	0.99
462_L	466_P	0.656	0.99
131_A	139_G	0.655	0.99
140_P	165_E	0.655	0.99
379_K	383_R	0.654	0.99
58_V	67_H	0.654	0.99
420_L	423_I	0.653	0.99
297_K	300_L	0.653	0.99
211_L	215_L	0.652	0.99
400_L	404_A	0.652	0.99
145_T	152_G	0.652	0.99
129_A	137_Y	0.652	0.99
384_L	387_L	0.651	0.99
44_Y	49_G	0.650	0.99
275_R	486_E	0.650	0.99
128_G	133_D	0.648	0.99
472_L	475_K	0.647	0.99
70_S	74_G	0.646	0.99
201_P	207_A	0.646	0.99
117_N	156_F	0.646	0.99
25_V	83_Y	0.644	0.99
478_P	489_W	0.644	0.99
210_F	216_L	0.641	0.99
11_V	17_L	0.641	0.99
224_L	231_Y	0.641	0.99
412_G	415_L	0.637	0.99
284_L	320_E	0.635	0.99
471_E	475_K	0.634	0.99
147_V	154_V	0.634	0.99
421_G	424_G	0.633	0.99
218_L	222_L	0.633	0.99
426_I	429_L	0.630	0.99
354_F	358_L	0.628	0.99
203_A	210_F	0.627	0.99
313_D	325_D	0.626	0.99
131_A	135_R	0.624	0.99
266_L	445_L	0.624	0.99
107_T	120_A	0.624	0.99
486_E	490_A	0.623	0.99
39_D	42_T	0.622	0.99
305_T	311_K	0.622	0.99
11_V	122_V	0.622	0.99
50_N	58_V	0.622	0.99
50_N	56_F	0.621	0.99
469_T	475_K	0.621	0.99
11_V	124_L	0.620	0.99
33_G	83_Y	0.619	0.99
434_L	438_R	0.619	0.99
208_L	214_N	0.619	0.99
284_L	289_Y	0.618	0.99
259_S	320_E	0.618	0.99
377_P	384_L	0.618	0.99
107_T	111_W	0.617	0.99
67_H	71_E	0.616	0.99
422_L	426_I	0.616	0.99
361_L	365_L	0.614	0.99
309_L	313_D	0.613	0.99
414_G	417_G	0.612	0.98
454_R	457_E	0.611	0.98
58_V	69_E	0.610	0.98
289_Y	312_D	0.610	0.98
199_A	205_Q	0.609	0.98
368_V	372_Y	0.607	0.98
229_L	233_L	0.606	0.98
424_G	428_L	0.604	0.98
29_G	32_H	0.604	0.98
145_T	151_G	0.604	0.98
419_A	431_F	0.602	0.98
473_F	486_E	0.602	0.98
401_L	405_A	0.601	0.98
350_L	353_K	0.601	0.98
342_D	345_K	0.600	0.98
260_P	280_T	0.600	0.98
449_W	452_F	0.599	0.98
211_L	218_L	0.597	0.98
465_A	472_L	0.597	0.98
205_Q	218_L	0.597	0.98
133_D	172_G	0.595	0.98
207_A	214_N	0.594	0.98
11_V	173_F	0.594	0.98
68_T	73_N	0.593	0.98
263_V	483_L	0.593	0.98
463_K	466_P	0.593	0.98
459_R	466_P	0.592	0.98
359_P	362_K	0.592	0.98
291_K	308_K	0.591	0.98
385_I	395_G	0.591	0.98
274_P	362_K	0.590	0.98
416_L	420_L	0.590	0.98
68_T	72_G	0.590	0.98
32_H	77_V	0.590	0.98
418_L	422_L	0.590	0.98
484_G	487_K	0.589	0.98
135_R	170_R	0.589	0.98
258_L	449_W	0.588	0.98
289_Y	315_D	0.587	0.98
158_T	167_L	0.585	0.98
417_G	421_G	0.585	0.98
23_I	33_G	0.584	0.98
451_G	454_R	0.584	0.98
133_D	138_T	0.584	0.98
307_L	316_L	0.583	0.98
452_F	456_L	0.582	0.98
144_G	149_V	0.582	0.98
38_R	42_T	0.581	0.98
381_R	385_I	0.581	0.98
27_F	30_I	0.580	0.98
358_L	361_L	0.579	0.98
261_A	361_L	0.578	0.98
383_R	386_A	0.577	0.98
128_G	131_A	0.577	0.98
131_A	137_Y	0.575	0.98
