GREMLIN Database
DUF2127 - Predicted membrane protein (DUF2127)
PFAM: PF09900 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (136)
Sequences: 11744 (7873)
Seq/√Len: 675.1
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_V90_L3.9051.00
13_G82_L2.6971.00
6_A89_W2.5211.00
114_L123_V2.4521.00
118_P123_V2.3891.00
50_R54_H2.3551.00
102_A105_L2.3141.00
114_L118_P2.1681.00
119_S122_K2.1481.00
20_G75_L2.0581.00
10_L85_G2.0041.00
99_T136_L1.9721.00
33_A37_E1.9621.00
134_V138_R1.9471.00
104_A133_V1.9291.00
17_L78_A1.8681.00
100_I137_L1.8521.00
63_T66_T1.8181.00
120_W124_A1.7681.00
113_E122_K1.7511.00
8_F12_K1.7361.00
54_H58_K1.7251.00
24_L71_A1.6871.00
65_S69_F1.6811.00
21_I25_L1.6721.00
88_L99_T1.6691.00
107_I130_L1.6341.00
114_L126_L1.6101.00
68_R72_A1.5241.00
112_Y116_R1.5151.00
34_D38_R1.5011.00
58_K61_H1.4741.00
117_R122_K1.4071.00
100_I136_L1.4041.00
79_A83_V1.3481.00
20_G24_L1.3421.00
23_L74_A1.3331.00
121_L124_A1.3161.00
34_D37_E1.2791.00
57_D60_S1.2671.00
42_E45_L1.2631.00
38_R42_E1.2591.00
113_E117_R1.2481.00
69_F73_G1.2171.00
35_L38_R1.2031.00
54_H57_D1.1981.00
120_W123_V1.1881.00
57_D61_H1.1751.00
4_L7_L1.1751.00
107_I133_V1.1611.00
100_I133_V1.1581.00
37_E41_R1.1531.00
80_L102_A1.1481.00
64_P68_R1.1371.00
87_G92_K1.1061.00
51_F55_L1.1001.00
53_R57_D1.0991.00
52_A55_L1.0881.00
66_T69_F1.0871.00
7_L11_L1.0841.00
18_A22_G1.0831.00
123_V127_V1.0801.00
114_L117_R1.0611.00
111_I115_V1.0501.00
6_A85_G1.0481.00
110_E126_L1.0321.00
51_F54_H1.0141.00
78_A82_L1.0121.00
14_L82_L1.0101.00
93_R96_E1.0071.00
115_V118_P0.9991.00
100_I104_A0.9981.00
65_S68_R0.9951.00
13_G17_L0.9831.00
6_A10_L0.9811.00
2_L91_R0.9721.00
103_T133_V0.9661.00
83_V98_L0.9651.00
19_L74_A0.9581.00
98_L102_A0.9341.00
27_L68_R0.9321.00
3_R89_W0.9321.00
112_Y115_V0.9251.00
9_K16_L0.9191.00
81_K105_L0.9181.00
130_L134_V0.9161.00
111_I126_L0.9121.00
99_T103_T0.9111.00
47_P51_F0.9081.00
30_R34_D0.9051.00
105_L109_L0.9031.00
4_L8_F0.9021.00
79_A82_L0.9011.00
98_L101_I0.8981.00
23_L26_L0.8981.00
49_D52_A0.8981.00
83_V87_G0.8821.00
118_P122_K0.8801.00
56_L59_A0.8741.00
19_L22_G0.8581.00
23_L70_L0.8551.00
55_L58_K0.8551.00
20_G71_A0.8481.00
12_K15_L0.8451.00
36_A59_A0.8391.00
16_L74_A0.8311.00
97_W101_I0.8301.00
6_A9_K0.8231.00
83_V95_A0.8191.00
39_L43_L0.8181.00
37_E40_A0.8131.00
72_A76_A0.8081.00
82_L86_V0.8061.00
31_D34_D0.8061.00
37_E60_S0.8021.00
39_L42_E0.8001.00
113_E116_R0.7961.00
9_K12_K0.7941.00
5_I132_I0.7821.00
124_A128_V0.7611.00
16_L81_K0.7591.00
38_R41_R0.7581.00
107_I126_L0.7571.00
112_Y122_K0.7551.00
13_G85_G0.7541.00
49_D53_R0.7501.00
30_R35_L0.7461.00
12_K81_K0.7431.00
22_G25_L0.7391.00
74_A81_K0.7381.00
92_K95_A0.7371.00
56_L60_S0.7361.00
116_R122_K0.7351.00
2_L96_E0.7251.00
10_L82_L0.7221.00
6_A88_L0.7101.00
3_R7_L0.7041.00
13_G78_A0.7021.00
121_L125_L0.6981.00
24_L28_H0.6981.00
86_V92_K0.6931.00
102_A106_F0.6871.00
40_A44_H0.6831.00
55_L59_A0.6751.00
33_A60_S0.6741.00
10_L95_A0.6701.00
11_L15_L0.6631.00
32_L35_L0.6621.00
71_A75_L0.6561.00
3_R6_A0.6561.00
80_L98_L0.6471.00
75_L79_A0.6391.00
17_L75_L0.6381.00
20_G74_A0.6361.00
101_I105_L0.6331.00
36_A40_A0.6321.00
8_F81_K0.6291.00
24_L75_L0.6261.00
41_R45_L0.6181.00
76_A81_K0.6161.00
122_K135_Y0.6081.00
69_F72_A0.6041.00
35_L39_L0.6041.00
107_I111_I0.6001.00
25_L28_H0.5991.00
15_L19_L0.5981.00
62_L67_L0.5951.00
127_V131_A0.5941.00
11_L14_L0.5901.00
21_I24_L0.5871.00
110_E125_L0.5831.00
91_R96_E0.5801.00
45_L48_D0.5791.00
7_L10_L0.5751.00
58_K62_L0.5751.00
32_L36_A0.5751.00
46_D49_D0.5751.00
39_L44_H0.5681.00
16_L106_F0.5671.00
14_L18_A0.5661.00
64_P67_L0.5641.00
27_L30_R0.5621.00
78_A81_K0.5611.00
44_H47_P0.5601.00
126_L130_L0.5591.00
129_N135_Y0.5541.00
33_A36_A0.5541.00
84_E99_T0.5521.00
31_D35_L0.5501.00
68_R71_A0.5411.00
47_P55_L0.5391.00
5_I12_K0.5281.00
132_I135_Y0.5261.00
125_L128_V0.5240.99
10_L89_W0.5230.99
3_R91_R0.5210.99
83_V90_L0.5190.99
108_P129_N0.5180.99
27_L31_D0.5130.99
20_G78_A0.5110.99
76_A102_A0.5040.99
25_L30_R0.5020.99
10_L14_L0.5000.99
43_L47_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w5aC 1 0.2071 3.9 0.93 Contact Map
3rlfF 1 0.3357 3.8 0.93 Contact Map
1b9uA 1 0.1714 2.1 0.939 Contact Map
3wu2A 1 0.6643 1.3 0.945 Contact Map
4mo1A 1 0.4 1.3 0.946 Contact Map
1fftB 1 0.3071 1.2 0.947 Contact Map
1x9gA 3 0.4786 1.2 0.947 Contact Map
3j08A 2 0.4786 1.2 0.947 Contact Map
1iijA 1 0.25 1.1 0.949 Contact Map
1orqC 4 0.3857 1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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