GREMLIN Database
DUF2115 - Uncharacterized protein conserved in archaea (DUF2115)
PFAM: PF09888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (163)
Sequences: 674 (466)
Seq/√Len: 36.5
META: 0.858

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_E138_G6.9571.00
30_E33_K4.1201.00
139_V162_K3.0581.00
156_C159_C2.9161.00
21_L26_G2.8831.00
54_T118_E2.8201.00
37_P41_E2.7001.00
42_R132_K2.4001.00
144_V148_Q2.2890.99
46_Y49_E2.2670.99
113_M120_G2.2050.99
134_E164_T2.1650.99
57_E118_E2.1100.99
124_G133_V2.0120.99
77_E81_E1.8850.98
17_S20_D1.8240.97
39_Y128_P1.8130.97
79_L83_W1.8100.97
7_E11_K1.8090.97
4_E7_E1.8020.97
146_D149_K1.7900.97
54_T112_T1.7530.96
148_Q154_A1.7450.96
3_G6_L1.7380.96
49_E125_T1.7230.96
35_L47_F1.7130.96
82_F113_M1.7010.96
3_G17_S1.6500.95
2_K117_E1.6230.95
34_Y65_D1.5870.94
28_L93_W1.5690.93
56_H60_L1.5670.93
82_F126_P1.5450.93
6_L10_K1.5370.93
65_D69_M1.5200.92
5_L13_A1.5140.92
128_P144_V1.5070.92
82_F114_F1.4940.92
42_R126_P1.4900.92
3_G68_T1.4820.91
47_F155_L1.4710.91
39_Y129_G1.4640.91
2_K9_L1.4360.90
145_R160_P1.4210.89
61_H64_G1.3900.88
130_G158_F1.3510.87
109_S140_Y1.3160.85
47_F52_F1.3080.85
129_G143_P1.3060.85
79_L110_A1.2930.84
12_E114_F1.2120.80
24_I31_E1.2090.80
77_E80_K1.2050.80
127_F133_V1.1740.78
101_F118_E1.1600.77
6_L66_F1.1590.77
148_Q157_P1.1580.77
92_A98_E1.1560.77
66_F69_M1.1440.76
142_C156_C1.1400.76
144_V151_V1.1370.76
28_L47_F1.1360.76
69_M111_Y1.1330.76
104_L108_I1.1290.75
81_E132_K1.1250.75
41_E49_E1.1200.75
25_S54_T1.1010.73
157_P160_P1.0980.73
150_D154_A1.0970.73
11_K70_D1.0780.72
156_C161_A1.0620.71
49_E53_G1.0610.71
73_I79_L1.0510.70
82_F110_A1.0480.70
10_K111_Y1.0430.69
78_E150_D1.0430.69
6_L115_V1.0410.69
67_S70_D1.0370.69
75_D81_E1.0360.69
34_Y51_L1.0230.68
36_P110_A1.0140.67
74_I115_V1.0100.67
151_V157_P1.0100.67
145_R151_V1.0020.66
146_D163_Q0.9790.64
11_K14_L0.9780.64
142_C159_C0.9740.64
3_G69_M0.9620.63
21_L52_F0.9590.63
46_Y125_T0.9450.62
123_V133_V0.9440.61
32_I147_K0.9440.61
155_L160_P0.9390.61
27_R32_I0.9360.61
6_L11_K0.9270.60
57_E65_D0.9210.60
9_L117_E0.9210.60
4_E97_D0.9200.59
89_Q154_A0.9180.59
142_C145_R0.9060.58
54_T108_I0.9040.58
4_E9_L0.9040.58
11_K15_R0.9030.58
133_V160_P0.8980.58
83_W110_A0.8910.57
58_I88_E0.8790.56
127_F130_G0.8760.56
143_P154_A0.8670.55
59_K158_F0.8640.55
8_I77_E0.8540.54
15_R74_I0.8530.54
27_R43_L0.8530.54
2_K54_T0.8450.53
118_E132_K0.8440.53
102_R164_T0.8370.52
95_E98_E0.8350.52
36_P52_F0.8300.52
13_A18_I0.8190.51
54_T58_I0.8100.50
129_G133_V0.8090.50
28_L103_L0.8000.49
105_Y126_P0.7890.48
82_F155_L0.7850.48
144_V154_A0.7720.47
145_R148_Q0.7710.46
95_E117_E0.7710.46
91_F117_E0.7670.46
46_Y52_F0.7650.46
93_W102_R0.7650.46
