GREMLIN Database
DUF2099 - Uncharacterized protein conserved in archaea (DUF2099)
PFAM: PF09872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 257 (255)
Sequences: 545 (362)
Seq/√Len: 22.7
META: 0.855

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L111_V5.5381.00
33_K39_K4.2741.00
9_A46_V3.6571.00
12_V20_E3.2911.00
159_I166_I3.2541.00
27_E40_E2.9761.00
98_D130_V2.9180.99
47_K51_E2.9140.99
62_P129_E2.8240.99
177_E207_R2.7790.99
84_G251_L2.7710.99
100_A134_I2.7260.99
9_A22_G2.6990.99
3_I60_C2.6370.99
171_A195_V2.5930.99
96_V149_I2.5550.98
18_V21_V2.5500.98
102_T154_G2.5490.98
135_E144_P2.5290.98
51_E55_K2.5260.98
23_E43_K2.5080.98
69_D109_E2.4920.98
118_M121_L2.4360.98
148_R153_A2.4160.98
132_E136_E2.3860.98
157_K161_L2.3730.98
97_C114_I2.3570.97
52_F56_D2.2230.96
201_S204_E2.1160.95
90_I167_A2.0890.95
41_I45_A2.0880.95
143_D148_R2.0790.95
179_I190_I2.0380.94
155_V190_I2.0030.93
77_A214_I1.9660.93
180_R192_I1.9500.92
178_K181_E1.9250.92
249_K253_L1.9010.91
122_V146_T1.8930.91
36_R52_F1.8670.91
81_L90_I1.8170.89
153_A156_K1.7460.87
81_L93_A1.7420.87
97_C115_G1.7090.86
81_L241_V1.6800.85
81_L85_L1.6340.84
193_F214_I1.6320.84
57_F117_R1.6250.83
165_K189_D1.6230.83
12_V22_G1.5930.82
41_I46_V1.5870.82
131_I144_P1.5620.81
172_S175_D1.5300.79
73_V77_A1.5280.79
131_I141_V1.5270.79
116_G130_V1.5270.79
231_A234_Q1.5190.79
67_E137_E1.5040.78
49_N53_R1.5030.78
210_E230_K1.4960.78
14_R123_E1.4960.78
110_L137_E1.4420.75
67_E109_E1.4400.75
98_D118_M1.4170.74
2_V12_V1.4090.73
143_D146_T1.4020.73
13_I19_V1.3640.71
66_L133_R1.3460.70
88_G170_V1.3400.69
71_D74_G1.3050.67
194_A197_T1.2870.66
110_L139_G1.2830.66
44_E48_E1.2780.66
133_R137_E1.2760.65
81_L193_F1.2660.65
42_T45_A1.2420.63
247_K250_E1.2320.63
193_F241_V1.2290.63
18_V47_K1.2270.62
177_E181_E1.2260.62
81_L167_A1.2260.62
207_R211_N1.2130.61
134_I139_G1.2020.61
80_I252_L1.2000.61
43_K46_V1.1920.60
71_D116_G1.1870.60
150_D153_A1.1840.60
83_T255_R1.1770.59
54_I202_E1.1670.58
130_V133_R1.1600.58
107_N110_L1.1520.57
45_A48_E1.1360.56
197_T215_V1.1360.56
67_E107_N1.1170.55
125_S128_P1.1070.54
32_F53_R1.0990.54
32_F38_I1.0990.54
32_F37_G1.0940.53
74_G216_T1.0920.53
32_F36_R1.0900.53
2_V123_E1.0850.53
156_K182_L1.0790.52
53_R119_S1.0770.52
66_L110_L1.0730.52
22_G128_P1.0370.50
148_R181_E1.0350.49
167_A193_F1.0300.49
177_E211_N1.0290.49
231_A241_V1.0270.49
116_G227_A1.0230.49
135_E138_G1.0170.48
128_P225_E1.0110.48
110_L114_I1.0080.48
233_L253_L1.0060.47
32_F52_F1.0040.47
191_L251_L0.9860.46
214_I241_V0.9660.45
166_I188_V0.9650.45
114_I231_A0.9620.44
24_P42_T0.9600.44
252_L255_R0.9480.43
152_V208_L0.9440.43
32_F49_N0.9430.43
31_L195_V0.9390.43
54_I61_T0.9360.43
60_C98_D0.9340.42
