GREMLIN Database
DUF2185 - Protein of unknown function (DUF2185)
PFAM: PF09951 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (82)
Sequences: 2712 (2150)
Seq/√Len: 237.4
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_D43_D2.8231.00
6_R36_D2.6181.00
17_M66_L2.4181.00
42_M48_F2.3421.00
33_F42_M2.3111.00
5_D9_V2.2431.00
41_Y47_N2.1561.00
69_A75_F2.1191.00
2_I48_F2.0741.00
27_D31_R2.0431.00
18_Y31_R1.9891.00
20_E31_R1.9681.00
12_R36_D1.9651.00
62_S77_R1.8851.00
5_D49_A1.7831.00
6_R12_R1.7461.00
4_S48_F1.7141.00
54_N58_N1.6341.00
6_R10_D1.6301.00
51_Y55_T1.6031.00
8_T51_Y1.5661.00
69_A73_S1.5561.00
57_A64_I1.5351.00
23_D31_R1.4961.00
17_M32_F1.4621.00
8_T56_I1.3761.00
6_R34_S1.3551.00
69_A72_G1.3251.00
33_F48_F1.3021.00
78_D81_G1.2331.00
60_D77_R1.1641.00
54_N57_A1.1571.00
14_V60_D1.1551.00
66_L75_F1.1181.00
13_P62_S1.1171.00
44_D47_N1.1101.00
3_A56_I1.1011.00
55_T59_Y1.0951.00
79_E82_E1.0511.00
3_A8_T1.0361.00
28_S53_V1.0041.00
32_F56_I0.9931.00
2_I23_D0.9701.00
38_S41_Y0.9401.00
70_P73_S0.9281.00
14_V32_F0.9031.00
58_N64_I0.8750.99
55_T58_N0.8690.99
54_N64_I0.8690.99
26_E52_D0.8620.99
21_E71_V0.8600.99
53_V56_I0.8510.99
54_N59_Y0.8480.99
11_G59_Y0.8370.99
7_I32_F0.8310.99
78_D82_E0.8280.99
32_F53_V0.8220.99
2_I50_I0.8190.99
32_F63_I0.8100.99
8_T49_A0.8080.99
22_P28_S0.7990.99
32_F66_L0.7980.99
52_D55_T0.7860.99
76_E79_E0.7750.99
4_S42_M0.7660.98
23_D26_E0.7640.98
12_R34_S0.7500.98
5_D47_N0.7390.98
57_A63_I0.7370.98
63_I67_L0.7290.98
16_Y74_A0.7080.97
56_I63_I0.6960.97
4_S34_S0.6910.97
19_R29_G0.6850.97
3_A51_Y0.6850.97
53_V57_A0.6830.97
9_V49_A0.6810.97
14_V63_I0.6760.97
15_G36_D0.6670.96
39_D42_M0.6600.96
10_D36_D0.6590.96
18_Y33_F0.6550.96
22_P27_D0.6480.96
32_F67_L0.6410.95
3_A7_I0.6350.95
38_S61_P0.6300.95
14_V17_M0.6190.95
24_N50_I0.6150.94
50_I55_T0.6150.94
4_S33_F0.6130.94
58_N63_I0.6080.94
13_P60_D0.6000.94
51_Y56_I0.5970.93
10_D39_D0.5970.93
16_Y72_G0.5960.93
46_D49_A0.5950.93
69_A74_A0.5930.93
64_I67_L0.5920.93
4_S41_Y0.5880.93
73_S77_R0.5860.93
28_S67_L0.5770.92
20_E23_D0.5740.92
21_E78_D0.5720.92
62_S81_G0.5670.92
6_R41_Y0.5560.91
7_I34_S0.5550.91
57_A67_L0.5540.91
16_Y33_F0.5510.90
15_G34_S0.5510.90
2_I40_E0.5500.90
21_E70_P0.5490.90
24_N74_A0.5420.90
35_G38_S0.5340.89
23_D27_D0.5320.89
17_M63_I0.5210.88
7_I13_P0.5170.87
42_M76_E0.5130.87
48_F53_V0.5120.87
17_M75_F0.5120.87
17_M62_S0.5050.86
21_E25_E0.5010.86
24_N71_V0.5010.86
1_C57_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lydA 1 0.5882 39.6 0.864 Contact Map
2qklA 1 0.4588 37.9 0.866 Contact Map
4b6hA 1 0.5412 16.9 0.887 Contact Map
1q67A 2 0.4706 15.1 0.889 Contact Map
4qhwA 1 0.9529 8.5 0.901 Contact Map
2cr3A 1 0.3412 7 0.905 Contact Map
3j7aI 1 0.4941 4.9 0.911 Contact Map
4ioyX 1 0.2588 3 0.92 Contact Map
4h63K 1 0.4471 2.9 0.921 Contact Map
4khoA 1 0.4 2.8 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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