GREMLIN Database
DUF2167 - Protein of unknown function (DUF2167)
PFAM: PF09935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 238 (233)
Sequences: 3229 (2632)
Seq/√Len: 172.5
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E100_K3.5561.00
6_T17_K3.4801.00
129_E139_N3.2071.00
99_K105_P2.8771.00
225_K229_K2.6271.00
151_K185_K2.5121.00
93_E96_E2.5101.00
26_D29_D2.4121.00
131_K139_N2.3821.00
113_E169_K2.3711.00
182_N185_K2.3571.00
85_K89_E2.3361.00
190_F197_V2.2771.00
97_E101_R2.2751.00
92_E107_E2.2051.00
191_N194_G2.1371.00
15_T182_N2.0641.00
225_K228_W2.0571.00
79_D82_E2.0171.00
228_W232_V2.0151.00
183_E186_R2.0001.00
76_D119_A1.9901.00
18_L49_I1.9741.00
214_L217_F1.9621.00
8_K182_N1.9561.00
69_Y151_K1.9271.00
6_T15_T1.8741.00
105_P133_G1.8541.00
106_L132_F1.8451.00
91_T108_L1.8321.00
107_E131_K1.8121.00
81_D114_P1.7831.00
96_E99_K1.7731.00
144_N155_S1.7701.00
219_K223_F1.7691.00
61_V159_V1.7281.00
144_N157_N1.7211.00
227_F231_I1.7101.00
30_A48_M1.6931.00
222_A226_K1.6791.00
109_V131_K1.6751.00
230_L234_G1.6481.00
21_G52_A1.6361.00
229_K236_A1.6331.00
219_K222_A1.6321.00
60_V156_L1.6251.00
33_L37_W1.6211.00
221_L225_K1.5961.00
25_L29_D1.5941.00
221_L224_L1.5621.00
85_K88_K1.5411.00
186_R189_D1.5161.00
184_G189_D1.5091.00
38_G103_Y1.5081.00
67_D153_V1.5011.00
59_F159_V1.4901.00
106_L130_L1.4851.00
138_E163_D1.4681.00
67_D200_Y1.4641.00
26_D30_A1.4351.00
13_Q185_K1.4281.00
226_K230_L1.4231.00
227_F230_L1.4181.00
65_D153_V1.4061.00
230_L233_V1.4051.00
216_L219_K1.3811.00
113_E116_H1.3811.00
66_D151_K1.3721.00
232_V236_A1.3571.00
231_I234_G1.3471.00
160_A168_V1.3441.00
217_F221_L1.3331.00
71_K197_V1.3271.00
113_E125_Y1.3091.00
82_E86_S1.3091.00
32_R35_E1.3051.00
220_L223_F1.3011.00
82_E85_K1.2981.00
224_L228_W1.2961.00
87_M128_K1.2961.00
232_V235_V1.2861.00
130_L140_T1.2611.00
88_K92_E1.2441.00
109_V139_N1.2411.00
209_A212_A1.2211.00
183_E189_D1.2151.00
199_A203_A1.2091.00
149_G181_F1.2001.00
96_E100_K1.1781.00
210_V214_L1.1751.00
64_Y69_Y1.1741.00
112_A127_A1.1741.00
217_F220_L1.1691.00
104_P133_G1.1641.00
160_A164_Q1.1551.00
223_F227_F1.1511.00
226_K229_K1.1461.00
60_V172_A1.1411.00
87_M130_L1.1241.00
87_M108_L1.1161.00
229_K233_V1.1151.00
3_G26_D1.1151.00
72_D117_Y1.1111.00
95_N105_P1.1111.00
109_V129_E1.1081.00
211_A216_L1.1011.00
180_E186_R1.0971.00
65_D155_S1.0951.00
25_L33_L1.0941.00
196_K200_Y1.0891.00
33_L48_M1.0861.00
86_S89_E1.0861.00
112_A129_E1.0841.00
99_K133_G1.0831.00
203_A207_A1.0821.00
171_A174_Q1.0621.00
69_Y197_V1.0611.00
