GREMLIN Database
DUF2203 - Uncharacterized conserved protein (DUF2203)
PFAM: PF09969 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 122 (122)
Sequences: 14028 (9360)
Seq/√Len: 847.4
META: 0.981

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_E114_E3.6521.00
9_N105_E3.4831.00
81_R100_K3.1831.00
93_R111_E2.9551.00
78_D81_R2.9181.00
2_L94_E2.8121.00
89_L94_E2.4561.00
90_R95_V2.3511.00
75_E96_Y2.2991.00
26_R30_R2.2291.00
25_L61_R2.0281.00
26_R80_D1.9821.00
13_P17_P1.9651.00
23_V101_L1.9431.00
88_A95_V1.8841.00
5_L9_N1.7121.00
14_L18_L1.7091.00
18_L68_E1.6271.00
28_E58_L1.6001.00
21_D65_A1.5241.00
107_E121_P1.5171.00
19_L23_V1.5121.00
63_R67_E1.4911.00
114_E118_G1.4831.00
69_L74_V1.4781.00
18_L65_A1.4541.00
2_L89_L1.4261.00
25_L58_L1.4021.00
85_D98_C1.3861.00
77_K85_D1.3831.00
11_L72_L1.3791.00
16_R20_E1.3751.00
68_E72_L1.3711.00
16_R104_D1.3701.00
20_E101_L1.3541.00
115_G118_G1.3191.00
88_A97_L1.2971.00
9_N106_I1.2911.00
48_G52_R1.2711.00
85_D110_H1.2681.00
77_K83_L1.2641.00
21_D61_R1.2211.00
14_L72_L1.2211.00
3_F73_G1.2051.00
15_V69_L1.2041.00
87_P94_E1.1971.00
14_L17_P1.1771.00
16_R102_G1.1711.00
65_A68_E1.1301.00
114_E120_K1.1261.00
5_L106_I1.1241.00
14_L68_E1.1221.00
74_V84_V1.1181.00
96_Y112_L1.0861.00
35_E51_L1.0761.00
6_E10_A1.0761.00
104_D107_E1.0721.00
89_L92_G1.0471.00
20_E24_E1.0381.00
67_E70_E1.0381.00
67_E71_E1.0331.00
36_L39_L1.0281.00
59_A63_R0.9971.00
51_L54_E0.9951.00
49_A53_A0.9951.00
8_A74_V0.9861.00
22_L62_L0.9861.00
28_E32_L0.9831.00
4_T7_E0.9441.00
11_L14_L0.9381.00
28_E54_E0.9291.00
87_P96_Y0.9211.00
61_R65_A0.9171.00
12_L15_V0.9151.00
28_E31_E0.9151.00
15_V84_V0.9141.00
16_R101_L0.9081.00
25_L62_L0.9031.00
24_E28_E0.8951.00
35_E38_A0.8941.00
19_L101_L0.8911.00
29_L59_A0.8861.00
35_E39_L0.8851.00
25_L65_A0.8751.00
21_D25_L0.8611.00
75_E87_P0.8461.00
18_L21_D0.8421.00
43_I47_G0.8411.00
54_E58_L0.8371.00
22_L65_A0.8351.00
33_E37_E0.8131.00
108_F121_P0.8101.00
98_C110_H0.8091.00
15_V72_L0.8081.00
56_E59_A0.8061.00
66_L79_L0.7931.00
25_L28_E0.7881.00
27_R31_E0.7811.00
36_L40_A0.7731.00
57_R60_E0.7711.00
70_E75_E0.7701.00
90_R122_L0.7631.00
49_A52_R0.7621.00
78_D82_G0.7551.00
18_L69_L0.7551.00
23_V26_R0.7481.00
33_E55_L0.7471.00
32_L54_E0.7451.00
32_L58_L0.7341.00
38_A41_A0.7311.00
48_G51_L0.7251.00
109_W120_K0.7151.00
5_L122_L0.7141.00
90_R93_R0.7061.00
56_E60_E0.7041.00
87_P112_L0.6991.00
30_R33_E0.6971.00
40_A44_R0.6901.00
83_L100_K0.6801.00
19_L76_V0.6791.00
15_V19_L0.6761.00
100_K116_F0.6731.00
81_R101_L0.6711.00
50_E54_E0.6681.00
111_E120_K0.6651.00
21_D24_E0.6641.00
52_R55_L0.6591.00
66_L70_E0.6471.00
41_A44_R0.6401.00
26_R79_L0.6341.00
110_H115_G0.6281.00
43_I46_N0.6231.00
88_A96_Y0.6211.00
42_R45_G0.6151.00
55_L59_A0.6151.00
39_L43_I0.6101.00
40_A43_I0.6091.00
17_P20_E0.6061.00
77_K98_C0.6061.00
19_L22_L0.5981.00
32_L51_L0.5971.00
11_L74_V0.5971.00
83_L115_G0.5931.00
61_R64_E0.5921.00
50_E53_A0.5901.00
30_R34_E0.5861.00
17_P21_D0.5831.00
70_E76_V0.5741.00
9_N12_L0.5721.00
38_A42_R0.5721.00
27_R30_R0.5711.00
48_G56_E0.5711.00
3_F11_L0.5641.00
72_L84_V0.5631.00
98_C103_E0.5601.00
20_E23_V0.5581.00
12_L16_R0.5571.00
94_E112_L0.5551.00
3_F86_F0.5531.00
11_L86_F0.5491.00
3_F74_V0.5461.00
42_R47_G0.5441.00
18_L72_L0.5431.00
96_Y113_D0.5421.00
8_A106_I0.5311.00
12_L19_L0.5281.00
19_L84_V0.5231.00
90_R109_W0.5221.00
88_A94_E0.5191.00
42_R46_N0.5151.00
34_E38_A0.5151.00
23_V27_R0.5141.00
83_L116_F0.5131.00
24_E27_R0.5121.00
77_K96_Y0.5091.00
22_L76_V0.5081.00
44_R47_G0.5051.00
54_E57_R0.5031.00
33_E43_I0.5031.00
58_L61_R0.5021.00
76_V79_L0.5011.00
53_A57_R0.5001.00
2_L88_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ccwB 2 0.877 30.7 0.897 Contact Map
4rsiA 1 0.3197 23.2 0.902 Contact Map
4jrbA 1 0.6393 14.7 0.911 Contact Map
3pmrA 2 0.4508 12.3 0.914 Contact Map
3mq9A 4 0.5902 10.8 0.916 Contact Map
4bwnA 2 0.5574 9.3 0.919 Contact Map
3umhA 1 0.4262 8.7 0.92 Contact Map
4fdgB 1 0.1639 7.4 0.922 Contact Map
3ja85 1 0.1885 6.9 0.923 Contact Map
3kbtA 1 0.4672 6.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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