GREMLIN Database
DUF2207 - Predicted membrane protein (DUF2207)
PFAM: PF09972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 493 (452)
Sequences: 8866 (7873)
Seq/√Len: 370.3
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_D123_T4.0341.00
6_D119_S3.7751.00
12_N18_D3.7481.00
18_D88_R3.6241.00
452_F476_Y3.4641.00
10_T123_T3.3911.00
136_A139_G3.2881.00
18_D86_T3.1711.00
283_D287_R3.1241.00
20_T86_T3.0031.00
59_R64_E2.9891.00
282_V481_I2.9391.00
264_G276_D2.9101.00
141_G144_G2.7941.00
162_P165_E2.7941.00
12_N16_S2.7471.00
22_T84_V2.7371.00
263_V449_W2.6461.00
38_R41_P2.5991.00
115_I118_A2.5591.00
22_T82_T2.4541.00
322_A364_A2.4201.00
24_T82_T2.4171.00
26_D80_E2.3971.00
107_T118_A2.3461.00
250_E448_R2.3341.00
456_L485_V2.2881.00
122_V169_V2.2631.00
17_L102_L2.2621.00
135_R138_T2.2591.00
459_R463_K2.2431.00
3_T26_D2.2401.00
89_V92_A2.2281.00
264_G273_D2.1991.00
8_D121_T2.1871.00
10_T20_T2.1361.00
444_E448_R2.1351.00
258_L263_V2.1301.00
453_K457_E2.1221.00
4_S117_N2.1061.00
107_T115_I2.1021.00
283_D286_V2.0671.00
283_D320_E2.0621.00
261_A280_T2.0051.00
105_N168_T1.9821.00
287_R320_E1.9731.00
24_T80_E1.9591.00
106_V120_A1.9461.00
5_F107_T1.9411.00
109_N166_G1.9301.00
308_K311_K1.9281.00
293_E307_L1.9061.00
439_T442_G1.9011.00
260_P283_D1.8941.00
108_G111_W1.8401.00
321_R325_D1.8401.00
20_T84_V1.8201.00
141_G145_T1.8191.00
137_Y140_P1.8161.00
236_R240_R1.7761.00
256_D448_R1.7731.00
3_T116_D1.7601.00
393_V397_A1.7271.00
443_A447_D1.7251.00
460_L463_K1.7131.00
132_G139_G1.7101.00
49_G52_R1.7051.00
101_E170_R1.6981.00
76_L81_H1.6871.00
308_K316_L1.6791.00
8_D22_T1.6781.00
461_R465_A1.6701.00
284_L324_L1.6551.00
112_D164_G1.6471.00
280_T320_E1.6271.00
458_D461_R1.6251.00
17_L92_A1.6241.00
273_D276_D1.6181.00
77_V81_H1.6161.00
96_F99_H1.6071.00
3_T80_E1.5871.00
386_A390_L1.5761.00
144_G147_V1.5711.00
441_K444_E1.5581.00
135_R139_G1.5221.00
384_L388_G1.5191.00
259_S319_Y1.4811.00
205_Q209_A1.4801.00
89_V104_W1.4701.00
17_L89_V1.4691.00
69_E72_G1.4661.00
227_L231_Y1.4661.00
150_D153_T1.4651.00
458_D462_L1.4591.00
440_A444_E1.4581.00
457_E485_V1.4571.00
4_S24_T1.4451.00
312_D316_L1.4451.00
16_S88_R1.4361.00
132_G138_T1.4341.00
383_R387_L1.4261.00
202_S206_R1.4191.00
456_L476_Y1.4171.00
264_G268_D1.4101.00
460_L464_E1.4061.00
388_G392_L1.4061.00
25_V34_I1.4021.00
174_P197_K1.3881.00
21_E38_R1.3881.00
285_A292_I1.3861.00
268_D276_D1.3861.00
419_A423_I1.3801.00
310_K313_D1.3801.00
267_L453_K1.3701.00
202_S205_Q1.3611.00
5_F23_I1.3521.00
259_S262_E1.3441.00
450_L453_K1.3411.00
445_L448_R1.3401.00
340_L344_V1.3341.00
307_L310_K1.3311.00
355_Y359_P1.3301.00
71_E74_G1.3271.00
103_Y170_R1.3161.00
254_P452_F1.3141.00
438_R446_L1.3041.00
420_L424_G1.2931.00
293_E305_T1.2921.00
201_P205_Q1.2921.00
122_V171_V1.2891.00
395_G399_A1.2881.00
96_F101_E1.2811.00
