GREMLIN Database
YjhX_toxin - Putative toxin of bacterial toxin-antitoxin pair
PFAM: PF09857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 896 (542)
Seq/√Len: 58.8
META: 0.759

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E42_R3.7241.00
72_R76_E3.1811.00
7_E53_K3.0981.00
61_A71_T3.0221.00
73_R77_A2.8231.00
16_Q39_D2.4661.00
8_Q12_H2.4201.00
36_F42_R2.4161.00
52_R55_K2.0141.00
16_Q84_N1.8381.00
53_K57_K1.8120.99
1_M7_E1.7540.99
53_K78_V1.7450.99
35_C43_L1.6500.99
47_T50_L1.6300.99
23_E34_E1.6230.99
33_V46_C1.5250.98
10_V46_C1.4630.98
71_T75_L1.4210.97
35_C46_C1.3850.97
6_A10_V1.3780.97
13_A43_L1.3610.96
22_H30_I1.3570.96
30_I51_F1.3250.96
10_V29_R1.2840.95
16_Q85_R1.2740.95
41_W71_T1.2310.94
24_R60_I1.2180.93
45_D81_Q1.1890.92
63_R69_R1.1370.90
72_R75_L1.1360.90
59_L77_A1.1260.90
23_E36_F1.1140.90
27_R55_K1.1070.89
20_I48_L1.1010.89
73_R76_E1.0970.89
2_N59_L1.0850.88
52_R56_R1.0840.88
22_H71_T1.0500.87
67_P79_R1.0170.85
22_H33_V0.9760.82
19_R69_R0.9600.81
3_I39_D0.9360.80
24_R41_W0.9310.79
43_L59_L0.9290.79
4_S7_E0.9140.78
19_R53_K0.9090.78
1_M6_A0.9080.77
28_G43_L0.8980.77
23_E32_E0.8900.76
12_H78_V0.8860.76
6_A45_D0.8840.76
10_V71_T0.8760.75
13_A16_Q0.8750.75
2_N77_A0.8620.74
37_T44_S0.8450.72
2_N5_R0.8420.72
38_R65_G0.8380.72
43_L46_C0.8360.71
61_A75_L0.8260.70
49_A64_G0.8200.70
38_R51_F0.8160.70
5_R59_L0.8130.69
35_C56_R0.8100.69
13_A41_W0.8050.69
22_H29_R0.8000.68
36_F60_I0.7960.68
12_H15_A0.7690.65
10_V50_L0.7530.63
2_N81_Q0.7470.63
21_E34_E0.7320.61
59_L71_T0.7320.61
39_D78_V0.7250.60
2_N45_D0.7240.60
2_N35_C0.7150.59
27_R30_I0.7110.59
46_C50_L0.7070.58
49_A56_R0.7040.58
41_W60_I0.6960.57
61_A66_G0.6880.56
26_D64_G0.6800.56
22_H65_G0.6790.55
34_E41_W0.6730.55
8_Q78_V0.6700.54
21_E85_R0.6640.54
75_L82_L0.6630.54
10_V45_D0.6620.54
18_G53_K0.6610.53
37_T42_R0.6570.53
55_K66_G0.6550.53
33_V48_L0.6490.52
1_M47_T0.6430.51
50_L61_A0.6400.51
11_L14_L0.6340.50
28_G32_E0.6270.50
25_D31_V0.6210.49
2_N46_C0.6190.49
70_I74_G0.6190.49
63_R66_G0.6120.48
20_I46_C0.6120.48
24_R28_G0.6030.47
77_A80_A0.6000.47
6_A55_K0.5990.47
55_K63_R0.5910.46
13_A83_D0.5860.45
31_V66_G0.5850.45
22_H78_V0.5830.45
24_R71_T0.5800.44
10_V43_L0.5800.44
35_C45_D0.5660.43
26_D49_A0.5600.42
7_E24_R0.5570.42
26_D65_G0.5560.42
60_I66_G0.5530.42
8_Q79_R0.5500.41
65_G80_A0.5470.41
1_M4_S0.5430.40
2_N43_L0.5410.40
21_E36_F0.5390.40
30_I33_V0.5380.40
22_H31_V0.5280.39
24_R36_F0.5250.39
22_H80_A0.5200.38
51_F70_I0.5180.38
26_D58_R0.5180.38
3_I23_E0.5160.38
32_E55_K0.5070.37
81_Q84_N0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9176 81.2 0.893 Contact Map
2rkhA 2 0.8353 64.6 0.906 Contact Map
2x4hA 3 0.8588 57 0.91 Contact Map
3l9fA 2 0.8941 55.2 0.911 Contact Map
1s3jA 2 0.8706 52.2 0.913 Contact Map
2rdpA 2 0.8706 50.4 0.914 Contact Map
3cdhA 4 0.8706 50.2 0.914 Contact Map
3bddA 2 0.8706 50.1 0.914 Contact Map
2e1nA 2 0.9294 49.9 0.914 Contact Map
4o5vA 2 0.8588 47.7 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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