DUF2130 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF2130 - Uncharacterized protein conserved in bacteria (DUF2130)

PFAM:	PF09903	Sequences: KLKKKEKEKQLKDLDKQIEELKRMKAEQSTQLQGEVLELHLEEELNKLRAFPNAFDKINEVKKGSRGGDYIFREFQVRNESGQECGSIMFESKNENDETATKKWNEDWLKKLKKDRREKKAEYAVLVSLLEPKDELYNEGFGRYDGVWVCRPQFFIPLATLLRNALINSLKAKAELEGKGEKMEDLYNYLTKLNDFGNEFRQNVEAIVEKFKTMIEEIDKELQKIWKKREKQIENVRLATAGMYGNKAQDITIKKLTRN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	259 (232)
Sequences:	5273 (2929)
Seq/√Len:	192.3
META:	0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_I	21_L	4.412	1.00
9_K	13_D	4.053	1.00
11_L	14_L	2.974	1.00
205_E	209_E	2.828	1.00
4_K	7_K	2.777	1.00
10_Q	15_D	2.339	1.00
44_E	47_K	2.330	1.00
14_L	18_I	2.319	1.00
116_R	124_A	2.299	1.00
138_N	142_G	2.287	1.00
7_K	10_Q	2.280	1.00
215_I	219_D	2.271	1.00
17_Q	20_E	2.263	1.00
37_L	92_S	2.177	1.00
216_E	220_K	2.166	1.00
90_F	159_A	2.123	1.00
14_L	17_Q	2.112	1.00
18_I	26_A	2.110	1.00
19_E	22_K	2.072	1.00
222_L	225_I	2.034	1.00
12_K	16_K	1.988	1.00
212_K	216_E	1.980	1.00
4_K	8_E	1.940	1.00
62_K	65_S	1.929	1.00
201_R	205_E	1.916	1.00
12_K	15_D	1.886	1.00
111_K	115_D	1.879	1.00
7_K	11_L	1.857	1.00
217_E	228_K	1.829	1.00
65_S	111_K	1.795	1.00
168_N	171_K	1.773	1.00
42_E	46_N	1.756	1.00
125_V	162_L	1.720	1.00
213_T	217_E	1.714	1.00
114_K	118_E	1.696	1.00
60_E	63_K	1.666	1.00
14_L	21_L	1.659	1.00
234_E	238_L	1.624	1.00
224_K	228_K	1.615	1.00
22_K	27_E	1.612	1.00
110_K	114_K	1.606	1.00
30_T	33_Q	1.604	1.00
3_K	6_E	1.593	1.00
42_E	60_E	1.584	1.00
5_K	9_K	1.577	1.00
8_E	12_K	1.558	1.00
41_L	92_S	1.556	1.00
14_L	26_A	1.554	1.00
164_N	168_N	1.552	1.00
158_L	161_L	1.539	1.00
215_I	234_E	1.515	1.00
17_Q	21_L	1.500	1.00
41_L	155_F	1.488	1.00
7_K	18_I	1.485	1.00
223_Q	238_L	1.482	1.00
246_N	250_D	1.476	1.00
94_N	129_L	1.470	1.00
51_F	159_A	1.466	1.00
42_E	70_Y	1.458	1.00
111_K	118_E	1.450	1.00
151_R	154_F	1.444	1.00
150_C	158_L	1.416	1.00
223_Q	227_K	1.403	1.00
79_N	83_Q	1.386	1.00
17_Q	22_K	1.385	1.00
202_Q	206_A	1.376	1.00
225_I	229_R	1.357	1.00
57_K	78_R	1.356	1.00
109_L	113_K	1.346	1.00
112_L	124_A	1.339	1.00
144_Y	149_V	1.333	1.00
78_R	84_E	1.322	1.00
134_D	144_Y	1.310	1.00
128_S	131_E	1.304	1.00
