GREMLIN Database
DUF2083 - Predicted transcriptional regulator (DUF2083)
PFAM: PF09856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (157)
Sequences: 3807 (1927)
Seq/√Len: 153.8
META: 0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E68_R5.8181.00
60_L98_I4.5571.00
52_T55_R3.8581.00
11_P100_H3.4831.00
10_V104_L3.4721.00
16_R24_S2.7091.00
12_F104_L2.6401.00
19_R51_A2.6331.00
148_D151_R2.5611.00
97_E100_H2.3651.00
3_Q8_R2.2191.00
72_I94_L2.1811.00
62_E118_A2.1631.00
16_R25_K2.1351.00
61_A71_C2.0361.00
58_T70_F1.9051.00
68_R118_A1.8541.00
71_C93_G1.8471.00
111_D114_D1.8101.00
52_T57_L1.7951.00
100_H103_R1.7621.00
54_G75_T1.7121.00
78_K90_F1.6871.00
124_S127_L1.6391.00
13_F30_T1.6251.00
64_P129_E1.6221.00
79_P87_R1.6191.00
68_R98_I1.5841.00
70_F107_A1.5821.00
22_N137_A1.5771.00
48_E51_A1.5721.00
1_T4_R1.5221.00
63_M123_V1.5141.00
70_F110_L1.5021.00
50_F75_T1.4901.00
17_V91_A1.4761.00
64_P130_R1.4691.00
146_R151_R1.4591.00
125_C128_C1.3821.00
13_F19_R1.3381.00
67_A97_E1.3301.00
60_L110_L1.3031.00
24_S27_F1.3031.00
13_F93_G1.2771.00
17_V46_V1.2621.00
50_F91_A1.2371.00
15_V46_V1.2371.00
83_F105_V1.2361.00
77_S89_R1.2281.00
13_F95_G1.2001.00
48_E119_T1.1991.00
30_T34_F1.1911.00
61_A121_I1.1771.00
62_E130_R1.1771.00
48_E55_R1.1621.00
84_G108_D1.1591.00
45_N71_C1.1441.00
43_L135_Q1.1421.00
120_P132_D1.1341.00
70_F96_C1.1321.00
142_G156_P1.1261.00
131_P140_P1.1221.00
53_P75_T1.1080.99
131_P143_R1.0980.99
35_A124_S1.0810.99
90_F135_Q1.0710.99
35_A91_A1.0560.99
108_D114_D1.0550.99
150_N153_G1.0470.99
32_F38_G1.0390.99
32_F35_A1.0390.99
120_P130_R1.0240.99
146_R149_E1.0100.99
101_A104_L1.0100.99
23_I34_F1.0080.99
10_V96_C0.9980.99
32_F61_A0.9850.99
58_T83_F0.9830.99
50_F54_G0.9640.99
13_F31_G0.9610.99
40_A47_H0.9580.98
133_C136_R0.9470.98
45_N73_A0.9340.98
29_A47_H0.9300.98
56_I75_T0.9170.98
98_I118_A0.9100.98
102_D113_D0.9040.98
63_M121_I0.9020.98
54_G77_S0.9010.98
43_L51_A0.9000.98
129_E141_L0.8970.98
43_L71_C0.8920.98
19_R48_E0.8910.98
14_F25_K0.8900.98
123_V127_L0.8880.98
142_G147_V0.8820.97
60_L118_A0.8810.97
14_F24_S0.8740.97
38_G156_P0.8700.97
124_S135_Q0.8660.97
62_E115_P0.8650.97
51_A89_R0.8630.97
18_D22_N0.8610.97
14_F27_F0.8540.97
15_V93_G0.8540.97
39_G96_C0.8540.97
151_R154_V0.8520.97
54_G89_R0.8480.97
35_A40_A0.8460.97
26_R34_F0.8450.97
37_F40_A0.8430.97
45_N93_G0.8290.96
73_A93_G0.8270.96
60_L112_L0.8040.96
27_F127_L0.8020.95
147_V150_N0.8010.95
60_L68_R0.8000.95
56_I106_Y0.7980.95
150_N154_V0.7970.95
102_D108_D0.7970.95
96_C106_Y0.7950.95
13_F71_C0.7820.95
78_K130_R0.7710.94
62_E66_G0.7620.94
144_P153_G0.7600.94
