GREMLIN Database
DUF2103 - Predicted metal-binding protein (DUF2103)
PFAM: PF09876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (87)
Sequences: 1621 (818)
Seq/√Len: 87.7
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_E13_I4.1571.00
65_K78_F3.4151.00
84_S87_E3.0431.00
85_K89_E3.0361.00
89_E93_R2.6611.00
59_T62_G2.1851.00
61_N80_V2.1681.00
12_T16_G2.1261.00
66_L79_I2.1091.00
38_G74_V1.9521.00
33_R82_T1.9171.00
13_I71_G1.9141.00
21_P25_R1.7961.00
67_I74_V1.7711.00
27_A35_I1.7281.00
81_T84_S1.5211.00
82_T90_E1.4690.99
46_S49_G1.4340.99
16_G21_P1.3660.99
87_E90_E1.3470.99
8_I12_T1.3330.99
39_V78_F1.3050.99
12_T17_R1.2750.98
49_G56_T1.2630.98
16_G68_A1.2500.98
66_L80_V1.2450.98
42_V73_A1.2250.98
86_E90_E1.2000.98
59_T65_K1.1860.98
44_G52_R1.1850.98
27_A30_P1.1690.97
90_E93_R1.1520.97
51_L66_L1.1500.97
85_K88_L1.1310.97
68_A81_T1.1180.96
8_I13_I1.1130.96
9_E40_I1.0930.96
35_I70_S1.0500.95
25_R50_K1.0330.94
31_E82_T1.0300.94
41_R44_G1.0280.94
83_L86_E1.0250.94
7_K37_P1.0190.94
69_R74_V0.9830.93
47_A52_R0.9730.93
86_E89_E0.9680.92
8_I14_I0.9630.92
51_L71_G0.9500.92
84_S90_E0.9160.90
53_V56_T0.9040.89
37_P67_I0.8920.89
49_G52_R0.8860.89
44_G49_G0.8790.88
33_R61_N0.8710.88
25_R28_A0.8700.88
26_L64_W0.8670.87
29_N64_W0.8610.87
16_G20_I0.8600.87
41_R50_K0.8460.86
26_L91_A0.8410.86
83_L87_E0.8350.85
8_I17_R0.8310.85
42_V50_K0.8300.85
49_G54_K0.8160.84
73_A86_E0.8150.84
9_E12_T0.8060.83
37_P76_E0.7680.80
89_E92_I0.7660.80
7_K12_T0.7610.80
21_P24_E0.7560.79
11_S71_G0.7440.78
31_E87_E0.7380.78
8_I27_A0.7330.77
29_N91_A0.7320.77
7_K34_S0.7320.77
87_E91_A0.7200.76
53_V68_A0.7190.76
48_R56_T0.7180.76
40_I73_A0.7170.76
41_R77_V0.7080.75
45_R48_R0.6980.74
23_L26_L0.6920.73
12_T69_R0.6890.73
26_L55_V0.6860.72
59_T78_F0.6740.71
7_K23_L0.6690.70
5_K34_S0.6670.70
48_R54_K0.6590.69
15_G70_S0.6550.69
51_L54_K0.6530.69
16_G32_I0.6440.67
36_I69_R0.6440.67
15_G21_P0.6430.67
82_T86_E0.6420.67
69_R72_G0.6410.67
45_R70_S0.6380.67
30_P91_A0.6260.65
88_L92_I0.6230.65
20_I24_E0.6220.65
13_I17_R0.6040.63
24_E68_A0.6020.62
46_S54_K0.6010.62
43_R69_R0.5980.62
9_E37_P0.5910.61
9_E34_S0.5850.60
9_E77_V0.5840.60
74_V80_V0.5820.60
13_I20_I0.5760.59
52_R55_V0.5740.59
3_K27_A0.5740.59
67_I76_E0.5720.58
87_E92_I0.5700.58
7_K36_I0.5680.58
39_V65_K0.5650.57
28_A85_K0.5650.57
17_R23_L0.5560.56
29_N66_L0.5500.55
82_T89_E0.5450.55
36_I78_F0.5440.55
87_E93_R0.5410.54
7_K20_I0.5400.54
7_K78_F0.5380.54
31_E64_W0.5340.53
41_R54_K0.5320.53
68_A77_V0.5230.52
45_R49_G0.5210.52
76_E79_I0.5200.51
28_A90_E0.5110.50
36_I59_T0.5050.49
34_S68_A0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j38Z 1 0.7551 11.9 0.9 Contact Map
4ujpa 1 0.7041 10.7 0.902 Contact Map
4nhrA 2 0.2551 8.3 0.907 Contact Map
2r76A 2 0.2449 8 0.908 Contact Map
3zeyU 1 0.7857 7.6 0.909 Contact Map
4w23Z 1 0.7653 6.8 0.911 Contact Map
4bpe8 1 0.7857 6.3 0.912 Contact Map
3j60Z 1 0.7959 5.8 0.914 Contact Map
2iayA 1 0.8571 4.6 0.918 Contact Map
3j7a2 1 0.4184 4.4 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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