GREMLIN Database
DUF2098 - Uncharacterized protein conserved in archaea (DUF2098)
PFAM: PF09871 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (92)
Sequences: 604 (419)
Seq/√Len: 43.6
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A43_I3.7391.00
9_R14_G2.8061.00
23_K26_E2.6941.00
81_D84_K2.3581.00
88_Q91_E2.3051.00
70_K74_K2.0070.99
11_P47_E1.8830.99
32_A46_L1.8640.99
23_K40_Y1.8400.99
31_W47_E1.7770.98
91_E94_G1.7740.98
79_E84_K1.7490.98
12_R33_L1.6970.98
13_T17_G1.6890.97
58_K61_D1.6500.97
78_E81_D1.6300.97
42_R45_T1.5820.96
7_R48_P1.5800.96
56_E63_E1.5560.96
17_G35_D1.5300.95
9_R16_V1.4530.94
86_S89_S1.4460.94
33_L40_Y1.4090.93
14_G51_E1.4010.93
28_G37_T1.3640.92
25_E28_G1.3550.91
80_L84_K1.3230.90
86_S92_G1.2460.88
2_I8_V1.2430.87
54_K59_K1.2400.87
5_G10_Y1.2170.86
11_P14_G1.2160.86
54_K58_K1.1980.85
25_E29_E1.1910.85
2_I19_V1.1880.85
10_Y13_T1.1740.84
65_D73_E1.1720.84
72_R75_E1.1640.84
70_K73_E1.1570.83
71_E74_K1.1530.83
2_I49_A1.1150.81
62_R69_I1.1070.80
38_G45_T1.0860.79
28_G52_S1.0750.78
79_E83_A1.0510.77
21_D33_L1.0450.76
21_D40_Y1.0290.75
4_V26_E1.0170.74
66_L75_E1.0050.74
18_K48_P0.9930.73
57_K61_D0.9890.72
3_K6_S0.9870.72
63_E69_I0.9560.70
88_Q93_G0.9350.68
16_V44_D0.9310.68
13_T35_D0.9300.68
12_R49_A0.9260.67
73_E76_F0.9180.67
85_N88_Q0.9170.67
62_R65_D0.9110.66
60_E66_L0.8920.64
39_L46_L0.8890.64
33_L38_G0.8590.61
64_E70_K0.8570.61
65_D68_E0.8520.61
20_L38_G0.8520.61
30_V60_E0.8510.61
88_Q92_G0.8470.60
9_R13_T0.8400.60
14_G17_G0.8370.59
25_E30_V0.8340.59
2_I6_S0.8270.58
6_S9_R0.8190.58
71_E75_E0.8150.57
18_K40_Y0.8110.57
19_V32_A0.8100.57
10_Y15_T0.8080.57
54_K78_E0.7980.56
33_L43_I0.7840.54
90_C94_G0.7820.54
67_E78_E0.7770.54
67_E70_K0.7760.54
62_R66_L0.7720.53
46_L52_S0.7630.52
22_I67_E0.7510.51
69_I78_E0.7440.51
47_E50_D0.7400.50
18_K91_E0.7380.50
4_V27_D0.7240.49
6_S49_A0.7210.48
20_L51_E0.7190.48
83_A93_G0.7160.48
18_K42_R0.7040.47
56_E60_E0.7030.47
34_L48_P0.7020.47
55_K60_E0.6890.45
68_E73_E0.6890.45
65_D70_K0.6840.45
56_E69_I0.6820.45
42_R87_D0.6740.44
80_L83_A0.6700.44
57_K63_E0.6630.43
68_E72_R0.6630.43
18_K85_N0.6620.43
31_W45_T0.6610.43
16_V49_A0.6600.43
9_R53_E0.6440.41
85_N92_G0.6340.40
6_S48_P0.6240.39
12_R35_D0.6110.38
55_K58_K0.6070.38
15_T37_T0.5960.37
12_R91_E0.5860.36
63_E68_E0.5850.36
25_E48_P0.5800.35
8_V37_T0.5760.35
15_T50_D0.5750.35
16_V36_S0.5720.35
27_D44_D0.5690.34
9_R51_E0.5630.34
43_I48_P0.5590.33
4_V21_D0.5580.33
28_G39_L0.5550.33
12_R23_K0.5550.33
68_E71_E0.5530.33
19_V79_E0.5490.33
89_S92_G0.5440.32
59_K66_L0.5410.32
19_V30_V0.5410.32
83_A87_D0.5350.31
29_E50_D0.5350.31
46_L70_K0.5280.31
9_R90_C0.5250.31
47_E51_E0.5210.30
79_E82_E0.5090.29
54_K57_K0.5090.29
63_E73_E0.5080.29
20_L35_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qp2A 1 0.5957 49.5 0.87 Contact Map
2lt1A 1 0.6064 36.6 0.88 Contact Map
4l5gA 1 0.9255 33.9 0.882 Contact Map
2lt4A 1 0.617 25.5 0.889 Contact Map
4kbmB 1 0.8298 24.2 0.89 Contact Map
1ix5A 1 0.4574 22.9 0.892 Contact Map
3p8bB 2 0.5426 21.9 0.893 Contact Map
3mlqE 1 0.4468 19.5 0.895 Contact Map
4p5nA 2 0.5532 19.1 0.895 Contact Map
2lq8A 1 0.5213 16.9 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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