GREMLIN Database
DUF2125 - Uncharacterized protein conserved in bacteria (DUF2125)
PFAM: PF09898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 317 (312)
Sequences: 2926 (2401)
Seq/√Len: 135.9
META: 0.807

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_A46_D4.9811.00
58_W83_Q4.3851.00
15_W19_E3.2171.00
137_D164_G3.2091.00
117_L120_L3.1171.00
144_R157_D2.9431.00
19_E22_A2.7611.00
301_F306_V2.7601.00
114_S142_H2.7331.00
105_A109_G2.7161.00
7_Q11_G2.7131.00
211_W216_G2.6101.00
162_L165_L2.5981.00
28_C44_C2.4521.00
236_G250_L2.4421.00
13_D31_L2.4161.00
99_S119_D2.4131.00
102_S106_S2.3951.00
7_Q10_A2.3871.00
26_V49_L2.3761.00
43_T62_E2.3501.00
17_A20_A2.2431.00
262_D279_A2.2411.00
271_P274_A2.2131.00
13_D17_A2.2021.00
28_C31_L2.1961.00
4_A40_F2.1571.00
47_P60_A2.1221.00
241_D245_R2.0651.00
306_V314_G2.0571.00
103_L107_L2.0551.00
240_L246_P2.0351.00
9_E13_D2.0131.00
119_D137_D1.9491.00
299_L308_L1.9051.00
209_R212_R1.8991.00
305_R312_P1.8781.00
43_T64_L1.8451.00
281_G284_L1.8331.00
253_T296_T1.8291.00
103_L106_S1.8191.00
265_V275_A1.8031.00
308_L313_L1.7911.00
19_E24_R1.7771.00
3_Y7_Q1.7451.00
76_I142_H1.7441.00
67_A75_L1.7401.00
300_T307_F1.7231.00
301_F316_A1.7081.00
30_S45_D1.7011.00
217_R239_A1.6941.00
9_E31_L1.6691.00
219_E237_T1.6671.00
6_G9_E1.6551.00
41_E66_V1.6461.00
33_V42_V1.6411.00
16_R26_V1.6281.00
44_C47_P1.6101.00
5_A33_V1.6021.00
278_A281_G1.5931.00
226_Q231_I1.5891.00
8_A33_V1.5871.00
306_V316_A1.5731.00
3_Y6_G1.5651.00
16_R28_C1.5391.00
307_F313_L1.5181.00
68_Q76_I1.5091.00
11_G14_A1.4871.00
5_A9_E1.4781.00
211_W215_G1.4611.00
9_E33_V1.4481.00
102_S107_L1.4321.00
106_S110_L1.4211.00
71_D74_H1.4091.00
107_L110_L1.4051.00
64_L78_E1.3971.00
281_G285_L1.3931.00
48_S59_S1.3901.00
27_S48_S1.3841.00
8_A11_G1.3841.00
31_L44_C1.3791.00
65_A77_A1.3551.00
286_A289_G1.3521.00
105_A110_L1.3491.00
92_P96_A1.3411.00
74_H108_R1.3341.00
241_D247_D1.3301.00
208_L211_W1.3281.00
104_R107_L1.3211.00
289_G293_G1.3191.00
213_A216_G1.3161.00
50_A57_A1.3071.00
118_D138_H1.3061.00
68_Q74_H1.3001.00
2_F5_A1.2871.00
104_R108_R1.2821.00
39_R74_H1.2791.00
146_A157_D1.2731.00
143_L156_I1.2651.00
39_R76_I1.2421.00
36_F40_F1.2401.00
39_R66_V1.2201.00
253_T294_A1.2181.00
256_G259_A1.2151.00
45_D62_E1.2091.00
305_R315_P1.2081.00
245_R304_G1.2061.00
20_A23_G1.2021.00
46_D61_P1.1951.00
237_T249_A1.1931.00
51_D54_G1.1881.00
158_L193_L1.1800.99
297_L308_L1.1770.99
307_F312_P1.1740.99
74_H142_H1.1730.99
