DUF2126 - PFAM28P - GREMLIN Contacts

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DUF2126 - Putative amidoligase enzyme (DUF2126)

PFAM:	PF09899	Sequences: DPCEVEFEFEMSVTRIHEDPRVTKPYTDEQWAAIDALGEQVDADLAAGDVRLTMGGEPTFVSIDDMDGAEWNTAALGPTKRELADDLIRRLRDRFAPGGLLHYGQGKWYPGEPLPRWALSLYWRKDGEPIWRDPALIADERKDYGATAEDAERFLEALAERLGLDPDYVQPAYEDPWYYLWKERRLPVNVDPLDSKLDDPEERARLARVFERGLDKPVGYVLPLQRWQAGPRWRSGPWFLRRGRLFLIPGDSPMGLRLPLDSLPWVPPEDYPYIHPRDPFAPRPPLPDAAAAAAAAAAAAAAAAAAAAARAPARGESAAGVVRTALCVEPRDGRLYVFMPPLERLEDYLELVAAIEATAAELGLPVVIEGYPPPRDPRLNVLKVTPDPGVIEVNIHPAASWDELVENTETLYEEARQSRLGTEKFMLDGRHTGTGGGNHVVLGGATPADSPFLRRPDLLRSLITYWQNHPSLSYLFSGLFIGPTSQAPRVDEARHDSLYELEIAFAQIPRPEPPPPWLVDRLLRNLLVDVTGNTHRAEFCIDKLYSPDSPTGRLGLLEFRAFEMPPHARMSLAQQLLLRALVARFWREPYRGPLVRWGTELHDRFMLPHFVWQDFLDVLADLRAAGYPFDPEWFAPHFEFRFPRYGEVEVGGVELELRQALEPWHVLGEEGAAGGTVRYVDSSVERLQVKVTGLTPGRHVVTCNGRRVPLQPTGTAGEFVAGVRYRAWQPPSALHPTIGVHAPLVFDLVDTWNGRSLGGCTYHVAHPGGRNYDTFPVNAYEAESRRLARFFPHGHTPGPMAPPPEEPNPEFPFTLDLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	818 (817)
Sequences:	2573 (1510)
Seq/√Len:	52.8
META:	0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_E	402_D	4.792	1.00
130_I	349_L	4.604	1.00
44_D	627_Y	4.355	1.00
442_L	582_V	4.327	1.00
154_F	358_T	4.220	1.00
508_I	523_L	4.174	1.00
398_A	407_N	3.975	1.00
460_R	505_F	3.931	1.00
154_F	158_L	3.890	1.00
152_E	156_E	3.887	1.00
147_T	150_D	3.870	1.00
465_Y	621_D	3.782	1.00
490_V	501_L	3.701	1.00
133_D	360_A	3.686	1.00
44_D	587_R	3.626	1.00
774_T	781_E	3.545	1.00
410_T	414_E	3.500	1.00
113_P	201_E	3.424	1.00
86_D	418_S	3.357	1.00
471_S	615_F	3.235	1.00
738_I	741_H	3.202	1.00
655_L	748_L	3.154	1.00
172_A	254_M	3.137	1.00
413_E	417_Q	3.059	1.00
226_R	347_D	3.017	1.00
155_L	169_V	2.991	1.00
584_R	625_A	2.978	1.00
178_Y	181_W	2.974	1.00
463_I	523_L	2.929	1.00
414_E	417_Q	2.896	1.00
45_L	50_V	2.884	1.00
339_M	348_Y	2.840	1.00
219_G	254_M	2.819	1.00
496_D	811_F	2.804	1.00
155_L	328_V	2.799	1.00
125_K	380_N	2.746	1.00
64_D	419_R	2.708	1.00
525_N	528_V	2.580	1.00
645_Y	659_Q	2.562	1.00
94_R	414_E	2.555	1.00
452_F	557_L	2.536	1.00
224_L	326_L	2.527	1.00
94_R	410_T	2.519	1.00
79_T	82_E	2.518	1.00
28_D	569_R	2.515	1.00
69_A	74_A	2.499	1.00
706_R	805_E	2.480	1.00
100_L	352_V	2.471	1.00
172_A	245_L	2.462	1.00
619_L	631_P	2.455	1.00
161_R	357_A	2.443	1.00
63_I	416_R	2.438	1.00
551_T	554_L	2.411	1.00
328_V	337_V	2.384	1.00
128_E	288_D	2.371	1.00
121_L	382_L	2.367	1.00
35_D	39_E	2.354	1.00
726_R	729_Q	2.351	1.00
240_L	245_L	2.349	1.00
648_V	655_L	2.343	1.00
600_E	604_R	2.340	1.00
48_G	587_R	2.332	1.00
161_R	361_E	2.298	1.00
619_L	623_R	2.285	1.00
150_D	153_R	2.278	1.00
691_V	694_L	2.277	1.00
221_V	254_M	2.257	1.00
33_A	630_D	2.254	1.00
464_T	468_N	2.248	1.00
647_E	654_E	2.237	1.00
707_R	803_P	2.231	1.00
70_E	79_T	2.229	1.00
199_D	202_E	2.206	1.00
656_E	688_Q	2.173	1.00
172_A	221_V	2.172	1.00
157_A	361_E	2.168	1.00
35_D	405_V	2.168	1.00
701_V	748_L	2.167	1.00
355_I	366_V	2.166	1.00
596_R	810_E	2.163	1.00
62_S	83_L	2.146	1.00
612_W	635_A	2.092	1.00
745_V	761_T	2.088	1.00
803_P	806_E	2.086	1.00
63_I	419_R	2.068	1.00
144_Y	334_R	2.052	1.00
151_A	220_Y	2.048	1.00
723_V	746_F	2.047	1.00
467_Q	498_L	2.032	1.00
51_R	449_D	2.019	1.00
468_N	590_Y	2.019	1.00
90_R	414_E	2.017	1.00
481_I	661_L	2.007	1.00
337_V	355_I	1.996	1.00
345_L	379_L	1.995	1.00
612_W	616_L	1.969	1.00
670_E	732_S	1.963	1.00
396_H	407_N	1.958	1.00
283_R	377_P	1.952	1.00
581_L	585_F	1.948	1.00
654_E	692_T	1.946	1.00
26_Y	636_P	1.934	1.00
85_D	119_L	1.932	1.00
508_I	522_L	1.928	1.00
65_D	68_G	1.925	1.00
49_D	449_D	1.912	0.99
701_V	710_L	1.912	0.99
460_R	464_T	1.900	0.99
90_R	417_Q	1.892	0.99
407_N	410_T	1.887	0.99
539_F	557_L	1.884	0.99
158_L	358_T	1.876	0.99
