GREMLIN Database
DUF2148 - Uncharacterized protein containing a ferredoxin domain (DUF2148)
PFAM: PF09918 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (67)
Sequences: 2605 (1120)
Seq/√Len: 136.9
META: 0.948

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_I53_Y3.4811.00
41_R52_V2.9741.00
36_I54_G2.6981.00
16_L32_I2.6651.00
22_T26_L2.6511.00
21_K27_N2.3121.00
46_L49_V2.1281.00
20_V55_I2.1201.00
46_L52_V1.8371.00
33_M36_I1.8341.00
4_P9_L1.8321.00
22_T25_D1.7631.00
28_V57_L1.7601.00
37_G54_G1.5621.00
9_L51_I1.4941.00
24_A27_N1.4941.00
33_M56_P1.4811.00
3_P38_V1.4661.00
21_K25_D1.4411.00
10_I14_I1.4381.00
3_P8_N1.4131.00
6_A9_L1.3931.00
38_V41_R1.3901.00
22_T27_N1.3471.00
32_I53_Y1.3071.00
44_G48_E1.2901.00
28_V59_A1.2741.00
2_G5_C1.1881.00
39_A43_L1.1610.99
38_V42_K1.1330.99
58_S64_P1.1310.99
5_C11_D1.1150.99
10_I16_L1.0920.99
4_P8_N1.0590.99
20_V32_I0.9150.97
30_N57_L0.9050.97
23_A30_N0.8930.97
62_K67_D0.8910.96
8_N35_S0.8830.96
17_G32_I0.8800.96
7_F53_Y0.8770.96
21_K24_A0.8640.96
16_L53_Y0.8330.95
19_A23_A0.7900.93
58_S65_F0.7620.92
13_G17_G0.7580.92
47_G50_D0.7500.91
41_R51_I0.7460.91
4_P50_D0.7280.90
40_A46_L0.7280.90
16_L20_V0.7040.89
27_N30_N0.6970.88
29_D62_K0.6940.88
11_D34_Y0.6930.88
7_F34_Y0.6770.87
34_Y38_V0.6740.86
6_A51_I0.6690.86
20_V30_N0.6610.85
12_L51_I0.6550.85
60_T64_P0.6540.85
39_A42_K0.6500.84
40_A45_L0.6500.84
11_D15_A0.6420.84
35_S39_A0.6370.83
8_N26_L0.6320.83
25_D35_S0.6260.82
29_D47_G0.6100.80
64_P67_D0.6080.80
15_A18_S0.6020.79
24_A63_N0.6000.79
19_A27_N0.5800.77
63_N67_D0.5790.77
62_K65_F0.5740.76
3_P49_V0.5730.76
16_L19_A0.5710.76
31_R68_R0.5610.75
41_R48_E0.5480.73
44_G51_I0.5420.72
41_R50_D0.5420.72
63_N66_F0.5420.72
4_P64_P0.5420.72
12_L61_G0.5410.72
8_N11_D0.5390.72
49_V52_V0.5360.71
47_G51_I0.5350.71
18_S55_I0.5330.71
7_F42_K0.5320.71
6_A50_D0.5290.70
8_N22_T0.5250.70
31_R54_G0.5210.69
8_N61_G0.5190.69
18_S62_K0.5170.68
37_G61_G0.5150.68
11_D35_S0.5130.68
30_N54_G0.5130.68
46_L50_D0.5090.67
6_A10_I0.5060.67
42_K51_I0.5040.67
10_I52_V0.5010.66
17_G40_A0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n2sA 2 1 35.6 0.879 Contact Map
2wzvA 2 0.9853 35.6 0.879 Contact Map
1zchA 2 1 32.2 0.882 Contact Map
2ymvA 1 0.8824 29.5 0.884 Contact Map
3gb5A 2 0.9118 22.6 0.89 Contact Map
3e10A 2 0.9706 21.5 0.891 Contact Map
3gagA 4 1 21 0.892 Contact Map
3gr3A 2 1 19.8 0.893 Contact Map
3of4A 3 1 19.6 0.893 Contact Map
1f5vA 2 1 17.6 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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