27_A31_R1.0551.00
190_F193_S1.0450.99
24_F27_A1.0450.99
124_L202_L1.0290.99
161_D164_Q1.0180.99
37_W59_F1.0150.99
8_K15_T1.0140.99
91_T107_E1.0120.99
224_L227_F1.0110.99
10_G13_Q1.0070.99
74_D203_A1.0060.99
24_F47_G1.0060.99
24_F45_E1.0020.99
164_Q168_V1.0000.99
196_K199_A0.9990.99
20_E52_A0.9950.99
204_A208_G0.9900.99
220_L224_L0.9740.99
67_D70_V0.9730.99
166_A169_K0.9640.99
7_I18_L0.9560.99
222_A228_W0.9540.99
231_I235_V0.9530.99
30_A45_E0.9530.99
94_A97_E0.9520.99
233_V236_A0.9520.99
214_L218_A0.9500.99
28_A31_R0.9450.99
64_Y185_K0.9420.99
70_V153_V0.9310.99
78_I83_L0.9310.99
154_L179_V0.9280.99
214_L219_K0.9230.99
108_L130_L0.9200.99
209_A214_L0.9170.99
27_A45_E0.9130.99
42_D45_E0.9080.99
23_R52_A0.9070.99
17_K180_E0.9020.98
211_A214_L0.8990.98
112_A165_L0.8900.98
116_H125_Y0.8880.98
30_A50_F0.8720.98
167_A171_A0.8690.98
127_A165_L0.8600.98
32_R36_L0.8580.98
66_D196_K0.8580.98
90_G93_E0.8560.98
28_A32_R0.8560.98
119_A122_H0.8560.98
218_A226_K0.8470.98
31_R45_E0.8460.98
222_A229_K0.8430.98
125_Y173_K0.8390.98
222_A225_K0.8360.97
122_H188_A0.8360.97
48_M59_F0.8150.97
168_V171_A0.8110.97
86_S90_G0.8050.97
203_A209_A0.8030.97
19_P22_F0.8030.97
84_L108_L0.8020.97
218_A223_F0.8010.97
218_A221_L0.8010.97
95_N99_K0.8000.97
132_F140_T0.7930.97
112_A166_A0.7800.96
108_L128_K0.7800.96
24_F62_F0.7770.96
45_E61_V0.7740.96
154_L181_F0.7710.96
117_Y122_H0.7690.96
112_A141_L0.7680.96
31_R43_G0.7680.96
223_F226_K0.7650.96
204_A211_A0.7600.96
89_E92_E0.7540.95
219_K228_W0.7540.95
77_K85_K0.7520.95
201_G204_A0.7510.95
228_W231_I0.7480.95
46_L154_L0.7480.95
58_W171_A0.7420.95
23_R50_F0.7380.95
217_F222_A0.7380.95
91_T106_L0.7380.95
13_Q151_K0.7370.95
53_D56_P0.7360.95
212_A219_K0.7350.95
125_Y172_A0.7290.94
147_V156_L0.7290.94
34_L45_E0.7280.94
71_K199_A0.7280.94
64_Y151_K0.7270.94
89_E93_E0.7260.94
31_R42_D0.7230.94
95_N98_R0.7170.94
31_R35_E0.7160.94
8_K12_G0.7160.94
212_A217_F0.7120.94
203_A206_V0.7080.94
62_F156_L0.7070.94
30_A61_V0.7010.93
145_T172_A0.7010.93
62_F154_L0.6970.93
50_F54_E0.6950.93
60_V158_L0.6930.93
13_Q182_N0.6920.93
22_F171_A0.6910.93
81_D85_K0.6880.93
219_K224_L0.6790.92
5_G18_L0.6770.92
214_L222_A0.6760.92
118_D125_Y0.6710.92
92_E96_E0.6710.92
14_A154_L0.6700.92
183_E188_A0.6630.91
12_G185_K0.6610.91
10_G46_L0.6580.91
106_L140_T0.6530.91
129_E162_P0.6520.90
104_P134_D0.6500.90
33_L57_S0.6490.90
34_L61_V0.6490.90
33_L50_F0.6470.90
224_L230_L0.6460.90
226_K233_V0.6430.90
7_I16_L0.6380.90
199_A209_A0.6380.90
228_W236_A0.6370.89
