GREMLIN Database
DUF2155 - Uncharacterized protein conserved in bacteria (DUF2155)
PFAM: PF09923 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (89)
Sequences: 5950 (3018)
Seq/√Len: 319.9
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_E70_S2.9361.00
34_R52_Q2.8341.00
19_P22_E2.7691.00
47_T69_A2.5211.00
23_T30_E2.4471.00
38_T88_D2.3691.00
25_R30_E2.3531.00
52_Q64_S2.3281.00
18_V24_V2.2471.00
32_T54_D2.2071.00
34_R50_F2.1421.00
63_F75_N2.0291.00
49_A86_L2.0091.00
51_L67_M1.9371.00
4_R15_D1.9121.00
5_G26_F1.8981.00
23_T32_T1.7961.00
30_E56_L1.7561.00
55_D79_H1.7531.00
2_V17_E1.7461.00
48_A68_F1.6771.00
5_G16_F1.6531.00
50_F64_S1.6371.00
30_E54_D1.5711.00
29_L53_V1.3611.00
20_V33_V1.2611.00
16_F24_V1.2451.00
37_R48_A1.2041.00
71_S74_L1.1961.00
2_V5_G1.1661.00
18_V33_V1.1621.00
28_T55_D1.1571.00
42_E45_P1.1511.00
53_V77_L1.1401.00
3_L51_L1.1381.00
32_T52_Q1.1241.00
7_D81_V1.1241.00
53_V84_V1.1041.00
15_D87_L1.1001.00
56_L60_E1.0901.00
41_P44_P1.0891.00
38_T47_T1.0831.00
38_T43_E1.0821.00
1_A33_V1.0781.00
25_R56_L1.0701.00
4_R13_T1.0651.00
14_S24_V1.0191.00
62_V77_L1.0081.00
2_V15_D1.0071.00
55_D62_V0.9811.00
21_G34_R0.9811.00
4_R87_L0.9491.00
5_G14_S0.9161.00
36_C89_C0.9151.00
77_L84_V0.8571.00
16_F26_F0.8481.00
10_T13_T0.8481.00
76_A85_W0.8471.00
67_M77_L0.8341.00
68_F71_S0.8331.00
57_R60_E0.8031.00
28_T58_P0.7971.00
33_V49_A0.7881.00
2_V88_D0.7801.00
57_R61_P0.7660.99
47_T88_D0.7620.99
33_V36_C0.7570.99
18_V22_E0.7560.99
40_P43_E0.7440.99
58_P61_P0.7410.99
5_G84_V0.7400.99
41_P45_P0.7090.99
14_S26_F0.7080.99
29_L77_L0.7060.99
84_V87_L0.7020.99
47_T86_L0.6990.99
36_C83_D0.6960.99
3_L18_V0.6950.99
27_G31_I0.6940.99
31_I84_V0.6920.99
18_V32_T0.6890.99
28_T57_R0.6710.99
35_A39_R0.6680.99
4_R85_W0.6670.99
28_T61_P0.6500.98
25_R58_P0.6370.98
9_I14_S0.6350.98
39_R47_T0.6350.98
79_H82_Y0.6330.98
39_R72_P0.6160.98
37_R85_W0.6090.97
56_L59_D0.6040.97
25_R28_T0.6030.97
5_G29_L0.6030.97
38_T46_E0.5970.97
39_R43_E0.5970.97
50_F75_N0.5950.97
53_V67_M0.5850.97
80_P83_D0.5810.97
7_D10_T0.5790.97
3_L16_F0.5770.97
26_F31_I0.5760.96
18_V88_D0.5710.96
53_V62_V0.5700.96
3_L84_V0.5670.96
60_E64_S0.5660.96
50_F85_W0.5610.96
17_E60_E0.5600.96
39_R48_A0.5570.96
75_N78_E0.5540.96
73_A78_E0.5500.95
54_D61_P0.5490.95
73_A76_A0.5450.95
65_G75_N0.5430.95
6_L78_E0.5420.95
75_N85_W0.5400.95
6_L11_G0.5380.95
53_V71_S0.5370.95
29_L55_D0.5360.95
78_E85_W0.5280.94
46_E71_S0.5280.94
9_I81_V0.5260.94
4_R19_P0.5230.94
50_F77_L0.5230.94
54_D59_D0.5230.94
67_M86_L0.5170.94
9_I26_F0.5150.94
39_R45_P0.5130.93
52_Q68_F0.5110.93
19_P23_T0.5080.93
34_R64_S0.5040.93
63_F72_P0.5020.93
19_P33_V0.5010.93
29_L36_C0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y9yB 1 0.9101 16.2 0.896 Contact Map
4gt9A 3 0.7416 10.3 0.905 Contact Map
3hgbA 1 0.9551 6.6 0.913 Contact Map
3cfuA 1 0.7865 6.5 0.913 Contact Map
3pieA 1 0.3371 5.8 0.915 Contact Map
4ic6A 4 0.8764 5.2 0.917 Contact Map
3cddA 3 0.9438 5.1 0.917 Contact Map
2hzmA 1 0.9551 4.8 0.918 Contact Map
2x2uA 2 0.6629 4.7 0.918 Contact Map
1y96A 1 0.5506 4.4 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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