GREMLIN Database
DUF2196 - Uncharacterized conserved protein (DUF2196)
PFAM: PF09962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (60)
Sequences: 6714 (2815)
Seq/√Len: 363.4
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D49_R3.6941.00
15_E60_E3.2671.00
15_E29_E3.2671.00
13_R29_E2.8791.00
18_L21_D2.6831.00
15_E27_L2.6101.00
4_N41_T2.1671.00
18_L54_Q2.1571.00
21_D26_K2.1511.00
8_I32_V2.1461.00
4_N7_N1.9331.00
9_K12_L1.7901.00
13_R31_I1.6711.00
16_I54_Q1.6191.00
27_L59_K1.6061.00
3_T7_N1.5141.00
10_P34_D1.3841.00
31_I51_E1.3241.00
33_K51_E1.2221.00
33_K49_R1.2091.00
27_L60_E1.2051.00
44_H59_K1.1931.00
3_T41_T1.0961.00
37_T42_H1.0681.00
17_V59_K1.0401.00
6_S40_P0.9431.00
12_L61_I0.9351.00
19_K55_V0.9101.00
47_K55_V0.8581.00
19_K22_Q0.8571.00
49_R55_V0.8471.00
19_K47_K0.8161.00
42_H57_R0.7981.00
8_I12_L0.7881.00
36_L42_H0.7731.00
5_R35_I0.7661.00
42_H47_K0.7551.00
10_P35_I0.7491.00
17_V25_G0.7431.00
20_Q54_Q0.7421.00
16_I50_L0.7331.00
39_S46_I0.7281.00
49_R52_D0.7261.00
31_I52_D0.7261.00
39_S44_H0.6980.99
14_V32_V0.6950.99
44_H47_K0.6930.99
45_G56_G0.6920.99
16_I48_V0.6800.99
17_V22_Q0.6790.99
20_Q26_K0.6630.99
10_P51_E0.6600.99
16_I56_G0.6600.99
8_I58_V0.6580.99
33_K53_G0.6570.99
3_T59_K0.6500.99
49_R53_G0.6400.99
18_L28_T0.6390.99
35_I46_I0.6240.99
22_Q25_G0.6160.98
33_K52_D0.6070.98
3_T15_E0.5960.98
28_T54_Q0.5940.98
36_L44_H0.5940.98
5_R8_I0.5860.98
28_T52_D0.5840.98
12_L32_V0.5680.97
8_I35_I0.5680.97
22_Q36_L0.5630.97
5_R46_I0.5590.97
17_V23_R0.5490.97
10_P33_K0.5490.97
46_I61_I0.5470.97
31_I40_P0.5400.97
6_S9_K0.5390.96
21_D28_T0.5370.96
13_R41_T0.5330.96
24_T28_T0.5320.96
22_Q47_K0.5250.96
24_T40_P0.5240.96
3_T44_H0.5220.96
25_G28_T0.5210.96
36_L47_K0.5200.96
19_K24_T0.5160.95
14_V56_G0.5140.95
47_K57_R0.5080.95
50_L56_G0.5060.95
10_P31_I0.5030.95
38_K44_H0.5020.95
4_N40_P0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vw4Q 1 0.9016 17.3 0.853 Contact Map
3dlmA 1 0.8361 15.3 0.857 Contact Map
4hikA 1 0.9508 13.9 0.859 Contact Map
1kl9A 2 0.7213 13.2 0.86 Contact Map
4w20Y 1 0.9344 13 0.861 Contact Map
3j61Y 1 0.8852 12.1 0.863 Contact Map
3bboW 1 0.8689 10.3 0.867 Contact Map
3psiA 1 0.9016 9.5 0.869 Contact Map
1vq8T 1 0.9344 8.9 0.871 Contact Map
2j5uA 4 0.8525 8.7 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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