GREMLIN Database
DUF2141 - Uncharacterized protein conserved in bacteria (DUF2141)
PFAM: PF09912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (108)
Sequences: 14177 (11045)
Seq/√Len: 1062.8
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_T101_K3.9871.00
12_Q66_G3.4971.00
55_T103_E3.3731.00
65_N71_D3.1371.00
15_V46_V2.7071.00
67_N71_D2.6811.00
6_L13_V2.5951.00
64_E81_G2.3831.00
61_F70_L2.1351.00
14_R61_F2.1311.00
2_T45_T2.1251.00
7_R81_G2.0801.00
20_S23_G1.8571.00
14_R36_V1.8161.00
73_N77_I1.7231.00
2_T43_T1.7201.00
57_A100_A1.7111.00
62_H81_G1.7001.00
73_N79_K1.6981.00
3_V60_V1.6851.00
12_Q36_V1.5671.00
53_P106_G1.4671.00
8_N64_E1.4131.00
18_Y59_A1.4101.00
73_N76_G1.3861.00
96_S99_D1.3641.00
97_F101_K1.3631.00
25_P59_A1.3371.00
9_D42_G1.2981.00
67_N80_E1.2621.00
16_A59_A1.2311.00
105_G108_D1.2181.00
85_S102_F1.2111.00
18_Y23_G1.1981.00
4_T43_T1.1961.00
53_P105_G1.1791.00
35_A46_V1.1711.00
93_G99_D1.1631.00
65_N80_E1.1501.00
24_F100_A1.1471.00
24_F57_A1.1361.00
53_P104_V1.1251.00
98_E101_K1.1201.00
53_P107_G1.1171.00
70_L82_Y1.1071.00
17_L48_F1.0791.00
60_V83_G1.0771.00
11_G62_H1.0651.00
17_L51_L1.0611.00
17_L58_V1.0571.00
82_Y90_G1.0521.00
72_T76_G1.0451.00
19_D23_G1.0411.00
84_F100_A1.0351.00
13_V44_A1.0231.00
27_K30_K1.0081.00
14_R68_G0.9981.00
74_F79_K0.9501.00
9_D39_I0.9381.00
71_D80_E0.9321.00
19_D52_P0.9211.00
31_A34_G0.9121.00
64_E80_E0.9031.00
12_Q68_G0.9011.00
39_I44_A0.8971.00
12_Q38_P0.8831.00
10_K64_E0.8661.00
6_L39_I0.8551.00
63_D67_N0.8511.00
35_A38_P0.8441.00
21_E98_E0.8431.00
15_V48_F0.8421.00
41_A44_A0.8251.00
58_V83_G0.8251.00
28_G31_A0.8231.00
47_T50_D0.8191.00
17_L56_Y0.8091.00
3_V13_V0.8091.00
84_F88_A0.8081.00
15_V35_A0.7991.00
3_V6_L0.7961.00
88_A99_D0.7911.00
9_D41_A0.7791.00
37_V46_V0.7791.00
7_R64_E0.7731.00
83_G87_N0.7721.00
6_L44_A0.7711.00
18_Y31_A0.7631.00
35_A48_F0.7591.00
36_V39_I0.7451.00
72_T75_L0.7451.00
20_S24_F0.7411.00
1_V58_V0.7351.00
93_G96_S0.7301.00
95_P100_A0.7261.00
15_V60_V0.7131.00
94_P100_A0.7071.00
8_N62_H0.7041.00
23_G29_G0.7001.00
71_D79_K0.6971.00
16_A34_G0.6951.00
3_V15_V0.6941.00
21_E25_P0.6921.00
63_D68_G0.6921.00
1_V48_F0.6911.00
9_D40_K0.6881.00
37_V44_A0.6851.00
70_L80_E0.6841.00
88_A100_A0.6831.00
59_A84_F0.6601.00
19_D32_V0.6561.00
51_L54_G0.6531.00
35_A49_E0.6501.00
104_V107_G0.6431.00
70_L79_K0.6411.00
34_G37_V0.6261.00
55_T97_F0.6251.00
23_G30_K0.6231.00
90_G93_G0.6191.00
40_K44_A0.6171.00
51_L56_Y0.6151.00
48_F51_L0.6131.00
59_A82_Y0.6081.00
6_L81_G0.6071.00
87_N90_G0.6031.00
57_A85_S0.6031.00
61_F81_G0.6011.00
77_I82_Y0.5941.00
17_L50_D0.5931.00
16_A61_F0.5901.00
36_V68_G0.5881.00
90_G99_D0.5861.00
51_L104_V0.5851.00
82_Y87_N0.5841.00
19_D56_Y0.5821.00
86_N101_K0.5811.00
84_F99_D0.5791.00
6_L60_V0.5691.00
70_L78_P0.5571.00
20_S97_F0.5561.00
27_K31_A0.5561.00
46_V49_E0.5531.00
72_T77_I0.5501.00
58_V102_F0.5491.00
8_N42_G0.5481.00
24_F59_A0.5411.00
84_F90_G0.5401.00
23_G31_A0.5391.00
7_R10_K0.5291.00
55_T98_E0.5291.00
12_Q35_A0.5231.00
18_Y30_K0.5221.00
30_K38_P0.5221.00
8_N39_I0.5221.00
6_L62_H0.5211.00
6_L9_D0.5171.00
52_P55_T0.5111.00
9_D44_A0.5111.00
56_Y102_F0.5051.00
13_V60_V0.5031.00
57_A97_F0.5011.00
53_P108_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghpA 1 0.8661 16.3 0.898 Contact Map
2xwxA 2 0.6607 10.2 0.907 Contact Map
3gf8A 1 0.9554 9.5 0.908 Contact Map
1nqjA 1 0.5804 8.5 0.91 Contact Map
3iduA 1 0.6607 8.3 0.911 Contact Map
4m29A 1 0.7321 7.3 0.913 Contact Map
3payA 4 0.8482 6.9 0.914 Contact Map
3jqwA 1 0.6071 6.6 0.914 Contact Map
4qtqA 1 0.9196 6.5 0.915 Contact Map
3vnyA 3 0.8304 5.8 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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