DUF2167 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF2167 - Protein of unknown function (DUF2167)

PFAM:	PF09935	Sequences: QYGPGTIKLGGGQATLKLPEGFRFLDAADARRLLELWGNPPDGGELGMIFPADESPSWFVVFEYDDDGYVKDDDADKIDADELLKSMKEGTEEANEERKKRGYPPLELVGWAEPPHYDAATHKLYWAKELKFGDSDGENTLNYNTRVLGRKGVLSLNLVADPDQLAAVKPAAKQLLAGVEFNEGKRYADFNPSGDKVAAYGLAALVAGAVAAKLGLFAKLLAFLKKFWKLIVVGVAAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	238 (233)
Sequences:	3229 (2632)
Seq/√Len:	172.5
META:	0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_E	100_K	3.556	1.00
6_T	17_K	3.480	1.00
129_E	139_N	3.207	1.00
99_K	105_P	2.877	1.00
225_K	229_K	2.627	1.00
151_K	185_K	2.512	1.00
93_E	96_E	2.510	1.00
26_D	29_D	2.412	1.00
131_K	139_N	2.382	1.00
113_E	169_K	2.371	1.00
182_N	185_K	2.357	1.00
85_K	89_E	2.336	1.00
190_F	197_V	2.277	1.00
97_E	101_R	2.275	1.00
92_E	107_E	2.205	1.00
191_N	194_G	2.137	1.00
15_T	182_N	2.064	1.00
225_K	228_W	2.057	1.00
79_D	82_E	2.017	1.00
228_W	232_V	2.015	1.00
183_E	186_R	2.000	1.00
76_D	119_A	1.990	1.00
18_L	49_I	1.974	1.00
214_L	217_F	1.962	1.00
8_K	182_N	1.956	1.00
69_Y	151_K	1.927	1.00
6_T	15_T	1.874	1.00
105_P	133_G	1.854	1.00
106_L	132_F	1.845	1.00
91_T	108_L	1.832	1.00
107_E	131_K	1.812	1.00
81_D	114_P	1.783	1.00
96_E	99_K	1.773	1.00
144_N	155_S	1.770	1.00
219_K	223_F	1.769	1.00
61_V	159_V	1.728	1.00
144_N	157_N	1.721	1.00
227_F	231_I	1.710	1.00
30_A	48_M	1.693	1.00
222_A	226_K	1.679	1.00
109_V	131_K	1.675	1.00
230_L	234_G	1.648	1.00
21_G	52_A	1.636	1.00
229_K	236_A	1.633	1.00
219_K	222_A	1.632	1.00
60_V	156_L	1.625	1.00
33_L	37_W	1.621	1.00
221_L	225_K	1.596	1.00
25_L	29_D	1.594	1.00
221_L	224_L	1.562	1.00
85_K	88_K	1.541	1.00
186_R	189_D	1.516	1.00
184_G	189_D	1.509	1.00
38_G	103_Y	1.508	1.00
67_D	153_V	1.501	1.00
59_F	159_V	1.490	1.00
106_L	130_L	1.485	1.00
138_E	163_D	1.468	1.00
67_D	200_Y	1.464	1.00
26_D	30_A	1.435	1.00
13_Q	185_K	1.428	1.00
226_K	230_L	1.423	1.00
227_F	230_L	1.418	1.00
65_D	153_V	1.406	1.00
230_L	233_V	1.405	1.00
216_L	219_K	1.381	1.00
113_E	116_H	1.381	1.00
66_D	151_K	1.372	1.00
232_V	236_A	1.357	1.00
231_I	234_G	1.347	1.00
160_A	168_V	1.344	1.00
217_F	221_L	1.333	1.00
71_K	197_V	1.327	1.00
113_E	125_Y	1.309	1.00
