GREMLIN Database
DUF2126 - Putative amidoligase enzyme (DUF2126)
PFAM: PF09899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 818 (817)
Sequences: 2573 (1510)
Seq/√Len: 52.8
META: 0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_E402_D4.7921.00
130_I349_L4.6041.00
44_D627_Y4.3551.00
442_L582_V4.3271.00
154_F358_T4.2201.00
508_I523_L4.1741.00
398_A407_N3.9751.00
460_R505_F3.9311.00
154_F158_L3.8901.00
152_E156_E3.8871.00
147_T150_D3.8701.00
465_Y621_D3.7821.00
490_V501_L3.7011.00
133_D360_A3.6861.00
44_D587_R3.6261.00
774_T781_E3.5451.00
410_T414_E3.5001.00
113_P201_E3.4241.00
86_D418_S3.3571.00
471_S615_F3.2351.00
738_I741_H3.2021.00
655_L748_L3.1541.00
172_A254_M3.1371.00
413_E417_Q3.0591.00
226_R347_D3.0171.00
155_L169_V2.9911.00
584_R625_A2.9781.00
178_Y181_W2.9741.00
463_I523_L2.9291.00
414_E417_Q2.8961.00
45_L50_V2.8841.00
339_M348_Y2.8401.00
219_G254_M2.8191.00
496_D811_F2.8041.00
155_L328_V2.7991.00
125_K380_N2.7461.00
64_D419_R2.7081.00
525_N528_V2.5801.00
645_Y659_Q2.5621.00
94_R414_E2.5551.00
452_F557_L2.5361.00
224_L326_L2.5271.00
94_R410_T2.5191.00
79_T82_E2.5181.00
28_D569_R2.5151.00
69_A74_A2.4991.00
706_R805_E2.4801.00
100_L352_V2.4711.00
172_A245_L2.4621.00
619_L631_P2.4551.00
161_R357_A2.4431.00
63_I416_R2.4381.00
551_T554_L2.4111.00
328_V337_V2.3841.00
128_E288_D2.3711.00
121_L382_L2.3671.00
35_D39_E2.3541.00
726_R729_Q2.3511.00
240_L245_L2.3491.00
648_V655_L2.3431.00
600_E604_R2.3401.00
48_G587_R2.3321.00
161_R361_E2.2981.00
619_L623_R2.2851.00
150_D153_R2.2781.00
691_V694_L2.2771.00
221_V254_M2.2571.00
33_A630_D2.2541.00
464_T468_N2.2481.00
647_E654_E2.2371.00
707_R803_P2.2311.00
70_E79_T2.2291.00
199_D202_E2.2061.00
656_E688_Q2.1731.00
172_A221_V2.1721.00
157_A361_E2.1681.00
35_D405_V2.1681.00
701_V748_L2.1671.00
355_I366_V2.1661.00
596_R810_E2.1631.00
62_S83_L2.1461.00
612_W635_A2.0921.00
745_V761_T2.0881.00
803_P806_E2.0861.00
63_I419_R2.0681.00
144_Y334_R2.0521.00
151_A220_Y2.0481.00
723_V746_F2.0471.00
467_Q498_L2.0321.00
51_R449_D2.0191.00
468_N590_Y2.0191.00
90_R414_E2.0171.00
481_I661_L2.0071.00
337_V355_I1.9961.00
345_L379_L1.9951.00
612_W616_L1.9691.00
670_E732_S1.9631.00
396_H407_N1.9581.00
283_R377_P1.9521.00
581_L585_F1.9481.00
654_E692_T1.9461.00
26_Y636_P1.9341.00
85_D119_L1.9321.00
508_I522_L1.9281.00
65_D68_G1.9251.00
49_D449_D1.9120.99
701_V710_L1.9120.99
460_R464_T1.9000.99
90_R417_Q1.8920.99
407_N410_T1.8870.99
539_F557_L1.8840.99
158_L358_T1.8760.99
63_I421_G1.8600.99
41_V580_A1.8580.99
772_Y784_S1.8530.99
120_S383_K1.8450.99
149_E152_E1.8410.99
615_F619_L1.8390.99
221_V245_L1.8370.99
280_F448_A1.8280.99
277_R281_A1.8240.99
195_S210_F1.8230.99
352_V368_I1.8230.99
44_D48_G1.8060.99
170_Q245_L1.8000.99
