GREMLIN Database
DUF2160 - Predicted small integral membrane protein (DUF2160)
PFAM: PF09928 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (88)
Sequences: 3355 (1418)
Seq/√Len: 151.1
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_W29_S2.9121.00
54_G80_Y2.8021.00
23_T27_I2.7631.00
83_A87_W2.6391.00
51_S81_A2.5911.00
26_E31_G2.3571.00
59_H73_A2.0751.00
58_I80_Y2.0681.00
14_V18_L2.0381.00
33_P41_E1.9801.00
52_L56_A1.8601.00
59_H77_S1.8421.00
35_R39_P1.8201.00
10_I14_V1.7751.00
35_R41_E1.7621.00
17_L21_G1.7401.00
6_W10_I1.7391.00
59_H74_L1.7201.00
80_Y84_V1.6561.00
18_L48_L1.6231.00
55_S77_S1.6211.00
22_M48_L1.5531.00
59_H70_L1.5531.00
19_L23_T1.5121.00
53_L57_F1.4551.00
13_I17_L1.3471.00
7_P10_I1.3451.00
24_V28_R1.3071.00
69_P72_I1.2781.00
29_S44_R1.2641.00
40_I50_I1.2191.00
22_M25_W1.2021.00
21_G25_W1.1911.00
16_A20_A1.1851.00
85_F88_V1.1831.00
54_G84_V1.1511.00
29_S32_A1.1401.00
74_L78_L1.1341.00
54_G58_I1.1240.99
75_A79_V1.1040.99
6_W9_A1.0510.99
31_G43_T1.0500.99
61_A64_G1.0230.99
57_F61_A1.0220.99
31_G44_R1.0160.99
11_F14_V1.0150.99
13_I16_A0.9840.99
42_T46_D0.9790.99
68_T72_I0.9790.99
62_W66_V0.9550.98
63_L70_L0.9540.98
78_L82_A0.9520.98
71_W74_L0.9100.98
37_I88_V0.8710.97
15_I18_L0.8690.97
30_P44_R0.8690.97
20_A24_V0.8670.97
26_E44_R0.8670.97
35_R40_I0.8660.97
18_L21_G0.8540.97
72_I75_A0.8390.96
21_G29_S0.8310.96
82_A87_W0.8210.96
11_F56_A0.8200.96
26_E32_A0.8170.96
74_L77_S0.8080.95
81_A85_F0.8070.95
69_P74_L0.8030.95
1_W4_W0.7730.94
55_S59_H0.7590.94
84_V88_V0.7490.93
37_I83_A0.7420.93
43_T49_F0.7420.93
61_A65_L0.7360.93
20_A23_T0.7230.92
62_W68_T0.7130.91
62_W72_I0.7100.91
80_Y83_A0.7010.91
75_A81_A0.6990.91
66_V69_P0.6970.90
25_W82_A0.6820.89
39_P88_V0.6800.89
60_L64_G0.6780.89
22_M26_E0.6700.89
22_M30_P0.6670.88
79_V82_A0.6640.88
21_G28_R0.6590.88
34_R47_R0.6560.88
55_S81_A0.6510.87
69_P75_A0.6450.87
25_W31_G0.6420.86
62_W76_I0.6350.86
10_I17_L0.6330.86
70_L77_S0.6280.85
5_T8_T0.6270.85
72_I76_I0.6250.85
26_E35_R0.6240.85
55_S80_Y0.6230.85
71_W78_L0.6140.84
13_I20_A0.6080.83
7_P39_P0.5900.81
14_V74_L0.5800.80
70_L74_L0.5760.80
11_F19_L0.5740.80
7_P13_I0.5670.79
62_W70_L0.5640.79
22_M50_I0.5620.78
51_S55_S0.5610.78
12_F56_A0.5600.78
63_L74_L0.5600.78
39_P85_F0.5560.78
73_A77_S0.5560.78
22_M44_R0.5480.77
17_L28_R0.5470.76
21_G24_V0.5410.76
16_A56_A0.5360.75
82_A86_R0.5350.75
10_I13_I0.5270.74
25_W32_A0.5270.74
73_A78_L0.5230.73
37_I54_G0.5220.73
19_L22_M0.5200.73
22_M29_S0.5170.72
43_T63_L0.5170.72
33_P43_T0.5130.72
15_I52_L0.5100.71
19_L30_P0.5090.71
31_G39_P0.5070.71
38_L80_Y0.5060.71
32_A50_I0.5020.70
83_A86_R0.5010.70
46_D50_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02B 1 0.3523 2.5 0.94 Contact Map
1jb0M 1 0.2955 2.3 0.941 Contact Map
4ev6A 3 0.3523 1.8 0.944 Contact Map
4c7rA 3 0.9432 1.7 0.945 Contact Map
4pd6A 3 0.4318 1.4 0.948 Contact Map
2wswA 3 0.9886 1.4 0.948 Contact Map
4i0uA 4 0.3295 1.3 0.948 Contact Map
3s8fC 1 0.3523 1.2 0.949 Contact Map
3s0xA 1 0.8068 1.2 0.95 Contact Map
3c02A 3 0.3182 1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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