64_E	68_T	0.574	0.98
306_L	328_F	0.573	0.98
300_L	303_K	0.571	0.98
156_F	169_V	0.571	0.98
120_A	156_F	0.571	0.98
414_G	418_L	0.571	0.98
34_I	83_Y	0.570	0.98
306_L	311_K	0.569	0.98
417_G	420_L	0.569	0.98
394_L	398_L	0.569	0.98
377_P	381_R	0.566	0.98
130_A	139_G	0.565	0.97
9_I	102_L	0.565	0.97
129_A	132_G	0.565	0.97
283_D	317_S	0.565	0.97
35_Y	111_W	0.564	0.97
277_I	323_L	0.563	0.97
124_L	171_V	0.562	0.97
464_E	467_P	0.561	0.97
473_F	477_L	0.561	0.97
205_Q	213_D	0.561	0.97
339_G	342_D	0.558	0.97
397_A	400_L	0.557	0.97
49_G	56_F	0.557	0.97
42_T	74_G	0.557	0.97
143_D	148_I	0.557	0.97
474_E	481_I	0.552	0.97
343_E	347_S	0.552	0.97
46_D	52_R	0.551	0.97
413_A	416_L	0.549	0.97
388_G	395_G	0.548	0.97
200_E	203_A	0.548	0.97
131_A	136_A	0.547	0.97
368_V	371_G	0.547	0.97
419_A	422_L	0.547	0.97
59_R	81_H	0.546	0.97
216_L	220_L	0.544	0.97
45_Y	49_G	0.542	0.97
355_Y	358_L	0.542	0.97
251_Y	455_Y	0.542	0.97
369_E	372_Y	0.541	0.97
35_Y	112_D	0.540	0.97
419_A	424_G	0.540	0.97
417_G	425_L	0.539	0.97
419_A	429_L	0.538	0.97
413_A	427_V	0.538	0.97
210_F	224_L	0.537	0.97
455_Y	472_L	0.536	0.97
451_G	455_Y	0.536	0.97
31_R	83_Y	0.536	0.97
40_I	89_V	0.534	0.96
142_T	148_I	0.533	0.96
202_S	207_A	0.532	0.96
65_P	70_S	0.527	0.96
421_G	425_L	0.526	0.96
130_A	136_A	0.526	0.96
224_L	229_L	0.526	0.96
220_L	227_L	0.524	0.96
287_R	316_L	0.523	0.96
369_E	373_F	0.523	0.96
424_G	427_V	0.522	0.96
50_N	53_R	0.522	0.96
207_A	210_F	0.522	0.96
32_H	83_Y	0.522	0.96
9_I	120_A	0.522	0.96
207_A	212_L	0.522	0.96
241_D	437_A	0.521	0.96
290_L	324_L	0.521	0.96
362_K	365_L	0.521	0.96
61_G	68_T	0.521	0.96
128_G	136_A	0.517	0.96
66_Y	73_N	0.515	0.96
425_L	432_A	0.513	0.96
60_D	65_P	0.513	0.96
423_I	427_V	0.511	0.95
218_L	225_L	0.511	0.95
471_E	474_E	0.510	0.95
369_E	374_D	0.510	0.95
144_G	151_G	0.508	0.95
129_A	139_G	0.505	0.95
209_A	218_L	0.505	0.95
26_D	78_P	0.503	0.95
174_P	201_P	0.503	0.95
418_L	425_L	0.502	0.95
270_G	438_R	0.502	0.95
46_D	56_F	0.502	0.95
213_D	231_Y	0.501	0.95
203_A	208_L	0.501	0.95
380_V	383_R	0.500	0.95
378_D	382_G	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2m20A	2	0.1176	17.5	0.965	Contact Map
2yu3A	1	0.1927	13	0.967	Contact Map
2fp7A	1	0.0406	8.4	0.97	Contact Map
2ks1B	1	0.0892	6.9	0.971	Contact Map
2jwaA	2	0.0892	5.8	0.972	Contact Map
3hd7A	1	0.1846	5.5	0.972	Contact Map
2l2tA	2	0.0892	5.4	0.972	Contact Map
3j6da	3	0.2414	5.4	0.972	Contact Map
3u1jA	1	0.0041	5.3	0.973	Contact Map
2ggvA	1	0.0507	4.8	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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