395_I407_N1.7980.99
714_G718_E1.7950.99
74_A77_G1.7890.99
196_K210_F1.7880.99
726_R733_A1.7820.99
254_M327_C1.7820.99
749_V800_M1.7800.99
655_L701_V1.7750.99
50_V582_V1.7630.99
623_R628_P1.7590.99
701_V708_V1.7570.99
62_S68_G1.7550.99
691_V710_L1.7300.99
85_D89_R1.7300.99
168_Y235_S1.7240.99
27_T30_Q1.7130.99
157_A161_R1.7130.99
607_L722_G1.7120.99
612_W638_F1.6960.99
460_R591_R1.6910.99
88_I121_L1.6720.99
497_S528_V1.6690.99
43_A47_A1.6690.99
464_T505_F1.6680.99
700_V751_T1.6490.98
754_G799_P1.6480.98
159_A169_V1.6470.98
653_V699_H1.6450.98
726_R740_V1.6320.98
66_M421_G1.6320.98
427_L775_F1.6310.98
525_N667_L1.6210.98
623_R630_D1.6200.98
182_K202_E1.6010.98
266_V271_Y1.5960.98
559_F578_L1.5950.98
568_A571_S1.5880.98
407_N411_L1.5820.98
161_R358_T1.5820.98
358_T362_L1.5780.98
280_F545_Y1.5720.98
632_E635_A1.5710.98
88_I384_V1.5690.98
70_E78_P1.5670.98
146_A364_L1.5670.98
189_N265_W1.5670.98
671_G677_V1.5670.98
649_E654_E1.5640.98
26_Y34_I1.5540.98
170_Q240_L1.5510.98
510_R591_R1.5340.97
587_R627_Y1.5340.97
100_L368_I1.5330.97
584_R622_L1.5270.97
464_T594_L1.5210.97
468_N592_G1.5190.97
137_I367_V1.5180.97
83_L86_D1.5180.97
695_T699_H1.5040.97
85_D140_E1.5020.97
426_M479_L1.4980.97
648_V748_L1.4810.97
584_R621_D1.4780.97
708_V721_A1.4750.97
280_F447_P1.4740.97
34_I573_A1.4710.97
620_A624_A1.4610.97
715_T809_P1.4610.97
502_E596_R1.4590.97
702_T749_V1.4520.96
442_L452_F1.4450.96
440_V575_Q1.4440.96
644_R647_E1.4420.96
707_R805_E1.4400.96
193_L244_R1.4380.96
519_V523_L1.4270.96
64_D83_L1.4240.96
653_V748_L1.4240.96
164_L168_Y1.4210.96
336_Y367_V1.4180.96
475_L611_V1.4150.96
613_Q652_G1.4080.96
339_M368_I1.4080.96
498_L501_L1.4070.96
616_L631_P1.4000.96
609_H690_K1.3990.96
408_T571_S1.3970.96
177_W181_W1.3970.96
689_V701_V1.3910.95
571_S575_Q1.3790.95
610_F711_Q1.3770.95
339_M352_V1.3760.95
460_R508_I1.3740.95
427_L774_T1.3690.95
79_T83_L1.3670.95
729_Q733_A1.3600.95
158_L326_L1.3600.95
706_R806_E1.3600.95
143_D334_R1.3400.94
67_D775_F1.3350.94
622_L629_F1.3320.94
3_C9_F1.3300.94
65_D79_T1.3280.94
595_V695_T1.3260.94
226_R350_E1.3250.94
132_R357_A1.3240.94
157_A160_E1.3230.94
85_D103_Y1.3210.94
690_K718_E1.3190.94
409_E569_R1.3140.94
711_Q813_F1.3120.94
266_V272_P1.3080.94
449_D454_R1.3060.94
584_R588_E1.3050.94
155_L220_Y1.3020.94
205_R251_D1.3000.94
136_L363_G1.2970.93
384_V391_I1.2970.93
150_D364_L1.2960.93
715_T718_E1.2950.93
342_L355_I1.2880.93
312_P317_S1.2840.93
725_Y742_A1.2770.93
441_V452_F1.2740.93
546_S552_G1.2710.93
747_D795_H1.2700.93
409_E568_A1.2690.93
623_R631_P1.2660.93
88_I382_L1.2640.93
749_V803_P1.2580.92
122_Y372_P1.2570.92
89_R101_L1.2570.92
610_F813_F1.2560.92
600_E716_A1.2560.92
505_F523_L1.2510.92
267_P270_D1.2490.92
146_A365_P1.2480.92
628_P631_P1.2440.92
