GREMLIN Database
DUF2180 - Uncharacterized protein conserved in archaea (DUF2180)
PFAM: PF09947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (66)
Sequences: 708 (424)
Seq/√Len: 52.2
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_K14_D3.6841.00
2_K12_D2.9341.00
5_D24_M2.3031.00
16_V28_M2.0591.00
31_A57_I2.0321.00
20_I23_G2.0061.00
42_G46_P1.9931.00
24_M55_P1.6560.98
7_A28_M1.5620.98
5_D61_T1.5500.98
17_A31_A1.5410.97
17_A57_I1.5260.97
16_V31_A1.4970.97
11_K29_E1.4490.96
59_C62_C1.4120.96
25_G47_S1.4060.96
3_C6_C1.3380.94
8_K28_M1.3210.94
41_G45_F1.2730.93
43_Y46_P1.2390.92
8_K61_T1.2260.91
5_D55_P1.2260.91
14_D63_H1.2230.91
41_G46_P1.2220.91
15_A24_M1.2090.91
32_I63_H1.1820.89
6_C13_T1.1780.89
10_G33_R1.1740.89
6_C19_C1.1740.89
26_L60_P1.1730.89
26_L31_A1.1420.88
4_Y9_E1.0910.85
13_T25_G1.0780.85
33_R57_I1.0660.84
54_L65_A1.0570.83
41_G44_P1.0340.82
39_W64_A0.9970.80
16_V26_L0.9910.79
54_L61_T0.9900.79
45_F48_K0.9550.77
55_P61_T0.9520.76
9_E35_E0.9380.75
18_I25_G0.9170.74
34_E60_P0.9110.73
7_A41_G0.8970.72
21_V58_L0.8950.72
52_K64_A0.8710.70
37_P44_P0.8580.69
19_C30_H0.8500.68
17_A24_M0.8330.66
11_K66_L0.8160.65
56_R62_C0.8080.64
26_L57_I0.7940.63
31_A60_P0.7910.62
10_G14_D0.7770.61
13_T29_E0.7760.61
12_D17_A0.7690.60
27_C62_C0.7660.60
16_V60_P0.7540.59
40_E44_P0.7530.59
24_M33_R0.7450.58
28_M31_A0.7250.56
7_A53_K0.7160.55
25_G64_A0.7060.54
21_V24_M0.7030.53
12_D29_E0.6900.52
43_Y48_K0.6890.52
49_K57_I0.6840.51
37_P66_L0.6830.51
2_K17_A0.6740.50
19_C22_C0.6730.50
2_K24_M0.6650.49
37_P52_K0.6610.49
27_C59_C0.6560.48
22_C27_C0.6560.48
17_A33_R0.6540.48
25_G37_P0.6480.48
15_A26_L0.6440.47
18_I26_L0.6420.47
35_E56_R0.6180.44
25_G52_K0.6120.44
1_M49_K0.6050.43
22_C59_C0.5990.43
61_T65_A0.5980.42
12_D66_L0.5940.42
51_P55_P0.5750.40
40_E43_Y0.5730.40
7_A16_V0.5720.40
9_E32_I0.5620.39
25_G34_E0.5450.37
25_G28_M0.5430.37
51_P54_L0.5420.37
2_K7_A0.5380.36
10_G64_A0.5350.36
13_T18_I0.5350.36
7_A17_A0.5210.35
44_P47_S0.5170.34
20_I54_L0.5100.34
41_G50_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mpxA 1 0 64 0.805 Contact Map
3zyqA 1 0.8507 60.8 0.809 Contact Map
1dvpA 2 0.8507 55.5 0.815 Contact Map
1vfyA 1 0.8507 46 0.825 Contact Map
1wfkA 1 0.8358 45.9 0.825 Contact Map
1x4uA 1 0.9403 45 0.826 Contact Map
2yw8A 1 0.8209 44.3 0.827 Contact Map
1z2qA 1 0.8507 43.3 0.828 Contact Map
1jocA 2 0.8209 42.5 0.829 Contact Map
1y02A 1 0.6716 39.6 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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