40_F69_V1.1590.99
224_R233_V1.1530.99
63_L79_F1.1470.99
168_P173_L1.1400.99
25_V50_A1.1350.99
87_D90_G1.1290.99
60_A83_Q1.1230.99
70_Y76_I1.1180.99
124_R127_G1.1150.99
66_V76_I1.1140.99
8_A40_F1.1040.99
76_I106_S1.0990.99
12_L42_V1.0970.99
290_G293_G1.0880.99
106_S109_G1.0880.99
146_A150_P1.0880.99
262_D266_A1.0860.99
47_P63_L1.0840.99
281_G286_A1.0790.99
112_R116_V1.0780.99
302_Q307_F1.0750.99
261_L279_A1.0730.99
197_G202_P1.0570.99
146_A149_S1.0560.99
171_G175_A1.0540.99
19_E23_G1.0490.99
24_R52_P1.0420.99
39_R68_Q1.0390.99
103_L110_L1.0350.99
249_A302_Q1.0260.99
28_C82_P1.0260.99
217_R237_T1.0250.99
6_G10_A1.0230.99
183_G186_I1.0230.99
34_G43_T1.0220.98
230_L259_A1.0210.98
188_A191_L1.0200.98
285_L288_P1.0170.98
126_A129_L1.0120.98
67_A70_Y1.0040.98
307_F310_P1.0020.98
34_G41_E0.9960.98
254_V257_L0.9910.98
103_L109_G0.9910.98
138_H163_D0.9860.98
41_E69_V0.9840.98
251_T298_P0.9830.98
230_L260_L0.9780.98
224_R231_I0.9780.98
66_V78_E0.9780.98
41_E64_L0.9760.98
137_D163_D0.9680.98
24_R49_L0.9580.98
168_P171_G0.9570.98
288_P291_L0.9560.98
190_L222_R0.9530.98
38_F76_I0.9470.98
142_H159_A0.9460.98
38_F68_Q0.9450.97
50_A56_L0.9440.97
140_E144_R0.9430.97
136_A139_L0.9400.97
113_A117_L0.9380.97
212_R216_G0.9380.97
5_A40_F0.9320.97
275_A279_A0.9280.97
116_V138_H0.9270.97
209_R244_G0.9270.97
170_L177_P0.9240.97
120_L136_A0.9200.97
238_L250_L0.9170.97
170_L173_L0.9100.97
112_R142_H0.9100.97
195_D218_L0.9050.97
2_F6_G0.9030.97
48_S57_A0.8970.97
13_D16_R0.8960.97
143_L158_L0.8920.96
238_L248_G0.8850.96
116_V142_H0.8850.96
102_S108_R0.8760.96
20_A24_R0.8750.96
39_R70_Y0.8710.96
87_D93_S0.8700.96
76_I159_A0.8630.96
82_P98_W0.8630.96
200_P203_R0.8610.96
169_P173_L0.8600.96
38_F78_E0.8590.96
231_I255_A0.8580.96
87_D91_G0.8580.96
275_A281_G0.8570.96
44_C98_W0.8570.96
252_L299_L0.8480.95
167_A170_L0.8480.95
20_A27_S0.8470.95
265_V270_L0.8460.95
257_L282_L0.8450.95
199_K204_R0.8430.95
40_F67_A0.8420.95
270_L273_N0.8410.95
265_V272_P0.8410.95
245_R301_F0.8380.95
15_W26_V0.8360.95
72_P75_L0.8360.95
269_L275_A0.8290.95
191_L195_D0.8280.95
306_V315_P0.8270.95
41_E68_Q0.8260.95
171_G176_L0.8240.94
286_A290_G0.8240.94
266_A269_L0.8230.94
68_Q71_D0.8220.94
76_I144_R0.8200.94
79_F83_Q0.8200.94
295_L298_P0.8190.94
295_L311_I0.8180.94
41_E78_E0.8180.94
14_A17_A0.8140.94
26_V51_D0.8110.94
19_E26_V0.8110.94
78_E102_S0.8100.94
105_A108_R0.8080.94
212_R244_G0.8050.94
243_D303_D0.7990.94
3_Y10_A0.7980.93
70_Y142_H0.7970.93