194_A212_A0.9330.42
54_I57_F0.9330.42
110_L134_I0.9330.42
50_I57_F0.9270.42
126_P131_I0.9240.42
50_I143_D0.9240.42
50_I53_R0.9240.42
165_K251_L0.9230.42
3_I114_I0.9230.42
6_L118_M0.9210.42
15_D125_S0.9210.42
121_L149_I0.9190.41
159_I188_V0.9180.41
104_I140_I0.9170.41
62_P127_I0.9150.41
66_L255_R0.9120.41
15_D80_I0.9080.41
230_K242_F0.9080.41
215_V223_I0.9070.41
165_K191_L0.9010.40
106_T163_Y0.8980.40
106_T138_G0.8870.39
46_V50_I0.8800.39
25_L198_T0.8760.39
116_G119_S0.8720.38
17_K184_P0.8700.38
35_A46_V0.8590.37
57_F60_C0.8550.37
245_T249_K0.8520.37
114_I120_G0.8490.37
73_V135_E0.8490.37
99_G115_G0.8330.36
35_A74_G0.8300.36
114_I195_V0.8290.36
5_A46_V0.8290.36
34_K123_E0.8280.36
94_V111_V0.8260.35
173_A200_I0.8200.35
67_E77_A0.8190.35
123_E237_T0.8190.35
13_I217_A0.8180.35
125_S131_I0.8150.35
234_Q237_T0.8000.34
183_E190_I0.7990.34
189_D247_K0.7950.33
35_A73_V0.7940.33
49_N119_S0.7920.33
212_A215_V0.7890.33
235_A255_R0.7870.33
12_V16_G0.7860.33
106_T134_I0.7840.33
40_E223_I0.7800.33
59_M98_D0.7790.32
238_S256_A0.7760.32
1_H4_E0.7740.32
209_F226_I0.7720.32
119_S216_T0.7690.32
237_T256_A0.7670.32
157_K160_E0.7620.31
215_V249_K0.7620.31
84_G92_A0.7600.31
151_Q193_F0.7580.31
96_V151_Q0.7530.31
12_V21_V0.7520.31
138_G167_A0.7510.31
26_I219_A0.7490.31
33_K121_L0.7470.31
196_H218_C0.7470.31
19_V108_P0.7450.30
16_G63_N0.7440.30
95_I114_I0.7430.30
93_A187_G0.7310.30
2_V117_R0.7300.30
173_A207_R0.7300.30
163_Y174_E0.7230.29
140_I192_I0.7210.29
96_V121_L0.7210.29
156_K185_E0.7210.29
205_A223_I0.7180.29
132_E137_E0.7180.29
36_R53_R0.7170.29
89_L194_A0.7110.29
127_I198_T0.7100.28
13_I60_C0.7100.28
125_S149_I0.7080.28
169_T192_I0.7040.28
11_V52_F0.7020.28
42_T69_D0.7010.28
90_I117_R0.6980.28
80_I83_T0.6980.28
9_A90_I0.6980.28
195_V252_L0.6970.28
42_T194_A0.6970.28
206_E211_N0.6940.28
31_L194_A0.6910.27
38_I245_T0.6900.27
66_L130_V0.6880.27
62_P164_K0.6850.27
6_L32_F0.6850.27
48_E55_K0.6850.27
202_E225_E0.6800.27
36_R68_M0.6780.27
145_E155_V0.6770.27
85_L193_F0.6760.27
49_N72_F0.6760.27
100_A103_V0.6760.27
128_P170_V0.6730.26
77_A169_T0.6710.26
12_V19_V0.6650.26
171_A175_D0.6650.26
62_P100_A0.6630.26
28_Y193_F0.6620.26
43_K123_E0.6590.26
95_I111_V0.6570.26
17_K144_P0.6570.26
66_L137_E0.6570.26
87_R250_E0.6550.25
155_V168_V0.6540.25
65_E169_T0.6520.25
100_A232_L0.6510.25
221_K230_K0.6510.25
92_A104_I0.6500.25
15_D88_G0.6490.25
3_I50_I0.6490.25
119_S196_H0.6470.25
98_D141_V0.6470.25
82_S256_A0.6470.25
2_V14_R0.6470.25
74_G194_A0.6460.25
6_L39_K0.6460.25
140_I157_K0.6450.25
113_G119_S0.6440.25
229_K239_I0.6440.25
232_L235_A0.6440.25
239_I256_A0.6430.25
42_T103_V0.6420.25
189_D201_S0.6370.25
206_E210_E0.6370.25
13_I95_I0.6360.24
216_T235_A0.6330.24