163_R	167_I	1.301	1.00
9_K	12_K	1.295	1.00
7_K	14_L	1.283	1.00
68_G	89_M	1.283	1.00
148_W	161_L	1.282	1.00
199_E	231_K	1.276	1.00
16_K	20_E	1.272	1.00
85_C	167_I	1.260	1.00
231_K	234_E	1.259	1.00
31_Q	63_K	1.257	1.00
210_K	231_K	1.250	1.00
13_D	16_K	1.246	1.00
5_K	8_E	1.245	1.00
21_L	26_A	1.245	1.00
89_M	124_A	1.234	1.00
6_E	10_Q	1.230	1.00
15_D	19_E	1.229	1.00
213_T	228_K	1.220	1.00
122_E	198_N	1.212	1.00
10_Q	13_D	1.209	1.00
112_L	126_L	1.197	1.00
10_Q	14_L	1.187	1.00
188_N	191_T	1.175	1.00
44_E	155_F	1.175	1.00
56_D	143_R	1.165	1.00
3_K	7_K	1.159	1.00
89_M	119_K	1.158	1.00
48_L	156_I	1.123	1.00
89_M	121_A	1.114	1.00
165_A	169_S	1.111	1.00
127_V	150_C	1.109	1.00
18_I	22_K	1.102	1.00
104_W	107_D	1.101	1.00
222_L	226_W	1.097	1.00
61_V	71_I	1.094	1.00
15_D	18_I	1.091	1.00
40_H	44_E	1.088	1.00
117_R	209_E	1.084	1.00
9_K	36_V	1.083	1.00
16_K	19_E	1.083	1.00
226_W	229_R	1.080	1.00
36_V	40_H	1.079	1.00
2_L	5_K	1.058	1.00
204_V	208_V	1.050	1.00
181_E	184_E	1.045	1.00
55_F	80_E	1.044	1.00
184_E	188_N	1.036	1.00
71_I	89_M	1.018	1.00
20_E	23_R	1.014	1.00
216_E	219_D	1.010	1.00
63_K	111_K	1.008	1.00
210_K	235_N	1.001	1.00
238_L	241_A	0.999	1.00
150_C	154_F	0.999	1.00
71_I	87_S	0.997	1.00
63_K	118_E	0.990	0.99
213_T	216_E	0.987	0.99
43_E	47_K	0.986	0.99
124_A	147_V	0.980	0.99
176_L	179_K	0.972	0.99
227_K	231_K	0.969	0.99
226_W	230_E	0.968	0.99
207_I	240_T	0.966	0.99
37_L	129_L	0.955	0.99
114_K	235_N	0.951	0.99
117_R	145_D	0.949	0.99
206_A	209_E	0.948	0.99
218_I	233_I	0.944	0.99
208_V	212_K	0.940	0.99
249_Q	252_T	0.923	0.99
206_A	235_N	0.919	0.99
6_E	9_K	0.919	0.99
210_K	213_T	0.916	0.99
28_Q	33_Q	0.912	0.99
250_D	255_K	0.906	0.99
40_H	43_E	0.905	0.99
169_S	172_A	0.901	0.99
19_E	23_R	0.898	0.99
229_R	232_Q	0.896	0.99
76_Q	83_Q	0.895	0.99
39_L	42_E	0.894	0.99
106_E	144_Y	0.884	0.99
51_F	160_T	0.881	0.99
39_L	43_E	0.881	0.99
246_N	249_Q	0.877	0.99
214_M	218_I	0.873	0.99
131_E	138_N	0.859	0.99
76_Q	81_S	0.851	0.98
250_D	253_I	0.851	0.98
13_D	17_Q	0.845	0.98
179_K	184_E	0.844	0.98
66_R	118_E	0.843	0.98
247_K	253_I	0.839	0.98
109_L	144_Y	0.837	0.98
140_G	154_F	0.835	0.98
225_I	228_K	0.832	0.98
71_I	119_K	0.819	0.98
106_E	143_R	0.810	0.98
217_E	221_E	0.809	0.98
