GREMLIN Database
DUF2190 - Uncharacterized conserved protein (DUF2190)
PFAM: PF09956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (102)
Sequences: 6043 (5134)
Seq/√Len: 508.3
META: 0.909

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_A44_G2.8141.00
67_K86_L2.5391.00
53_E102_R2.5251.00
32_G46_V2.3201.00
35_L47_A2.2481.00
18_A39_A2.2481.00
47_A52_F2.1551.00
62_I90_A2.1131.00
68_V90_A2.0901.00
62_I101_V2.0631.00
92_E102_R2.0481.00
20_A23_D1.9931.00
12_T45_A1.9351.00
56_K94_A1.9081.00
18_A40_A1.8061.00
66_D79_T1.7781.00
77_V87_I1.7291.00
10_T45_A1.6221.00
9_D49_E1.6151.00
53_E100_T1.6031.00
25_V46_V1.5951.00
71_D74_A1.5941.00
57_A60_A1.5891.00
19_V34_A1.5481.00
12_T43_T1.5211.00
63_A66_D1.5171.00
36_T45_A1.4891.00
20_A37_D1.4871.00
62_I68_V1.4561.00
57_A76_V1.4071.00
24_V31_V1.3851.00
48_V104_R1.3591.00
39_A42_E1.3571.00
31_V87_I1.3311.00
86_L89_V1.2591.00
95_A98_D1.2301.00
13_Y46_V1.2151.00
10_T35_L1.2151.00
15_A38_A1.1841.00
29_S67_K1.1651.00
94_A98_D1.1411.00
23_D34_A1.1171.00
17_A40_A1.0861.00
69_Y86_L1.0741.00
91_V102_R1.0461.00
13_Y19_V1.0401.00
10_T47_A1.0181.00
32_G48_V1.0151.00
35_L52_F1.0121.00
54_L77_V1.0011.00
63_A93_A0.9901.00
5_V102_R0.9881.00
5_V53_E0.9771.00
49_E104_R0.9761.00
21_S37_D0.9721.00
72_A75_K0.9691.00
64_V93_A0.9541.00
60_A79_T0.9531.00
26_V31_V0.9481.00
15_A19_V0.9441.00
54_L87_I0.9411.00
49_E52_F0.9381.00
15_A44_G0.9241.00
67_K89_V0.9241.00
6_Q51_V0.9221.00
14_T43_T0.9181.00
68_V77_V0.9151.00
26_V85_T0.8801.00
11_I91_V0.8731.00
51_V91_V0.8731.00
14_T64_V0.8701.00
38_A42_E0.8691.00
24_V87_I0.8671.00
24_V70_W0.8481.00
25_V34_A0.8451.00
25_V32_G0.8411.00
8_G51_V0.8281.00
16_P40_A0.8211.00
68_V103_V0.7911.00
19_V23_D0.7851.00
33_V54_L0.7851.00
29_S85_T0.7831.00
80_T84_N0.7821.00
30_L89_V0.7801.00
64_V92_E0.7771.00
61_A96_A0.7581.00
34_A38_A0.7501.00
58_A97_G0.7471.00
56_K62_I0.7411.00
90_A101_V0.7411.00
66_D90_A0.7321.00
78_T81_A0.7261.00
66_D93_A0.7221.00
80_T83_G0.7171.00
4_Y7_P0.7171.00
82_T85_T0.7011.00
4_Y50_G0.6971.00
70_W75_K0.6911.00
34_A44_G0.6911.00
9_D47_A0.6881.00
4_Y47_A0.6871.00
51_V102_R0.6851.00
19_V38_A0.6851.00
19_V44_G0.6831.00
59_A96_A0.6791.00
70_W74_A0.6771.00
21_S36_T0.6671.00
13_Y27_V0.6651.00
68_V88_G0.6641.00
71_D75_K0.6591.00
29_S66_D0.6551.00
69_Y80_T0.6541.00
15_A18_A0.6531.00
24_V33_V0.6511.00
64_V91_V0.6441.00
60_A78_T0.6421.00
95_A99_T0.6401.00
62_I79_T0.6281.00
18_A37_D0.6251.00
62_I66_D0.6231.00
69_Y84_N0.6221.00
6_Q91_V0.6191.00
89_V104_R0.6181.00
94_A97_G0.6151.00
78_T84_N0.5950.99
26_V72_A0.5940.99
38_A46_V0.5810.99
23_D37_D0.5800.99
62_I77_V0.5780.99
81_A84_N0.5750.99
92_E98_D0.5710.99
74_A78_T0.5680.99
58_A94_A0.5630.99
27_V64_V0.5620.99
24_V34_A0.5600.99
61_A93_A0.5600.99
69_Y78_T0.5580.99
54_L103_V0.5510.99
7_P10_T0.5480.99
55_P76_V0.5450.99
27_V30_L0.5440.99
31_V70_W0.5400.99
13_Y48_V0.5400.99
15_A40_A0.5370.99
19_V25_V0.5360.99
17_A75_K0.5230.99
13_Y64_V0.5190.98
13_Y38_A0.5170.98
87_I103_V0.5150.98
39_A44_G0.5140.98
33_V52_F0.5100.98
63_A79_T0.5040.98
81_A85_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3teeA 1 0.6952 17.4 0.87 Contact Map
3frnA 1 0.8 16.5 0.871 Contact Map
3lazA 2 0.5048 11.8 0.88 Contact Map
3k3sA 2 0.4857 8.8 0.886 Contact Map
3v77A 5 0.5619 8.6 0.887 Contact Map
3s52A 2 0.5333 7.1 0.891 Contact Map
1gttA 1 0.6 7.1 0.891 Contact Map
4dbfA 2 0.5619 6.9 0.891 Contact Map
2eb4A 5 0.5429 6.2 0.894 Contact Map
4p5nA 2 0.4667 6 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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