GREMLIN Database
DUF2177 - Predicted membrane protein (DUF2177)
PFAM: PF09945 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (122)
Sequences: 8135 (5990)
Seq/√Len: 542.3
META: 0.932

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_V76_Y3.3311.00
93_L101_L2.7961.00
78_A112_T2.6531.00
31_Q102_K2.6301.00
55_G83_V2.5781.00
72_R76_Y2.4511.00
70_W120_T2.2861.00
41_N44_A2.2501.00
11_V121_A2.0951.00
67_A72_R2.0901.00
56_L115_T2.0821.00
82_L112_T1.9691.00
25_K29_R1.8551.00
99_W104_T1.8071.00
27_F106_V1.7971.00
78_A116_A1.7141.00
13_L17_A1.7121.00
88_Y95_T1.6611.00
92_N95_T1.6371.00
8_T122_G1.6341.00
93_L104_T1.6271.00
8_T57_V1.6191.00
74_L116_A1.6071.00
51_L86_A1.5961.00
44_A93_L1.5911.00
105_V109_A1.5001.00
86_A108_I1.4991.00
26_G30_P1.4661.00
89_D104_T1.4631.00
74_L120_T1.4481.00
90_L108_I1.4271.00
34_D98_D1.4051.00
62_L66_E1.4021.00
41_N93_L1.3821.00
73_A77_G1.3811.00
37_A41_N1.3801.00
31_Q100_P1.3391.00
58_V79_L1.3221.00
59_F79_L1.2881.00
118_V122_G1.2641.00
113_V117_L1.2481.00
34_D96_L1.2461.00
82_L108_I1.2381.00
84_A87_T1.2251.00
59_F80_F1.2181.00
48_F52_Y1.2181.00
7_A122_G1.2081.00
52_Y84_A1.2011.00
64_A73_A1.2001.00
77_G119_A1.1821.00
42_W46_I1.1781.00
48_F90_L1.1691.00
9_L53_I1.1691.00
71_L75_L1.1681.00
27_F103_V1.1521.00
17_A21_G1.1251.00
28_Y89_D1.0921.00
23_V26_G1.0861.00
54_A58_V1.0611.00
109_A113_V1.0501.00
40_P44_A1.0371.00
48_F87_T1.0281.00
55_G80_F1.0181.00
82_L86_A1.0161.00
80_F83_V1.0141.00
102_K106_V0.9901.00
59_F83_V0.9851.00
79_L83_V0.9831.00
11_V118_V0.9801.00
51_L82_L0.9691.00
38_D97_K0.9681.00
2_L6_L0.9621.00
77_G116_A0.9611.00
51_L90_L0.9561.00
57_V62_L0.9441.00
37_A40_P0.9411.00
5_Y54_A0.9311.00
92_N96_L0.9281.00
89_D99_W0.9181.00
88_Y96_L0.9161.00
52_Y115_T0.9131.00
90_L104_T0.9111.00
4_L57_V0.8971.00
15_L117_L0.8931.00
8_T53_I0.8871.00
27_F31_Q0.8781.00
80_F84_A0.8631.00
117_L120_T0.8471.00
68_G123_Y0.8381.00
101_L105_V0.8371.00
28_Y103_V0.8241.00
70_W74_L0.8221.00
22_L25_K0.8191.00
3_K7_A0.8081.00
17_A22_L0.7931.00
31_Q34_D0.7881.00
12_F114_L0.7761.00
9_L13_L0.7711.00
44_A90_L0.7641.00
66_E72_R0.7561.00
60_A77_G0.7491.00
46_I50_L0.7411.00
71_L74_L0.7401.00
22_L26_G0.7391.00
47_L90_L0.7351.00
32_L36_L0.7311.00
56_L119_A0.7311.00
117_L121_A0.7231.00
6_L10_V0.7231.00
20_L89_D0.7221.00
7_A11_V0.7171.00
27_F102_K0.7161.00
14_A18_V0.7071.00
70_W123_Y0.7051.00
32_L96_L0.7001.00
113_V116_A0.6991.00
14_A17_A0.6951.00
45_A49_Y0.6901.00
102_K105_V0.6901.00
54_A79_L0.6881.00
72_R75_L0.6861.00
18_V22_L0.6851.00
53_I57_V0.6851.00
32_L95_T0.6801.00
58_V75_L0.6741.00
68_G72_R0.6731.00
114_L118_V0.6641.00
12_F52_Y0.6581.00
31_Q103_V0.6571.00
52_Y87_T0.6551.00
109_A112_T0.6521.00
18_V21_G0.6511.00
60_A73_A0.6451.00
56_L61_V0.6441.00
5_Y9_L0.6411.00
43_A46_I0.6371.00
48_F94_A0.6331.00
75_L78_A0.6291.00
33_G36_L0.6271.00
86_A90_L0.6261.00
12_F53_I0.6261.00
11_V15_L0.6251.00
110_W114_L0.6171.00
69_S72_R0.6151.00
114_L117_L0.6131.00
4_L7_A0.6031.00
51_L83_V0.5981.00
35_L96_L0.5941.00
4_L8_T0.5850.99
29_R36_L0.5850.99
58_V83_V0.5830.99
35_L98_D0.5800.99
60_A80_F0.5750.99
23_V30_P0.5720.99
8_T61_V0.5720.99
11_V14_A0.5620.99
21_G42_W0.5590.99
112_T116_A0.5590.99
32_L99_W0.5580.99
19_W28_Y0.5580.99
40_P45_A0.5540.99
60_A64_A0.5520.99
104_T108_I0.5500.99
8_T118_V0.5480.99
89_D108_I0.5450.99
44_A94_A0.5440.99
45_A94_A0.5420.99
26_G29_R0.5420.99
32_L35_L0.5410.99
100_P103_V0.5380.99
116_A120_T0.5320.99
25_K30_P0.5300.99
34_D37_A0.5290.99
21_G25_K0.5280.99
108_I112_T0.5280.99
84_A115_T0.5240.99
34_D100_P0.5210.99
13_L46_I0.5180.99
34_D38_D0.5180.99
24_A30_P0.5170.99
80_F115_T0.5100.99
98_D102_K0.5050.99
43_A47_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rddB 1 0.2984 7.3 0.908 Contact Map
3qnqA 2 0.3468 2.3 0.928 Contact Map
2ru8A 1 0.2661 2.2 0.929 Contact Map
2l8sA 1 0.25 0.8 0.945 Contact Map
4he8J 1 0.5 0.8 0.946 Contact Map
4hygA 3 0.8952 0.7 0.948 Contact Map
2m3eA 1 0.2823 0.7 0.949 Contact Map
1ijdA 3 0.2339 0.6 0.949 Contact Map
2m20A 2 0.2016 0.6 0.95 Contact Map
4gx0A 3 0.6855 0.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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