GREMLIN Database
DUF2182 - Predicted metal-binding integral membrane protein (DUF2182)
PFAM: PF09948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (186)
Sequences: 15123 (10053)
Seq/√Len: 737.1
META: 0.954

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L185_G3.6061.00
47_V133_V3.4891.00
160_L177_A3.3521.00
113_H127_R3.3211.00
123_R127_R3.2181.00
5_V49_T2.9361.00
99_C134_G2.7161.00
91_Q164_E2.7101.00
46_L122_L2.6721.00
170_G174_A2.4091.00
163_A167_L2.2431.00
81_G185_G2.2031.00
171_R175_R2.1981.00
39_L118_A2.1791.00
172_R175_R2.1751.00
20_V41_V2.0971.00
162_L166_L2.0931.00
51_F133_V2.0381.00
16_A20_V1.9611.00
88_G182_I1.9351.00
119_R123_R1.9311.00
23_Y27_A1.9101.00
99_C131_Y1.9011.00
25_R29_R1.8821.00
169_W172_R1.8801.00
19_M40_F1.8591.00
74_R79_L1.8231.00
143_L154_M1.7731.00
78_L82_A1.7611.00
43_G129_G1.7251.00
24_A37_T1.6601.00
107_L111_L1.6461.00
60_W64_R1.6351.00
61_A65_A1.6231.00
142_L146_L1.6041.00
172_R176_A1.5731.00
59_Q63_H1.5361.00
52_G56_Y1.4861.00
88_G178_G1.4851.00
163_A173_V1.4731.00
15_S165_K1.4641.00
51_F55_A1.4381.00
143_L157_L1.4381.00
97_D101_R1.4361.00
31_G34_R1.4041.00
91_Q96_K1.3871.00
158_A162_L1.3331.00
21_L25_R1.3241.00
97_D171_R1.3041.00
39_L121_A1.3041.00
109_F127_R1.2871.00
152_A155_A1.2861.00
146_L153_W1.2851.00
17_A21_L1.2431.00
148_V154_M1.2301.00
61_A64_R1.2241.00
102_H131_Y1.2241.00
31_G35_A1.2191.00
169_W173_V1.2171.00
43_G122_L1.2131.00
39_L122_L1.1971.00
9_A13_L1.1951.00
79_L82_A1.1951.00
174_A177_A1.1911.00
92_L178_G1.1901.00
71_A75_A1.1831.00
69_S73_A1.1831.00
171_R174_A1.1631.00
27_A36_A1.1581.00
174_A178_G1.1441.00
75_A78_L1.1401.00
114_W124_M1.1361.00
82_A86_A1.1291.00
19_M22_L1.1291.00
89_L94_P1.1251.00
125_G129_G1.1251.00
108_G112_R1.1111.00
81_G85_L1.0931.00
151_L154_M1.0861.00
120_G124_M1.0831.00
117_G120_G1.0731.00
20_V40_F1.0691.00
108_G111_L1.0671.00
83_V145_V1.0571.00
5_V9_A1.0491.00
25_R28_R1.0411.00
173_V176_A1.0401.00
13_L41_V1.0321.00
72_M75_A1.0321.00
182_I186_V1.0231.00
96_K164_E1.0201.00
47_V126_L1.0091.00
17_A24_A1.0041.00
27_A30_R1.0021.00
30_R116_D0.9971.00
105_S108_G0.9971.00
154_M161_V0.9961.00
60_W63_H0.9931.00
56_Y59_Q0.9931.00
96_K100_L0.9831.00
64_R68_L0.9821.00
46_L50_A0.9761.00
139_L181_L0.9741.00
115_R120_G0.9651.00
97_D175_R0.9641.00
57_A61_A0.9631.00
20_V37_T0.9571.00
183_A187_L0.9541.00
152_A156_A0.9411.00
170_G173_V0.9401.00
115_R123_R0.9381.00
179_V183_A0.9341.00
50_A54_A0.9331.00
110_L113_H0.9181.00
23_Y37_T0.9041.00
98_A101_R0.9011.00
90_Y138_A0.8981.00
63_H68_L0.8961.00
43_G125_G0.8951.00
72_M76_S0.8941.00
157_L161_V0.8901.00
98_A102_H0.8851.00
42_A46_L0.8821.00
23_Y36_A0.8771.00
126_L130_L0.8761.00
102_H112_R0.8681.00
68_L74_R0.8621.00
146_L157_L0.8591.00
13_L45_L0.8571.00
94_P98_A0.8501.00
111_L114_W0.8471.00
160_L181_L0.8471.00
56_Y60_W0.8391.00
106_P109_F0.8311.00
24_A27_A0.8311.00
83_V141_A0.8241.00
175_R179_V0.8231.00
69_S72_M0.8211.00
80_A145_V0.8201.00
106_P110_L0.8081.00
93_T96_K0.8041.00
19_M26_V0.8021.00
104_R108_G0.7991.00
83_V142_L0.7951.00
68_L72_M0.7841.00
74_R80_A0.7801.00