277_R283_R1.2440.92
583_A627_Y1.2420.92
84_A391_I1.2400.92
606_M661_L1.2400.92
465_Y584_R1.2400.92
707_R806_E1.2350.92
700_V707_R1.2330.92
217_P220_Y1.2260.91
749_V802_P1.2260.91
48_G583_A1.2240.91
462_L582_V1.2240.91
191_D244_R1.2220.91
653_V757_L1.2190.91
118_A385_T1.2180.91
130_I352_V1.2140.91
507_Q737_T1.2130.91
243_G246_F1.2130.91
742_A765_A1.2060.91
148_A216_K1.2050.91
113_P209_V1.2040.91
334_R367_V1.2030.91
46_A400_S1.1990.90
40_Q44_D1.1940.90
726_R739_G1.1930.90
225_Q234_R1.1910.90
178_Y182_K1.1870.90
139_D142_K1.1860.90
667_L677_V1.1860.90
621_D753_N1.1850.90
40_Q43_A1.1850.90
236_G322_V1.1850.90
192_P197_L1.1830.90
754_G801_A1.1780.90
707_R804_P1.1660.89
573_A634_F1.1650.89
239_F243_G1.1630.89
100_L339_M1.1620.89
64_D68_G1.1610.89
276_P551_T1.1600.89
588_E624_A1.1590.89
430_R479_L1.1530.89
715_T808_N1.1450.88
139_D367_V1.1430.88
278_D281_A1.1350.88
184_R211_E1.1340.88
706_R803_P1.1270.87
236_G239_F1.1240.87
146_A150_D1.1240.87
310_R320_G1.1240.87
508_I514_P1.1220.87
81_R119_L1.1220.87
49_D454_R1.1210.87
37_L629_F1.1180.87
265_W268_P1.1170.87
155_L326_L1.1170.87
316_E320_G1.1140.87
132_R360_A1.1140.87
148_A330_P1.1130.87
133_D136_L1.1130.87
158_L328_V1.1120.87
462_L578_L1.1110.87
181_W185_R1.1110.87
780_Y784_S1.0980.86
184_R207_A1.0980.86
609_H613_Q1.0960.86
770_R788_A1.0960.86
81_R140_E1.0880.86
729_Q739_G1.0860.85
621_D625_A1.0850.85
195_S206_L1.0840.85
612_W631_P1.0800.85
345_L349_L1.0800.85
142_K145_G1.0790.85
505_F737_T1.0790.85
441_V637_H1.0790.85
195_S207_A1.0780.85
160_E166_P1.0770.85
765_A771_N1.0730.85
772_Y788_A1.0720.85
771_N788_A1.0710.85
432_T487_A1.0710.85
400_S403_E1.0690.84
493_A497_S1.0660.84
763_H791_F1.0650.84
464_T522_L1.0640.84
118_A383_K1.0590.84
130_I379_L1.0590.84
406_E410_T1.0570.84
86_D90_R1.0560.84
198_D215_D1.0550.84
756_S800_M1.0550.84
344_R347_D1.0550.84
83_L418_S1.0540.84
326_L355_I1.0520.84
701_V723_V1.0510.83
375_R382_L1.0500.83
467_Q594_L1.0500.83
661_L787_L1.0480.83
193_L246_F1.0460.83
146_A336_Y1.0450.83
691_V701_V1.0450.83
770_R773_D1.0450.83
245_L254_M1.0440.83
617_D752_W1.0420.83
88_I103_Y1.0400.83
231_P347_D1.0390.83
26_Y30_Q1.0380.83
221_V325_A1.0360.83
212_R218_V1.0360.83
507_Q510_R1.0320.82
179_Y182_K1.0320.82
350_E354_A1.0310.82
277_R344_R1.0300.82
68_G79_T1.0300.82
26_Y637_H1.0290.82
464_T508_I1.0290.82
92_R134_P1.0260.82
458_L523_L1.0260.82
467_Q595_V1.0230.82
62_S421_G1.0220.82
796_T800_M1.0210.82
742_A764_V1.0200.82
156_E166_P1.0190.82
406_E409_E1.0160.81
133_D363_G1.0160.81
76_L118_A1.0140.81
35_D402_D1.0120.81
317_S320_G1.0090.81
740_V765_A1.0080.81
218_V254_M1.0050.81
73_T77_G1.0030.80
165_D168_Y1.0000.80
411_L422_T0.9990.80
348_Y368_I0.9980.80
88_I101_L0.9980.80
462_L559_F0.9950.80
190_V195_S0.9940.80