63_I	421_G	1.860	0.99
41_V	580_A	1.858	0.99
772_Y	784_S	1.853	0.99
120_S	383_K	1.845	0.99
149_E	152_E	1.841	0.99
615_F	619_L	1.839	0.99
221_V	245_L	1.837	0.99
280_F	448_A	1.828	0.99
277_R	281_A	1.824	0.99
195_S	210_F	1.823	0.99
352_V	368_I	1.823	0.99
44_D	48_G	1.806	0.99
170_Q	245_L	1.800	0.99
395_I	407_N	1.798	0.99
714_G	718_E	1.795	0.99
74_A	77_G	1.789	0.99
196_K	210_F	1.788	0.99
726_R	733_A	1.782	0.99
254_M	327_C	1.782	0.99
749_V	800_M	1.780	0.99
655_L	701_V	1.775	0.99
50_V	582_V	1.763	0.99
623_R	628_P	1.759	0.99
701_V	708_V	1.757	0.99
62_S	68_G	1.755	0.99
691_V	710_L	1.730	0.99
85_D	89_R	1.730	0.99
168_Y	235_S	1.724	0.99
27_T	30_Q	1.713	0.99
157_A	161_R	1.713	0.99
607_L	722_G	1.712	0.99
612_W	638_F	1.696	0.99
460_R	591_R	1.691	0.99
88_I	121_L	1.672	0.99
497_S	528_V	1.669	0.99
43_A	47_A	1.669	0.99
464_T	505_F	1.668	0.99
700_V	751_T	1.649	0.98
754_G	799_P	1.648	0.98
159_A	169_V	1.647	0.98
653_V	699_H	1.645	0.98
726_R	740_V	1.632	0.98
66_M	421_G	1.632	0.98
427_L	775_F	1.631	0.98
525_N	667_L	1.621	0.98
623_R	630_D	1.620	0.98
182_K	202_E	1.601	0.98
266_V	271_Y	1.596	0.98
559_F	578_L	1.595	0.98
568_A	571_S	1.588	0.98
407_N	411_L	1.582	0.98
161_R	358_T	1.582	0.98
358_T	362_L	1.578	0.98
280_F	545_Y	1.572	0.98
632_E	635_A	1.571	0.98
88_I	384_V	1.569	0.98
70_E	78_P	1.567	0.98
146_A	364_L	1.567	0.98
189_N	265_W	1.567	0.98
671_G	677_V	1.567	0.98
649_E	654_E	1.564	0.98
26_Y	34_I	1.554	0.98
170_Q	240_L	1.551	0.98
510_R	591_R	1.534	0.97
587_R	627_Y	1.534	0.97
100_L	368_I	1.533	0.97
584_R	622_L	1.527	0.97
464_T	594_L	1.521	0.97
468_N	592_G	1.519	0.97
137_I	367_V	1.518	0.97
83_L	86_D	1.518	0.97
695_T	699_H	1.504	0.97
85_D	140_E	1.502	0.97
426_M	479_L	1.498	0.97
648_V	748_L	1.481	0.97
584_R	621_D	1.478	0.97
708_V	721_A	1.475	0.97
280_F	447_P	1.474	0.97
34_I	573_A	1.471	0.97
620_A	624_A	1.461	0.97
715_T	809_P	1.461	0.97
502_E	596_R	1.459	0.97
702_T	749_V	1.452	0.96
442_L	452_F	1.445	0.96
440_V	575_Q	1.444	0.96
644_R	647_E	1.442	0.96
707_R	805_E	1.440	0.96
193_L	244_R	1.438	0.96
519_V	523_L	1.427	0.96
64_D	83_L	1.424	0.96
653_V	748_L	1.424	0.96
164_L	168_Y	1.421	0.96
336_Y	367_V	1.418	0.96
475_L	611_V	1.415	0.96
613_Q	652_G	1.408	0.96
339_M	368_I	1.408	0.96
498_L	501_L	1.407	0.96
616_L	631_P	1.400	0.96
609_H	690_K	1.399	0.96
408_T	571_S	1.397	0.96
177_W	181_W	1.397	0.96
689_V	701_V	1.391	0.95
571_S	575_Q	1.379	0.95
610_F	711_Q	1.377	0.95
339_M	352_V	1.376	0.95
460_R	508_I	1.374	0.95
427_L	774_T	1.369	0.95
79_T	83_L	1.367	0.95
729_Q	733_A	1.360	0.95
158_L	326_L	1.360	0.95
706_R	806_E	1.360	0.95
143_D	334_R	1.340	0.94
67_D	775_F	1.335	0.94
622_L	629_F	1.332	0.94
3_C	9_F	1.330	0.94
65_D	79_T	1.328	0.94
595_V	695_T	1.326	0.94
226_R	350_E	1.325	0.94
132_R	357_A	1.324	0.94
157_A	160_E	1.323	0.94
85_D	103_Y	1.321	0.94
690_K	718_E	1.319	0.94
409_E	569_R	1.314	0.94
711_Q	813_F	1.312	0.94
266_V	272_P	1.308	0.94
449_D	454_R	1.306	0.94
584_R	588_E	1.305	0.94
155_L	220_Y	1.302	0.94
205_R	251_D	1.300	0.94
136_L	363_G	1.297	0.93
384_V	391_I	1.297	0.93
150_D	364_L	1.296	0.93
715_T	718_E	1.295	0.93
342_L	355_I	1.288	0.93
312_P	317_S	1.284	0.93
725_Y	742_A	1.277	0.93
441_V	452_F	1.274	0.93
546_S	552_G	1.271	0.93
747_D	795_H	1.270	0.93
409_E	568_A	1.269	0.93
623_R	631_P	1.266	0.93
88_I	382_L	1.264	0.93
749_V	803_P	1.258	0.92
122_Y	372_P	1.257	0.92
89_R	101_L	1.257	0.92
610_F	813_F	1.256	0.92
600_E	716_A	1.256	0.92
505_F	523_L	1.251	0.92
267_P	270_D	1.249	0.92
146_A	365_P	1.248	0.92
628_P	631_P	1.244	0.92
277_R	283_R	1.244	0.92
583_A	627_Y	1.242	0.92
84_A	391_I	1.240	0.92
606_M	661_L	1.240	0.92
465_Y	584_R	1.240	0.92
707_R	806_E	1.235	0.92
700_V	707_R	1.233	0.92
217_P	220_Y	1.226	0.91
749_V	802_P	1.226	0.91
48_G	583_A	1.224	0.91
462_L	582_V	1.224	0.91
