GREMLIN Database
DUF2183 - Uncharacterized conserved protein (DUF2183)
PFAM: PF09949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (99)
Sequences: 6460 (4145)
Seq/√Len: 416.6
META: 0.845

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_R87_E3.8001.00
66_R93_L3.0361.00
85_A95_I2.9471.00
3_Y27_G2.7161.00
83_E87_E2.4961.00
59_L84_I2.4601.00
82_A86_R2.4471.00
52_L83_E2.4341.00
73_S97_I2.4071.00
5_S31_L2.4001.00
60_E88_F2.1731.00
56_R88_F2.1541.00
56_R60_E2.0651.00
6_S47_G1.9441.00
19_L29_L1.8931.00
59_L91_R1.8931.00
59_L92_V1.8351.00
57_R61_T1.7741.00
73_S99_D1.6911.00
37_T40_G1.6761.00
6_S50_H1.5711.00
4_V55_I1.5251.00
2_F30_L1.5191.00
68_I94_A1.5161.00
52_L56_R1.4721.00
48_R76_H1.4191.00
83_E86_R1.3531.00
59_L67_F1.3201.00
19_L24_F1.3051.00
40_G43_R1.2831.00
52_L87_E1.2621.00
2_F28_P1.2171.00
69_L92_V1.2051.00
30_L54_A1.2031.00
20_R26_A1.1711.00
6_S75_Q1.0991.00
79_E82_A1.0751.00
82_A85_A1.0681.00
55_I84_I1.0541.00
2_F62_F1.0431.00
38_L41_L1.0401.00
50_H54_A1.0391.00
17_E21_R1.0321.00
16_E20_R1.0311.00
7_S15_L1.0221.00
52_L80_I1.0211.00
53_A57_R1.0071.00
57_R60_E1.0051.00
58_L67_F1.0041.00
8_P11_L0.9941.00
46_S49_E0.9931.00
2_F58_L0.9881.00
54_A57_R0.9711.00
71_G77_D0.9561.00
55_I59_L0.9401.00
15_L29_L0.9101.00
11_L14_P0.9071.00
6_S48_R0.9061.00
52_L84_I0.8851.00
49_E53_A0.8821.00
16_E26_A0.8741.00
28_P65_L0.8621.00
7_S10_N0.8551.00
58_L61_T0.8471.00
47_G50_H0.8421.00
12_Y16_E0.8421.00
67_F91_R0.8341.00
81_Y97_I0.8321.00
55_I80_I0.8221.00
7_S11_L0.8201.00
88_F91_R0.8161.00
40_G44_S0.7791.00
66_R90_G0.7771.00
8_P75_Q0.7721.00
76_H79_E0.7691.00
36_P40_G0.7671.00
48_R80_I0.7591.00
36_P41_L0.7571.00
2_F65_L0.7531.00
48_R52_L0.7501.00
1_F24_F0.7341.00
51_K77_D0.7321.00
51_K72_D0.7101.00
68_I96_Y0.7061.00
35_G38_L0.7051.00
9_W12_Y0.7011.00
18_F22_N0.6981.00
62_F65_L0.6961.00
14_P17_E0.6891.00
14_P21_R0.6871.00
15_L31_L0.6861.00
20_R23_G0.6841.00
37_T43_R0.6841.00
50_H80_I0.6771.00
32_R43_R0.6670.99
39_D42_F0.6600.99
8_P32_R0.6540.99
50_H53_A0.6520.99
4_V30_L0.6420.99
6_S9_W0.6370.99
53_A56_R0.6330.99
70_I74_G0.6320.99
13_D17_E0.6270.99
7_S32_R0.6210.99
78_P82_A0.6160.99
76_H80_I0.6160.99
36_P42_F0.6140.99
3_Y25_P0.6040.99
37_T42_F0.6030.99
9_W31_L0.6010.99
39_D46_S0.5990.99
84_I88_F0.5940.99
65_L73_S0.5930.99
32_R75_Q0.5920.99
47_G52_L0.5910.99
47_G76_H0.5880.99
47_G75_Q0.5820.99
4_V58_L0.5790.99
41_L45_G0.5600.98
77_D97_I0.5600.98
56_R84_I0.5590.98
16_E19_L0.5580.98
32_R47_G0.5530.98
59_L69_L0.5490.98
3_Y24_F0.5430.98
17_E20_R0.5430.98
59_L88_F0.5410.98
32_R50_H0.5360.98
60_E64_D0.5330.98
66_R91_R0.5310.97
42_F45_G0.5290.97
41_L44_S0.5280.97
7_S31_L0.5270.97
5_S9_W0.5260.97
43_R47_G0.5250.97
38_L43_R0.5230.97
40_G45_G0.5210.97
47_G80_I0.5170.97
10_N14_P0.5130.97
78_P95_I0.5120.97
4_V74_G0.5110.97
35_G40_G0.5080.97
24_F85_A0.5070.97
44_S47_G0.5070.97
79_E83_E0.5050.97
46_S50_H0.5040.97
30_L58_L0.5030.96
9_W34_W0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i33A 2 0.83 71.5 0.854 Contact Map
4xrpA 2 0.86 47.9 0.874 Contact Map
4gxtA 1 0.92 45 0.876 Contact Map
3zvlA 1 0.9 42.7 0.878 Contact Map
3pctA 2 0.83 40 0.88 Contact Map
2o2xA 1 0.99 37.7 0.882 Contact Map
4fypA 2 0.82 34.4 0.884 Contact Map
2gmwA 1 0.99 30.2 0.887 Contact Map
4ovyA 2 0.93 30 0.887 Contact Map
2wm8A 1 0.78 28.7 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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