165_K247_K0.6300.24
8_K22_G0.6270.24
93_A235_A0.6250.24
188_V238_S0.6240.24
13_I237_T0.6210.24
203_E223_I0.6200.24
26_I38_I0.6200.24
170_V194_A0.6190.24
146_T153_A0.6170.24
15_D129_E0.6160.23
224_R239_I0.6160.23
89_L198_T0.6130.23
12_V61_T0.6120.23
85_L247_K0.6110.23
209_F244_L0.6080.23
172_S178_K0.6070.23
92_A192_I0.6060.23
96_V210_E0.6050.23
9_A92_A0.6050.23
115_G120_G0.6050.23
44_E47_K0.6040.23
3_I118_M0.6040.23
167_A200_I0.6000.23
115_G118_M0.6000.23
97_C118_M0.5990.23
49_N117_R0.5990.23
27_E104_I0.5990.23
233_L243_A0.5970.23
21_V113_G0.5950.22
99_G114_I0.5920.22
3_I98_D0.5890.22
44_E167_A0.5860.22
103_V141_V0.5840.22
134_I141_V0.5830.22
86_R214_I0.5830.22
38_I49_N0.5830.22
196_H216_T0.5810.22
153_A221_K0.5810.22
19_V104_I0.5810.22
93_A148_R0.5800.22
95_I193_F0.5770.22
204_E225_E0.5760.22
152_V165_K0.5730.21
74_G139_G0.5690.21
26_I198_T0.5680.21
10_R18_V0.5680.21
49_N196_H0.5670.21
193_F216_T0.5670.21
76_G112_Q0.5650.21
227_A234_Q0.5620.21
6_L41_I0.5610.21
97_C163_Y0.5580.21
52_F96_V0.5580.21
95_I197_T0.5570.21
106_T243_A0.5570.21
95_I215_V0.5570.21
115_G231_A0.5550.21
53_R196_H0.5540.21
4_E196_H0.5540.21
116_G141_V0.5540.21
35_A72_F0.5510.20
49_N113_G0.5510.20
77_A147_A0.5480.20
61_T163_Y0.5480.20
54_I174_E0.5450.20
104_I182_L0.5450.20
92_A156_K0.5450.20
192_I206_E0.5430.20
5_A50_I0.5430.20
8_K19_V0.5390.20
42_T46_V0.5380.20
173_A192_I0.5380.20
202_E222_H0.5360.20
36_R48_E0.5360.20
142_L223_I0.5360.20
63_N221_K0.5340.20
152_V174_E0.5340.20
135_E209_F0.5340.20
104_I176_A0.5340.20
135_E214_I0.5320.20
73_V242_F0.5310.20
142_L157_K0.5300.19
241_V251_L0.5290.19
16_G218_C0.5290.19
34_K80_I0.5280.19
80_I132_E0.5280.19
151_Q208_L0.5280.19
66_L235_A0.5260.19
150_D245_T0.5220.19
176_A196_H0.5220.19
13_I215_V0.5210.19
93_A193_F0.5210.19
9_A43_K0.5200.19
10_R118_M0.5200.19
83_T96_V0.5170.19
133_R179_I0.5170.19
75_F196_H0.5150.19
59_M167_A0.5140.19
6_L38_I0.5130.19
168_V176_A0.5100.19
74_G86_R0.5080.19
53_R74_G0.5080.19
11_V178_K0.5080.19
200_I215_V0.5080.19
33_K37_G0.5070.18
6_L216_T0.5070.18
5_A11_V0.5070.18
41_I193_F0.5060.18
21_V72_F0.5040.18
17_K24_P0.5030.18
6_L34_K0.5010.18
153_A243_A0.5010.18
172_S235_A0.5010.18
169_T208_L0.5000.18
10_R61_T0.5000.18
231_A243_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hutA 1 0.7626 53.9 0.968 Contact Map
2obnA 2 0.642 46.8 0.969 Contact Map
3zihA 2 0.2996 32.6 0.972 Contact Map
4omfB 1 0.6187 28.6 0.973 Contact Map
3zieA 2 0.2996 24.9 0.973 Contact Map
3nytA 2 0.786 23.3 0.974 Contact Map
4f06A 1 0.7588 22.1 0.974 Contact Map
3uk0A 1 0.7782 20.3 0.974 Contact Map
3ou5A 2 0.7237 18.9 0.975 Contact Map
4utuA 2 0.7393 18.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.