46_V93_G0.7570.94
41_C136_R0.7560.94
34_F93_G0.7490.93
31_G126_R0.7470.93
124_S152_R0.7460.93
143_R146_R0.7380.93
45_N59_Q0.7370.93
153_G156_P0.7290.93
4_R9_G0.7240.92
146_R154_V0.7220.92
49_A91_A0.7150.92
51_A57_L0.7110.92
60_L70_F0.7100.92
72_I106_Y0.7030.91
70_F104_L0.6970.91
34_F157_Y0.6940.91
146_R157_Y0.6870.90
17_V50_F0.6840.90
128_C133_C0.6770.90
16_R90_F0.6770.90
44_W71_C0.6760.89
128_C136_R0.6710.89
32_F71_C0.6700.89
142_G151_R0.6690.89
38_G96_C0.6660.89
153_G157_Y0.6640.89
52_T75_T0.6630.89
51_A58_T0.6630.89
45_N119_T0.6620.88
144_P150_N0.6590.88
124_S142_G0.6580.88
81_G85_A0.6570.88
4_R7_A0.6560.88
62_E120_P0.6560.88
88_R135_Q0.6520.88
76_V92_I0.6510.88
114_D117_A0.6450.87
138_F156_P0.6420.87
3_Q11_P0.6410.87
36_R49_A0.6400.87
22_N39_G0.6380.87
77_S87_R0.6380.87
46_V69_Y0.6370.87
104_L108_D0.6320.86
22_N106_Y0.6300.86
61_A119_T0.6260.86
29_A95_G0.6250.85
125_C136_R0.6180.85
43_L143_R0.6180.85
89_R92_I0.6170.85
122_G125_C0.6110.84
122_G133_C0.6060.84
144_P147_V0.6050.84
23_I28_S0.5990.83
38_G97_E0.5990.83
29_A35_A0.5990.83
152_R157_Y0.5970.83
27_F30_T0.5950.83
14_F92_I0.5950.83
111_D115_P0.5930.82
46_V126_R0.5920.82
115_P118_A0.5910.82
29_A99_R0.5870.82
39_G74_R0.5830.81
74_R92_I0.5820.81
18_D23_I0.5820.81
60_L111_D0.5820.81
154_V157_Y0.5790.81
144_P154_V0.5770.81
127_L141_L0.5770.81
41_C122_G0.5760.81
109_G112_L0.5750.80
38_G124_S0.5720.80
101_A112_L0.5700.80
56_I74_R0.5670.80
142_G145_L0.5620.79
151_R155_S0.5570.78
75_T92_I0.5540.78
139_P156_P0.5540.78
39_G130_R0.5530.78
35_A93_G0.5400.76
63_M119_T0.5390.76
134_P144_P0.5370.76
17_V45_N0.5320.75
33_P124_S0.5270.74
138_F152_R0.5270.74
22_N96_C0.5250.74
45_N57_L0.5250.74
83_F153_G0.5240.74
5_P10_V0.5220.74
61_A70_F0.5210.74
125_C133_C0.5210.74
98_I112_L0.5170.73
140_P146_R0.5160.73
147_V155_S0.5160.73
17_V93_G0.5130.72
146_R153_G0.5130.72
101_A107_A0.5110.72
3_Q6_G0.5100.72
10_V103_R0.5100.72
149_E154_V0.5090.72
36_R126_R0.5080.72
74_R94_L0.5080.72
145_L155_S0.5070.72
147_V152_R0.5070.72
5_P8_R0.5060.71
149_E156_P0.5050.71
146_R150_N0.5050.71
58_T110_L0.5020.71
112_L117_A0.5010.71
26_R37_F0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mhgA 2 0.2611 12.6 0.947 Contact Map
3kxtA 1 0.2166 7.7 0.952 Contact Map
4o0cA 2 0.3439 6.7 0.953 Contact Map
3ph9A 1 0.4713 3.7 0.959 Contact Map
4k9zA 3 0.2739 2.9 0.961 Contact Map
1r4wA 2 0.3121 2.8 0.961 Contact Map
3fk8A 1 0.4204 2.5 0.962 Contact Map
3l9vA 1 0.3057 2.3 0.963 Contact Map
3kcmA 1 0.4331 2.2 0.963 Contact Map
3kh7A 1 0.4395 2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0064 seconds.