8_A42_V0.7960.93
104_R109_G0.7940.93
103_L108_R0.7910.93
62_E80_P0.7880.93
244_G247_D0.7860.93
89_G92_P0.7840.93
79_F82_P0.7840.93
61_P80_P0.7830.93
142_H157_D0.7740.92
242_A247_D0.7740.92
4_A72_P0.7720.92
38_F66_V0.7710.92
169_P172_P0.7660.92
60_A80_P0.7650.92
64_L80_P0.7640.92
270_L274_A0.7630.92
192_G221_R0.7620.92
235_S251_T0.7610.92
39_R142_H0.7600.92
273_N277_A0.7590.92
257_L295_L0.7580.92
103_L311_I0.7580.92
283_G289_G0.7540.91
192_G195_D0.7540.91
241_D246_P0.7530.91
84_T95_T0.7530.91
274_A277_A0.7510.91
279_A282_L0.7500.91
4_A7_Q0.7500.91
301_F304_G0.7490.91
249_A300_T0.7470.91
139_L162_L0.7450.91
306_V313_L0.7410.91
44_C82_P0.7370.90
211_W240_L0.7360.90
212_R241_D0.7340.90
172_P177_P0.7340.90
144_R159_A0.7300.90
69_V72_P0.7290.90
286_A291_L0.7260.90
116_V140_E0.7260.90
68_Q102_S0.7250.90
70_Y74_H0.7240.90
176_L179_D0.7230.90
113_A116_V0.7220.90
229_D259_A0.7180.89
88_P91_G0.7160.89
65_A75_L0.7160.89
76_I102_S0.7130.89
273_N276_A0.7110.89
169_P177_P0.7090.89
275_A278_A0.7090.89
204_R207_A0.7070.89
272_P283_G0.7040.88
14_A18_R0.7040.88
239_A247_D0.7020.88
194_T221_R0.6990.88
59_S86_A0.6990.88
172_P179_D0.6990.88
228_G263_A0.6960.88
36_F41_E0.6950.88
16_R31_L0.6930.88
207_A212_R0.6920.88
237_T301_F0.6910.87
188_A192_G0.6900.87
52_P55_G0.6900.87
96_A122_L0.6880.87
16_R20_A0.6810.87
271_P275_A0.6800.87
117_L122_L0.6790.87
190_L195_D0.6760.86
183_G189_L0.6710.86
173_L179_D0.6710.86
76_I104_R0.6690.86
112_R120_L0.6680.86
66_V74_H0.6680.86
175_A178_F0.6680.86
278_A284_L0.6670.86
311_I314_G0.6610.85
247_D301_F0.6610.85
197_G201_W0.6590.85
58_W67_A0.6590.85
13_D139_L0.6580.85
96_A99_S0.6540.84
78_E142_H0.6510.84
67_A72_P0.6510.84
81_G306_V0.6500.84
196_F217_R0.6450.84
302_Q305_R0.6450.84
89_G98_W0.6430.83
291_L294_A0.6420.83
259_A263_A0.6400.83
85_L95_T0.6400.83
32_S43_T0.6390.83
310_P313_L0.6390.83
11_G18_R0.6370.83
78_E104_R0.6370.83
222_R233_V0.6370.83
173_L178_F0.6360.83
302_Q306_V0.6340.83
282_L285_L0.6340.83
41_E159_A0.6330.82
274_A280_A0.6320.82
274_A278_A0.6280.82
111_E117_L0.6280.82
116_V119_D0.6280.82
234_A250_L0.6280.82
68_Q78_E0.6270.82
39_R106_S0.6260.82
249_A298_P0.6220.81
6_G48_S0.6210.81
181_D186_I0.6210.81
267_A304_G0.6200.81
61_P218_L0.6180.81
147_P155_A0.6160.81
305_R314_G0.6110.80
102_S110_L0.6100.80
307_F315_P0.6100.80
20_A28_C0.6100.80
209_R213_A0.6100.80
270_L278_A0.6090.80
270_L275_A0.6080.80
175_A181_D0.6070.80
59_S84_T0.6060.80
183_G228_G0.6050.80
279_A288_P0.6020.79