191_D	244_R	1.222	0.91
653_V	757_L	1.219	0.91
118_A	385_T	1.218	0.91
130_I	352_V	1.214	0.91
507_Q	737_T	1.213	0.91
243_G	246_F	1.213	0.91
742_A	765_A	1.206	0.91
148_A	216_K	1.205	0.91
113_P	209_V	1.204	0.91
334_R	367_V	1.203	0.91
46_A	400_S	1.199	0.90
40_Q	44_D	1.194	0.90
726_R	739_G	1.193	0.90
225_Q	234_R	1.191	0.90
178_Y	182_K	1.187	0.90
139_D	142_K	1.186	0.90
667_L	677_V	1.186	0.90
621_D	753_N	1.185	0.90
40_Q	43_A	1.185	0.90
236_G	322_V	1.185	0.90
192_P	197_L	1.183	0.90
754_G	801_A	1.178	0.90
707_R	804_P	1.166	0.89
573_A	634_F	1.165	0.89
239_F	243_G	1.163	0.89
100_L	339_M	1.162	0.89
64_D	68_G	1.161	0.89
276_P	551_T	1.160	0.89
588_E	624_A	1.159	0.89
430_R	479_L	1.153	0.89
715_T	808_N	1.145	0.88
139_D	367_V	1.143	0.88
278_D	281_A	1.135	0.88
184_R	211_E	1.134	0.88
706_R	803_P	1.127	0.87
236_G	239_F	1.124	0.87
146_A	150_D	1.124	0.87
310_R	320_G	1.124	0.87
508_I	514_P	1.122	0.87
81_R	119_L	1.122	0.87
49_D	454_R	1.121	0.87
37_L	629_F	1.118	0.87
265_W	268_P	1.117	0.87
155_L	326_L	1.117	0.87
316_E	320_G	1.114	0.87
132_R	360_A	1.114	0.87
148_A	330_P	1.113	0.87
133_D	136_L	1.113	0.87
158_L	328_V	1.112	0.87
462_L	578_L	1.111	0.87
181_W	185_R	1.111	0.87
780_Y	784_S	1.098	0.86
184_R	207_A	1.098	0.86
609_H	613_Q	1.096	0.86
770_R	788_A	1.096	0.86
81_R	140_E	1.088	0.86
729_Q	739_G	1.086	0.85
621_D	625_A	1.085	0.85
195_S	206_L	1.084	0.85
612_W	631_P	1.080	0.85
345_L	349_L	1.080	0.85
142_K	145_G	1.079	0.85
505_F	737_T	1.079	0.85
441_V	637_H	1.079	0.85
195_S	207_A	1.078	0.85
160_E	166_P	1.077	0.85
765_A	771_N	1.073	0.85
772_Y	788_A	1.072	0.85
771_N	788_A	1.071	0.85
432_T	487_A	1.071	0.85
400_S	403_E	1.069	0.84
493_A	497_S	1.066	0.84
763_H	791_F	1.065	0.84
464_T	522_L	1.064	0.84
118_A	383_K	1.059	0.84
130_I	379_L	1.059	0.84
406_E	410_T	1.057	0.84
86_D	90_R	1.056	0.84
198_D	215_D	1.055	0.84
756_S	800_M	1.055	0.84
344_R	347_D	1.055	0.84
83_L	418_S	1.054	0.84
326_L	355_I	1.052	0.84
701_V	723_V	1.051	0.83
375_R	382_L	1.050	0.83
467_Q	594_L	1.050	0.83
661_L	787_L	1.048	0.83
193_L	246_F	1.046	0.83
146_A	336_Y	1.045	0.83
691_V	701_V	1.045	0.83
770_R	773_D	1.045	0.83
245_L	254_M	1.044	0.83
617_D	752_W	1.042	0.83
88_I	103_Y	1.040	0.83
231_P	347_D	1.039	0.83
26_Y	30_Q	1.038	0.83
221_V	325_A	1.036	0.83
212_R	218_V	1.036	0.83
507_Q	510_R	1.032	0.82
179_Y	182_K	1.032	0.82
350_E	354_A	1.031	0.82
277_R	344_R	1.030	0.82
68_G	79_T	1.030	0.82
26_Y	637_H	1.029	0.82
464_T	508_I	1.029	0.82
92_R	134_P	1.026	0.82
458_L	523_L	1.026	0.82
467_Q	595_V	1.023	0.82
62_S	421_G	1.022	0.82
796_T	800_M	1.021	0.82
742_A	764_V	1.020	0.82
156_E	166_P	1.019	0.82
406_E	409_E	1.016	0.81
133_D	363_G	1.016	0.81
76_L	118_A	1.014	0.81
35_D	402_D	1.012	0.81
317_S	320_G	1.009	0.81
740_V	765_A	1.008	0.81
218_V	254_M	1.005	0.81
73_T	77_G	1.003	0.80
165_D	168_Y	1.000	0.80
411_L	422_T	0.999	0.80
348_Y	368_I	0.998	0.80
88_I	101_L	0.998	0.80
462_L	559_F	0.995	0.80
190_V	195_S	0.994	0.80
105_Q	108_W	0.993	0.80
702_T	802_P	0.993	0.80
465_Y	625_A	0.992	0.80
76_L	119_L	0.990	0.80
613_Q	616_L	0.989	0.80
172_A	240_L	0.988	0.79
649_E	652_G	0.983	0.79
35_D	573_A	0.983	0.79
399_A	403_E	0.983	0.79
50_V	586_W	0.983	0.79
185_R	242_R	0.982	0.79
475_L	615_F	0.982	0.79
179_Y	209_V	0.980	0.79
19_D	661_L	0.980	0.79
653_V	691_V	0.980	0.79
708_V	748_L	0.980	0.79
648_V	758_G	0.979	0.79
32_A	35_D	0.975	0.79
580_A	629_F	0.975	0.79
516_P	563_E	0.973	0.78
595_V	752_W	0.969	0.78
63_I	83_L	0.965	0.78
546_S	551_T	0.965	0.78
657_L	687_L	0.965	0.78
119_L	367_V	0.964	0.78
611_V	642_F	0.964	0.78
5_V	9_F	0.962	0.78
240_L	243_G	0.961	0.78
284_P	287_P	0.961	0.78
395_I	398_A	0.961	0.78
205_R	209_V	0.960	0.77
90_R	413_E	0.959	0.77
95_F	410_T	0.959	0.77
51_R	454_R	0.956	0.77
438_N	571_S	0.951	0.77
713_T	718_E	0.949	0.77
