GREMLIN Database
DUF2170 - Uncharacterized protein conserved in bacteria (DUF2170)
PFAM: PF09938 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (136)
Sequences: 850 (527)
Seq/√Len: 45.2
META: 0.771

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_S114_D3.7831.00
73_F77_L3.5901.00
71_A74_N2.9401.00
36_I48_L2.7681.00
65_D97_G2.5001.00
64_V91_I2.4581.00
64_V70_R2.4451.00
23_S39_H2.2241.00
88_S105_A2.1971.00
54_Q105_A2.1881.00
29_G32_P2.0530.99
11_L119_I2.0330.99
106_L110_S2.0100.99
75_E79_R1.9370.99
8_A12_A1.8890.99
71_A75_E1.8650.99
67_V120_E1.8620.99
84_F102_M1.8230.99
70_R74_N1.7930.98
40_E44_L1.7630.98
50_V55_I1.7450.98
63_P66_E1.7330.98
3_T10_A1.7030.98
90_G103_F1.6980.98
59_T126_A1.6750.98
53_E115_I1.6670.98
122_L125_N1.6390.97
114_D117_H1.5440.96
80_T88_S1.5220.96
46_I59_T1.5000.95
14_S116_V1.4930.95
4_T8_A1.4610.95
42_G73_F1.4530.94
48_L69_D1.4310.94
77_L133_Y1.4210.94
89_F129_A1.4160.94
54_Q85_P1.3780.93
103_F119_I1.3420.92
41_Y123_A1.3390.92
77_L89_F1.3190.91
81_H88_S1.3100.91
70_R75_E1.3080.91
110_S122_L1.2700.89
5_E9_E1.2650.89
106_L122_L1.2510.89
81_H103_F1.2510.89
64_V79_R1.2480.89
107_S117_H1.2450.88
21_F24_V1.2140.87
28_E32_P1.2030.87
54_Q103_F1.1990.86
80_T133_Y1.1960.86
52_G108_A1.1510.84
127_I130_L1.1430.84
56_L105_A1.1370.83
74_N100_Y1.1060.82
42_G130_L1.0930.81
120_E133_Y1.0850.80
46_I119_I1.0820.80
49_T101_V1.0710.79
44_L126_A1.0630.79
2_W7_L1.0590.79
60_Y101_V1.0430.78
81_H105_A1.0420.78
48_L57_V1.0300.77
115_I136_F1.0230.76
55_I108_A1.0200.76
8_A34_L1.0190.76
34_L132_A1.0180.76
64_V74_N1.0140.76
109_S117_H1.0050.75
60_Y99_Y0.9920.74
21_F25_E0.9850.73
118_E121_T0.9780.73
15_E23_S0.9730.72
109_S114_D0.9530.71
16_L19_G0.9490.71
87_S125_N0.9400.70
36_I97_G0.9300.69
3_T9_E0.9250.69
38_M73_F0.9190.68
77_L80_T0.9190.68
43_D73_F0.9180.68
54_Q81_H0.9130.68
60_Y90_G0.9100.67
15_E18_G0.9060.67
89_F92_E0.9000.66
83_L105_A0.8950.66
62_W74_N0.8910.66
81_H89_F0.8850.65
22_A25_E0.8760.64
4_T34_L0.8760.64
19_G24_V0.8690.64
48_L124_D0.8660.63
41_Y127_I0.8610.63
43_D123_A0.8600.63
73_F82_K0.8570.63
107_S118_E0.8550.62
123_A130_L0.8500.62
51_S115_I0.8500.62
49_T92_E0.8440.61
92_E101_V0.8370.61
102_M126_A0.8330.60
86_L104_G0.8320.60
14_S20_G0.8150.59
113_E116_V0.8090.58
28_E116_V0.8030.58
84_F129_A0.8010.57
44_L131_E0.7960.57
6_S9_E0.7870.56
21_F26_L0.7820.56
47_F50_V0.7810.55
5_E15_E0.7670.54
31_E34_L0.7650.54
49_T52_G0.7550.53
45_P66_E0.7540.53
81_H129_A0.7460.52
35_Q92_E0.7390.51
65_D134_E0.7360.51
12_A15_E0.7360.51
56_L88_S0.7360.51
46_I87_S0.7300.51
53_E68_K0.7200.50
82_K101_V0.7130.49
64_V95_D0.7030.48
56_L103_F0.7000.48
57_V106_L0.7000.48
26_L115_I0.7000.48
14_S17_V0.7000.48
58_E81_H0.6990.48
24_V32_P0.6990.48
52_G114_D0.6910.47
38_M123_A0.6890.47
121_T124_D0.6830.46
82_K90_G0.6810.46
35_Q47_F0.6810.46
6_S10_A0.6750.45
2_W10_A0.6740.45
57_V122_L0.6700.45
78_L88_S0.6680.45
52_G99_Y0.6570.43
58_E77_L0.6550.43
4_T49_T0.6480.43
65_D115_I0.6470.43
5_E51_S0.6390.42
103_F110_S0.6390.42
67_V90_G0.6200.40
20_G24_V0.6170.40
68_K115_I0.6170.40
6_S15_E0.6170.40
58_E88_S0.6160.40
30_E69_D0.6100.39
57_V133_Y0.6100.39
93_T98_D0.6090.39
118_E122_L0.6060.39
33_V89_F0.6010.38
90_G110_S0.5970.38
67_V105_A0.5950.38
73_F130_L0.5940.38
18_G22_A0.5880.37
76_A136_F0.5880.37
38_M42_G0.5870.37
10_A113_E0.5840.37
72_A95_D0.5820.36
57_V60_Y0.5820.36
32_P113_E0.5780.36
93_T134_E0.5760.36
59_T99_Y0.5730.36
49_T89_F0.5700.35
83_L95_D0.5690.35
124_D128_D0.5680.35
9_E13_E0.5670.35
3_T12_A0.5670.35
76_A121_T0.5600.35
79_R114_D0.5600.35
56_L84_F0.5580.34
54_Q87_S0.5500.34
27_I66_E0.5480.33
91_I97_G0.5480.33
117_H133_Y0.5470.33
93_T108_A0.5470.33
26_L90_G0.5430.33
84_F105_A0.5420.33
22_A36_I0.5420.33
58_E84_F0.5410.33
34_L108_A0.5410.33
73_F102_M0.5390.33
3_T66_E0.5330.32
38_M119_I0.5320.32
38_M62_W0.5310.32
127_I134_E0.5270.32
79_R91_I0.5240.31
102_M129_A0.5220.31
32_P37_T0.5220.31
29_G50_V0.5180.31
13_E18_G0.5160.31
19_G55_I0.5140.31
7_L74_N0.5130.30
34_L121_T0.5080.30
24_V110_S0.5060.30
23_S113_E0.5030.30
23_S37_T0.5020.30
99_Y115_I0.5000.29
64_V98_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2plgA 4 0.8978 50.1 0.918 Contact Map
1jyoA 2 0.9124 39.3 0.923 Contact Map
3epuA 3 0.8686 14.3 0.938 Contact Map
2xgaA 2 0.8175 12.7 0.939 Contact Map
2bp1A 2 0.2774 12.1 0.94 Contact Map
1ry9A 2 0.8467 11.8 0.94 Contact Map
1xkpC 1 0.8467 10.3 0.942 Contact Map
3cx5A 1 0.6569 9.6 0.943 Contact Map
1hr6B 1 0.7518 9.6 0.943 Contact Map
4mt1A 3 0.8759 8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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