306_L309_L1.2791.00
461_R464_E1.2731.00
462_L465_A1.2701.00
9_I17_L1.2691.00
305_T308_K1.2611.00
286_V474_E1.2571.00
46_D50_N1.2571.00
249_P454_R1.2491.00
145_T148_I1.2471.00
374_D377_P1.2451.00
133_D136_A1.2401.00
3_T24_T1.2331.00
281_L290_L1.2261.00
53_R58_V1.2251.00
459_R462_L1.2231.00
123_T153_T1.2201.00
210_F214_N1.2191.00
385_I389_I1.2181.00
149_V152_G1.2131.00
7_V106_V1.2131.00
446_L450_L1.2121.00
211_L214_N1.2111.00
489_W493_F1.2061.00
9_I106_V1.2041.00
460_L465_A1.2021.00
473_F493_F1.2011.00
78_P81_H1.2001.00
208_L211_L1.1921.00
148_I151_G1.1911.00
69_E73_N1.1901.00
358_L362_K1.1881.00
280_T283_D1.1851.00
428_L431_F1.1831.00
99_H170_R1.1831.00
472_L476_Y1.1771.00
312_D315_D1.1741.00
93_L102_L1.1681.00
466_P469_T1.1511.00
54_V58_V1.1481.00
198_I201_P1.1471.00
313_D316_L1.1451.00
133_D139_G1.1411.00
103_Y168_T1.1411.00
459_R465_A1.1351.00
69_E74_G1.1251.00
441_K445_L1.1251.00
143_D146_A1.1221.00
136_A140_P1.1161.00
12_N88_R1.1131.00
322_A360_A1.1131.00
280_T323_L1.1021.00
351_K355_Y1.1011.00
427_V430_L1.0991.00
343_E346_L1.0961.00
51_G54_V1.0951.00
261_A365_L1.0941.00
397_A401_L1.0931.00
382_G386_A1.0931.00
107_T166_G1.0891.00
307_L311_K1.0871.00
291_K307_L1.0871.00
201_P204_A1.0831.00
457_E488_K1.0831.00
142_T145_T1.0821.00
214_N218_L1.0771.00
309_L312_D1.0771.00
425_L429_L1.0741.00
132_G137_Y1.0721.00
373_F376_N1.0721.00
382_G385_I1.0691.00
359_P363_K1.0661.00
392_L395_G1.0631.00
118_A167_L1.0591.00
209_A213_D1.0591.00
291_K309_L1.0561.00
124_L173_F1.0541.00
226_L230_Y1.0521.00
159_R165_E1.0481.00
70_S73_N1.0471.00
134_V137_Y1.0421.00
134_V139_G1.0411.00
268_D273_D1.0401.00
55_R58_V1.0391.00
134_V138_T1.0371.00
130_A133_D1.0371.00
235_W241_D1.0371.00
445_L449_W1.0291.00
46_D51_G1.0291.00
224_L228_L1.0261.00
58_V66_Y1.0251.00
326_A357_A1.0231.00
310_K316_L1.0211.00
10_T18_D1.0211.00
95_F100_D1.0181.00
121_T153_T1.0171.00
317_S320_E1.0141.00
232_F236_R1.0031.00
106_V118_A1.0031.00
305_T310_K1.0031.00
390_L394_L1.0011.00
426_I430_L0.9951.00
149_V154_V0.9921.00
133_D137_Y0.9901.00
280_T319_Y0.9871.00
47_V51_G0.9821.00
47_V52_R0.9811.00
306_L310_K0.9731.00
373_F377_P0.9661.00
35_Y39_D0.9661.00
215_L218_L0.9651.00
203_A207_A0.9631.00
161_L166_G0.9611.00
352_N355_Y0.9611.00
488_K492_A0.9581.00
149_V153_T0.9561.00
415_L419_A0.9541.00
47_V54_V0.9521.00
443_A446_L0.9501.00
111_W115_I0.9501.00
105_N166_G0.9481.00
117_N157_T0.9481.00
4_S119_S0.9451.00
305_T309_L0.9441.00
66_Y70_S0.9401.00
44_Y48_D0.9391.00
16_S90_R0.9381.00
49_G54_V0.9371.00
221_L225_L0.9351.00
219_L223_L0.9331.00
76_L79_G0.9331.00
424_G431_F0.9331.00
449_W483_L0.9321.00
144_G148_I0.9301.00
210_F213_D0.9281.00
51_G58_V0.9281.00
345_K348_S0.9261.00
299_G302_G0.9251.00
281_L327_L0.9231.00
11_V102_L0.9211.00
309_L316_L0.9191.00
342_D346_L0.9181.00
44_Y47_V0.9171.00
65_P69_E0.9141.00
