GREMLIN Database
DUF2149 - Uncharacterized conserved protein (DUF2149)
PFAM: PF09919 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (90)
Sequences: 2144 (1418)
Seq/√Len: 149.4
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R78_T4.2661.00
74_E81_R3.5801.00
14_F18_L3.1441.00
79_A87_L3.1191.00
1_L5_V3.0401.00
8_F11_A2.6921.00
72_E83_E2.6731.00
37_D55_K2.4331.00
8_F12_L2.1031.00
4_V8_F2.0591.00
18_L22_L2.0311.00
76_L87_L1.6601.00
79_A89_Y1.6571.00
62_Y65_T1.6531.00
30_E33_T1.5611.00
43_N46_K1.4411.00
4_V7_L1.4181.00
16_V19_L1.3941.00
63_K66_G1.3501.00
4_V10_V1.3171.00
58_E86_R1.3121.00
42_K52_I1.2481.00
75_R79_A1.2271.00
22_L26_L1.2001.00
55_K60_E1.1781.00
79_A82_L1.1661.00
82_L89_Y1.1611.00
67_E70_S1.1571.00
7_L16_V1.1471.00
18_L23_V1.1441.00
20_L24_S1.1341.00
44_P49_M1.1250.99
16_V21_A1.0960.99
23_V28_L1.0910.99
50_E63_K1.0860.99
43_N47_P1.0760.99
37_D41_V1.0620.99
14_F19_L1.0620.99
13_V19_L1.0520.99
12_L15_A1.0480.99
6_N9_D1.0300.99
36_E44_P1.0270.99
45_G48_N1.0170.99
39_T51_I1.0020.99
11_A17_A0.9870.99
41_V49_M0.9870.99
28_L31_L0.9770.99
3_G10_V0.9750.99
40_I43_N0.9650.98
14_F21_A0.9530.98
37_D46_K0.9510.98
7_L10_V0.9350.98
39_T42_K0.9310.98
5_V14_F0.9300.98
37_D43_N0.9300.98
10_V21_A0.9210.98
45_G49_M0.9140.98
3_G11_A0.9090.98
22_L25_S0.9030.98
24_S27_N0.8970.97
58_E66_G0.8880.97
20_L25_S0.8800.97
80_Y85_G0.8750.97
44_P50_E0.8740.97
36_E42_K0.8170.96
47_P50_E0.8160.96
39_T43_N0.8160.96
35_K60_E0.8110.95
68_I72_E0.8080.95
31_L38_V0.8050.95
76_L81_R0.8040.95
42_K61_R0.7820.94
37_D45_G0.7730.94
40_I54_K0.7660.94
37_D40_I0.7560.93
82_L86_R0.7550.93
39_T54_K0.7520.93
16_V26_L0.7490.93
44_P48_N0.7340.92
4_V20_L0.7220.92
8_F16_V0.7190.91
57_E66_G0.7090.91
42_K83_E0.7070.91
21_A79_A0.6860.89
38_V54_K0.6820.89
77_G85_G0.6810.89
37_D56_G0.6780.89
24_S33_T0.6750.89
7_L20_L0.6720.88
39_T50_E0.6640.88
41_V45_G0.6600.88
83_E88_I0.6570.87
40_I45_G0.6500.87
11_A84_D0.6440.86
44_P47_P0.6430.86
38_V41_V0.6330.85
25_S29_T0.6250.85
82_L87_L0.6140.84
32_L38_V0.6130.83
75_R89_Y0.6120.83
9_D13_V0.6120.83
82_L88_I0.6110.83
38_V52_I0.6020.82
2_D20_L0.6000.82
84_D90_V0.5870.81
2_D14_F0.5840.80
73_G88_I0.5830.80
84_D89_Y0.5820.80
82_L91_P0.5810.80
85_G90_V0.5770.80
28_L40_I0.5750.79
55_K64_V0.5700.79
5_V13_V0.5670.78
43_N49_M0.5610.78
87_L91_P0.5600.78
73_G82_L0.5590.78
35_K72_E0.5580.77
14_F20_L0.5570.77
39_T49_M0.5460.76
73_G81_R0.5410.75
53_V67_E0.5410.75
77_G80_Y0.5390.75
1_L10_V0.5390.75
41_V44_P0.5380.75
70_S73_G0.5360.75
75_R90_V0.5300.74
13_V17_A0.5140.71
71_G82_L0.5140.71
13_V25_S0.5110.71
29_T32_L0.5060.70
59_I70_S0.5050.70
2_D5_V0.5020.70
78_T83_E0.5010.70
42_K45_G0.5010.70
71_G84_D0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jw1A 1 0.2065 16.2 0.899 Contact Map
4x2zA 1 0.4674 6.3 0.916 Contact Map
1v58A 2 0.5326 5.4 0.919 Contact Map
1j72A 2 0.2717 4.8 0.92 Contact Map
1scfA 4 0 4.3 0.923 Contact Map
4tllB 2 0.3587 4.2 0.923 Contact Map
3q6lA 1 0.913 3.9 0.924 Contact Map
3j6da 3 0.4348 3.8 0.925 Contact Map
2yheA 3 0.5761 3.6 0.926 Contact Map
4a60A 1 0.913 3.3 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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