82_E	86_S	1.309	1.00
32_R	35_E	1.305	1.00
220_L	223_F	1.301	1.00
82_E	85_K	1.298	1.00
224_L	228_W	1.296	1.00
87_M	128_K	1.296	1.00
232_V	235_V	1.286	1.00
130_L	140_T	1.261	1.00
88_K	92_E	1.244	1.00
109_V	139_N	1.241	1.00
209_A	212_A	1.221	1.00
183_E	189_D	1.215	1.00
199_A	203_A	1.209	1.00
149_G	181_F	1.200	1.00
96_E	100_K	1.178	1.00
210_V	214_L	1.175	1.00
64_Y	69_Y	1.174	1.00
112_A	127_A	1.174	1.00
217_F	220_L	1.169	1.00
104_P	133_G	1.164	1.00
160_A	164_Q	1.155	1.00
223_F	227_F	1.151	1.00
226_K	229_K	1.146	1.00
60_V	172_A	1.141	1.00
87_M	130_L	1.124	1.00
87_M	108_L	1.116	1.00
229_K	233_V	1.115	1.00
3_G	26_D	1.115	1.00
72_D	117_Y	1.111	1.00
95_N	105_P	1.111	1.00
109_V	129_E	1.108	1.00
211_A	216_L	1.101	1.00
180_E	186_R	1.097	1.00
65_D	155_S	1.095	1.00
25_L	33_L	1.094	1.00
196_K	200_Y	1.089	1.00
33_L	48_M	1.086	1.00
86_S	89_E	1.086	1.00
112_A	129_E	1.084	1.00
99_K	133_G	1.083	1.00
203_A	207_A	1.082	1.00
171_A	174_Q	1.062	1.00
69_Y	197_V	1.061	1.00
27_A	31_R	1.055	1.00
190_F	193_S	1.045	0.99
24_F	27_A	1.045	0.99
124_L	202_L	1.029	0.99
161_D	164_Q	1.018	0.99
37_W	59_F	1.015	0.99
8_K	15_T	1.014	0.99
91_T	107_E	1.012	0.99
224_L	227_F	1.011	0.99
10_G	13_Q	1.007	0.99
74_D	203_A	1.006	0.99
24_F	47_G	1.006	0.99
24_F	45_E	1.002	0.99
164_Q	168_V	1.000	0.99
196_K	199_A	0.999	0.99
20_E	52_A	0.995	0.99
204_A	208_G	0.990	0.99
220_L	224_L	0.974	0.99
67_D	70_V	0.973	0.99
166_A	169_K	0.964	0.99
7_I	18_L	0.956	0.99
222_A	228_W	0.954	0.99
231_I	235_V	0.953	0.99
30_A	45_E	0.953	0.99
94_A	97_E	0.952	0.99
233_V	236_A	0.952	0.99
214_L	218_A	0.950	0.99
28_A	31_R	0.945	0.99
64_Y	185_K	0.942	0.99
70_V	153_V	0.931	0.99
78_I	83_L	0.931	0.99
154_L	179_V	0.928	0.99
214_L	219_K	0.923	0.99
108_L	130_L	0.920	0.99
209_A	214_L	0.917	0.99
27_A	45_E	0.913	0.99
42_D	45_E	0.908	0.99
23_R	52_A	0.907	0.99
17_K	180_E	0.902	0.98
211_A	214_L	0.899	0.98
112_A	165_L	0.890	0.98
116_H	125_Y	0.888	0.98
30_A	50_F	0.872	0.98
167_A	171_A	0.869	0.98
127_A	165_L	0.860	0.98
32_R	36_L	0.858	0.98
66_D	196_K	0.858	0.98
90_G	93_E	0.856	0.98
28_A	32_R	0.856	0.98
119_A	122_H	0.856	0.98
218_A	226_K	0.847	0.98
31_R	45_E	0.846	0.98
222_A	229_K	0.843	0.98
125_Y	173_K	0.839	0.98
222_A	225_K	0.836	0.97
122_H	188_A	0.836	0.97
