GREMLIN Database
DUF2095 - Uncharacterized protein conserved in archaea (DUF2095)
PFAM: PF09868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (113)
Sequences: 545 (395)
Seq/√Len: 37.2
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_Q113_S4.2581.00
81_A111_V4.0281.00
73_R118_K3.2631.00
26_N29_K3.1471.00
89_E103_R3.1271.00
85_I102_L3.0881.00
76_D80_Q3.0501.00
68_V88_L2.8801.00
65_N71_F2.8171.00
72_I81_A2.5481.00
104_K108_E2.5201.00
82_E86_D2.5091.00
61_F64_Y2.3281.00
105_Q109_K2.2670.99
17_K32_E1.9580.98
121_G124_F1.8080.97
89_E96_K1.7660.97
19_E23_M1.6810.96
120_E124_F1.6160.95
112_R117_K1.6140.95
64_Y68_V1.6040.94
86_D103_R1.5620.94
71_F84_I1.5170.93
118_K123_Y1.4880.92
52_E55_K1.4030.89
76_D117_K1.3920.89
26_N31_L1.3210.86
121_G125_K1.2980.85
29_K35_N1.2710.84
78_E111_V1.2650.84
82_E103_R1.2520.83
30_E110_G1.2300.82
94_I98_Y1.2210.81
71_F124_F1.1660.78
31_L126_H1.1590.78
95_T98_Y1.1500.77
59_D62_R1.1350.76
29_K33_E1.1260.76
69_I118_K1.1150.75
119_E125_K1.0950.74
80_Q120_E1.0810.73
78_E92_G1.0770.72
99_A103_R1.0550.71
96_K100_E1.0460.70
67_D70_D1.0040.67
19_E22_K1.0000.67
72_I85_I0.9970.66
95_T101_E0.9910.66
45_D48_E0.9860.66
46_E80_Q0.9680.64
72_I102_L0.9490.63
69_I72_I0.9480.63
19_E72_I0.9480.63
76_D84_I0.9460.62
65_N87_Y0.9320.61
14_E20_F0.9180.60
20_F31_L0.9150.60
84_I117_K0.9020.59
20_F28_A0.9000.58
79_E121_G0.8960.58
82_E107_K0.8870.57
69_I73_R0.8770.56
97_E111_V0.8750.56
18_E103_R0.8640.55
91_R97_E0.8500.54
60_K80_Q0.8460.54
22_K77_T0.8410.53
38_S121_G0.8400.53
64_Y70_D0.8350.53
40_D58_S0.8300.52
76_D112_R0.8210.52
72_I111_V0.8180.51
59_D124_F0.8160.51
83_E106_L0.8150.51
34_E108_E0.8090.51
88_L94_I0.8070.50
36_K82_E0.8070.50
89_E99_A0.7910.49
83_E94_I0.7870.49
69_I102_L0.7850.48
80_Q112_R0.7770.48
63_G124_F0.7730.47
33_E65_N0.7710.47
26_N62_R0.7620.46
108_E121_G0.7510.45
35_N38_S0.7430.45
39_I43_R0.7430.45
69_I75_C0.7410.45
75_C88_L0.7390.44
98_Y102_L0.7360.44
80_Q124_F0.7340.44
50_V54_E0.7280.43
106_L114_F0.7280.43
75_C84_I0.7270.43
23_M126_H0.7220.43
47_E72_I0.7160.42
65_N101_E0.7020.41
18_E78_E0.6970.41
41_S122_Y0.6960.41
42_V87_Y0.6960.41
84_I91_R0.6950.41
88_L123_Y0.6950.41
39_I105_Q0.6950.41
42_V122_Y0.6910.40
100_E108_E0.6890.40
20_F87_Y0.6810.39
36_K69_I0.6760.39
49_A97_E0.6710.39
36_K40_D0.6710.39
38_S41_S0.6660.38
72_I91_R0.6650.38
19_E67_D0.6620.38
51_E79_E0.6550.37
23_M82_E0.6530.37
94_I109_K0.6420.36
31_L67_D0.6380.36
35_N65_N0.6250.35
99_A113_S0.6250.35
63_G71_F0.6140.34
86_D116_P0.6140.34
85_I99_A0.6100.34
85_I105_Q0.6100.34
35_N72_I0.6090.33
16_D37_V0.6050.33
87_Y119_E0.6040.33
50_V86_D0.6030.33
100_E126_H0.6030.33
29_K111_V0.6010.33
100_E107_K0.6000.33
78_E107_K0.5990.33
37_V69_I0.5960.32
27_L74_R0.5950.32
28_A67_D0.5920.32
79_E97_E0.5860.32
70_D88_L0.5820.31
107_K122_Y0.5810.31
40_D70_D0.5810.31
19_E28_A0.5800.31
20_F114_F0.5770.31
88_L92_G0.5670.30
16_D19_E0.5660.30
103_R125_K0.5660.30
82_E120_E0.5640.30
28_A32_E0.5610.30
61_F84_I0.5600.30
73_R81_A0.5590.30
40_D63_G0.5530.29
119_E124_F0.5520.29
88_L93_E0.5510.29
44_T80_Q0.5510.29
78_E104_K0.5480.29
17_K22_K0.5460.29
36_K108_E0.5450.29
15_I28_A0.5440.29
94_I126_H0.5430.28
43_R73_R0.5410.28
99_A114_F0.5370.28
101_E105_Q0.5360.28
21_K39_I0.5360.28
27_L118_K0.5330.28
18_E38_S0.5300.28
77_T80_Q0.5210.27
76_D107_K0.5190.27
58_S95_T0.5130.26
79_E96_K0.5110.26
38_S92_G0.5100.26
98_Y122_Y0.5090.26
60_K84_I0.5050.26
53_E57_A0.5010.26
53_E95_T0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qweA 2 0.5814 15.7 0.941 Contact Map
4jupA 2 0.5504 10.7 0.945 Contact Map
2xvsA 1 0.3953 8.1 0.948 Contact Map
1ng7A 2 0.4419 8 0.949 Contact Map
4edgA 1 0.5814 7.7 0.949 Contact Map
4rhwE 1 0.5194 7.5 0.949 Contact Map
2wujA 2 0.3798 6.8 0.95 Contact Map
3ml6A 1 0.6279 6.1 0.951 Contact Map
2yy0A 6 0.3488 6.1 0.951 Contact Map
2choA 1 0.8527 5.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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