105_Q108_W0.9930.80
702_T802_P0.9930.80
465_Y625_A0.9920.80
76_L119_L0.9900.80
613_Q616_L0.9890.80
172_A240_L0.9880.79
649_E652_G0.9830.79
35_D573_A0.9830.79
399_A403_E0.9830.79
50_V586_W0.9830.79
185_R242_R0.9820.79
475_L615_F0.9820.79
179_Y209_V0.9800.79
19_D661_L0.9800.79
653_V691_V0.9800.79
708_V748_L0.9800.79
648_V758_G0.9790.79
32_A35_D0.9750.79
580_A629_F0.9750.79
516_P563_E0.9730.78
595_V752_W0.9690.78
63_I83_L0.9650.78
546_S551_T0.9650.78
657_L687_L0.9650.78
119_L367_V0.9640.78
611_V642_F0.9640.78
5_V9_F0.9620.78
240_L243_G0.9610.78
284_P287_P0.9610.78
395_I398_A0.9610.78
205_R209_V0.9600.77
90_R413_E0.9590.77
95_F410_T0.9590.77
51_R454_R0.9560.77
438_N571_S0.9510.77
713_T718_E0.9490.77
656_E690_K0.9490.77
770_R774_T0.9480.77
426_M430_R0.9470.77
68_G77_G0.9460.76
672_A677_V0.9450.76
726_R741_H0.9420.76
153_R362_L0.9410.76
164_L350_E0.9410.76
122_Y345_L0.9410.76
561_A578_L0.9380.76
683_S733_A0.9370.76
380_N399_A0.9360.76
729_Q738_I0.9320.75
761_T792_P0.9320.75
490_V498_L0.9300.75
154_F364_L0.9280.75
144_Y365_P0.9220.75
495_H665_H0.9220.75
36_A40_Q0.9220.75
679_Y730_P0.9210.74
270_D661_L0.9200.74
464_T523_L0.9180.74
211_E242_R0.9170.74
164_L224_L0.9160.74
708_V723_V0.9150.74
62_S419_R0.9130.74
92_R99_G0.9120.74
151_A330_P0.9110.74
22_V30_Q0.9060.73
405_V409_E0.9010.73
180_L197_L0.9000.73
731_P765_A0.8990.73
729_Q740_V0.8970.73
278_D550_P0.8960.72
19_D787_L0.8960.72
83_L419_R0.8960.72
154_F359_A0.8950.72
43_A46_A0.8930.72
619_L628_P0.8920.72
587_R625_A0.8920.72
531_T537_A0.8890.72
184_R242_R0.8880.72
202_E205_R0.8840.71
194_D207_A0.8830.71
194_D210_F0.8830.71
772_Y781_E0.8820.71
414_E418_S0.8820.71
651_G696_P0.8820.71
518_L522_L0.8790.71
44_D580_A0.8790.71
94_R406_E0.8780.71
270_D318_A0.8760.71
454_R586_W0.8720.70
360_A363_G0.8700.70
483_P665_H0.8700.70
293_A297_A0.8700.70
277_R346_E0.8670.70
441_V575_Q0.8640.70
193_L215_D0.8630.70
477_S611_V0.8630.70
140_E367_V0.8600.69
647_E792_P0.8580.69
474_Y601_L0.8560.69
401_W572_L0.8550.69
458_L463_I0.8550.69
130_I345_L0.8540.69
76_L81_R0.8540.69
692_T718_E0.8520.69
375_R383_K0.8500.68
157_A358_T0.8480.68
707_R751_T0.8450.68
143_D146_A0.8450.68
68_G78_P0.8440.68
342_L345_L0.8430.68
226_R231_P0.8420.68
189_N266_V0.8410.68
677_V771_N0.8400.67
426_M775_F0.8390.67
247_L254_M0.8380.67
310_R316_E0.8370.67
802_P807_P0.8360.67
597_W605_F0.8360.67
204_A210_F0.8350.67
166_P169_V0.8350.67
289_A292_A0.8340.67
464_T467_Q0.8330.67
95_F396_H0.8320.67
771_N784_S0.8320.67
471_S619_L0.8310.67
380_N403_E0.8310.67
35_D572_L0.8290.66
76_L79_T0.8290.66
525_N732_S0.8290.66
814_T817_L0.8280.66
227_W234_R0.8270.66
650_V758_G0.8220.66
716_A810_E0.8220.66
601_L605_F0.8220.66
427_L771_N0.8210.66
204_A207_A0.8190.65
770_R777_V0.8180.65
