GREMLIN Database
DUF2130 - Uncharacterized protein conserved in bacteria (DUF2130)
PFAM: PF09903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (232)
Sequences: 5273 (2929)
Seq/√Len: 192.3
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_I21_L4.4121.00
9_K13_D4.0531.00
11_L14_L2.9741.00
205_E209_E2.8281.00
4_K7_K2.7771.00
10_Q15_D2.3391.00
44_E47_K2.3301.00
14_L18_I2.3191.00
116_R124_A2.2991.00
138_N142_G2.2871.00
7_K10_Q2.2801.00
215_I219_D2.2711.00
17_Q20_E2.2631.00
37_L92_S2.1771.00
216_E220_K2.1661.00
90_F159_A2.1231.00
14_L17_Q2.1121.00
18_I26_A2.1101.00
19_E22_K2.0721.00
222_L225_I2.0341.00
12_K16_K1.9881.00
212_K216_E1.9801.00
4_K8_E1.9401.00
62_K65_S1.9291.00
201_R205_E1.9161.00
12_K15_D1.8861.00
111_K115_D1.8791.00
7_K11_L1.8571.00
217_E228_K1.8291.00
65_S111_K1.7951.00
168_N171_K1.7731.00
42_E46_N1.7561.00
125_V162_L1.7201.00
213_T217_E1.7141.00
114_K118_E1.6961.00
60_E63_K1.6661.00
14_L21_L1.6591.00
234_E238_L1.6241.00
224_K228_K1.6151.00
22_K27_E1.6121.00
110_K114_K1.6061.00
30_T33_Q1.6041.00
3_K6_E1.5931.00
42_E60_E1.5841.00
5_K9_K1.5771.00
8_E12_K1.5581.00
41_L92_S1.5561.00
14_L26_A1.5541.00
164_N168_N1.5521.00
158_L161_L1.5391.00
215_I234_E1.5151.00
17_Q21_L1.5001.00
41_L155_F1.4881.00
7_K18_I1.4851.00
223_Q238_L1.4821.00
246_N250_D1.4761.00
94_N129_L1.4701.00
51_F159_A1.4661.00
42_E70_Y1.4581.00
111_K118_E1.4501.00
151_R154_F1.4441.00
150_C158_L1.4161.00
223_Q227_K1.4031.00
79_N83_Q1.3861.00
17_Q22_K1.3851.00
202_Q206_A1.3761.00
225_I229_R1.3571.00
57_K78_R1.3561.00
109_L113_K1.3461.00
112_L124_A1.3391.00
144_Y149_V1.3331.00
78_R84_E1.3221.00
134_D144_Y1.3101.00
128_S131_E1.3041.00
163_R167_I1.3011.00
9_K12_K1.2951.00
7_K14_L1.2831.00
68_G89_M1.2831.00
148_W161_L1.2821.00
199_E231_K1.2761.00
16_K20_E1.2721.00
85_C167_I1.2601.00
231_K234_E1.2591.00
31_Q63_K1.2571.00
210_K231_K1.2501.00
13_D16_K1.2461.00
5_K8_E1.2451.00
21_L26_A1.2451.00
89_M124_A1.2341.00
6_E10_Q1.2301.00
15_D19_E1.2291.00
213_T228_K1.2201.00
122_E198_N1.2121.00
10_Q13_D1.2091.00
112_L126_L1.1971.00
10_Q14_L1.1871.00
188_N191_T1.1751.00
44_E155_F1.1751.00
56_D143_R1.1651.00
3_K7_K1.1591.00
89_M119_K1.1581.00
48_L156_I1.1231.00
89_M121_A1.1141.00
165_A169_S1.1111.00
127_V150_C1.1091.00
18_I22_K1.1021.00
104_W107_D1.1011.00
222_L226_W1.0971.00
61_V71_I1.0941.00
15_D18_I1.0911.00
40_H44_E1.0881.00
117_R209_E1.0841.00
9_K36_V1.0831.00
16_K19_E1.0831.00
226_W229_R1.0801.00
36_V40_H1.0791.00
2_L5_K1.0581.00
204_V208_V1.0501.00