656_E	690_K	0.949	0.77
770_R	774_T	0.948	0.77
426_M	430_R	0.947	0.77
68_G	77_G	0.946	0.76
672_A	677_V	0.945	0.76
726_R	741_H	0.942	0.76
153_R	362_L	0.941	0.76
164_L	350_E	0.941	0.76
122_Y	345_L	0.941	0.76
561_A	578_L	0.938	0.76
683_S	733_A	0.937	0.76
380_N	399_A	0.936	0.76
729_Q	738_I	0.932	0.75
761_T	792_P	0.932	0.75
490_V	498_L	0.930	0.75
154_F	364_L	0.928	0.75
144_Y	365_P	0.922	0.75
495_H	665_H	0.922	0.75
36_A	40_Q	0.922	0.75
679_Y	730_P	0.921	0.74
270_D	661_L	0.920	0.74
464_T	523_L	0.918	0.74
211_E	242_R	0.917	0.74
164_L	224_L	0.916	0.74
708_V	723_V	0.915	0.74
62_S	419_R	0.913	0.74
92_R	99_G	0.912	0.74
151_A	330_P	0.911	0.74
22_V	30_Q	0.906	0.73
405_V	409_E	0.901	0.73
180_L	197_L	0.900	0.73
731_P	765_A	0.899	0.73
729_Q	740_V	0.897	0.73
278_D	550_P	0.896	0.72
19_D	787_L	0.896	0.72
83_L	419_R	0.896	0.72
154_F	359_A	0.895	0.72
43_A	46_A	0.893	0.72
619_L	628_P	0.892	0.72
587_R	625_A	0.892	0.72
531_T	537_A	0.889	0.72
184_R	242_R	0.888	0.72
202_E	205_R	0.884	0.71
194_D	207_A	0.883	0.71
194_D	210_F	0.883	0.71
772_Y	781_E	0.882	0.71
414_E	418_S	0.882	0.71
651_G	696_P	0.882	0.71
518_L	522_L	0.879	0.71
44_D	580_A	0.879	0.71
94_R	406_E	0.878	0.71
270_D	318_A	0.876	0.71
454_R	586_W	0.872	0.70
360_A	363_G	0.870	0.70
483_P	665_H	0.870	0.70
293_A	297_A	0.870	0.70
277_R	346_E	0.867	0.70
441_V	575_Q	0.864	0.70
193_L	215_D	0.863	0.70
477_S	611_V	0.863	0.70
140_E	367_V	0.860	0.69
647_E	792_P	0.858	0.69
474_Y	601_L	0.856	0.69
401_W	572_L	0.855	0.69
458_L	463_I	0.855	0.69
130_I	345_L	0.854	0.69
76_L	81_R	0.854	0.69
692_T	718_E	0.852	0.69
375_R	383_K	0.850	0.68
157_A	358_T	0.848	0.68
707_R	751_T	0.845	0.68
143_D	146_A	0.845	0.68
68_G	78_P	0.844	0.68
342_L	345_L	0.843	0.68
226_R	231_P	0.842	0.68
189_N	266_V	0.841	0.68
677_V	771_N	0.840	0.67
426_M	775_F	0.839	0.67
247_L	254_M	0.838	0.67
310_R	316_E	0.837	0.67
802_P	807_P	0.836	0.67
597_W	605_F	0.836	0.67
204_A	210_F	0.835	0.67
166_P	169_V	0.835	0.67
289_A	292_A	0.834	0.67
464_T	467_Q	0.833	0.67
95_F	396_H	0.832	0.67
771_N	784_S	0.832	0.67
471_S	619_L	0.831	0.67
380_N	403_E	0.831	0.67
35_D	572_L	0.829	0.66
76_L	79_T	0.829	0.66
525_N	732_S	0.829	0.66
814_T	817_L	0.828	0.66
227_W	234_R	0.827	0.66
650_V	758_G	0.822	0.66
716_A	810_E	0.822	0.66
601_L	605_F	0.822	0.66
427_L	771_N	0.821	0.66
204_A	207_A	0.819	0.65
770_R	777_V	0.818	0.65
26_Y	573_A	0.818	0.65
694_L	710_L	0.816	0.65
346_E	378_R	0.815	0.65
200_P	204_A	0.815	0.65
507_Q	511_P	0.814	0.65
158_L	224_L	0.813	0.65
671_G	674_G	0.813	0.65
312_P	315_G	0.813	0.65
605_F	611_V	0.813	0.65
67_D	72_N	0.812	0.65
169_V	328_V	0.812	0.65
814_T	818_R	0.812	0.65
497_S	526_L	0.811	0.65
147_T	330_P	0.811	0.65
91_L	382_L	0.809	0.65
177_W	207_A	0.807	0.64
81_R	85_D	0.805	0.64
280_F	375_R	0.804	0.64
463_I	537_A	0.804	0.64
197_L	207_A	0.803	0.64
784_S	787_L	0.803	0.64
62_S	65_D	0.801	0.64
644_R	688_Q	0.801	0.64
145_G	334_R	0.801	0.64
102_H	339_M	0.800	0.64
431_H	434_T	0.799	0.64
791_F	794_G	0.797	0.63
515_P	523_L	0.797	0.63
593_P	697_G	0.797	0.63
291_A	294_A	0.796	0.63
402_D	406_E	0.795	0.63
45_L	582_V	0.795	0.63
196_K	202_E	0.795	0.63
355_I	368_I	0.794	0.63
96_A	99_G	0.792	0.63
274_I	343_E	0.791	0.63
22_V	422_T	0.788	0.62
190_V	210_F	0.786	0.62
139_D	144_Y	0.786	0.62
512_E	515_P	0.785	0.62
522_L	737_T	0.784	0.62
615_F	636_P	0.784	0.62
503_I	684_V	0.783	0.62
490_V	493_A	0.783	0.62
408_T	412_Y	0.782	0.62
421_G	431_H	0.781	0.62
82_E	86_D	0.781	0.62
293_A	296_A	0.781	0.62
615_F	634_F	0.780	0.62
396_H	410_T	0.780	0.62
100_L	348_Y	0.779	0.62
346_E	349_L	0.778	0.61
588_E	625_A	0.775	0.61
92_R	97_P	0.775	0.61
159_A	166_P	0.775	0.61
493_A	665_H	0.773	0.61
251_D	563_E	0.773	0.61
176_P	180_L	0.772	0.61
253_P	256_L	0.771	0.61
89_R	92_R	0.771	0.61
405_V	408_T	0.770	0.61
52_L	442_L	0.768	0.60
