GREMLIN Database
DUF2163 - Uncharacterized conserved protein (DUF2163)
PFAM: PF09931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 163 (158)
Sequences: 5884 (4677)
Seq/√Len: 372.1
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D51_A4.6241.00
34_G47_V3.2961.00
9_Q13_A2.8751.00
43_T48_T2.5651.00
145_R152_R2.4071.00
72_E129_T2.3971.00
156_G162_V2.3921.00
153_A157_D2.2531.00
122_T129_T2.1891.00
41_D48_T2.1691.00
96_R115_R2.1521.00
11_H103_N2.1111.00
6_A10_A2.0351.00
26_T98_E2.0231.00
44_F110_R2.0031.00
153_A159_R1.9911.00
24_R47_V1.9861.00
103_N109_Q1.9281.00
22_C100_F1.9161.00
118_I130_A1.9041.00
117_R138_A1.8821.00
58_S71_L1.8811.00
24_R98_E1.8801.00
98_E112_L1.8721.00
100_F110_R1.8441.00
24_R49_Y1.8411.00
24_R100_F1.8261.00
33_L92_Y1.8261.00
41_D50_R1.7931.00
106_D109_Q1.7771.00
24_R34_G1.6911.00
86_D91_R1.6901.00
75_G128_F1.6321.00
21_R101_R1.6241.00
44_F49_Y1.5721.00
21_R37_D1.5311.00
26_T32_V1.5281.00
27_R31_V1.5211.00
152_R159_R1.4891.00
38_H104_W1.4631.00
124_G129_T1.4531.00
58_S72_E1.4521.00
119_G133_R1.4511.00
50_R79_S1.4471.00
98_E115_R1.4471.00
74_T129_T1.4311.00
24_R32_V1.4291.00
11_H14_S1.4251.00
6_A9_Q1.4201.00
21_R57_A1.3671.00
158_A161_G1.3361.00
145_R159_R1.3271.00
117_R137_A1.3141.00
100_F112_L1.3021.00
5_S8_L1.2801.00
97_V132_L1.2641.00
157_D161_G1.2481.00
155_L162_V1.2391.00
148_Q152_R1.2291.00
56_T74_T1.2081.00
45_D110_R1.2031.00
116_G132_L1.1801.00
22_C102_V1.1711.00
20_A37_D1.1641.00
96_R117_R1.1491.00
11_H109_Q1.1441.00
63_S67_S1.1251.00
124_G127_A1.1211.00
74_T127_A1.1161.00
50_R81_A1.1081.00
103_N106_D1.0801.00
32_V47_V1.0611.00
25_I97_V1.0431.00
87_L121_V1.0391.00
78_S81_A1.0241.00
133_R137_A1.0151.00
137_A140_N1.0091.00
121_V130_A1.0011.00
63_S69_D0.9981.00
101_R111_V0.9581.00
14_S17_T0.9521.00
49_Y100_F0.9501.00
70_N131_E0.9491.00
38_H42_L0.9421.00
88_A123_R0.9421.00
21_R113_L0.9401.00
69_D134_G0.9341.00
26_T96_R0.9281.00
18_T105_A0.9281.00
23_W57_A0.9171.00
18_T103_N0.9151.00
144_G152_R0.9101.00
84_E88_A0.9041.00
8_L11_H0.8921.00
79_S82_I0.8911.00
70_N133_R0.8901.00
102_V110_R0.8821.00
94_G117_R0.8811.00
101_R113_L0.8811.00
120_E131_E0.8811.00
7_A109_Q0.8751.00
90_G93_D0.8711.00
62_Q114_F0.8661.00
75_G130_A0.8661.00
11_H17_T0.8641.00
20_A38_H0.8531.00
22_C49_Y0.8521.00
92_Y95_A0.8481.00
71_L99_I0.8291.00
22_C44_F0.8281.00
68_V137_A0.8241.00
94_G138_A0.8231.00
20_A42_L0.8211.00
151_C160_C0.8201.00
72_E131_E0.8171.00
12_L111_V0.8121.00
159_R162_V0.8091.00
44_F102_V0.8061.00
34_G50_R0.8021.00
22_C42_L0.8001.00
60_I71_L0.7971.00
19_L101_R0.7851.00
12_L19_L0.7841.00
138_A141_Q0.7821.00