5_K	12_K	0.808	0.98
48_L	160_T	0.806	0.98
233_I	236_V	0.802	0.98
13_D	20_E	0.797	0.98
231_K	235_N	0.797	0.98
117_R	206_A	0.793	0.98
28_Q	36_V	0.792	0.98
44_E	156_I	0.789	0.97
62_K	119_K	0.789	0.97
2_L	6_E	0.782	0.97
179_K	183_M	0.779	0.97
227_K	230_E	0.778	0.97
86_G	162_L	0.777	0.97
13_D	36_V	0.775	0.97
5_K	43_E	0.772	0.97
52_P	55_F	0.770	0.97
106_E	133_K	0.770	0.97
209_E	235_N	0.767	0.97
62_K	118_E	0.765	0.97
156_I	160_T	0.764	0.97
225_I	230_E	0.763	0.97
202_Q	205_E	0.760	0.97
206_A	210_K	0.758	0.97
220_K	228_K	0.756	0.97
17_Q	25_K	0.754	0.97
174_A	177_E	0.750	0.97
103_K	130_L	0.748	0.96
29_S	33_Q	0.742	0.96
177_E	180_G	0.742	0.96
209_E	213_T	0.741	0.96
3_K	8_E	0.737	0.96
123_Y	162_L	0.733	0.96
221_E	226_W	0.732	0.96
51_F	163_R	0.731	0.96
154_F	157_P	0.728	0.96
222_L	229_R	0.728	0.96
45_L	58_I	0.727	0.96
237_R	241_A	0.721	0.96
221_E	229_R	0.721	0.96
112_L	116_R	0.721	0.96
140_G	151_R	0.719	0.96
234_E	237_R	0.719	0.96
215_I	230_E	0.718	0.96
223_Q	242_G	0.717	0.96
35_E	63_K	0.713	0.95
44_E	48_L	0.709	0.95
197_G	200_F	0.703	0.95
237_R	240_T	0.701	0.95
248_A	251_I	0.697	0.95
178_G	181_E	0.695	0.95
116_R	122_E	0.695	0.95
71_I	121_A	0.694	0.95
8_E	15_D	0.693	0.95
183_M	187_Y	0.693	0.95
177_E	181_E	0.689	0.94
157_P	160_T	0.687	0.94
131_E	149_V	0.682	0.94
230_E	234_E	0.676	0.94
198_N	202_Q	0.675	0.94
23_R	27_E	0.673	0.94
106_E	109_L	0.669	0.94
172_A	176_L	0.664	0.93
13_D	32_L	0.654	0.93
35_E	42_E	0.651	0.93
241_A	244_Y	0.649	0.93
25_K	28_Q	0.649	0.93
113_K	117_R	0.647	0.92
35_E	39_L	0.645	0.92
172_A	175_E	0.642	0.92
131_E	151_R	0.637	0.92
134_D	139_E	0.637	0.92
207_I	236_V	0.637	0.92
211_F	215_I	0.632	0.92
10_Q	17_Q	0.627	0.91
65_S	118_E	0.626	0.91
85_C	173_K	0.624	0.91
43_E	134_D	0.621	0.91
69_D	93_K	0.620	0.91
8_E	11_L	0.617	0.91
211_F	240_T	0.615	0.90
245_G	248_A	0.614	0.90
101_T	130_L	0.613	0.90
219_D	223_Q	0.612	0.90
15_D	27_E	0.612	0.90
224_K	227_K	0.610	0.90
230_E	233_I	0.610	0.90
101_T	108_W	0.608	0.90
33_Q	43_E	0.608	0.90
171_K	175_E	0.603	0.90
103_K	107_D	0.600	0.89
234_E	246_N	0.598	0.89
247_K	254_K	0.597	0.89
55_F	78_R	0.597	0.89
46_N	56_D	0.595	0.89
13_D	31_Q	0.595	0.89
48_L	52_P	0.594	0.89
107_D	110_K	0.589	0.88