164_Q167_A0.6360.89
172_A175_L0.6330.89
143_Y165_L0.6320.89
150_R195_D0.6320.89
193_S196_K0.6310.89
18_L22_F0.6300.89
64_Y152_G0.6290.89
9_L47_G0.6280.89
146_R155_S0.6270.89
33_L36_L0.6260.89
91_T94_A0.6250.89
91_T130_L0.6230.88
83_L124_L0.6230.88
78_I124_L0.6080.87
87_M91_T0.6070.87
201_G206_V0.6060.87
118_D121_T0.6050.87
138_E161_D0.6020.87
229_K234_G0.6000.86
95_N107_E0.5980.86
22_F51_P0.5970.86
49_I175_L0.5970.86
54_E57_S0.5950.86
19_P178_G0.5930.86
134_D138_E0.5930.86
29_D32_R0.5910.86
223_F228_W0.5860.85
41_P45_E0.5840.85
9_L16_L0.5790.85
22_F178_G0.5780.84
225_K236_A0.5760.84
3_G7_I0.5730.84
83_L203_A0.5730.84
229_K232_V0.5700.84
228_W235_V0.5670.83
173_K177_A0.5670.83
148_L205_L0.5670.83
92_E95_N0.5640.83
227_F234_G0.5630.83
209_A213_K0.5580.82
216_L221_L0.5580.82
40_P103_Y0.5570.82
51_P143_Y0.5560.82
123_K147_V0.5560.82
27_A44_G0.5550.82
57_S164_Q0.5530.82
140_T162_P0.5520.82
169_K173_K0.5500.81
17_K178_G0.5480.81
77_K203_A0.5470.81
37_W48_M0.5470.81
216_L220_L0.5460.81
81_D110_G0.5440.81
221_L226_K0.5440.81
124_L206_V0.5430.81
146_R158_L0.5400.80
63_E157_N0.5400.80
222_A230_L0.5380.80
45_E63_E0.5370.80
104_P135_S0.5370.80
107_E133_G0.5360.80
197_V207_A0.5360.80
208_G211_A0.5360.80
188_A191_N0.5350.80
174_Q178_G0.5350.80
75_A117_Y0.5330.79
227_F233_V0.5330.79
132_F137_G0.5330.79
174_Q177_A0.5290.79
223_F235_V0.5290.79
34_L157_N0.5270.79
63_E130_L0.5270.79
84_L88_K0.5270.79
72_D122_H0.5260.78
160_A165_L0.5250.78
54_E167_A0.5230.78
167_A170_P0.5220.78
121_T177_A0.5220.78
13_Q189_D0.5210.78
198_A201_G0.5190.78
193_S197_V0.5170.77
7_I24_F0.5160.77
30_A157_N0.5160.77
116_H173_K0.5150.77
170_P173_K0.5150.77
180_E183_E0.5150.77
23_R158_L0.5150.77
212_A218_A0.5140.77
177_A180_E0.5110.76
48_M61_V0.5110.76
209_A218_A0.5100.76
123_K145_T0.5090.76
202_L207_A0.5080.76
34_L39_N0.5060.76
50_F56_P0.5050.76
44_G63_E0.5050.76
158_L175_L0.5050.76
218_A227_F0.5050.76
63_E155_S0.5020.75
216_L222_A0.5010.75
77_K196_K0.5010.75
194_G197_V0.5000.75
126_W146_R0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tu1A 2 0.5882 26.7 0.949 Contact Map
4u7tA 2 0.2521 11.6 0.956 Contact Map
2qrvA 2 0.2521 9.3 0.958 Contact Map
4nv4A 2 0.2185 5.2 0.963 Contact Map
3u4gA 2 0.3824 3.7 0.965 Contact Map
4me8A 1 0.2101 3.1 0.967 Contact Map
3lydA 2 0.6176 3 0.967 Contact Map
2opkA 2 0.2227 2.9 0.967 Contact Map
3l0zA 2 0.3445 2.9 0.967 Contact Map
2f4pA 2 0.3025 2.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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