85_L182_I0.7791.00
142_L145_V0.7791.00
109_F113_H0.7781.00
110_L114_W0.7751.00
15_S161_V0.7681.00
137_W140_M0.7661.00
54_A57_A0.7651.00
78_L81_G0.7651.00
46_L126_L0.7631.00
22_L26_V0.7611.00
177_A180_A0.7541.00
57_A60_W0.7521.00
84_L142_L0.7521.00
69_S75_A0.7451.00
66_A70_P0.7441.00
63_H66_A0.7421.00
104_R171_R0.7391.00
176_A180_A0.7351.00
143_L161_V0.7311.00
177_A181_L0.7271.00
100_L104_R0.7261.00
59_Q62_L0.7211.00
176_A179_V0.7191.00
59_Q68_L0.7141.00
55_A144_F0.7121.00
146_L156_A0.7091.00
20_V24_A0.7081.00
84_L184_L0.7061.00
147_G150_N0.7061.00
180_A184_L0.7061.00
16_A19_M0.6971.00
173_V177_A0.6971.00
112_R116_D0.6901.00
74_R77_P0.6881.00
138_A142_L0.6851.00
40_F128_H0.6851.00
118_A121_A0.6831.00
181_L184_L0.6801.00
161_V165_K0.6781.00
89_L93_T0.6751.00
52_G59_Q0.6691.00
36_A118_A0.6691.00
150_N154_M0.6671.00
44_Y128_H0.6661.00
36_A39_L0.6651.00
2_A6_V0.6641.00
104_R170_G0.6611.00
114_W117_G0.6601.00
117_G121_A0.6591.00
70_P74_R0.6581.00
121_A125_G0.6581.00
35_A118_A0.6541.00
3_M6_V0.6511.00
87_A142_L0.6461.00
88_G185_G0.6411.00
64_R67_L0.6381.00
109_F128_H0.6381.00
100_L164_E0.6361.00
86_A138_A0.6361.00
24_A29_R0.6331.00
47_V50_A0.6291.00
134_G140_M0.6271.00
88_G92_L0.6221.00
110_L120_G0.6221.00
149_M153_W0.6211.00
138_A141_A0.6161.00
3_M8_M0.6161.00
26_V114_W0.6131.00
169_W176_A0.6121.00
22_L110_L0.6051.00
38_A41_V0.6031.00
22_L25_R0.6031.00
32_R35_A0.6031.00
113_H123_R0.6011.00
90_Y95_L0.5991.00
115_R124_M0.5991.00
9_A45_L0.5971.00
155_A162_L0.5901.00
23_Y30_R0.5901.00
170_G175_R0.5861.00
8_M149_M0.5861.00
182_I185_G0.5841.00
109_F114_W0.5821.00
163_A166_L0.5811.00
92_L175_R0.5811.00
113_H116_D0.5801.00
62_L65_A0.5801.00
3_M7_M0.5771.00
86_A89_L0.5741.00
130_L134_G0.5731.00
27_A37_T0.5721.00
19_M110_L0.5721.00
43_G126_L0.5651.00
167_L173_V0.5641.00
163_A177_A0.5631.00
151_L155_A0.5631.00
124_M127_R0.5631.00
91_Q100_L0.5581.00
87_A138_A0.5561.00
85_L88_G0.5541.00
8_M143_L0.5541.00
146_L154_M0.5531.00
43_G47_V0.5521.00
62_L67_L0.5511.00
77_P81_G0.5441.00
144_F148_V0.5411.00
142_L181_L0.5381.00
62_L79_L0.5361.00
3_M59_Q0.5361.00
168_P171_R0.5361.00
22_L29_R0.5341.00
15_S162_L0.5331.00
81_G182_I0.5331.00
8_M161_V0.5331.00
91_Q135_C0.5311.00
19_M109_F0.5301.00
37_T41_V0.5261.00
154_M158_A0.5251.00
70_P73_A0.5201.00
75_A79_L0.5201.00
159_A163_A0.5191.00
96_K135_C0.5171.00
19_M128_H0.5141.00
21_L26_V0.5121.00
3_M150_N0.5111.00
130_L133_V0.5101.00
117_G124_M0.5101.00
160_L173_V0.5081.00
160_L174_A0.5061.00
47_V51_F0.5041.00
80_A83_V0.5031.00
158_A161_V0.5021.00
150_N153_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ogqB 1 0.3511 2.5 0.958 Contact Map
3wxwA 1 0.5266 1.5 0.963 Contact Map
2msqA 1 0.1223 1 0.967 Contact Map
1v54M 1 0.1383 0.9 0.968 Contact Map
1b4uB 2 0.3032 0.8 0.968 Contact Map
2mmuA 1 0.2287 0.8 0.968 Contact Map
2y69M 1 0.1383 0.7 0.97 Contact Map
2mn6B 2 0.2234 0.7 0.97 Contact Map
4rngA 2 0.4043 0.7 0.97 Contact Map
4g1uA 2 0.2553 0.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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