48_M	59_F	0.815	0.97
168_V	171_A	0.811	0.97
86_S	90_G	0.805	0.97
203_A	209_A	0.803	0.97
19_P	22_F	0.803	0.97
84_L	108_L	0.802	0.97
218_A	223_F	0.801	0.97
218_A	221_L	0.801	0.97
95_N	99_K	0.800	0.97
132_F	140_T	0.793	0.97
112_A	166_A	0.780	0.96
108_L	128_K	0.780	0.96
24_F	62_F	0.777	0.96
45_E	61_V	0.774	0.96
154_L	181_F	0.771	0.96
117_Y	122_H	0.769	0.96
112_A	141_L	0.768	0.96
31_R	43_G	0.768	0.96
223_F	226_K	0.765	0.96
204_A	211_A	0.760	0.96
89_E	92_E	0.754	0.95
219_K	228_W	0.754	0.95
77_K	85_K	0.752	0.95
201_G	204_A	0.751	0.95
228_W	231_I	0.748	0.95
46_L	154_L	0.748	0.95
58_W	171_A	0.742	0.95
23_R	50_F	0.738	0.95
217_F	222_A	0.738	0.95
91_T	106_L	0.738	0.95
13_Q	151_K	0.737	0.95
53_D	56_P	0.736	0.95
212_A	219_K	0.735	0.95
125_Y	172_A	0.729	0.94
147_V	156_L	0.729	0.94
34_L	45_E	0.728	0.94
71_K	199_A	0.728	0.94
64_Y	151_K	0.727	0.94
89_E	93_E	0.726	0.94
31_R	42_D	0.723	0.94
95_N	98_R	0.717	0.94
31_R	35_E	0.716	0.94
8_K	12_G	0.716	0.94
212_A	217_F	0.712	0.94
203_A	206_V	0.708	0.94
62_F	156_L	0.707	0.94
30_A	61_V	0.701	0.93
145_T	172_A	0.701	0.93
62_F	154_L	0.697	0.93
50_F	54_E	0.695	0.93
60_V	158_L	0.693	0.93
13_Q	182_N	0.692	0.93
22_F	171_A	0.691	0.93
81_D	85_K	0.688	0.93
219_K	224_L	0.679	0.92
5_G	18_L	0.677	0.92
214_L	222_A	0.676	0.92
118_D	125_Y	0.671	0.92
92_E	96_E	0.671	0.92
14_A	154_L	0.670	0.92
183_E	188_A	0.663	0.91
12_G	185_K	0.661	0.91
10_G	46_L	0.658	0.91
106_L	140_T	0.653	0.91
129_E	162_P	0.652	0.90
104_P	134_D	0.650	0.90
33_L	57_S	0.649	0.90
34_L	61_V	0.649	0.90
33_L	50_F	0.647	0.90
224_L	230_L	0.646	0.90
226_K	233_V	0.643	0.90
7_I	16_L	0.638	0.90
199_A	209_A	0.638	0.90
228_W	236_A	0.637	0.89
164_Q	167_A	0.636	0.89
172_A	175_L	0.633	0.89
143_Y	165_L	0.632	0.89
150_R	195_D	0.632	0.89
193_S	196_K	0.631	0.89
18_L	22_F	0.630	0.89
64_Y	152_G	0.629	0.89
9_L	47_G	0.628	0.89
146_R	155_S	0.627	0.89
33_L	36_L	0.626	0.89
91_T	94_A	0.625	0.89
91_T	130_L	0.623	0.88
83_L	124_L	0.623	0.88
78_I	124_L	0.608	0.87
87_M	91_T	0.607	0.87
201_G	206_V	0.606	0.87
118_D	121_T	0.605	0.87
138_E	161_D	0.602	0.87
229_K	234_G	0.600	0.86
95_N	107_E	0.598	0.86
22_F	51_P	0.597	0.86
49_I	175_L	0.597	0.86
54_E	57_S	0.595	0.86
19_P	178_G	0.593	0.86
134_D	138_E	0.593	0.86