181_E184_E1.0451.00
55_F80_E1.0441.00
184_E188_N1.0361.00
71_I89_M1.0181.00
20_E23_R1.0141.00
216_E219_D1.0101.00
63_K111_K1.0081.00
210_K235_N1.0011.00
238_L241_A0.9991.00
150_C154_F0.9991.00
71_I87_S0.9971.00
63_K118_E0.9900.99
213_T216_E0.9870.99
43_E47_K0.9860.99
124_A147_V0.9800.99
176_L179_K0.9720.99
227_K231_K0.9690.99
226_W230_E0.9680.99
207_I240_T0.9660.99
37_L129_L0.9550.99
114_K235_N0.9510.99
117_R145_D0.9490.99
206_A209_E0.9480.99
218_I233_I0.9440.99
208_V212_K0.9400.99
249_Q252_T0.9230.99
206_A235_N0.9190.99
6_E9_K0.9190.99
210_K213_T0.9160.99
28_Q33_Q0.9120.99
250_D255_K0.9060.99
40_H43_E0.9050.99
169_S172_A0.9010.99
19_E23_R0.8980.99
229_R232_Q0.8960.99
76_Q83_Q0.8950.99
39_L42_E0.8940.99
106_E144_Y0.8840.99
51_F160_T0.8810.99
39_L43_E0.8810.99
246_N249_Q0.8770.99
214_M218_I0.8730.99
131_E138_N0.8590.99
76_Q81_S0.8510.98
250_D253_I0.8510.98
13_D17_Q0.8450.98
179_K184_E0.8440.98
66_R118_E0.8430.98
247_K253_I0.8390.98
109_L144_Y0.8370.98
140_G154_F0.8350.98
225_I228_K0.8320.98
71_I119_K0.8190.98
106_E143_R0.8100.98
217_E221_E0.8090.98
5_K12_K0.8080.98
48_L160_T0.8060.98
233_I236_V0.8020.98
13_D20_E0.7970.98
231_K235_N0.7970.98
117_R206_A0.7930.98
28_Q36_V0.7920.98
44_E156_I0.7890.97
62_K119_K0.7890.97
2_L6_E0.7820.97
179_K183_M0.7790.97
227_K230_E0.7780.97
86_G162_L0.7770.97
13_D36_V0.7750.97
5_K43_E0.7720.97
52_P55_F0.7700.97
106_E133_K0.7700.97
209_E235_N0.7670.97
62_K118_E0.7650.97
156_I160_T0.7640.97
225_I230_E0.7630.97
202_Q205_E0.7600.97
206_A210_K0.7580.97
220_K228_K0.7560.97
17_Q25_K0.7540.97
174_A177_E0.7500.97
103_K130_L0.7480.96
29_S33_Q0.7420.96
177_E180_G0.7420.96
209_E213_T0.7410.96
3_K8_E0.7370.96
123_Y162_L0.7330.96
221_E226_W0.7320.96
51_F163_R0.7310.96
154_F157_P0.7280.96
222_L229_R0.7280.96
45_L58_I0.7270.96
237_R241_A0.7210.96
221_E229_R0.7210.96
112_L116_R0.7210.96
140_G151_R0.7190.96
234_E237_R0.7190.96
215_I230_E0.7180.96
223_Q242_G0.7170.96
35_E63_K0.7130.95
44_E48_L0.7090.95
197_G200_F0.7030.95
237_R240_T0.7010.95
248_A251_I0.6970.95
178_G181_E0.6950.95
116_R122_E0.6950.95
71_I121_A0.6940.95
8_E15_D0.6930.95
183_M187_Y0.6930.95
177_E181_E0.6890.94
157_P160_T0.6870.94
131_E149_V0.6820.94
230_E234_E0.6760.94
198_N202_Q0.6750.94
23_R27_E0.6730.94
106_E109_L0.6690.94
172_A176_L0.6640.93
13_D32_L0.6540.93
35_E42_E0.6510.93
241_A244_Y0.6490.93
25_K28_Q0.6490.93
113_K117_R0.6470.92
35_E39_L0.6450.92
172_A175_E0.6420.92
131_E151_R0.6370.92
134_D139_E0.6370.92
207_I236_V0.6370.92
211_F215_I0.6320.92