120_E133_R0.7791.00
27_R92_Y0.7781.00
5_S9_Q0.7691.00
42_L102_V0.7671.00
23_W97_V0.7631.00
25_I95_A0.7611.00
85_A89_A0.7611.00
27_R91_R0.7541.00
71_L114_F0.7501.00
118_I132_L0.7501.00
112_L115_R0.7391.00
86_D92_Y0.7321.00
5_S13_A0.7321.00
117_R133_R0.7231.00
22_C110_R0.7201.00
154_V157_D0.7191.00
28_R95_A0.7040.99
11_H19_L0.6990.99
61_E69_D0.6930.99
20_A36_T0.6900.99
25_I92_Y0.6840.99
69_D114_F0.6810.99
87_L128_F0.6790.99
122_T131_E0.6780.99
12_L101_R0.6770.99
10_A13_A0.6760.99
50_R53_S0.6690.99
153_A156_G0.6660.99
14_S19_L0.6600.99
45_D49_Y0.6580.99
102_V107_P0.6540.99
80_D83_T0.6490.99
28_R94_G0.6480.99
9_Q19_L0.6470.99
47_V50_R0.6460.99
27_R33_L0.6390.99
107_P110_R0.6390.99
5_S10_A0.6370.99
57_A60_I0.6370.99
84_E123_R0.6370.99
60_I116_G0.6300.99
88_A91_R0.6290.99
121_V128_F0.6280.99
119_G131_E0.6280.99
105_A109_Q0.6200.99
8_L111_V0.6190.99
7_A10_A0.6180.99
79_S83_T0.6160.99
86_D89_A0.6130.99
10_A14_S0.6110.98
6_A14_S0.6100.98
83_T86_D0.6090.98
86_D90_G0.6080.98
71_L132_L0.6060.98
29_D91_R0.6050.98
34_G49_Y0.6030.98
6_A13_A0.6010.98
140_N144_G0.6000.98
61_E70_N0.6000.98
43_T46_G0.5980.98
27_R30_G0.5970.98
115_R135_L0.5900.98
44_F47_V0.5850.98
99_I116_G0.5850.98
8_L12_L0.5840.98
137_A141_Q0.5840.98
37_D57_A0.5840.98
77_L87_L0.5770.98
5_S19_L0.5770.98
60_I114_F0.5700.98
114_F132_L0.5680.98
68_V133_R0.5680.98
150_T154_V0.5680.98
12_L17_T0.5510.97
90_G95_A0.5490.97
23_W37_D0.5470.97
69_D136_A0.5420.97
10_A16_A0.5400.97
20_A104_W0.5360.97
42_L107_P0.5360.97
145_R153_A0.5350.97
143_V149_P0.5350.97
44_F100_F0.5340.97
39_D104_W0.5340.97
23_W35_F0.5320.96
38_H102_V0.5320.96
23_W73_V0.5310.96
7_A11_H0.5300.96
92_Y147_Y0.5290.96
18_T104_W0.5290.96
114_F149_P0.5290.96
8_L19_L0.5280.96
99_I114_F0.5260.96
123_R126_G0.5260.96
60_I64_L0.5250.96
62_Q69_D0.5250.96
22_C36_T0.5250.96
11_H105_A0.5240.96
75_G87_L0.5180.96
114_F134_G0.5180.96
53_S81_A0.5140.96
7_A106_D0.5130.96
48_T51_A0.5130.96
9_Q15_G0.5110.96
73_V132_L0.5100.95
24_R44_F0.5090.95
57_A71_L0.5090.95
26_T47_V0.5050.95
152_R162_V0.5050.95
5_S109_Q0.5040.95
84_E87_L0.5040.95
53_S56_T0.5030.95
133_R140_N0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d37A 5 0.6503 13.8 0.922 Contact Map
1wruA 3 0.681 12 0.924 Contact Map
3cddA 3 0.7301 8.1 0.93 Contact Map
5a21H 1 0.8712 6 0.934 Contact Map
4lx3A 1 0.3865 3.2 0.942 Contact Map
3fbyA 3 0.411 2.5 0.945 Contact Map
4g4fA 4 0.3006 2.3 0.946 Contact Map
3b64A 3 0.2454 2 0.948 Contact Map
3b9tA 4 0.3497 1.9 0.949 Contact Map
4v2xA 2 0.7239 1.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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