26_Y573_A0.8180.65
694_L710_L0.8160.65
346_E378_R0.8150.65
200_P204_A0.8150.65
507_Q511_P0.8140.65
158_L224_L0.8130.65
671_G674_G0.8130.65
312_P315_G0.8130.65
605_F611_V0.8130.65
67_D72_N0.8120.65
169_V328_V0.8120.65
814_T818_R0.8120.65
497_S526_L0.8110.65
147_T330_P0.8110.65
91_L382_L0.8090.65
177_W207_A0.8070.64
81_R85_D0.8050.64
280_F375_R0.8040.64
463_I537_A0.8040.64
197_L207_A0.8030.64
784_S787_L0.8030.64
62_S65_D0.8010.64
644_R688_Q0.8010.64
145_G334_R0.8010.64
102_H339_M0.8000.64
431_H434_T0.7990.64
791_F794_G0.7970.63
515_P523_L0.7970.63
593_P697_G0.7970.63
291_A294_A0.7960.63
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207_A242_R0.5200.35
749_V756_S0.5200.35
761_T793_H0.5200.35
253_P331_R0.5200.35
28_D43_A0.5190.35
148_A212_R0.5190.35
667_L735_H0.5190.35
33_A40_Q0.5180.35
92_R103_Y0.5180.35
73_T84_A0.5180.35
11_M441_V0.5180.35
276_P549_S0.5170.35
148_A406_E0.5170.35
418_S537_A0.5170.35
121_L181_W0.5170.35
689_V760_C0.5170.35
400_S404_L0.5160.35
396_H414_E0.5160.35
403_E406_E0.5160.35
88_I137_I0.5160.35
178_Y249_P0.5160.35
550_P559_F0.5150.35
239_F267_P0.5150.35
137_I140_E0.5140.34
490_V499_Y0.5140.34
327_C336_Y0.5140.34
424_K525_N0.5140.34
35_D90_R0.5140.34
648_V791_F0.5130.34
396_H810_E0.5130.34
84_A87_L0.5120.34
697_G751_T0.5120.34
209_V212_R0.5120.34
148_A326_L0.5120.34
243_G261_D0.5110.34
160_E361_E0.5110.34
18_E434_T0.5110.34
220_Y582_V0.5110.34
139_D143_D0.5090.34
41_V65_D0.5090.34
463_I498_L0.5090.34
460_R496_D0.5090.34
584_R647_E0.5090.34
651_G748_L0.5090.34
620_A623_R0.5090.34
242_R441_V0.5090.34
320_G522_L0.5080.34
130_I515_P0.5080.34
382_L613_Q0.5080.34
422_T464_T0.5080.34
138_A151_A0.5080.34
457_D511_P0.5070.34
76_L201_E0.5070.34
135_A363_G0.5070.34
236_G615_F0.5070.34
34_I619_L0.5070.34
237_P557_L0.5060.34
537_A549_S0.5060.34
561_A621_D0.5060.34
88_I97_P0.5060.34
766_H769_G0.5060.34
305_A368_I0.5050.34
224_L342_L0.5050.34
185_R212_R0.5050.34
164_L228_Q0.5050.34
310_R315_G0.5040.33
590_Y617_D0.5040.33
185_R239_F0.5040.33
575_Q615_F0.5030.33
471_S611_V0.5020.33
637_H671_G0.5020.33
487_A592_G0.5020.33
699_H807_P0.5020.33
545_Y652_G0.5020.33
46_A655_L0.5010.33
467_Q495_H0.5010.33
326_L339_M0.5010.33
323_R383_K0.5000.33
70_E114_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcbA 1 0.0538 59.3 0.991 Contact Map
3mceA 2 0.0623 45.2 0.992 Contact Map
3npeA 1 0.1394 43.1 0.992 Contact Map
4bolA 2 0.1919 40.7 0.992 Contact Map
1r8gA 2 0.401 33.8 0.992 Contact Map
2y3sA 2 0.1357 30.3 0.993 Contact Map
1w1oA 1 0.1149 20.5 0.993 Contact Map
4u5rA 3 0.1443 19.5 0.993 Contact Map
4mlaA 1 0.1222 19.4 0.993 Contact Map
4ijrA 2 0.0807 17.9 0.993 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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