289_Y324_L0.9131.00
377_P380_V0.9121.00
8_D20_T0.9091.00
283_D319_Y0.9031.00
374_D437_A0.9011.00
23_I111_W0.8981.00
32_H76_L0.8971.00
147_V151_G0.8951.00
220_L224_L0.8931.00
31_R34_I0.8931.00
450_L454_R0.8921.00
66_Y69_E0.8901.00
248_V251_Y0.8891.00
59_R62_A0.8891.00
199_A202_S0.8881.00
222_L226_L0.8871.00
225_L229_L0.8861.00
233_L237_R0.8851.00
278_T481_I0.8841.00
207_A211_L0.8821.00
200_E206_R0.8821.00
143_D147_V0.8811.00
204_A208_L0.8791.00
206_R209_A0.8771.00
468_E492_A0.8751.00
23_I34_I0.8751.00
6_D121_T0.8751.00
465_A469_T0.8741.00
265_Y272_V0.8741.00
389_I393_V0.8691.00
9_I122_V0.8671.00
458_D465_A0.8661.00
93_L100_D0.8651.00
59_R63_P0.8651.00
203_A206_R0.8651.00
322_A326_A0.8641.00
340_L346_L0.8631.00
259_S317_S0.8601.00
387_L391_L0.8591.00
244_P247_I0.8591.00
218_L224_L0.8571.00
458_D463_K0.8571.00
46_D49_G0.8531.00
228_L232_F0.8491.00
52_R55_R0.8471.00
134_V140_P0.8471.00
453_K485_V0.8461.00
344_V348_S0.8461.00
25_V35_Y0.8411.00
205_Q208_L0.8401.00
396_V400_L0.8391.00
380_V384_L0.8371.00
306_L316_L0.8301.00
25_V30_I0.8301.00
378_D381_R0.8291.00
245_G447_D0.8271.00
227_L230_Y0.8261.00
64_E69_E0.8251.00
438_R443_A0.8201.00
106_V169_V0.8191.00
381_R384_L0.8171.00
411_G415_L0.8151.00
350_L357_A0.8121.00
121_T155_F0.8121.00
284_L316_L0.8121.00
132_G136_A0.8071.00
223_L227_L0.8061.00
272_V276_D0.8051.00
308_K312_D0.8041.00
263_V482_A0.8021.00
201_P214_N0.8021.00
60_D64_E0.7971.00
119_S155_F0.7951.00
230_Y234_L0.7951.00
235_W239_G0.7931.00
473_F490_A0.7901.00
129_A136_A0.7891.00
459_R464_E0.7881.00
308_K313_D0.7881.00
473_F478_P0.7861.00
208_L212_L0.7841.00
53_R56_F0.7801.00
32_H75_T0.7791.00
371_G441_K0.7791.00
256_D445_L0.7771.00
473_F489_W0.7771.00
265_Y366_Y0.7761.00
67_H70_S0.7751.00
239_G435_M0.7751.00
198_I202_S0.7731.00
96_F170_R0.7731.00
116_D160_P0.7721.00
388_G391_L0.7691.00
263_V479_Y0.7691.00
284_L323_L0.7671.00
260_P279_A0.7671.00
392_L396_V0.7671.00
135_R140_P0.7661.00
99_H172_G0.7651.00
131_A134_V0.7651.00
344_V347_S0.7651.00
204_A207_A0.7631.00
146_A151_G0.7611.00
258_L262_E0.7571.00
350_L354_F0.7571.00
488_K491_K0.7571.00
362_K366_Y0.7551.00
46_D54_V0.7551.00
148_I152_G0.7531.00
381_R388_G0.7511.00
67_H73_N0.7511.00
161_L167_L0.7511.00
275_R482_A0.7511.00
233_L236_R0.7491.00
470_P473_F0.7491.00
55_R90_R0.7471.00
316_L320_E0.7461.00
209_A214_N0.7451.00
5_F115_I0.7401.00
119_S157_T0.7371.00
77_V83_Y0.7371.00
347_S351_K0.7351.00
385_I388_G0.7351.00
139_G168_T0.7341.00
199_A203_A0.7341.00
354_F357_A0.7331.00
228_L231_Y0.7331.00
224_L227_L0.7321.00
132_G135_R0.7311.00
357_A361_L0.7291.00
368_V376_N0.7281.00
49_G53_R0.7271.00
398_L402_L0.7261.00
60_D63_P0.7261.00
201_P206_R0.7251.00
25_V113_V0.7241.00
360_A364_A0.7201.00
47_V58_V0.7201.00
101_E172_G0.7191.00
51_G56_F0.7181.00
120_A155_F0.7161.00
242_P443_A0.7151.00
444_E447_D0.7141.00