234_A306_V0.6010.79
47_P83_Q0.6010.79
136_A165_L0.5980.79
10_A13_D0.5980.79
173_L177_P0.5960.79
258_E283_G0.5940.78
60_A79_F0.5900.78
81_G97_D0.5890.78
212_R240_L0.5890.78
12_L16_R0.5870.78
62_E66_V0.5870.78
60_A82_P0.5840.77
282_L286_A0.5830.77
275_A280_A0.5820.77
28_C98_W0.5800.77
77_A134_A0.5770.76
140_E161_R0.5760.76
312_P315_P0.5760.76
248_G301_F0.5760.76
259_A262_D0.5750.76
288_P292_E0.5730.76
208_L240_L0.5700.75
61_P82_P0.5700.75
277_A284_L0.5690.75
252_L272_P0.5680.75
38_F41_E0.5670.75
70_Y244_G0.5670.75
41_E70_Y0.5660.75
52_P63_L0.5650.75
128_A131_A0.5650.75
255_A294_A0.5650.75
234_A251_T0.5650.75
241_D244_G0.5650.75
141_L156_I0.5640.75
160_L224_R0.5620.74
198_P214_A0.5600.74
38_F74_H0.5580.74
278_A306_V0.5570.74
46_D49_L0.5570.74
127_G131_A0.5560.74
123_D171_G0.5550.74
183_G192_G0.5520.73
295_L308_L0.5520.73
38_F62_E0.5510.73
99_S118_D0.5510.73
251_T296_T0.5500.73
102_S109_G0.5500.73
111_E115_L0.5490.73
177_P181_D0.5480.73
222_R227_W0.5470.72
211_W241_D0.5460.72
24_R28_C0.5430.72
260_L264_L0.5420.72
211_W268_G0.5420.72
111_E116_V0.5410.72
186_I191_L0.5410.72
1_W37_P0.5410.72
134_A165_L0.5380.71
300_T306_V0.5360.71
36_F83_Q0.5360.71
168_P172_P0.5360.71
212_R239_A0.5350.71
74_H116_V0.5340.71
177_P180_A0.5330.71
113_A127_G0.5330.71
276_A284_L0.5330.71
284_L287_K0.5310.70
237_T302_Q0.5290.70
304_G316_A0.5260.70
119_D126_A0.5260.70
258_E279_A0.5240.69
239_A249_A0.5220.69
212_R247_D0.5220.69
74_H112_R0.5210.69
93_S96_A0.5210.69
28_C72_P0.5210.69
314_G317_P0.5200.69
66_V70_Y0.5200.69
57_A86_A0.5200.69
24_R36_F0.5180.68
70_Y85_L0.5160.68
216_G240_L0.5160.68
46_D59_S0.5160.68
162_L241_D0.5130.68
38_F156_I0.5130.68
250_L294_A0.5130.68
261_L278_A0.5130.68
90_G132_P0.5100.67
277_A281_G0.5060.67
12_L164_G0.5050.66
38_F142_H0.5050.66
62_E81_G0.5050.66
189_L192_G0.5050.66
25_V81_G0.5040.66
15_W18_R0.5040.66
208_L213_A0.5030.66
215_G239_A0.5020.66
21_A52_P0.5020.66
66_V142_H0.5010.66
7_Q137_D0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ypjA 1 0.4448 7.9 0.955 Contact Map
3gm8A 1 0.4196 7.3 0.956 Contact Map
3whjA 2 0.2461 6.3 0.957 Contact Map
4b0yA 1 0.1577 5.2 0.958 Contact Map
2kgsA 1 0.2965 4.2 0.96 Contact Map
2q1fA 1 0.3375 4.2 0.96 Contact Map
2nqcA 1 0.1356 4.2 0.96 Contact Map
3jx8A 4 0.6656 3.4 0.962 Contact Map
2vrsA 3 0.2145 3.3 0.962 Contact Map
3ul4A 1 0.4259 3.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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