142_K	365_P	0.768	0.60
195_S	202_E	0.766	0.60
383_K	396_H	0.766	0.60
9_F	242_R	0.766	0.60
699_H	757_L	0.764	0.60
487_A	661_L	0.764	0.60
402_D	405_V	0.763	0.60
471_S	617_D	0.763	0.60
687_L	760_C	0.763	0.60
530_V	601_L	0.761	0.60
336_Y	395_I	0.761	0.60
467_Q	637_H	0.759	0.60
715_T	807_P	0.758	0.59
84_A	256_L	0.758	0.59
611_V	615_F	0.758	0.59
91_L	414_E	0.758	0.59
212_R	217_P	0.757	0.59
452_F	606_M	0.755	0.59
465_Y	590_Y	0.755	0.59
515_P	518_L	0.754	0.59
248_I	327_C	0.753	0.59
815_L	818_R	0.751	0.59
372_P	383_K	0.749	0.59
460_R	510_R	0.749	0.59
465_Y	618_V	0.748	0.58
138_A	144_Y	0.747	0.58
113_P	199_D	0.747	0.58
22_V	26_Y	0.747	0.58
345_L	371_Y	0.746	0.58
128_E	132_R	0.746	0.58
212_R	329_E	0.745	0.58
528_V	537_A	0.744	0.58
96_A	100_L	0.743	0.58
528_V	668_G	0.743	0.58
194_D	198_D	0.743	0.58
591_R	624_A	0.743	0.58
137_I	365_P	0.741	0.58
672_A	675_G	0.740	0.58
381_V	441_V	0.739	0.58
408_T	575_Q	0.739	0.58
53_T	445_A	0.738	0.57
200_P	210_F	0.736	0.57
348_Y	373_P	0.735	0.57
683_S	730_P	0.735	0.57
440_V	559_F	0.734	0.57
327_C	460_R	0.734	0.57
619_L	634_F	0.733	0.57
703_C	708_V	0.733	0.57
181_W	184_R	0.733	0.57
449_D	586_W	0.733	0.57
292_A	296_A	0.732	0.57
756_S	792_P	0.732	0.57
210_F	265_W	0.731	0.57
30_Q	34_I	0.730	0.57
17_H	644_R	0.728	0.56
694_L	719_F	0.728	0.56
600_E	813_F	0.728	0.56
65_D	69_A	0.728	0.56
88_I	119_L	0.727	0.56
383_K	523_L	0.727	0.56
62_S	355_I	0.726	0.56
559_F	575_Q	0.726	0.56
77_G	84_A	0.725	0.56
651_G	699_H	0.725	0.56
749_V	754_G	0.722	0.56
464_T	592_G	0.722	0.56
182_K	210_F	0.722	0.56
270_D	317_S	0.722	0.56
83_L	421_G	0.722	0.56
62_S	422_T	0.721	0.56
432_T	659_Q	0.721	0.56
471_S	634_F	0.720	0.56
444_G	452_F	0.720	0.56
291_A	296_A	0.720	0.56
40_Q	628_P	0.719	0.55
176_P	209_V	0.718	0.55
689_V	708_V	0.718	0.55
375_R	554_L	0.717	0.55
92_R	96_A	0.716	0.55
426_M	431_H	0.716	0.55
695_T	752_W	0.715	0.55
198_D	216_K	0.714	0.55
181_W	242_R	0.714	0.55
312_P	318_A	0.714	0.55
206_L	210_F	0.712	0.55
164_L	235_S	0.711	0.55
702_T	799_P	0.710	0.55
481_I	487_A	0.710	0.55
120_S	381_V	0.709	0.54
518_L	737_T	0.708	0.54
725_Y	741_H	0.706	0.54
171_P	702_T	0.705	0.54
621_D	629_F	0.704	0.54
452_F	575_Q	0.704	0.54
754_G	800_M	0.704	0.54
675_G	679_Y	0.702	0.54
346_E	444_G	0.702	0.54
74_A	413_E	0.702	0.54
694_L	701_V	0.701	0.54
313_A	316_E	0.701	0.54
155_L	337_V	0.701	0.54
215_D	244_R	0.701	0.54
266_V	321_V	0.700	0.53
33_A	41_V	0.700	0.53
611_V	627_Y	0.700	0.53
355_I	364_L	0.699	0.53
292_A	295_A	0.698	0.53
339_M	355_I	0.698	0.53
757_L	793_H	0.698	0.53
745_V	794_G	0.697	0.53
122_Y	381_V	0.697	0.53
176_P	246_F	0.696	0.53
29_E	33_A	0.696	0.53
468_N	637_H	0.696	0.53
296_A	300_A	0.696	0.53
195_S	209_V	0.696	0.53
219_G	327_C	0.694	0.53
11_M	674_G	0.693	0.53
184_R	559_F	0.693	0.53
195_S	204_A	0.693	0.53
573_A	615_F	0.693	0.53
608_P	688_Q	0.692	0.53
227_W	232_R	0.692	0.53
584_R	624_A	0.691	0.53
752_W	755_R	0.690	0.52
549_S	671_G	0.688	0.52
290_A	294_A	0.688	0.52
604_R	813_F	0.688	0.52
6_E	163_G	0.688	0.52
72_N	424_K	0.686	0.52
679_Y	748_L	0.686	0.52
63_I	418_S	0.685	0.52
725_Y	729_Q	0.684	0.52
501_L	526_L	0.684	0.52
171_P	217_P	0.684	0.52
530_V	575_Q	0.683	0.52
655_L	691_V	0.682	0.52
493_A	530_V	0.681	0.51
159_A	164_L	0.680	0.51
600_E	605_F	0.679	0.51
181_W	202_E	0.678	0.51
812_P	818_R	0.677	0.51
712_P	719_F	0.676	0.51
89_R	139_D	0.675	0.51
48_G	627_Y	0.674	0.51
330_P	335_L	0.674	0.51
740_V	743_P	0.673	0.51
153_R	157_A	0.672	0.51
19_D	22_V	0.671	0.50
14_T	17_H	0.671	0.50
210_F	441_V	0.670	0.50
5_V	8_E	0.670	0.50
698_R	752_W	0.669	0.50
19_D	66_M	0.669	0.50
54_M	579_R	0.669	0.50
609_H	621_D	0.667	0.50
383_K	554_L	0.666	0.50
537_A	557_L	0.666	0.50
499_Y	509_P	0.666	0.50
176_P	181_W	0.666	0.50
568_A	572_L	0.665	0.50
493_A	496_D	0.665	0.50
