GREMLIN Database
DUF2158 - Uncharacterized small protein (DUF2158)
PFAM: PF09926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (45)
Sequences: 4187 (3435)
Seq/√Len: 512.0
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_V14_K3.5171.00
31_V49_P3.2561.00
18_E34_V2.8021.00
40_K43_Q1.9391.00
32_E46_T1.8851.00
34_V51_S1.7591.00
7_R14_K1.6601.00
37_D40_K1.6561.00
48_P51_S1.6441.00
10_S16_T1.5991.00
34_V44_R1.5811.00
30_T46_T1.5381.00
37_D43_Q1.4741.00
13_P36_F1.4331.00
18_E51_S1.3541.00
17_V31_V1.1341.00
37_D41_L1.1161.00
32_E44_R1.1081.00
2_V48_P1.1061.00
19_S32_E1.1061.00
5_V9_K1.0891.00
2_V50_D1.0721.00
5_V10_S1.0001.00
20_V31_V0.9741.00
9_K16_T0.9621.00
26_D29_D0.9551.00
16_T36_F0.9491.00
18_E44_R0.9321.00
30_T48_P0.8651.00
34_V41_L0.8581.00
41_L45_G0.8351.00
5_V16_T0.8291.00
8_L16_T0.7991.00
21_G28_G0.7821.00
19_S26_D0.7671.00
18_E32_E0.7601.00
7_R13_P0.7601.00
15_M47_F0.7241.00
33_C47_F0.7191.00
36_F47_F0.7101.00
21_G32_E0.6961.00
20_V49_P0.6671.00
41_L47_F0.6621.00
39_K43_Q0.6551.00
18_E48_P0.6531.00
21_G26_D0.6411.00
8_L36_F0.6271.00
26_D30_T0.6030.99
7_R12_G0.5900.99
4_D30_T0.5860.99
35_W43_Q0.5780.99
27_G30_T0.5690.99
2_V17_V0.5630.99
4_D17_V0.5600.99
36_F40_K0.5590.99
21_G27_G0.5440.99
2_V51_S0.5420.99
36_F41_L0.5390.99
6_V31_V0.5360.99
32_E45_G0.5280.99
13_P39_K0.5270.99
19_S29_D0.5230.99
19_S46_T0.5170.98
7_R43_Q0.5140.98
38_G41_L0.5080.98
29_D39_K0.5010.98
6_V17_V0.5000.98
3_G6_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fl7A 1 0.9038 66.1 0.758 Contact Map
4jjnK 1 1 60.9 0.766 Contact Map
1m4zA 4 1 46.6 0.784 Contact Map
4ksiA 5 0.9231 30 0.806 Contact Map
3kr4A 5 0.8846 27.6 0.809 Contact Map
1gytA 6 0.8846 27.2 0.81 Contact Map
3ij3A 5 0.8846 27.1 0.81 Contact Map
2hc9A 5 0.9038 26.8 0.811 Contact Map
3peiA 5 0.8846 26.6 0.811 Contact Map
1lamA 5 0.8846 26.6 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0041 seconds.