148_W	160_T	0.587	0.88
79_N	171_K	0.587	0.88
165_A	168_N	0.584	0.88
86_G	166_L	0.583	0.88
123_Y	165_A	0.581	0.88
175_E	182_K	0.580	0.88
146_G	205_E	0.580	0.88
217_E	225_I	0.579	0.88
236_V	240_T	0.577	0.87
51_F	156_I	0.577	0.87
81_S	174_A	0.571	0.87
2_L	9_K	0.571	0.87
70_Y	92_S	0.570	0.87
9_K	17_Q	0.566	0.86
110_K	145_D	0.565	0.86
170_L	174_A	0.565	0.86
83_Q	170_L	0.565	0.86
168_N	172_A	0.565	0.86
104_W	108_W	0.564	0.86
76_Q	85_C	0.563	0.86
178_G	182_K	0.562	0.86
55_F	79_N	0.562	0.86
246_N	252_T	0.562	0.86
247_K	250_D	0.561	0.86
88_I	125_V	0.561	0.86
37_L	40_H	0.558	0.86
66_R	223_Q	0.558	0.86
34_G	69_D	0.555	0.85
197_G	201_R	0.552	0.85
204_V	240_T	0.551	0.85
35_E	60_E	0.550	0.85
183_M	190_L	0.548	0.85
104_W	128_S	0.547	0.84
90_F	125_V	0.544	0.84
61_V	67_G	0.544	0.84
85_C	120_K	0.542	0.84
250_D	254_K	0.542	0.84
87_S	122_E	0.541	0.84
208_V	233_I	0.539	0.84
47_K	139_E	0.539	0.84
162_L	165_A	0.537	0.83
117_R	205_E	0.536	0.83
240_T	244_Y	0.535	0.83
141_F	157_P	0.535	0.83
175_E	180_G	0.534	0.83
143_R	149_V	0.534	0.83
38_E	93_K	0.534	0.83
215_I	237_R	0.533	0.83
176_L	188_N	0.528	0.82
151_R	155_F	0.527	0.82
39_L	63_K	0.527	0.82
246_N	251_I	0.527	0.82
203_N	210_K	0.527	0.82
32_L	40_H	0.524	0.82
11_L	15_D	0.524	0.82
2_L	7_K	0.523	0.82
40_H	152_P	0.522	0.82
206_A	239_A	0.520	0.81
22_K	26_A	0.520	0.81
25_K	29_S	0.518	0.81
134_D	142_G	0.518	0.81
43_E	46_N	0.515	0.81
170_L	173_K	0.515	0.81
245_G	250_D	0.515	0.81
199_E	238_L	0.513	0.81
140_G	153_Q	0.512	0.80
109_L	149_V	0.512	0.80
34_G	38_E	0.510	0.80
214_M	221_E	0.510	0.80
111_K	114_K	0.510	0.80
38_E	69_D	0.509	0.80
246_N	254_K	0.509	0.80
65_S	119_K	0.507	0.80
176_L	180_G	0.506	0.80
157_P	161_L	0.506	0.80
110_K	235_N	0.505	0.80
249_Q	253_I	0.501	0.79
182_K	187_Y	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y88A	5	0.6525	91.1	0.908	Contact Map
4oc8A	4	0.6332	85.3	0.917	Contact Map
4f0qA	4	0.7027	85.2	0.917	Contact Map
1xmxA	2	0.6139	53.8	0.935	Contact Map
3ziaJ	1	0	11.5	0.953	Contact Map
1ug7A	1	0.2317	10.4	0.954	Contact Map
3bm3A	2	0.6911	9.8	0.955	Contact Map
2gb7A	2	0.7683	9.6	0.955	Contact Map
1gmjA	2	0.1313	8.7	0.956	Contact Map
3zifN	3	0.1313	6.6	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.