209_A212_L0.7131.00
391_L395_G0.7121.00
23_I115_I0.7110.99
262_E317_S0.7100.99
234_L238_V0.7080.99
9_I19_V0.7070.99
259_S280_T0.7060.99
311_K316_L0.7050.99
204_A209_A0.7030.99
6_D22_T0.7030.99
300_L304_K0.7020.99
212_L216_L0.7010.99
435_M438_R0.7010.99
154_V171_V0.6980.99
66_Y71_E0.6980.99
206_R210_F0.6960.99
372_Y376_N0.6950.99
155_F158_T0.6950.99
490_A493_F0.6950.99
61_G64_E0.6940.99
420_L431_F0.6940.99
200_E204_A0.6920.99
317_S370_K0.6920.99
420_L425_L0.6900.99
7_V107_T0.6900.99
29_G112_D0.6900.99
244_P447_D0.6880.99
141_G146_A0.6870.99
202_S209_A0.6870.99
47_V50_N0.6860.99
102_L173_F0.6850.99
280_T284_L0.6840.99
51_G55_R0.6820.99
418_L421_G0.6790.99
25_V31_R0.6780.99
44_Y52_R0.6780.99
464_E468_E0.6750.99
299_G303_K0.6740.99
212_L215_L0.6740.99
363_K367_K0.6700.99
370_K441_K0.6700.99
48_D52_R0.6680.99
130_A134_V0.6670.99
267_L450_L0.6670.99
60_D81_H0.6660.99
258_L372_Y0.6650.99
129_A133_D0.6650.99
258_L445_L0.6640.99
213_D216_L0.6640.99
52_R56_F0.6630.99
50_N54_V0.6620.99
206_R211_L0.6620.99
200_E205_Q0.6610.99
63_P66_Y0.6600.99
301_L304_K0.6600.99
350_L355_Y0.6590.99
469_T472_L0.6590.99
399_A402_L0.6590.99
232_F235_W0.6570.99
462_L466_P0.6560.99
131_A139_G0.6550.99
140_P165_E0.6550.99
379_K383_R0.6540.99
58_V67_H0.6540.99
420_L423_I0.6530.99
297_K300_L0.6530.99
211_L215_L0.6520.99
400_L404_A0.6520.99
145_T152_G0.6520.99
129_A137_Y0.6520.99
384_L387_L0.6510.99
44_Y49_G0.6500.99
275_R486_E0.6500.99
128_G133_D0.6480.99
472_L475_K0.6470.99
70_S74_G0.6460.99
201_P207_A0.6460.99
117_N156_F0.6460.99
25_V83_Y0.6440.99
478_P489_W0.6440.99
210_F216_L0.6410.99
11_V17_L0.6410.99
224_L231_Y0.6410.99
412_G415_L0.6370.99
284_L320_E0.6350.99
471_E475_K0.6340.99
147_V154_V0.6340.99
421_G424_G0.6330.99
218_L222_L0.6330.99
426_I429_L0.6300.99
354_F358_L0.6280.99
203_A210_F0.6270.99
313_D325_D0.6260.99
131_A135_R0.6240.99
266_L445_L0.6240.99
107_T120_A0.6240.99
486_E490_A0.6230.99
39_D42_T0.6220.99
305_T311_K0.6220.99
11_V122_V0.6220.99
50_N58_V0.6220.99
50_N56_F0.6210.99
469_T475_K0.6210.99
11_V124_L0.6200.99
33_G83_Y0.6190.99
434_L438_R0.6190.99
208_L214_N0.6190.99
284_L289_Y0.6180.99
259_S320_E0.6180.99
377_P384_L0.6180.99
107_T111_W0.6170.99
67_H71_E0.6160.99
422_L426_I0.6160.99
361_L365_L0.6140.99
309_L313_D0.6130.99
414_G417_G0.6120.98
454_R457_E0.6110.98
58_V69_E0.6100.98
289_Y312_D0.6100.98
199_A205_Q0.6090.98
368_V372_Y0.6070.98
229_L233_L0.6060.98
424_G428_L0.6040.98
29_G32_H0.6040.98
145_T151_G0.6040.98
419_A431_F0.6020.98
473_F486_E0.6020.98
401_L405_A0.6010.98
350_L353_K0.6010.98
342_D345_K0.6000.98
260_P280_T0.6000.98
449_W452_F0.5990.98
211_L218_L0.5970.98
465_A472_L0.5970.98
205_Q218_L0.5970.98
133_D172_G0.5950.98
207_A214_N0.5940.98
11_V173_F0.5940.98
68_T73_N0.5930.98
263_V483_L0.5930.98
463_K466_P0.5930.98
459_R466_P0.5920.98