169_V	330_P	0.662	0.49
290_A	293_A	0.662	0.49
267_P	321_V	0.661	0.49
185_R	261_D	0.661	0.49
575_Q	637_H	0.661	0.49
684_V	735_H	0.661	0.49
730_P	733_A	0.660	0.49
113_P	205_R	0.658	0.49
621_D	638_F	0.658	0.49
525_N	726_R	0.658	0.49
634_F	637_H	0.658	0.49
312_P	316_E	0.657	0.49
154_F	157_A	0.657	0.49
531_T	665_H	0.657	0.49
498_L	522_L	0.657	0.49
50_V	454_R	0.656	0.49
9_F	85_D	0.656	0.49
493_A	725_Y	0.655	0.49
242_R	246_F	0.654	0.49
639_E	658_R	0.654	0.49
119_L	382_L	0.654	0.49
41_V	576_L	0.654	0.49
544_L	557_L	0.653	0.49
699_H	705_G	0.653	0.49
286_L	345_L	0.652	0.48
526_L	734_L	0.652	0.48
699_H	712_P	0.652	0.48
179_Y	214_L	0.652	0.48
163_G	357_A	0.652	0.48
584_R	587_R	0.651	0.48
761_T	791_F	0.651	0.48
714_G	717_G	0.650	0.48
42_D	46_A	0.648	0.48
315_G	318_A	0.648	0.48
367_V	539_F	0.648	0.48
136_L	365_P	0.647	0.48
441_V	556_L	0.646	0.48
371_Y	395_I	0.646	0.48
380_N	396_H	0.646	0.48
183_E	197_L	0.645	0.48
103_Y	367_V	0.645	0.48
748_L	757_L	0.645	0.48
239_F	467_Q	0.644	0.48
464_T	591_R	0.644	0.48
749_V	806_E	0.643	0.47
131_W	136_L	0.643	0.47
576_L	756_S	0.643	0.47
182_K	185_R	0.642	0.47
606_M	611_V	0.641	0.47
548_D	552_G	0.641	0.47
20_P	27_T	0.640	0.47
3_C	8_E	0.640	0.47
412_Y	571_S	0.638	0.47
444_G	448_A	0.638	0.47
44_D	47_A	0.638	0.47
202_E	209_V	0.636	0.47
508_I	519_V	0.636	0.47
539_F	612_W	0.635	0.47
121_L	236_G	0.634	0.47
721_A	810_E	0.634	0.47
74_A	465_Y	0.632	0.46
86_D	419_R	0.631	0.46
121_L	375_R	0.631	0.46
499_Y	684_V	0.630	0.46
78_P	82_E	0.629	0.46
82_E	141_R	0.629	0.46
496_D	530_V	0.629	0.46
289_A	293_A	0.629	0.46
811_F	814_T	0.629	0.46
86_D	89_R	0.628	0.46
121_L	497_S	0.628	0.46
146_A	330_P	0.627	0.46
726_R	737_T	0.627	0.46
587_R	624_A	0.627	0.46
683_S	726_R	0.627	0.46
62_S	67_D	0.626	0.46
358_T	364_L	0.625	0.46
157_A	362_L	0.625	0.46
231_P	350_E	0.624	0.45
158_L	162_L	0.623	0.45
765_A	772_Y	0.623	0.45
427_L	781_E	0.622	0.45
359_A	363_G	0.622	0.45
702_T	754_G	0.622	0.45
464_T	526_L	0.622	0.45
30_Q	636_P	0.621	0.45
609_H	688_Q	0.621	0.45
152_E	684_V	0.620	0.45
487_A	548_D	0.619	0.45
198_D	417_Q	0.619	0.45
184_R	239_F	0.619	0.45
30_Q	635_A	0.619	0.45
98_G	101_L	0.618	0.45
637_H	791_F	0.618	0.45
702_T	707_R	0.617	0.45
362_L	365_P	0.617	0.45
11_M	76_L	0.617	0.45
290_A	302_A	0.616	0.45
107_K	110_P	0.616	0.45
205_R	471_S	0.615	0.45
64_D	418_S	0.615	0.45
411_L	645_Y	0.615	0.45
88_I	99_G	0.615	0.45
182_K	199_D	0.615	0.45
119_L	140_E	0.615	0.45
375_R	447_P	0.614	0.44
31_W	569_R	0.613	0.44
136_L	359_A	0.613	0.44
667_L	732_S	0.611	0.44
622_L	784_S	0.610	0.44
342_L	347_D	0.610	0.44
105_Q	256_L	0.609	0.44
768_G	778_N	0.609	0.44
467_Q	621_D	0.609	0.44
726_R	738_I	0.609	0.44
30_Q	632_E	0.609	0.44
812_P	816_D	0.608	0.44
670_E	680_V	0.608	0.44
304_A	308_A	0.608	0.44
210_F	637_H	0.608	0.44
36_A	47_A	0.607	0.44
18_E	22_V	0.607	0.44
348_Y	352_V	0.606	0.44
4_E	130_I	0.606	0.44
179_Y	210_F	0.605	0.44
81_R	103_Y	0.604	0.43
200_P	314_R	0.604	0.43
567_H	590_Y	0.603	0.43
619_L	629_F	0.603	0.43
11_M	226_R	0.603	0.43
49_D	586_W	0.603	0.43
186_L	190_V	0.602	0.43
330_P	809_P	0.601	0.43
383_K	733_A	0.601	0.43
218_V	537_A	0.601	0.43
29_E	32_A	0.600	0.43
699_H	703_C	0.600	0.43
103_Y	137_I	0.600	0.43
559_F	612_W	0.600	0.43
153_R	216_K	0.599	0.43
452_F	539_F	0.599	0.43
761_T	794_G	0.599	0.43
183_E	213_G	0.599	0.43
198_D	244_R	0.598	0.43
352_V	497_S	0.598	0.43
148_A	217_P	0.598	0.43
188_V	239_F	0.598	0.43
648_V	653_V	0.597	0.43
155_L	222_L	0.597	0.43
508_I	511_P	0.596	0.43
650_V	748_L	0.596	0.43
289_A	294_A	0.596	0.43
508_I	512_E	0.595	0.42
89_R	103_Y	0.595	0.42
381_V	554_L	0.595	0.42
526_L	726_R	0.594	0.42
213_G	507_Q	0.594	0.42
39_E	42_D	0.594	0.42
30_Q	569_R	0.594	0.42
700_V	803_P	0.593	0.42
88_I	92_R	0.593	0.42
81_R	367_V	0.593	0.42