29_D	32_R	0.591	0.86
223_F	228_W	0.586	0.85
41_P	45_E	0.584	0.85
9_L	16_L	0.579	0.85
22_F	178_G	0.578	0.84
225_K	236_A	0.576	0.84
3_G	7_I	0.573	0.84
83_L	203_A	0.573	0.84
229_K	232_V	0.570	0.84
228_W	235_V	0.567	0.83
173_K	177_A	0.567	0.83
148_L	205_L	0.567	0.83
92_E	95_N	0.564	0.83
227_F	234_G	0.563	0.83
209_A	213_K	0.558	0.82
216_L	221_L	0.558	0.82
40_P	103_Y	0.557	0.82
51_P	143_Y	0.556	0.82
123_K	147_V	0.556	0.82
27_A	44_G	0.555	0.82
57_S	164_Q	0.553	0.82
140_T	162_P	0.552	0.82
169_K	173_K	0.550	0.81
17_K	178_G	0.548	0.81
77_K	203_A	0.547	0.81
37_W	48_M	0.547	0.81
216_L	220_L	0.546	0.81
81_D	110_G	0.544	0.81
221_L	226_K	0.544	0.81
124_L	206_V	0.543	0.81
146_R	158_L	0.540	0.80
63_E	157_N	0.540	0.80
222_A	230_L	0.538	0.80
45_E	63_E	0.537	0.80
104_P	135_S	0.537	0.80
107_E	133_G	0.536	0.80
197_V	207_A	0.536	0.80
208_G	211_A	0.536	0.80
188_A	191_N	0.535	0.80
174_Q	178_G	0.535	0.80
75_A	117_Y	0.533	0.79
227_F	233_V	0.533	0.79
132_F	137_G	0.533	0.79
174_Q	177_A	0.529	0.79
223_F	235_V	0.529	0.79
34_L	157_N	0.527	0.79
63_E	130_L	0.527	0.79
84_L	88_K	0.527	0.79
72_D	122_H	0.526	0.78
160_A	165_L	0.525	0.78
54_E	167_A	0.523	0.78
167_A	170_P	0.522	0.78
121_T	177_A	0.522	0.78
13_Q	189_D	0.521	0.78
198_A	201_G	0.519	0.78
193_S	197_V	0.517	0.77
7_I	24_F	0.516	0.77
30_A	157_N	0.516	0.77
116_H	173_K	0.515	0.77
170_P	173_K	0.515	0.77
180_E	183_E	0.515	0.77
23_R	158_L	0.515	0.77
212_A	218_A	0.514	0.77
177_A	180_E	0.511	0.76
48_M	61_V	0.511	0.76
209_A	218_A	0.510	0.76
123_K	145_T	0.509	0.76
202_L	207_A	0.508	0.76
34_L	39_N	0.506	0.76
50_F	56_P	0.505	0.76
44_G	63_E	0.505	0.76
158_L	175_L	0.505	0.76
218_A	227_F	0.505	0.76
63_E	155_S	0.502	0.75
216_L	222_A	0.501	0.75
77_K	196_K	0.501	0.75
194_G	197_V	0.500	0.75
126_W	146_R	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1tu1A	2	0.5882	26.7	0.949	Contact Map
4u7tA	2	0.2521	11.6	0.956	Contact Map
2qrvA	2	0.2521	9.3	0.958	Contact Map
4nv4A	2	0.2185	5.2	0.963	Contact Map
3u4gA	2	0.3824	3.7	0.965	Contact Map
4me8A	1	0.2101	3.1	0.967	Contact Map
3lydA	2	0.6176	3	0.967	Contact Map
2opkA	2	0.2227	2.9	0.967	Contact Map
3l0zA	2	0.3445	2.9	0.967	Contact Map
2f4pA	2	0.3025	2.8	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.