41_E45_P0.7630.46
24_I104_L0.7570.45
37_P108_I0.7560.45
144_V155_L0.7560.45
7_E67_S0.7520.45
149_K152_P0.7430.44
66_F77_E0.7300.43
44_I48_T0.7300.43
70_D94_D0.7270.43
74_I117_E0.7260.43
21_L24_I0.7230.42
160_P163_Q0.7190.42
9_L31_E0.7150.42
154_A157_P0.7080.41
85_M155_L0.7040.41
148_Q151_V0.7030.41
150_D161_A0.7030.41
152_P163_Q0.7030.41
74_I79_L0.7020.41
24_I148_Q0.7010.40
86_L112_T0.6970.40
75_D114_F0.6960.40
149_K157_P0.6920.40
5_L9_L0.6910.40
85_M115_V0.6900.40
143_P150_D0.6900.40
52_F99_P0.6870.39
25_S122_P0.6780.39
23_Q33_K0.6730.38
33_K101_F0.6710.38
105_Y110_A0.6700.38
110_A113_M0.6700.38
25_S31_E0.6640.37
65_D74_I0.6610.37
86_L150_D0.6540.37
100_R123_V0.6480.36
11_K84_E0.6410.36
86_L154_A0.6400.35
17_S150_D0.6340.35
23_Q98_E0.6320.35
36_P132_K0.6310.35
104_L144_V0.6280.34
151_V154_A0.6260.34
83_W144_V0.6230.34
75_D109_S0.6210.34
82_F160_P0.6160.34
108_I135_E0.6160.34
90_C107_L0.6140.33
15_R19_F0.6140.33
31_E105_Y0.6140.33
24_I27_R0.6130.33
148_Q155_L0.6070.33
24_I89_Q0.6070.33
153_Y157_P0.5990.32
125_T128_P0.5920.32
9_L27_R0.5890.31
36_P82_F0.5890.31
7_E68_T0.5880.31
22_Q58_I0.5850.31
26_G41_E0.5840.31
154_A163_Q0.5820.31
81_E162_K0.5800.31
31_E92_A0.5760.30
10_K60_L0.5740.30
57_E164_T0.5720.30
145_R157_P0.5710.30
55_Y104_L0.5710.30
50_Q141_Y0.5700.30
43_L125_T0.5700.30
48_T100_R0.5670.30
58_I114_F0.5660.30
38_P91_F0.5620.29
125_T163_Q0.5600.29
97_D137_G0.5590.29
2_K6_L0.5570.29
152_P164_T0.5550.29
109_S134_E0.5540.29
103_L107_L0.5530.29
3_G71_E0.5530.29
60_L111_Y0.5510.29
6_L14_L0.5480.28
75_D80_K0.5460.28
32_I114_F0.5460.28
47_F158_F0.5410.28
83_W113_M0.5390.28
32_I44_I0.5350.28
37_P150_D0.5320.27
7_E23_Q0.5320.27
19_F109_S0.5310.27
56_H62_R0.5270.27
50_Q134_E0.5260.27
16_Y21_L0.5250.27
57_E81_E0.5240.27
48_T153_Y0.5240.27
18_I27_R0.5230.27
53_G150_D0.5230.27
119_P140_Y0.5210.27
141_Y162_K0.5200.27
28_L108_I0.5170.26
2_K5_L0.5150.26
152_P155_L0.5140.26
46_Y99_P0.5130.26
5_L124_G0.5120.26
20_D139_V0.5110.26
94_D102_R0.5110.26
27_R122_P0.5100.26
113_M151_V0.5100.26
100_R111_Y0.5080.26
3_G10_K0.5080.26
112_T120_G0.5050.25
69_M162_K0.5040.25
35_L94_D0.5040.25
22_Q134_E0.5040.25
85_M157_P0.5010.25
7_E135_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mzyA 2 0.4329 15.6 0.947 Contact Map
2w9yA 1 0.561 12.3 0.949 Contact Map
4yubA 2 0.3659 10.6 0.951 Contact Map
2rioA 2 0.4146 9.2 0.952 Contact Map
4fixA 3 0.3049 7.1 0.955 Contact Map
1zbtA 1 0.5366 7 0.955 Contact Map
2zfhA 3 0.2744 6.9 0.955 Contact Map
3d5aX 1 0.5732 6.8 0.955 Contact Map
4e98A 3 0.2805 6.7 0.955 Contact Map
2wbmA 1 0.5427 6.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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