265_W	323_R	0.592	0.42
272_P	550_P	0.592	0.42
141_R	145_G	0.592	0.42
95_F	407_N	0.592	0.42
505_F	594_L	0.592	0.42
119_L	336_Y	0.592	0.42
239_F	264_P	0.592	0.42
629_F	659_Q	0.592	0.42
132_R	368_I	0.591	0.42
76_L	88_I	0.590	0.42
565_P	571_S	0.589	0.42
17_H	753_N	0.589	0.42
525_N	661_L	0.588	0.42
307_A	690_K	0.588	0.42
99_G	121_L	0.587	0.42
236_G	539_F	0.587	0.42
580_A	622_L	0.587	0.42
172_A	247_L	0.584	0.41
151_A	328_V	0.584	0.41
438_N	565_P	0.584	0.41
514_P	519_V	0.583	0.41
155_L	224_L	0.583	0.41
253_P	694_L	0.583	0.41
208_R	251_D	0.583	0.41
732_S	735_H	0.582	0.41
224_L	315_G	0.582	0.41
299_A	302_A	0.582	0.41
481_I	528_V	0.582	0.41
292_A	297_A	0.582	0.41
812_P	815_L	0.582	0.41
703_C	746_F	0.581	0.41
765_A	780_Y	0.581	0.41
103_Y	606_M	0.581	0.41
11_M	468_N	0.580	0.41
158_L	354_A	0.580	0.41
653_V	694_L	0.580	0.41
28_D	32_A	0.580	0.41
190_V	209_V	0.580	0.41
423_E	608_P	0.577	0.41
19_D	639_E	0.577	0.41
291_A	297_A	0.576	0.41
372_P	379_L	0.576	0.41
13_V	18_E	0.575	0.40
561_A	638_F	0.575	0.40
164_L	167_D	0.575	0.40
201_E	372_P	0.575	0.40
650_V	653_V	0.574	0.40
442_L	445_A	0.574	0.40
282_P	613_Q	0.574	0.40
181_W	261_D	0.574	0.40
177_W	242_R	0.573	0.40
326_L	352_V	0.573	0.40
17_H	22_V	0.573	0.40
671_G	733_A	0.573	0.40
498_L	622_L	0.573	0.40
709_P	721_A	0.573	0.40
509_P	514_P	0.572	0.40
308_A	313_A	0.572	0.40
687_L	746_F	0.572	0.40
629_F	634_F	0.572	0.40
34_I	636_P	0.571	0.40
358_T	363_G	0.570	0.40
7_F	73_T	0.570	0.40
122_Y	375_R	0.570	0.40
273_Y	677_V	0.569	0.40
3_C	242_R	0.569	0.40
294_A	297_A	0.569	0.40
146_A	328_V	0.568	0.40
458_L	531_T	0.567	0.40
205_R	208_R	0.567	0.40
24_K	27_T	0.567	0.40
86_D	141_R	0.567	0.40
99_G	623_R	0.567	0.40
151_A	366_V	0.565	0.39
77_G	199_D	0.565	0.39
41_V	627_Y	0.565	0.39
452_F	627_Y	0.565	0.39
56_G	59_T	0.564	0.39
11_M	634_F	0.563	0.39
358_T	361_E	0.563	0.39
84_A	88_I	0.563	0.39
93_D	134_P	0.562	0.39
391_I	412_Y	0.562	0.39
145_G	364_L	0.561	0.39
30_Q	633_W	0.561	0.39
771_N	774_T	0.561	0.39
9_F	14_T	0.561	0.39
232_R	531_T	0.561	0.39
184_R	637_H	0.560	0.39
120_S	372_P	0.560	0.39
753_N	797_P	0.559	0.39
766_H	777_V	0.559	0.39
479_L	725_Y	0.559	0.39
411_L	551_T	0.559	0.39
229_A	248_I	0.558	0.39
474_Y	606_M	0.558	0.39
68_G	422_T	0.557	0.39
422_T	619_L	0.557	0.39
225_Q	537_A	0.557	0.39
460_R	509_P	0.557	0.39
225_Q	320_G	0.557	0.39
422_T	572_L	0.556	0.39
649_E	712_P	0.556	0.39
444_G	561_A	0.556	0.39
212_R	216_K	0.555	0.38
279_P	550_P	0.555	0.38
201_E	204_A	0.555	0.38
696_P	699_H	0.555	0.38
11_M	79_T	0.555	0.38
155_L	159_A	0.555	0.38
600_E	711_Q	0.555	0.38
19_D	26_Y	0.555	0.38
290_A	295_A	0.553	0.38
28_D	31_W	0.553	0.38
445_A	452_F	0.553	0.38
808_N	811_F	0.553	0.38
207_A	442_L	0.552	0.38
525_N	530_V	0.552	0.38
227_W	230_G	0.552	0.38
273_Y	346_E	0.552	0.38
204_A	208_R	0.551	0.38
575_Q	634_F	0.551	0.38
357_A	361_E	0.551	0.38
125_K	130_I	0.550	0.38
26_Y	67_D	0.550	0.38
749_V	801_A	0.550	0.38
667_L	733_A	0.549	0.38
62_S	66_M	0.549	0.38
559_F	606_M	0.548	0.38
173_Y	217_P	0.548	0.38
183_E	186_L	0.548	0.38
135_A	360_A	0.548	0.38
140_E	634_F	0.548	0.38
208_R	211_E	0.548	0.38
464_T	637_H	0.547	0.38
348_Y	726_R	0.546	0.38
177_W	184_R	0.546	0.38
784_S	788_A	0.546	0.38
483_P	496_D	0.545	0.37
539_F	549_S	0.545	0.37
654_E	711_Q	0.545	0.37
613_Q	617_D	0.544	0.37
778_N	783_E	0.544	0.37
295_A	299_A	0.544	0.37
37_L	706_R	0.544	0.37
642_F	661_L	0.544	0.37
213_G	216_K	0.544	0.37
173_Y	215_D	0.543	0.37
11_M	659_Q	0.543	0.37
235_S	544_L	0.543	0.37
713_T	720_V	0.543	0.37
290_A	296_A	0.543	0.37
266_V	273_Y	0.543	0.37
505_F	539_F	0.542	0.37
361_E	725_Y	0.542	0.37
493_A	787_L	0.542	0.37
134_P	345_L	0.541	0.37
787_L	791_F	0.541	0.37
670_E	673_A	0.541	0.37
684_V	687_L	0.540	0.37
487_A	540_C	0.540	0.37
85_D	88_I	0.540	0.37
11_M	637_H	0.540	0.37
