GREMLIN Database
DUF2085 - Predicted membrane protein (DUF2085)
PFAM: PF09858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (89)
Sequences: 10464 (7688)
Seq/√Len: 814.9
META: 0.972

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_T69_R3.9101.00
20_A73_N2.6141.00
10_H15_Q2.2771.00
8_S15_Q2.1971.00
19_C22_C2.1931.00
9_F20_A2.0671.00
16_L23_T2.0541.00
24_G77_L1.9941.00
5_P10_H1.9281.00
71_S75_L1.9031.00
61_G65_L1.8071.00
25_I83_F1.7181.00
9_F77_L1.7101.00
2_H7_R1.6911.00
57_M83_F1.6881.00
54_L83_F1.6651.00
28_G81_L1.6441.00
11_L16_L1.6411.00
53_A86_A1.6371.00
69_R75_L1.5741.00
62_L66_L1.5721.00
57_M79_T1.5361.00
25_I57_M1.5281.00
60_D79_T1.5201.00
64_Q71_S1.4721.00
50_L87_L1.4021.00
74_L78_L1.3661.00
23_T27_L1.3571.00
29_A88_A1.2581.00
63_T68_L1.1891.00
52_L56_P1.1821.00
63_T75_L1.1511.00
53_A82_L1.1481.00
8_S16_L1.1251.00
5_P15_Q1.1131.00
56_P79_T1.1021.00
72_T75_L1.0951.00
41_R45_L1.0801.00
73_N76_R1.0771.00
50_L53_A1.0701.00
32_G85_L1.0351.00
18_V22_C1.0221.00
57_M61_G0.9961.00
63_T67_G0.9841.00
43_P46_P0.9791.00
61_G71_S0.9721.00
44_P48_W0.9641.00
41_R47_L0.9631.00
32_G88_A0.9601.00
45_L49_L0.9571.00
54_L58_A0.9541.00
19_C26_Y0.9521.00
58_A62_L0.9311.00
62_L65_L0.9241.00
32_G36_F0.9001.00
46_P49_L0.8801.00
78_L82_L0.8791.00
40_R45_L0.8691.00
60_D69_R0.8641.00
50_L86_A0.8461.00
20_A24_G0.8441.00
83_F86_A0.8421.00
2_H8_S0.8341.00
61_G64_Q0.8311.00
2_H22_C0.8211.00
41_R46_P0.8161.00
60_D64_Q0.8161.00
33_L37_A0.8151.00
55_L59_L0.8091.00
18_V26_Y0.8031.00
42_L46_P0.7981.00
42_L47_L0.7941.00
43_P47_L0.7931.00
25_I80_G0.7831.00
67_G70_E0.7821.00
78_L81_L0.7821.00
73_N77_L0.7811.00
39_R42_L0.7801.00
24_G28_G0.7781.00
28_G32_G0.7761.00
42_L45_L0.7761.00
58_A61_G0.7731.00
40_R44_P0.7721.00
74_L77_L0.7631.00
4_I8_S0.7591.00
18_V23_T0.7531.00
3_Q8_S0.7461.00
59_L62_L0.7381.00
28_G84_G0.7371.00
56_P59_L0.7051.00
60_D71_S0.7021.00
56_P82_L0.6951.00
64_Q70_E0.6921.00
9_F16_L0.6831.00
54_L57_M0.6671.00
79_T82_L0.6641.00
4_I19_C0.6611.00
59_L63_T0.6591.00
41_R44_P0.6541.00
10_H14_Y0.6521.00
56_P60_D0.6501.00
10_H13_G0.6391.00
50_L54_L0.6361.00
82_L86_A0.6331.00
82_L85_L0.6311.00
2_H19_C0.6291.00
34_L37_A0.6281.00
28_G80_G0.6281.00
42_L48_W0.6241.00
85_L89_W0.6241.00
24_G73_N0.6021.00
7_R76_R0.6001.00
53_A56_P0.5981.00
4_I7_R0.5941.00
49_L52_L0.5911.00
35_L38_L0.5861.00
71_S76_R0.5681.00
54_L61_G0.5631.00
48_W51_L0.5581.00
51_L56_P0.5581.00
25_I29_A0.5571.00
51_L55_L0.5571.00
14_Y17_P0.5571.00
56_P83_F0.5531.00
51_L58_A0.5451.00
34_L38_L0.5421.00
44_P47_L0.5281.00
58_A65_L0.5271.00
3_Q29_A0.5261.00
55_L58_A0.5171.00
11_L14_Y0.5151.00
28_G85_L0.5111.00
19_C23_T0.5081.00
12_G15_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ffyA 1 0.3333 10.9 0.891 Contact Map
2k35A 1 0.2222 4.3 0.909 Contact Map
3w0fA 1 0.2667 2.8 0.918 Contact Map
3mpxA 1 0 2.2 0.922 Contact Map
3vk8A 1 0.2778 2.2 0.922 Contact Map
2d56A 1 0.2444 2.2 0.922 Contact Map
2j9rA 3 0.3222 2.1 0.923 Contact Map
2orwA 3 0.3111 1.8 0.926 Contact Map
4ldsA 2 0.9778 1.8 0.926 Contact Map
1ednA 2 0.0778 1.1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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