GREMLIN Database
DUF2189 - Predicted integral membrane protein (DUF2189)
PFAM: PF09955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (125)
Sequences: 9103 (5614)
Seq/√Len: 502.2
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R30_E3.1531.00
21_E25_R3.0411.00
33_S36_D2.6041.00
21_E24_R2.5261.00
87_R91_T2.5251.00
107_A111_A2.3971.00
84_D88_D2.2781.00
73_F97_A2.1831.00
51_L121_F2.0501.00
69_I105_V2.0481.00
58_I113_V2.0111.00
7_G59_F1.9991.00
104_A108_L1.9821.00
65_A109_F1.9701.00
25_R36_D1.9561.00
88_D94_E1.9131.00
31_P36_D1.7531.00
66_A102_G1.7441.00
83_S87_R1.7161.00
92_T95_G1.7041.00
69_I73_F1.6941.00
97_A101_V1.6671.00
36_D39_D1.5961.00
51_L120_S1.5281.00
81_S84_D1.4921.00
22_L26_R1.4671.00
57_V61_L1.4441.00
39_D42_R1.4161.00
116_I120_S1.3961.00
42_R45_S1.3851.00
67_A71_A1.3811.00
93_P97_A1.3731.00
2_F103_N1.3551.00
84_D87_R1.3541.00
49_A52_G1.3451.00
104_A107_A1.3441.00
73_F98_L1.3201.00
50_A54_L1.3141.00
58_I109_F1.3111.00
6_A9_A1.3021.00
21_E36_D1.2961.00
55_L113_V1.2611.00
24_R28_R1.2561.00
16_A20_Y1.2471.00
106_G110_A1.2161.00
64_R68_L1.2071.00
32_V36_D1.2041.00
55_L117_S1.1811.00
56_L60_L1.1751.00
25_R32_V1.1751.00
10_L113_V1.1711.00
100_V103_N1.1561.00
51_L117_S1.1431.00
54_L116_I1.1391.00
65_A105_V1.1241.00
46_G49_A1.1231.00
112_L116_I1.0991.00
58_I112_L1.0961.00
68_L72_L1.0821.00
41_W46_G1.0811.00
51_L124_L1.0701.00
64_R71_A1.0641.00
114_F118_V1.0631.00
17_V48_I1.0611.00
80_P84_D1.0571.00
17_V125_L1.0431.00
74_F88_D1.0391.00
70_Y74_F1.0361.00
11_V59_F1.0321.00
96_W100_V1.0311.00
113_V117_S1.0041.00
99_L103_N1.0021.00
3_P63_L1.0011.00
69_I98_L0.9991.00
111_A115_A0.9911.00
47_A50_A0.9841.00
61_L64_R0.9821.00
64_R67_A0.9511.00
93_P96_W0.9461.00
2_F6_A0.9461.00
73_F101_V0.9451.00
14_F52_G0.9351.00
66_A70_Y0.9251.00
108_L112_L0.9241.00
74_F94_E0.9211.00
82_L86_L0.9001.00
94_E97_A0.8981.00
12_G15_A0.8861.00
26_R32_V0.8731.00
52_G55_L0.8631.00
97_A100_V0.8601.00
40_V44_P0.8591.00
85_F89_V0.8561.00
101_V105_V0.8441.00
4_L8_F0.8421.00
61_L65_A0.8371.00
53_L57_V0.8251.00
19_L37_A0.8221.00
80_P83_S0.8151.00
57_V64_R0.8041.00
81_S85_F0.7901.00
79_P83_S0.7891.00
115_A118_V0.7811.00
82_L85_F0.7811.00
8_F11_V0.7741.00
18_G38_L0.7691.00
22_L37_A0.7681.00
47_A124_L0.7671.00
37_A41_W0.7541.00
34_W37_A0.7541.00
43_S46_G0.7471.00
33_S37_A0.7461.00
56_L67_A0.7421.00
31_P35_A0.7391.00
79_P88_D0.7381.00
34_W38_L0.7341.00
89_V98_L0.7311.00
60_L64_R0.7301.00
64_R72_L0.7151.00
14_F40_V0.7131.00
48_I124_L0.7091.00
48_I125_L0.7041.00
103_N107_A0.7011.00
119_V123_L0.6961.00
62_W106_G0.6951.00
30_E36_D0.6951.00
40_V43_S0.6871.00
86_L90_F0.6691.00
7_G11_V0.6631.00
28_R32_V0.6631.00
79_P82_L0.6551.00
59_F63_L0.6491.00
41_W44_P0.6371.00
50_A53_L0.6361.00
35_A39_D0.6271.00
71_A76_P0.6201.00
101_V104_A0.6151.00
33_S42_R0.6131.00
11_V14_F0.6111.00
19_L23_S0.6090.99
115_A119_V0.6090.99
81_S86_L0.6080.99
58_I116_I0.6040.99
37_A40_V0.6020.99
2_F5_A0.5990.99
32_V37_A0.5950.99
9_A59_F0.5950.99
9_A121_F0.5920.99
102_G106_G0.5880.99
83_S86_L0.5880.99
95_G98_L0.5860.99
5_A9_A0.5750.99
8_F23_S0.5720.99
23_S37_A0.5690.99
21_E26_R0.5660.99
100_V104_A0.5660.99
99_L102_G0.5640.99
38_L41_W0.5630.99
50_A64_R0.5620.99
74_F98_L0.5610.99
90_F94_E0.5600.99
62_W66_A0.5550.99
77_A84_D0.5550.99
102_G105_V0.5530.99
57_V67_A0.5510.99
107_A110_A0.5490.99
18_G40_V0.5480.99
105_V109_F0.5480.99
68_L71_A0.5420.99
87_R93_P0.5420.99
26_R30_E0.5390.99
102_G109_F0.5380.99
37_A52_G0.5380.99
49_A68_L0.5370.99
108_L111_A0.5350.99
21_E43_S0.5340.99
14_F56_L0.5330.99
77_A83_S0.5310.99
9_A15_A0.5270.99
35_A42_R0.5220.98
18_G48_I0.5210.98
18_G36_D0.5140.98
77_A80_P0.5120.98
4_L59_F0.5110.98
17_V40_V0.5090.98
19_L22_L0.5050.98
90_F95_G0.5010.98
117_S120_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ltoA 3 0.619 3.1 0.928 Contact Map
4cbcA 3 0.6111 2.4 0.932 Contact Map
3rkoJ 1 0.2381 2.2 0.933 Contact Map
4k0jA 3 0.1746 1.9 0.935 Contact Map
2wscL 1 0.8016 1.8 0.937 Contact Map
4cadC 1 0.7619 1.7 0.937 Contact Map
3j8eG 3 0.873 1.6 0.938 Contact Map
4gx0A 3 0.6508 1.4 0.94 Contact Map
3rlfF 1 0.9524 1.4 0.94 Contact Map
1q90G 1 0.2143 1.4 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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