359_P362_K0.5920.98
291_K308_K0.5910.98
385_I395_G0.5910.98
274_P362_K0.5900.98
416_L420_L0.5900.98
68_T72_G0.5900.98
32_H77_V0.5900.98
418_L422_L0.5900.98
484_G487_K0.5890.98
135_R170_R0.5890.98
258_L449_W0.5880.98
289_Y315_D0.5870.98
158_T167_L0.5850.98
417_G421_G0.5850.98
23_I33_G0.5840.98
451_G454_R0.5840.98
133_D138_T0.5840.98
307_L316_L0.5830.98
452_F456_L0.5820.98
144_G149_V0.5820.98
38_R42_T0.5810.98
381_R385_I0.5810.98
27_F30_I0.5800.98
358_L361_L0.5790.98
261_A361_L0.5780.98
383_R386_A0.5770.98
128_G131_A0.5770.98
131_A137_Y0.5750.98
64_E68_T0.5740.98
306_L328_F0.5730.98
300_L303_K0.5710.98
156_F169_V0.5710.98
120_A156_F0.5710.98
414_G418_L0.5710.98
34_I83_Y0.5700.98
306_L311_K0.5690.98
417_G420_L0.5690.98
394_L398_L0.5690.98
377_P381_R0.5660.98
130_A139_G0.5650.97
9_I102_L0.5650.97
129_A132_G0.5650.97
283_D317_S0.5650.97
35_Y111_W0.5640.97
277_I323_L0.5630.97
124_L171_V0.5620.97
464_E467_P0.5610.97
473_F477_L0.5610.97
205_Q213_D0.5610.97
339_G342_D0.5580.97
397_A400_L0.5570.97
49_G56_F0.5570.97
42_T74_G0.5570.97
143_D148_I0.5570.97
474_E481_I0.5520.97
343_E347_S0.5520.97
46_D52_R0.5510.97
413_A416_L0.5490.97
388_G395_G0.5480.97
200_E203_A0.5480.97
131_A136_A0.5470.97
368_V371_G0.5470.97
419_A422_L0.5470.97
59_R81_H0.5460.97
216_L220_L0.5440.97
45_Y49_G0.5420.97
355_Y358_L0.5420.97
251_Y455_Y0.5420.97
369_E372_Y0.5410.97
35_Y112_D0.5400.97
419_A424_G0.5400.97
417_G425_L0.5390.97
419_A429_L0.5380.97
413_A427_V0.5380.97
210_F224_L0.5370.97
455_Y472_L0.5360.97
451_G455_Y0.5360.97
31_R83_Y0.5360.97
40_I89_V0.5340.96
142_T148_I0.5330.96
202_S207_A0.5320.96
65_P70_S0.5270.96
421_G425_L0.5260.96
130_A136_A0.5260.96
224_L229_L0.5260.96
220_L227_L0.5240.96
287_R316_L0.5230.96
369_E373_F0.5230.96
424_G427_V0.5220.96
50_N53_R0.5220.96
207_A210_F0.5220.96
32_H83_Y0.5220.96
9_I120_A0.5220.96
207_A212_L0.5220.96
241_D437_A0.5210.96
290_L324_L0.5210.96
362_K365_L0.5210.96
61_G68_T0.5210.96
128_G136_A0.5170.96
66_Y73_N0.5150.96
425_L432_A0.5130.96
60_D65_P0.5130.96
423_I427_V0.5110.95
218_L225_L0.5110.95
471_E474_E0.5100.95
369_E374_D0.5100.95
144_G151_G0.5080.95
129_A139_G0.5050.95
209_A218_L0.5050.95
26_D78_P0.5030.95
174_P201_P0.5030.95
418_L425_L0.5020.95
270_G438_R0.5020.95
46_D56_F0.5020.95
213_D231_Y0.5010.95
203_A208_L0.5010.95
380_V383_R0.5000.95
378_D382_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1176 17.5 0.965 Contact Map
2yu3A 1 0.1927 13 0.967 Contact Map
2fp7A 1 0.0406 8.4 0.97 Contact Map
2ks1B 1 0.0892 6.9 0.971 Contact Map
2jwaA 2 0.0892 5.8 0.972 Contact Map
3hd7A 1 0.1846 5.5 0.972 Contact Map
2l2tA 2 0.0892 5.4 0.972 Contact Map
3j6da 3 0.2414 5.4 0.972 Contact Map
3u1jA 1 0.0041 5.3 0.973 Contact Map
2ggvA 1 0.0507 4.8 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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