GREMLIN Database
HigB_toxin - HigB_toxin, RelE-like toxic component of a toxin-antitoxin system
PFAM: PF09907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 20612 (11802)
Seq/√Len: 1390.8
META: 0.951

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_E6_E2.7221.00
43_K46_K2.5431.00
54_N57_R2.2901.00
53_I60_V2.2461.00
12_V17_W2.1801.00
7_A11_E2.0431.00
38_V55_Y2.0141.00
20_P32_I2.0051.00
16_D58_Q1.9671.00
18_K22_D1.9501.00
11_E26_T1.8511.00
31_D41_N1.7001.00
30_A38_V1.6581.00
4_P43_K1.6191.00
52_A63_R1.5191.00
19_S22_D1.4921.00
3_Q6_E1.4251.00
11_E27_F1.3771.00
18_K58_Q1.3731.00
9_Y13_K1.3711.00
17_W26_T1.3541.00
4_P42_I1.3491.00
33_V39_V1.3471.00
54_N61_Y1.2951.00
38_V53_I1.2921.00
29_S41_N1.2511.00
12_V60_V1.2361.00
37_R52_A1.2171.00
32_I35_N1.1791.00
69_A72_D1.1551.00
15_A26_T1.1251.00
23_V38_V1.1251.00
3_Q7_A1.0771.00
21_A25_A1.0621.00
49_L65_I1.0431.00
57_R61_Y1.0341.00
5_L42_I1.0321.00
50_I64_F1.0311.00
54_N59_I1.0241.00
35_N52_A1.0201.00
6_E10_R0.9681.00
40_F51_V0.9591.00
24_K31_D0.9581.00
32_I38_V0.9551.00
31_D39_V0.9391.00
8_W40_F0.9301.00
20_P24_K0.9151.00
51_V60_V0.9141.00
20_P55_Y0.9121.00
37_R64_F0.9041.00
5_L49_L0.8741.00
52_A61_Y0.8661.00
37_R63_R0.8571.00
7_A10_R0.8501.00
36_N52_A0.8311.00
22_D25_A0.8251.00
37_R50_I0.8231.00
52_A59_I0.8211.00
42_I49_L0.8121.00
9_Y12_V0.8111.00
50_I66_G0.8031.00
6_E9_Y0.8011.00
8_W12_V0.7981.00
67_T70_E0.7821.00
54_N63_R0.7741.00
69_A73_K0.7451.00
5_L65_I0.7311.00
37_R66_G0.7181.00
12_V49_L0.7171.00
17_W23_V0.7151.00
24_K41_N0.7041.00
33_V37_R0.6931.00
39_V50_I0.6881.00
23_V53_I0.6811.00
10_R14_K0.6741.00
4_P44_G0.6721.00
4_P47_Y0.6611.00
62_I65_I0.6531.00
31_D50_I0.6471.00
10_R13_K0.6391.00
33_V36_N0.6351.00
36_N54_N0.6161.00
21_A32_I0.6161.00
52_A57_R0.6101.00
41_N44_G0.6071.00
12_V15_A0.5981.00
21_A24_K0.5921.00
29_S44_G0.5721.00
4_P7_A0.5701.00
52_A56_R0.5701.00
32_I55_Y0.5601.00
34_G37_R0.5601.00
20_P31_D0.5481.00
29_S43_K0.5461.00
64_F72_D0.5371.00
2_E9_Y0.5261.00
45_N48_R0.5241.00
20_P38_V0.5211.00
28_P31_D0.5211.00
11_E15_A0.5171.00
27_F30_A0.5141.00
25_A28_P0.5091.00
12_V23_V0.5091.00
9_Y65_I0.5071.00
56_R59_I0.5021.00
24_K29_S0.5011.00
43_K47_Y0.5011.00
8_W49_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bpqB 1 0.9459 75 0.81 Contact Map
4nrnA 2 0.9459 74.2 0.811 Contact Map
3g5oB 1 0.8784 71.2 0.815 Contact Map
4fxiA 2 0.9865 62 0.827 Contact Map
4lttA 1 0.9595 61.8 0.827 Contact Map
2kheA 1 0.9595 53.7 0.835 Contact Map
1wmiA 2 0.9189 49.9 0.839 Contact Map
4ml2A 1 0.9459 32.9 0.855 Contact Map
3oeiC 2 0.8784 30.1 0.858 Contact Map
2a6sA 1 0.8784 20.6 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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