10_Q17_Q0.6270.91
65_S118_E0.6260.91
85_C173_K0.6240.91
43_E134_D0.6210.91
69_D93_K0.6200.91
8_E11_L0.6170.91
211_F240_T0.6150.90
245_G248_A0.6140.90
101_T130_L0.6130.90
219_D223_Q0.6120.90
15_D27_E0.6120.90
224_K227_K0.6100.90
230_E233_I0.6100.90
101_T108_W0.6080.90
33_Q43_E0.6080.90
171_K175_E0.6030.90
103_K107_D0.6000.89
234_E246_N0.5980.89
247_K254_K0.5970.89
55_F78_R0.5970.89
46_N56_D0.5950.89
13_D31_Q0.5950.89
48_L52_P0.5940.89
107_D110_K0.5890.88
148_W160_T0.5870.88
79_N171_K0.5870.88
165_A168_N0.5840.88
86_G166_L0.5830.88
123_Y165_A0.5810.88
175_E182_K0.5800.88
146_G205_E0.5800.88
217_E225_I0.5790.88
236_V240_T0.5770.87
51_F156_I0.5770.87
81_S174_A0.5710.87
2_L9_K0.5710.87
70_Y92_S0.5700.87
9_K17_Q0.5660.86
110_K145_D0.5650.86
170_L174_A0.5650.86
83_Q170_L0.5650.86
168_N172_A0.5650.86
104_W108_W0.5640.86
76_Q85_C0.5630.86
178_G182_K0.5620.86
55_F79_N0.5620.86
246_N252_T0.5620.86
247_K250_D0.5610.86
88_I125_V0.5610.86
37_L40_H0.5580.86
66_R223_Q0.5580.86
34_G69_D0.5550.85
197_G201_R0.5520.85
204_V240_T0.5510.85
35_E60_E0.5500.85
183_M190_L0.5480.85
104_W128_S0.5470.84
90_F125_V0.5440.84
61_V67_G0.5440.84
85_C120_K0.5420.84
250_D254_K0.5420.84
87_S122_E0.5410.84
208_V233_I0.5390.84
47_K139_E0.5390.84
162_L165_A0.5370.83
117_R205_E0.5360.83
240_T244_Y0.5350.83
141_F157_P0.5350.83
175_E180_G0.5340.83
143_R149_V0.5340.83
38_E93_K0.5340.83
215_I237_R0.5330.83
176_L188_N0.5280.82
151_R155_F0.5270.82
39_L63_K0.5270.82
246_N251_I0.5270.82
203_N210_K0.5270.82
32_L40_H0.5240.82
11_L15_D0.5240.82
2_L7_K0.5230.82
40_H152_P0.5220.82
206_A239_A0.5200.81
22_K26_A0.5200.81
25_K29_S0.5180.81
134_D142_G0.5180.81
43_E46_N0.5150.81
170_L173_K0.5150.81
245_G250_D0.5150.81
199_E238_L0.5130.81
140_G153_Q0.5120.80
109_L149_V0.5120.80
34_G38_E0.5100.80
214_M221_E0.5100.80
111_K114_K0.5100.80
38_E69_D0.5090.80
246_N254_K0.5090.80
65_S119_K0.5070.80
176_L180_G0.5060.80
157_P161_L0.5060.80
110_K235_N0.5050.80
249_Q253_I0.5010.79
182_K187_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y88A 5 0.6525 91.1 0.908 Contact Map
4oc8A 4 0.6332 85.3 0.917 Contact Map
4f0qA 4 0.7027 85.2 0.917 Contact Map
1xmxA 2 0.6139 53.8 0.935 Contact Map
3ziaJ 1 0 11.5 0.953 Contact Map
1ug7A 1 0.2317 10.4 0.954 Contact Map
3bm3A 2 0.6911 9.8 0.955 Contact Map
2gb7A 2 0.7683 9.6 0.955 Contact Map
1gmjA 2 0.1313 8.7 0.956 Contact Map
3zifN 3 0.1313 6.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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