8_E	14_T	0.540	0.37
92_R	98_G	0.539	0.37
73_T	765_A	0.538	0.37
499_Y	526_L	0.538	0.37
444_G	627_Y	0.538	0.37
66_M	88_I	0.538	0.37
463_I	508_I	0.538	0.37
312_P	320_G	0.537	0.37
133_D	149_E	0.536	0.37
159_A	235_S	0.535	0.36
765_A	770_R	0.535	0.36
13_V	47_A	0.535	0.36
801_A	805_E	0.535	0.36
125_K	379_L	0.535	0.36
118_A	251_D	0.534	0.36
68_G	83_L	0.534	0.36
179_Y	468_N	0.534	0.36
595_V	697_G	0.534	0.36
276_P	383_K	0.534	0.36
197_L	203_R	0.534	0.36
730_P	738_I	0.533	0.36
119_L	380_N	0.532	0.36
537_A	578_L	0.532	0.36
128_E	244_R	0.531	0.36
113_P	210_F	0.531	0.36
145_G	342_L	0.530	0.36
239_F	321_V	0.530	0.36
242_R	254_M	0.530	0.36
179_Y	184_R	0.530	0.36
680_V	732_S	0.530	0.36
567_H	637_H	0.530	0.36
699_H	751_T	0.529	0.36
409_E	572_L	0.528	0.36
653_V	711_Q	0.527	0.36
192_P	244_R	0.527	0.36
571_S	627_Y	0.527	0.36
16_I	22_V	0.527	0.36
14_T	307_A	0.527	0.36
100_L	173_Y	0.526	0.36
409_E	413_E	0.526	0.36
498_L	598_G	0.526	0.36
197_L	214_L	0.526	0.36
50_V	449_D	0.526	0.36
648_V	701_V	0.525	0.35
9_F	89_R	0.525	0.35
154_F	363_G	0.525	0.35
176_P	193_L	0.525	0.35
96_A	748_L	0.525	0.35
593_P	620_A	0.524	0.35
195_S	205_R	0.524	0.35
548_D	551_T	0.523	0.35
179_Y	213_G	0.523	0.35
474_Y	684_V	0.522	0.35
481_I	505_F	0.522	0.35
16_I	19_D	0.522	0.35
617_D	620_A	0.521	0.35
505_F	526_L	0.521	0.35
76_L	321_V	0.521	0.35
63_I	417_Q	0.521	0.35
140_E	334_R	0.521	0.35
29_E	160_E	0.520	0.35
207_A	242_R	0.520	0.35
749_V	756_S	0.520	0.35
761_T	793_H	0.520	0.35
253_P	331_R	0.520	0.35
28_D	43_A	0.519	0.35
148_A	212_R	0.519	0.35
667_L	735_H	0.519	0.35
33_A	40_Q	0.518	0.35
92_R	103_Y	0.518	0.35
73_T	84_A	0.518	0.35
11_M	441_V	0.518	0.35
276_P	549_S	0.517	0.35
148_A	406_E	0.517	0.35
418_S	537_A	0.517	0.35
121_L	181_W	0.517	0.35
689_V	760_C	0.517	0.35
400_S	404_L	0.516	0.35
396_H	414_E	0.516	0.35
403_E	406_E	0.516	0.35
88_I	137_I	0.516	0.35
178_Y	249_P	0.516	0.35
550_P	559_F	0.515	0.35
239_F	267_P	0.515	0.35
137_I	140_E	0.514	0.34
490_V	499_Y	0.514	0.34
327_C	336_Y	0.514	0.34
424_K	525_N	0.514	0.34
35_D	90_R	0.514	0.34
648_V	791_F	0.513	0.34
396_H	810_E	0.513	0.34
84_A	87_L	0.512	0.34
697_G	751_T	0.512	0.34
209_V	212_R	0.512	0.34
148_A	326_L	0.512	0.34
243_G	261_D	0.511	0.34
160_E	361_E	0.511	0.34
18_E	434_T	0.511	0.34
220_Y	582_V	0.511	0.34
139_D	143_D	0.509	0.34
41_V	65_D	0.509	0.34
463_I	498_L	0.509	0.34
460_R	496_D	0.509	0.34
584_R	647_E	0.509	0.34
651_G	748_L	0.509	0.34
620_A	623_R	0.509	0.34
242_R	441_V	0.509	0.34
320_G	522_L	0.508	0.34
130_I	515_P	0.508	0.34
382_L	613_Q	0.508	0.34
422_T	464_T	0.508	0.34
138_A	151_A	0.508	0.34
457_D	511_P	0.507	0.34
76_L	201_E	0.507	0.34
135_A	363_G	0.507	0.34
236_G	615_F	0.507	0.34
34_I	619_L	0.507	0.34
237_P	557_L	0.506	0.34
537_A	549_S	0.506	0.34
561_A	621_D	0.506	0.34
88_I	97_P	0.506	0.34
766_H	769_G	0.506	0.34
305_A	368_I	0.505	0.34
224_L	342_L	0.505	0.34
185_R	212_R	0.505	0.34
164_L	228_Q	0.505	0.34
310_R	315_G	0.504	0.33
590_Y	617_D	0.504	0.33
185_R	239_F	0.504	0.33
575_Q	615_F	0.503	0.33
471_S	611_V	0.502	0.33
637_H	671_G	0.502	0.33
487_A	592_G	0.502	0.33
699_H	807_P	0.502	0.33
545_Y	652_G	0.502	0.33
46_A	655_L	0.501	0.33
467_Q	495_H	0.501	0.33
326_L	339_M	0.501	0.33
323_R	383_K	0.500	0.33
70_E	114_L	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mcbA	1	0.0538	59.3	0.991	Contact Map
3mceA	2	0.0623	45.2	0.992	Contact Map
3npeA	1	0.1394	43.1	0.992	Contact Map
4bolA	2	0.1919	40.7	0.992	Contact Map
1r8gA	2	0.401	33.8	0.992	Contact Map
2y3sA	2	0.1357	30.3	0.993	Contact Map
1w1oA	1	0.1149	20.5	0.993	Contact Map
4u5rA	3	0.1443	19.5	0.993	Contact Map
4mlaA	1	0.1222	19.4	0.993	Contact Map
4ijrA	2	0.0807	17.9	0.993	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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