GREMLIN Database
AbiEi_2 - Transcriptional regulator, AbiEi antitoxin, Type IV TA system
PFAM: PF09952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 143 (139)
Sequences: 4160 (3323)
Seq/√Len: 281.8
META: 0.924

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_N7_E4.4291.00
113_V118_V3.3191.00
48_A113_V2.9791.00
54_A118_V2.9411.00
6_E10_D2.6861.00
86_L94_V2.6371.00
125_T130_G2.3101.00
58_L115_P2.2991.00
135_E139_E2.2431.00
10_D138_Y2.2361.00
9_L116_L2.2081.00
58_L118_V2.1291.00
30_R89_D2.1121.00
30_R93_N2.0871.00
53_S67_V1.9751.00
48_A99_P1.9381.00
21_R97_L1.9211.00
61_Y133_A1.9171.00
6_E138_Y1.8691.00
11_R14_E1.8391.00
123_L131_I1.8141.00
56_A64_P1.8101.00
11_R18_E1.7231.00
70_Y121_D1.6581.00
136_H140_E1.6351.00
52_E62_L1.5811.00
35_D38_K1.5811.00
61_Y136_H1.5721.00
131_I135_E1.5031.00
89_D93_N1.4921.00
49_W53_S1.4681.00
56_A60_P1.4471.00
51_G68_T1.4461.00
13_V123_L1.4311.00
37_W40_A1.4001.00
11_R15_A1.3771.00
74_E98_E1.3701.00
36_W40_A1.3531.00
33_D37_W1.3381.00
77_L81_A1.2811.00
79_E83_A1.2681.00
50_G113_V1.2271.00
55_A118_V1.2241.00
5_P9_L1.2211.00
58_L112_V1.2181.00
53_S57_L1.1711.00
66_T95_E1.1641.00
129_R132_E1.1611.00
24_L88_P1.1231.00
54_A113_V1.1211.00
79_E82_K1.0921.00
113_V117_L1.0871.00
52_E64_P1.0811.00
28_R92_G1.0781.00
133_A136_H1.0751.00
27_G30_R1.0711.00
13_V120_A1.0701.00
73_T76_D1.0701.00
137_I141_Y1.0681.00
81_A86_L1.0621.00
101_W114_P1.0561.00
10_D14_E1.0491.00
7_E10_D1.0481.00
17_P124_A1.0411.00
78_E81_A1.0361.00
25_L28_R1.0321.00
54_A112_V1.0271.00
45_A83_A1.0211.00
13_V119_Y1.0111.00
35_D39_E1.0041.00
106_E109_G0.9901.00
40_A45_A0.9851.00
27_G31_A0.9851.00
57_L111_D0.9811.00
15_A18_E0.9661.00
43_A46_G0.9501.00
59_T133_A0.9431.00
41_D44_E0.9401.00
115_P141_Y0.9371.00
71_V96_L0.9371.00
16_Y21_R0.9241.00
32_D36_W0.9181.00
128_G133_A0.9141.00
102_G105_E0.9121.00
113_V121_D0.9081.00
76_D79_E0.9031.00
41_D45_A0.8971.00
39_E46_G0.8901.00
68_T97_L0.8901.00
26_L98_E0.8881.00
14_E18_E0.8821.00
28_R95_E0.8741.00
52_E130_G0.8701.00
23_K95_E0.8691.00
100_F104_E0.8651.00
32_D37_W0.8631.00
68_T95_E0.8601.00
70_Y99_P0.8501.00
61_Y132_E0.8461.00
54_A64_P0.8391.00
37_W41_D0.8381.00
112_V118_V0.8231.00
59_T136_H0.8191.00
42_L45_A0.8150.99
54_A57_L0.8140.99
117_L120_A0.8100.99
36_W39_E0.8040.99
42_L47_A0.8030.99
55_A58_L0.7970.99
43_A47_A0.7880.99
119_Y123_L0.7840.99
5_P116_L0.7800.99
39_E43_A0.7780.99
26_L29_F0.7760.99
49_W67_V0.7750.99
99_P117_L0.7730.99
18_E21_R0.7690.99
55_A137_I0.7670.99
80_L84_L0.7540.99
105_E109_G0.7530.99
106_E111_D0.7510.99
55_A133_A0.7490.99
69_I96_L0.7360.99
25_L98_E0.7330.99
37_W42_L0.7310.99
33_D39_E0.7250.99
82_K88_P0.7250.99
64_P67_V0.7120.99
138_Y141_Y0.7110.99
52_E68_T0.7100.99
101_W104_E0.7090.99
39_E45_A0.7090.99
89_D92_G0.7040.98
13_V116_L0.6950.98
10_D13_V0.6900.98
25_L95_E0.6890.98
34_P38_K0.6850.98
125_T128_G0.6850.98
38_K46_G0.6820.98
100_F105_E0.6810.98
115_P137_I0.6770.98
49_W69_I0.6750.98
126_G131_I0.6730.98
44_E83_A0.6620.98
70_Y119_Y0.6600.98
19_R23_K0.6580.98
135_E138_Y0.6580.98
62_L130_G0.6570.98
7_E11_R0.6540.98
68_T125_T0.6520.98
25_L97_L0.6510.98
78_E82_K0.6330.97
100_F103_F0.6260.97
116_L120_A0.6240.97
131_I138_Y0.6240.97
127_D130_G0.6220.97
115_P118_V0.6210.97
130_G133_A0.6210.97
42_L49_W0.6210.97
102_G114_P0.6200.97
42_L46_G0.6160.97
32_D35_D0.6120.96
39_E42_L0.6120.96
32_D85_R0.6100.96
11_R27_G0.6070.96
20_L24_L0.6030.96
54_A58_L0.6020.96
62_L136_H0.5960.96
50_G118_V0.5920.96
24_L98_E0.5900.96
34_P37_W0.5880.95
52_E65_E0.5880.95
86_L96_L0.5820.95
82_K87_R0.5730.95
70_Y113_V0.5700.95
25_L29_F0.5680.95
26_L30_R0.5660.94
49_W112_V0.5650.94
41_D111_D0.5610.94
17_P21_R0.5540.94
40_A44_E0.5500.94
53_S64_P0.5500.94
114_P118_V0.5480.93
55_A122_L0.5480.93
116_L141_Y0.5470.93
49_W130_G0.5470.93
21_R29_F0.5440.93
73_T79_E0.5420.93
49_W111_D0.5390.93
123_L135_E0.5360.93
36_W42_L0.5310.92
38_K41_D0.5300.92
34_P39_E0.5290.92
2_L5_P0.5250.92
41_D83_A0.5230.92
77_L98_E0.5200.92
34_P47_A0.5190.92
48_A54_A0.5160.91
119_Y134_A0.5160.91
42_L69_I0.5130.91
36_W44_E0.5110.91
36_W43_A0.5090.91
99_P103_F0.5080.91
26_L81_A0.5070.91
61_Y116_L0.5070.91
81_A84_L0.5030.90
129_R133_A0.5010.90
38_K42_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zelA 1 0.9371 33.8 0.903 Contact Map
3ismC 1 0.2797 5.1 0.934 Contact Map
4gvpA 1 0.5175 3.6 0.939 Contact Map
4nbiA 2 0.7063 3 0.941 Contact Map
1a04A 1 0.5315 2.9 0.941 Contact Map
3c3wA 2 0.5175 2.8 0.942 Contact Map
3eulA 2 0.5315 2.8 0.942 Contact Map
2dulA 2 0.4056 2.7 0.942 Contact Map
2jnuA 1 0.4755 2.7 0.942 Contact Map
2qv0A 2 0.5105 2.6 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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